Этамзилат Раствор, 10 шт, 2 мл, 125 мг / мл, для инъекций

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Через 5 минут после внутривенного введения почками выделяется 20-30% введенного препарата полностью - через 4 часа."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Профилактика и остановка кровотечений: паренхиматозные и капиллярные кровотечения (в том числе травматическое в хирургии при операциях на сильно васкуляризированных органах и тканях при оперативных вмешательствах в стоматологической урологической офтальмологической отоларингологической практике кишечное почечное легочное кровотечения метро- и меноррагии при фибромиоме и др.) вторичные кровотечения на фоне тромбоцитопении и тромбоцитопатии гипокоагуляция гематурия внутричерепное кровоизлияние (в том числе у новорожденных и недоношенных детей) носовые кровотечения на фоне артериальной гипертензии кровотечения обусловленные приемом лекарственных средств геморрагический диатез (в том числе болезнь Верльгофа Виллебранда-Юргенса тромбоцитопатия) диабетическая микроангиопатия (геморрагическая диабетическая ретинопатия повторное кровоизлияние в сетчатку гемофтальм)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к любому ингредиенту препарата острая порфирия гемобластоз у детей тромбоз тромбоэмболия."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При кровотечениях на фоне передозировки антикоагулянтов беременность."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Безопасность применения этамзилата при беременности не установлена. 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Этамзилат можно вводить внутривенно капельно в 5% растворе глюкозы или в изотоническом растворе натрия хлорида."}},{"type":"paragraph","data":{"text":"Взрослым: с профилактической целью при оперативных вмешательствах препарат вводят внутривенно или внутримышечно за 1 час до операции в дозе 025-05 г (2-4 мл раствора 125 мг/мл) при необходимости во время операции внутривенно - в дозе 025-05 г (2-4 мл раствора 125 мг/мл) при опасности послеоперационного кровотечения внутривенно или внутримышечно - 05-075 г (4-6 мл раствора 125 мг/мл) равномерно в течение суток."}},{"type":"paragraph","data":{"text":"Детям: при необходимости во время операции вводят внутривенно из расчета 8-10 мг/кг массы тела."}},{"type":"paragraph","data":{"text":"Для остановки кровотечения вводят внутривенно или внутримышечно 025-05 г (2-4 мл раствора 125 мг/мл) после чего каждые 4-6 часов по 025 г (2 мл раствора 125 мг/мл) в течение 5-10 дней."}},{"type":"paragraph","data":{"text":"При лечении метро- и меноррагий препарат назначают в разовой дозе 025 г (2 мл раствора 125 мг/мл) внутривенно или внутримышечно каждые 6-8 часов в течение 5-10 дней."}},{"type":"paragraph","data":{"text":"При диабетической микроангиопатии препарат вводят внутримышечно в разовой дозе 025-05 г три раза в сутки в течение 10-14 дней."}},{"type":"paragraph","data":{"text":"В офтальмологии препарат вводят субконъюнктивально или ретробульбарно - в дозе 0125 г (1 мл раствора 125 мг/мл)."}},{"type":"paragraph","data":{"text":"Раствор для инъекций можно применять местно (стерильный тампон пропитывают и накладывают на рану."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Головная боль головокружение покраснение лица аллергическая сыпь парестезии нижних конечностей снижение артериального давления."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Нельзя смешивать Этамзилат с другими лекарственными средствами."}},{"type":"paragraph","data":{"text":"Введение препарата в дозе 10 мг/кг массы тела за 1 час до введения растворов декстранов со средней молекулярной массой 30000-40000 предотвращает антиагрегационное действие последних; введение Этамзилата после растворов декстранов не оказывает гемостатического действия."}},{"type":"paragraph","data":{"text":"Возможно сочетание Этамзилата с аминокапроновой кислотой и менадиона натрия бисульфитом."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Требуется соблюдать осторожность у пациентов у которых когда-либо наблюдался тромбоз или тромбоэмболия."}},{"type":"paragraph","data":{"text":"Препарат неэффективен у больных со сниженным числом тромбоцитов."}},{"type":"paragraph","data":{"text":"При геморрагических осложнениях связанных с передозировкой антикоагулянтов рекомендуется использовать специфические антидоты."}},{"type":"paragraph","data":{"text":"Использование этамзилата у больных с нарушенными показателями свертывающей системы крови возможно но оно должно быть дополнено введением препаратов устраняющих выявленный дефицит или дефект факторов свертывающей системы."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для инъекций 125 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"Биосинтез\", 440033, г. Пенза, ул. Дружбы, д. 4, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ОАО \"Биосинтез\""}}]}],"source":null},"description_toggle":false,"short_description":"Гемостатическое средство. Оказывает также ангиопротекторное и проагрегантное действие. Стимулирует образование тромбоцитов и их выход из костного мозга. Гемостатическому действию обусловленному активацией формирования тромбопластина в месте повреждения мелких сосудов и снижением образования в эндотелии сосудов простациклина PgI2 способствует повышению адгезии и агрегации тромбоцитов что в конечном счете приводит к остановке или уменьшению кровоточивости. Увеличивает скорость образования первичного тромба и усиливает его ретракцию практически не влияет на концентрацию фибриногена и протромбиновое время. Дозы более 2-10 мг/кг не приводят к большей выраженности эффекта. При повторных введениях тромбообразование усиливается. Обладая антигиалуронидазной активностью и стабилизируя аскорбиновую кислоту препятствует разрушению и способствует образованию в стенке капилляров мукополисахаридов с большой молекулярной массой повышает резистентность капилляров снижает их хрупкость нормализует проницаемость при патологических процессах. Уменьшает выход жидкости и диапедез форменных элементов крови из сосудистого русла улучшает микроциркуляцию. Не оказывает сосудосуживающего действия. Восстанавливает патологически измененное время кровотечения. На нормальные параметры системы гемостаза не влияет. Гемостатический аффект при внутривенном введении этамзилата наступает через 5-15 минут максимальный эффект проявляется через 1-2 часа. Действие продолжается в течение 4-6 часов затем в течение 24 часов постепенно ослабевает; при внутримышечном введении эффект наступает через 30-60 минут. Препарат хорошо абсорбируется при внутримышечном введении слабо связывается с белками плазмы и форменными элементами крови. Терапевтическая концентрация в крови - 005 - 002 мг/мл. