Флуоксетин Капсулы, 30 шт, 20 мг, для взрослых

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Препарат выделяется с грудным молоком (до 25% от концентрации в сыворотке крови)."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"-Депрессии различной этиологии."}},{"type":"paragraph","data":{"text":"-Обсессивно-компульсивные расстройства."}},{"type":"paragraph","data":{"text":"-Булимический невроз."}},{"type":"paragraph","data":{"text":"-Предменструальное дисфорическое расстройство."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность одновременный прием ингибиторов МАО (и в течение 14 дней после их отмены) тиоридазина (и в течение 5 нед после отмены флуоксетина) пимозида тяжелые нарушения функции почек (клиренс креатинина менее 10 мл/мин) и печени беременность период лактации возраст до 18 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Сахарный диабет эпилепсия судорожные расстройства (в т.ч. в анамнезе) суицидальная настроенность."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь."}},{"type":"paragraph","data":{"text":"Депрессия. Начальная доза составляет 20 мг 1 раз в сутки в первой половине дня независимо от приема пищи. При необходимости и переносимости доза может быть увеличена до 40-60 мг в сутки (на 20 мг в неделю) разделенных на 2-3 приема. Максимальная суточная доза - 80 мг. Терапевтический эффект препарата устанавливается через 1-4 недели после начала лечения у некоторых пациентов он может достигаться позже."}},{"type":"paragraph","data":{"text":"Обсессивно-компульсивные расстройства - рекомендованная доза составляет 20-60 мг в сутки. При нервной булимии рекомендованная доза составляет 60 мг в сутки разделенных на 2-3 приема."}},{"type":"paragraph","data":{"text":"Предменструальные дисфорические расстройства: рекомендованная доза составляет 20 мг в сутки У больных пожилого возраста рекомендуемая начальная суточная доза составляет 20 мг."}},{"type":"paragraph","data":{"text":"У больных с нарушениями функции печени и почек рекомендуется применение более низких доз и удлинение интервала между приемами."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны центральной нервной системы: усиление суицидальных тенденций тревога головная боль тремор ажитация повышенная раздражительность нарушение сна головокружение сонливость астенические расстройства уменьшение либидо маниакальные и судорожные расстройства."}},{"type":"paragraph","data":{"text":"Со стороны желудочно-кишечного тракта: снижение аппетита нарушение вкуса тошнота рвота сухость во рту или гиперсаливация диарея."}},{"type":"paragraph","data":{"text":"Со стороны мочеполовой системы: недержание или задержка мочи дисменорея вагинит снижение либидо половая дисфункция у мужчин (замедленная эякуляция)."}},{"type":"paragraph","data":{"text":"Редко встречаются аллергические реакции в виде кожной сыпи зуда озноба крапивницы повышения температуры тела боли в мышцах и суставах (возможно применение"}},{"type":"paragraph","data":{"text":"антигистаминных и стероидных препаратов) гипонатриемия ортостатическая гипотония тахикардия нарушение остроты зрения."}},{"type":"paragraph","data":{"text":"Прочие: повышенное потоотделение тахикардия системные нарушения со стороны легких почек или печени васкулиты."}},{"type":"paragraph","data":{"text":"Возможно развитие анорексии и уменьшение массы тела."}},{"type":"paragraph","data":{"text":"Указанные побочные эффекты чаще возникают в начале терапии флуоксетином или при повышении дозы препарата."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: ажитация маниакальные и судорожные расстройства нарушения сердечного ритма тахикардия тошнота рвота."}},{"type":"paragraph","data":{"text":"Лечение: специфические антагонисты к флуоксетину не найдены. Проводится симптоматическая терапия промывание желудка с назначением активированного угля при судорагах - диазепам поддержание дыхания сердечной деятельности температуры тела."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Усиливает эффекты алпразолама диазепама этилового спирта и гипогликемических лекарственных средств (ЛС)."}},{"type":"paragraph","data":{"text":"Повышает в плазме концентрацию фенитоина трициклических антидепрессантов мапротилина тразодона в 2 раза (необходимо на 50 % снижать дозу трициклических антидепрессантов при одновременном применении)."}},{"type":"paragraph","data":{"text":"Возможно повышение концентрации лития - риск развития токсических эффектов лития. Эти ЛС следует применять одновременно с осторожностью рекомендуется частое определение концентрации лития в сыворотке крови."}},{"type":"paragraph","data":{"text":"На фоне проведения электросудорожной терапии возможно развитие продолжительных эпилептических припадков."}},{"type":"paragraph","data":{"text":"Триптофан усиливает серотонинергические свойства флуоксетина (усиление ажитации двигательного беспокойства нарушений со стороны желудочно-кишечного тракта)."}},{"type":"paragraph","data":{"text":"Ингибиторы МАО повышают риск развития серотонинового синдрома (гипертермия озноб повышенное потоотделение миоклонус гиперрефлексия тремор диарея нарушения координации движений вегетативная лабильность психомоторное возбуждение бредовые расстройства угнетение сознания вплоть до комы)."}},{"type":"paragraph","data":{"text":"ЛС оказывающие угнетающее влияние на центральную нервную систему повышают риск развития побочных эффектов и усиления угнетающего действия на центральную нервную систему."}},{"type":"paragraph","data":{"text":"При одновременном применении с ЛС обладающими высокой степенью связывания с белками особенно с антикоагулянтами и дигитоксином возможно повышение концентрации в плазме свободных (несвязанных) ЛС и увеличение риска развития неблагоприятных эффектов. Флуоксетин усиливает действие гипогликемических препаратов и антикоагулянтов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"При лечении больных с дефицитом массы тела следует учитывать анорексигенные эффекты (возможна прогрессирующая потеря массы тела)."}},{"type":"paragraph","data":{"text":"У больных сахарным диабетом назначение флуоксетина повышает риск развития гипогликемии и гипергликемии - при его отмене. В связи с этим доза инсулина и/или любых др. гипогликемических ЛС применяемых внутрь должна быть скорректирована. До наступления значительного улучшения в лечении больные должны находиться под наблюдением врача."}},{"type":"paragraph","data":{"text":"Во время лечения следует воздерживаться от приема алкоголя и занятий потенциально опасными видами деятельности требующими повышенного внимания и быстроты психических и двигательных реакций."}},{"type":"paragraph","data":{"text":"После применения ингибиторов МАО назначение флуоксетина допускается не ранее 14 дней. Не следует применять ингибиторы МАО и/или тиоридазин ранее чем через 5 недель после отмены флуоксетина."}},{"type":"paragraph","data":{"text":"При развитии на фоне приёма флуоксетина судорожных припадков препарат следует отменить. При заболеваниях печени и в пожилом возрасте лечение следует начинать с минимальных доз."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 10 мг и 20 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Список Б. Хранить в сухом защищенном от света месте при температуре не выше 25 °С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не применять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Общество с ограниченной ответственностью \"Озон\" (ООО \"Озон\"), 445351, Самарская обл., г. Жигулёвск, ул. Гидростроителей, д. 6, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО \"Озон\""}}]}],"source":null},"description_toggle":false,"short_description":"Избирательно блокирует обратный нейрональный захват серотонина (5НТ) в синапсах нейронов центральной нервной системы. Ингибирование обратного захвата серотонина приводит к повышению концентрации этого нейромедиатора в синаптической щели усиливает и пролонгирует его действие на постсинаптические рецепторные участки. В терапевтических дозах флуоксетин блокирует захват серотонина тромбоцитами человека. Является слабым антагонистом мускариновых гистаминовых H1 адренергических а1 и а2 рецепторов мало влияет на обратный захват дофамина. Вызывает редукцию обсессивно- комиульсивных расстройств а также снижение аппетита что может привести к снижению массы тела. Не вызывает седативного эффекта. При приеме в средних терапевтических дозах практически не влияет на функции сердечно-сосудистой и других систем. При приеме внутрь препарат хорошо всасывается из желудочно-кишечного тракта (до 95% принятой дозы) применение с пищей незначительно тормозит всасывание флуоксетина. Максимальные концентрации в плазме крови достигаются через 6-8 часов. Биодоступность флуоксетина после приема внутрь составляет более 60 %. Препарат хорошо накапливается в тканях легко проникает через гематоэнцефалический барьер связывание с белками плазмы крови составляет более 90%. Метаболизируется в печени путем деметилироваиия до активного метаболита норфлуоксетина и ряда неидентифицированных метаболитов. Выводится почками величина клиренса флуоксетина составляет 94-704 мл/мин норфлуоксетина 60-336 мл/мин. Около 12 % препарата выделяется через желудочно-кишечный тракт. Период полувыведения флуоксетина составляет около 2-3 суток норфлуоксетина - 7-9 суток. У больных с печеночной недостаточностью период полувыведения флуоксетина и норфлуоксетина удлиняется. Препарат выделяется с грудным молоком (до 25% от концентрации в сыворотке крови).","substance":[{"id":1359,"title":"Флуоксетин","title_latin":"Fluoxetinum","slug":"fluoksetin_1359"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Флуоксетин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/83164/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/83164/share_default/"}},"diseases":[],"other_packages":[{"id":98379,"title":"Флуоксетин","subtitle":{"full":"Капсулы, 20 шт, 20 мг, для внутреннего применения, для взрослых, антидепрессант","short":"Капсулы, 20 шт, 20 мг","package":"20 шт, 20 мг"},"prescription":true,"catalog_section_id":100271,"manufacturer":{"id":5283,"title":"G.L. 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