Клотримазол подавляет рост и деление микроорганизмов и может оказывать фунгистатическое (задерживающее и останавливающее рост клеток грибов) или фунгицидное (приводящее к гибели грибов) действие. Клотримазол угнетает синтез эргостерола и связывается с фосфолипидами клеточной мембраны гриба что приводит к изменению проницаемости мембран клеток.
В конечном итоге воздействие клотримазола на грибковые клетки приводит к их гибели.
Спектр активности
Клотримазол характеризуется широким спектром противогрибковой активности:
Также он активен в отношении некоторых грамположительных бактерий возбудителя разноцветного лишая (Malassezia furfur) и возбудителя эритразмы.
Грибы устойчивые к клотримазолу встречаются крайне редко; есть данные только по отдельным штаммам Candida guilliermondii.
Не сообщалось о развитии устойчивости у чувствительных к клотримазолу грибов после пассажа Candida albicans и Trichophyton mentagrophytes.
He описано случаев развития устойчивости к клотримазолу у штаммов С. albicans устойчивых к полиеновым антибиотикам вследствие химической мутации.
Фармакокинетика:
Всасывание и распределение
Фармакокинетические исследования показали что клотримазол практически не всасывается в системный кровоток при нанесении препарата на неповрежденные или воспаленные участки кожи. Концентрации клотримазола в сыворотке крови были ниже предела обнаружения (0001 мкг/мл) подтверждая тот факт что клотримазол при наружном применении не приводит к клинически значимым системным эффектам. Концентрация в глубоких слоях эпидермиса выше чем минимальная подавляющая концентрация для дерматофитов. При наружном применении концентрация клотримазола в эпидермисе выше чем в дерме и подкожной клетчатке.
Метаболизм и выведение
Клотримазол распадается в печени до неактивных веществ выводимых из организма почками и кишечником.
Показания к применению
Для наружного лечения грибковых заболеваний кожи вызванных дерматофитами дрожжеподобными грибами плесневыми грибами а также возбудителями чувствительными к клотримазолу: микозы стоп кистей туловища кожных складок; кандидозный вульвит кандидозный баланит; отрубевидный лишай и эритразмы грибковыеинфекции наружного уха.
Противопоказания
Повышенная чувствительность к клотримазолу или другим компонентам препарата.
I триместр беременности.
С осторожностью
Беременность (II и III триместры) период лактации.
Применение при беременности и в период грудного вскармливания
Применение препарата при беременности допускается только в случае если по мнению врача потенциальная польза от применения крема для матери превышает возможный риск для плода.
Имеются ограниченные клинические данные о применении клотримазола у беременных женщин. Потенциальный риск для человека неизвестен.
Применение в I триместре беременности противопоказано.
Применение препарата в период грудного вскармливания допускается только в случае если по мнению врача потенциальная польза от применения крема для матери превышает возможный риск для ребенка. Нанесение препарата непосредственно на молочную железу при грудном вскармливании противопоказано.
Способ применения и дозы
Для наружного применения.
Крем следует наносить тонким слоем на пораженные участки кожи 2-3 раза в день.
Крем следует наносить на чистые сухие участки пораженной кожи (вымытой мылом с нейтральным pH) на стопы крем следует наносить между пальцами.
Продолжительность лечения зависит от тяжести заболевания его локализации эффективности лечения.
Продолжительность лечения:
- дерматомикозы - в течение 3-4 недель;
- эритразма - 2-4 недели;
- отрубевидный лишай - 1-3 недели;
- кандидозный вульвит и баланит - 1-2 недели.
Для профилактики рецидивов лечение следует продолжать по крайней мере в течение двух недель после исчезновения всех симптомов инфекции.
Если после 7 дней лечения не наступает улучшение симптоматики необходимо проконсультироваться с врачом.
Особые группы пациентов
Отсутствуют данные по коррекции дозы для детей пациентов пожилого возраста пациентов с нарушением функции почек и печени.
Побочное действие
Нежелательные явления представленные ниже перечислены в соответствии с поражением органов систем органов и частотой встречаемости.
Частота встречаемости определяется следующим образом: очень часто (≥1/10) часто (≥1/100 и <1/10) нечасто (≥1/1000 и <1/100) редко (≥1/10000 и <1/1000) очень редко (<1/10000 включая отдельные случаи) неизвестно (частота не может быть оценена но имеющимся на настоящий момент данным).
Нарушение со стороны иммунной системы: неизвестно - аллергическая реакция (проявляющаяся крапивницей обмороком снижением артериального давления одышкой);
Нарушение со стороны кожи и подкожных тканей: неизвестно - сыпь зуд пузырьковые высыпания шелушение боль или дискомфорт отек жжение раздражение.
Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции сообщите об этом врачу.
Передозировка
При случайном приеме препарата внутрь возможно проявление следующих симптомов: головокружение тошнота рвота.
При случайном приеме крема внутрь следует проводить симптоматическое лечение.
При наружном применении препарата передозировка маловероятна.
Взаимодействие с другими лекарственными средствами
Не изучалось.
Особые указания
Необходимо избегать попадания крема на слизистую оболочку глаз.
Не глотать.
Все инфицированные области следует лечить одновременно.
В состав препарата входит цетостеариловый спирт который может вызывать местные кожные реакции (например контактный дерматит).
При появлении симптомов повышенной чувствительности или раздражения лечение прекращают.
Данные лабораторных исследований свидетельствуют о том что использование контрацептивов содержащих латекс может вызвать их повреждение при совместном применении с клотримазолом. Следовательно эффективность таких контрацептивов может снижаться. Пациентам следует рекомендовать применение альтернативных методов контрацепции в течение по крайней мере пяти дней после применения клотримазола.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат не влияет па способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Крем для наружного применения 1%
Условия хранения
В защищенном от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не использовать после истечения срока годности.
Условия отпуска
Без рецепта
Производитель
Общество с ограниченной ответственностью "Озон" (ООО "Озон"), 445351, Самарская, обл., г. Жигулевск, ул. Гидростроителей, д. 6; д. 6, стр. 1; д. 6-А; д. 6-А, стр. 1, Россия
Организация, принимающая претензии потребителей
ООО "Атолл"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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18.06.15"}}]},{"id":2,"name":"Торговое название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Клотримазол"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"крем для наружного применения"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"В 100 г крема содержится:"}},{"type":"paragraph","data":{"text":"Активное вещество: клотримазол - 1,00 г."}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: динатрия эдетата дигидрат - 0,75 г; вода - 4,50 г; полоксамер 338 - 5,00 г; макрогол-4000 - 5,00 г; макрогол-1500 - 20,00 г; цетостеариловый спирт - 2,50 г; макрогол цетостеариловый эфир 20 - 2,50 г; пропиленгликоль - 29,45 г; макрогол-400 - до 100,00 г."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Однородный крем белого цвета."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противогрибковое средство"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"header","data":{"text":"Фармакодинамика:","level":3}},{"type":"paragraph","data":{"text":"Механизм действия"}},{"type":"paragraph","data":{"text":"Клотримазол подавляет рост и деление микроорганизмов и может оказывать фунгистатическое (задерживающее и останавливающее рост клеток грибов) или фунгицидное (приводящее к гибели грибов) действие. Клотримазол угнетает синтез эргостерола и связывается с фосфолипидами клеточной мембраны гриба что приводит к изменению проницаемости мембран клеток."}},{"type":"paragraph","data":{"text":"В конечном итоге воздействие клотримазола на грибковые клетки приводит к их гибели."}},{"type":"paragraph","data":{"text":"Спектр активности"}},{"type":"paragraph","data":{"text":"Клотримазол характеризуется широким спектром противогрибковой активности:"}},{"type":"paragraph","data":{"text":"- дерматофиты (Epidermophyton floccosum Microsporum canis Trichophyton mentagrophytes Trichophyton rubrum);"}},{"type":"paragraph","data":{"text":"- дрожжи (Candida spp. Cryptococcus neoformans);"}},{"type":"paragraph","data":{"text":"- диморфные грибы (Coccidioides immitis Histoplasma capsulatum Paracoccidioides brasiliensis);"}},{"type":"paragraph","data":{"text":"- простейшие (Trichomonasvaginalis)."}},{"type":"paragraph","data":{"text":"Также он активен в отношении некоторых грамположительных бактерий возбудителя разноцветного лишая (Malassezia furfur) и возбудителя эритразмы."}},{"type":"paragraph","data":{"text":"Грибы устойчивые к клотримазолу встречаются крайне редко; есть данные только по отдельным штаммам Candida guilliermondii."