Мазь белого или белого с желтоватым оттенком цвета
Фармакотерапевтическая группа
Противовирусное средство для местного применения
Фармакологические свойства
Фармакодинамика:
Ацикловир является противовирусным средством из группы синтетических аналогов ациклического пуринового нуклеозида - дезоксигуанидина являющегося компонентом ДНК. Ацикловир обладает высокой специфичностью в отношении вирусов Herpes simplex 1 и 2 типов вируса вызывающего ветряную оспу и опоясывающий лишай (Varicella zoster) вируса Эпштейна-Барр. Умеренно активен в отношении цитомегаловируса.
Ацикловир проникает непосредственно в инфицированные вирусом клетки. Клетки инфицированные вирусом продуцируют вирусную тимидинкиназу которая в свою очередь фосфорирует ацикловир до ацикловиртрифосфата являющегося активным и селективным ингибитором ДНК-полимеразы вирусов. Вероятно механизм ингибирования ацикловиртрифосфатом синтеза ДНК состоит в том что она является для этого фермента субстратом позволяющим осуществить связь 3'-5' необходимую для продления цепочки ДНК.
Таким образом осуществляется преждевременный разрыв цепи ДНК что приводит к подавлению репликации вируса.
Фармакокинетика:
При применении мази на интактной коже: всасывание минимальное. Пораженная кожа: всасывание умеренное.
Показания к применению
Инфекции кожи вызванные вирусом Herpes simplex 1 и 2 типов генитальный герпес опоясывающий лишай ветряная оспа.
Противопоказания
Гиперчувствительность к ацикловиру или какому-либо другому компоненту препарата.
Способ применения и дозы
Наружно. Мазь наносят на пораженные участки 5 раз в сутки примерно каждые 3 часа. Мазь наносят либо ватным тампоном либо чистыми руками чтобы избежать дополнительного инфицирования пораженных участков. Терапию следует продолжать до того времени пока на пузырьках не образуется корка либо пока они полностью не заживут. Продолжительность лечения - не менее 5 дней максимум 10 дней. В случае сохранения симптомов заболевания более 10 дней или при значительном усугублении симптомов следует обратиться к врачу.
Побочное действие
Гиперемия сухость шелушение кожи; жжение воспаление при попадании на слизистые оболочки. Возможно развитие аллергического дерматита.
Взаимодействие с другими лекарственными средствами
Усиление эффекта отмечается при одновременном назначении иммуностимулятора.
Особые указания
Мазь не следует наносить на слизистые оболочки полости рта глаз носа и влагалища. Эффективность лечения будет тем выше чем раньше оно начато (при первых признаках инфекции). Для реализации лечебного эффекта ацикловира имеет значение состояние иммунной системы организма. Пациентам со сниженным иммунитетом (при ВИЧ/СПИДе или после трансплантации костного мозга) на фоне местного применения мази ацикловира следует назначать системное введение препарата так же как в случае тяжелого и рецидивирующего течения герпетической инфекции.
Ацикловир не предупреждает передачу герпеса половым путем поэтому в период лечения необходимо воздерживаться от половых контактов даже при отсутствии клинических проявлений.
Эффективность и безопасность применения у детей не установлены.
Форма выпуска
Мазь для наружного применения 5 % по 5 и 10 г.
Условия хранения
Хранить при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
2 года. Не использовать по истечении срока годности указанного на упаковке.
Условия отпуска
По рецепту
Производитель
Акционерное общество "Муромский приборостроительный завод" (АО "МПЗ"), 602205, Владимирская обл., г. Муром, ул. 30 лет Победы, д. 1а, Россия
Организация, принимающая претензии потребителей
АО "МПЗ"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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