Возмещение недостатка углеводов в организме. Коррекция дегидратации вследствие рвоты, диареи, в послеоперационном периоде. Дезинтоксикационная инфузионная терапия. Коллапс, шок (как компонент различных кровезамещающих и противошоковых жидкостей). Используется для приготовления растворов лекарственных средств для в/в введения.
Изотонический раствор декстрозы (5%) используется для пополнения организма жидкостью. Кроме того, он является источником ценного питательного вещества, которое легко усваивается. При метаболизме глюкозы в тканях выделяется значительное количество энергии, необходимой для жизнедеятельности организма.
При в/в введении гипертонических растворов (10%, 20%, 40%) повышается осмотическое давление крови, усиливается ток жидкости из тканей в кровь, повышаются процессы обмена веществ, улучшается антитоксическая функция печени, усиливается сократительная деятельность сердечной мышцы, расширяются сосуды, увеличивается диурез.
Фармакокинетика
Во время введения раствора в первую очередь декстроза поступает во внутрисосудистое пространство с последующим переходом в клетки.
В процессе гликолиза глюкоза превращается в пируват или лактат. Далее лактат частично может посредством реакций цикла Кори вновь быть вовлечен в метаболизм глюкозы. Пируват полностью окисляется кислородом до CO2 и H2O. Продукты окисления глюкозы выводятся легкими (CO2) и почками (H2O).
В норме глюкоза не элиминируется почками. При патологических состояниях, таких как сахарный диабет, нарушения метаболизма с гипергликемией, когда концентрация глюкозы в крови превышает 180 мг/100 мл или 10 ммоль/л, глюкоза выводится почками (глюкозурия).
Показания к применению
Возмещение недостатка углеводов в организме. Коррекция дегидратации вследствие рвоты, диареи, в послеоперационном периоде. Дезинтоксикационная инфузионная терапия. Коллапс, шок (как компонент различных кровезамещающих и противошоковых жидкостей). Используется для приготовления растворов лекарственных средств для в/в введения.
При необходимости применения больших объемов могут проявляться противопоказания, связанные с дозой декстрозы и/или с перегрузкой объемом: гипергидратация; гипотоническая дегидратация.
С осторожностью
С осторожностью назначают декстрозу при хронической почечной недостаточности (олигоанурии).
Применение при беременности и в период грудного вскармливания
Возможно применение декстрозы при беременности и в период грудного вскармливания по показаниям. Следует контролировать концентрацию глюкозы в крови.
Способ применения и дозы
Растворы декстрозы вводят в/в капельно.
5% раствор: максимально до 150 капель/мин, максимальная суточная доза для взрослых - 2 л;
10% раствор: максимально до 60 капель/мин, максимальная суточная доза для взрослых - 500 мл;
20% раствор: максимально до 40 капель/мин, максимальная суточная доза для взрослых - 300 мл;
40% раствор: максимально до 30 капель/мин, максимальная суточная доза для взрослых - 250 мл.
Побочное действие
Со стороны обмена веществ: возможны нарушения ионного баланса, гипергликемия.
Со стороны сердечно-сосудистой системы: гиперволемия, острая левожелудочковая недостаточность.
Прочие: лихорадка.
Местные реакции: редко - местное раздражение, развитие инфекции, тромбофлебит.
Особые указания
С осторожностью назначают декстрозу при декомпенсированной сердечной недостаточности, хронической почечной недостаточности (олигоанурии), гипонатриемии.
Для повышения осмолярности 5% раствор декстрозы можно комбинировать с изотоническим раствором хлорида натрия.
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Следует контролировать концентрацию глюкозы в крови."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Растворы декстрозы вводят в/в капельно."}},{"type":"paragraph","data":{"text":"5% раствор: максимально до 150 капель/мин, максимальная суточная доза для взрослых - 2 л;"}},{"type":"paragraph","data":{"text":"10% раствор: максимально до 60 капель/мин, максимальная суточная доза для взрослых - 500 мл;"}},{"type":"paragraph","data":{"text":"20% раствор: максимально до 40 капель/мин, максимальная суточная доза для взрослых - 300 мл;"}},{"type":"paragraph","data":{"text":"40% раствор: максимально до 30 капель/мин, максимальная суточная доза для взрослых - 250 мл."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны обмена веществ:\u003c/i\u003e возможны нарушения ионного баланса, гипергликемия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e гиперволемия, острая левожелудочковая недостаточность."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e лихорадка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМестные реакции:\u003c/i\u003e редко - местное раздражение, развитие инфекции, тромбофлебит."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"С осторожностью назначают декстрозу при декомпенсированной сердечной недостаточности, хронической почечной недостаточности (олигоанурии), гипонатриемии."}},{"type":"paragraph","data":{"text":"Для повышения осмолярности 5% раствор декстрозы можно комбинировать с изотоническим раствором хлорида натрия."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cb\u003eРаствор для инфузий 5%\u003c/b\u003e\u003c/i\u003e"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.vidal.ru/drugs/firm/704\"\u003eКУРСКАЯ БИОФАБРИКА - ФИРМА \"БИОК\", ФГУП\u003c/a\u003e (Россия) "}}]}],"source":null},"description_toggle":false,"short_description":"Средство для регидратации и дезинтоксикации. 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