}},{"type":"paragraph","data":{"text":"Не сообщалось о развитии устойчивости у чувствительных к клотримазолу грибов после пассажа Candida albicans и Trichophyton mentagrophytes."}},{"type":"paragraph","data":{"text":"He описано случаев развития устойчивости к клотримазолу у штаммов С. albicans устойчивых к полиеновым антибиотикам вследствие химической мутации."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Всасывание и распределение"}},{"type":"paragraph","data":{"text":"Фармакокинетические исследования показали что клотримазол практически не всасывается в системный кровоток при нанесении препарата на неповрежденные или воспаленные участки кожи. Концентрации клотримазола в сыворотке крови были ниже предела обнаружения (0001 мкг/мл) подтверждая тот факт что клотримазол при наружном применении не приводит к клинически значимым системным эффектам. Концентрация в глубоких слоях эпидермиса выше чем минимальная подавляющая концентрация для дерматофитов. При наружном применении концентрация клотримазола в эпидермисе выше чем в дерме и подкожной клетчатке."}},{"type":"paragraph","data":{"text":"Метаболизм и выведение"}},{"type":"paragraph","data":{"text":"Клотримазол распадается в печени до неактивных веществ выводимых из организма почками и кишечником."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Для наружного лечения грибковых заболеваний кожи вызванных дерматофитами дрожжеподобными грибами плесневыми грибами а также возбудителями чувствительными к клотримазолу: микозы стоп кистей туловища кожных складок; кандидозный вульвит кандидозный баланит; отрубевидный лишай и эритразмы грибковыеинфекции наружного уха."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к клотримазолу или другим компонентам препарата."}},{"type":"paragraph","data":{"text":"I триместр беременности."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Беременность (II и III триместры) период лактации."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата при беременности допускается только в случае если по мнению врача потенциальная польза от применения крема для матери превышает возможный риск для плода."}},{"type":"paragraph","data":{"text":"Имеются ограниченные клинические данные о применении клотримазола у беременных женщин. Потенциальный риск для человека неизвестен."}},{"type":"paragraph","data":{"text":"Применение в I триместре беременности противопоказано."}},{"type":"paragraph","data":{"text":"Применение препарата в период грудного вскармливания допускается только в случае если по мнению врача потенциальная польза от применения крема для матери превышает возможный риск для ребенка. Нанесение препарата непосредственно на молочную железу при грудном вскармливании противопоказано."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Для наружного применения."}},{"type":"paragraph","data":{"text":"Крем следует наносить тонким слоем на пораженные участки кожи 2-3 раза в день."}},{"type":"paragraph","data":{"text":"Крем следует наносить на чистые сухие участки пораженной кожи (вымытой мылом с нейтральным pH) на стопы крем следует наносить между пальцами."}},{"type":"paragraph","data":{"text":"Продолжительность лечения зависит от тяжести заболевания его локализации эффективности лечения."}},{"type":"paragraph","data":{"text":"Продолжительность лечения:"}},{"type":"paragraph","data":{"text":"- дерматомикозы - в течение 3-4 недель;"}},{"type":"paragraph","data":{"text":"- эритразма - 2-4 недели;"}},{"type":"paragraph","data":{"text":"- отрубевидный лишай - 1-3 недели;"}},{"type":"paragraph","data":{"text":"- кандидозный вульвит и баланит - 1-2 недели."}},{"type":"paragraph","data":{"text":"Для профилактики рецидивов лечение следует продолжать по крайней мере в течение двух недель после исчезновения всех симптомов инфекции."}},{"type":"paragraph","data":{"text":"Если после 7 дней лечения не наступает улучшение симптоматики необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"Особые группы пациентов"}},{"type":"paragraph","data":{"text":"Отсутствуют данные по коррекции дозы для детей пациентов пожилого возраста пациентов с нарушением функции почек и печени."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Нежелательные явления представленные ниже перечислены в соответствии с поражением органов систем органов и частотой встречаемости."}},{"type":"paragraph","data":{"text":"Частота встречаемости определяется следующим образом: очень часто (≥1/10) часто (≥1/100 и <1/10) нечасто (≥1/1000 и <1/100) редко (≥1/10000 и <1/1000) очень редко (<1/10000 включая отдельные случаи) неизвестно (частота не может быть оценена но имеющимся на настоящий момент данным)."}},{"type":"paragraph","data":{"text":"Нарушение со стороны иммунной системы: неизвестно - аллергическая реакция (проявляющаяся крапивницей обмороком снижением артериального давления одышкой);"}},{"type":"paragraph","data":{"text":"Нарушение со стороны кожи и подкожных тканей: неизвестно - сыпь зуд пузырьковые высыпания шелушение боль или дискомфорт отек жжение раздражение."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются или Вы заметили любые другие побочные эффекты не указанные в инструкции сообщите об этом врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"При случайном приеме препарата внутрь возможно проявление следующих симптомов: головокружение тошнота рвота."}},{"type":"paragraph","data":{"text":"При случайном приеме крема внутрь следует проводить симптоматическое лечение."}},{"type":"paragraph","data":{"text":"При наружном применении препарата передозировка маловероятна."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не изучалось."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо избегать попадания крема на слизистую оболочку глаз."}},{"type":"paragraph","data":{"text":"Не глотать."}},{"type":"paragraph","data":{"text":"Все инфицированные области следует лечить одновременно."}},{"type":"paragraph","data":{"text":"В состав препарата входит цетостеариловый спирт который может вызывать местные кожные реакции (например контактный дерматит)."}},{"type":"paragraph","data":{"text":"При появлении симптомов повышенной чувствительности или раздражения лечение прекращают."}},{"type":"paragraph","data":{"text":"Данные лабораторных исследований свидетельствуют о том что использование контрацептивов содержащих латекс может вызвать их повреждение при совместном применении с клотримазолом. Следовательно эффективность таких контрацептивов может снижаться. Пациентам следует рекомендовать применение альтернативных методов контрацепции в течение по крайней мере пяти дней после применения клотримазола."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не влияет па способность управлять транспортными средствами и заниматься другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Крем для наружного применения 1%"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Озон\" (ООО \"Озон\"), 445351, Самарская, обл., г. Жигулевск, ул. Гидростроителей, д. 6; д. 6, стр. 1; д. 6-А; д. 6-А, стр. 1, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Атолл\""}}]}],"source":null},"description_toggle":false,"short_description":"Механизм действия Клотримазол подавляет рост и деление микроорганизмов и может оказывать фунгистатическое (задерживающее и останавливающее рост клеток грибов) или фунгицидное (приводящее к гибели грибов) действие. Клотримазол угнетает синтез эргостерола и связывается с фосфолипидами клеточной мембраны гриба что приводит к изменению проницаемости мембран клеток. В конечном итоге воздействие клотримазола на грибковые клетки приводит к их гибели. Спектр активности Клотримазол характеризуется широким спектром противогрибковой активности: - дерматофиты (Epidermophyton floccosum Microsporum canis Trichophyton mentagrophytes Trichophyton rubrum); - дрожжи (Candida spp. Cryptococcus neoformans); - диморфные грибы (Coccidioides immitis Histoplasma capsulatum Paracoccidioides brasiliensis); - простейшие (Trichomonasvaginalis). Также он активен в отношении некоторых грамположительных бактерий возбудителя разноцветного лишая (Malassezia furfur) и возбудителя эритразмы. Грибы устойчивые к клотримазолу встречаются крайне редко; есть данные только по отдельным штаммам Candida guilliermondii. Не сообщалось о развитии устойчивости у чувствительных к клотримазолу грибов после пассажа Candida albicans и Trichophyton mentagrophytes. He описано случаев развития устойчивости к клотримазолу у штаммов С. albicans устойчивых к полиеновым антибиотикам вследствие химической мутации. Всасывание и распределение Фармакокинетические исследования показали что клотримазол практически не всасывается в системный кровоток при нанесении препарата на неповрежденные или воспаленные участки кожи. Концентрации клотримазола в сыворотке крови были ниже предела обнаружения (0001 мкг/мл) подтверждая тот факт что клотримазол при наружном применении не приводит к клинически значимым системным эффектам. Концентрация в глубоких слоях эпидермиса выше чем минимальная подавляющая концентрация для дерматофитов. При наружном применении концентрация клотримазола в эпидермисе выше чем в дерме и подкожной клетчатке. 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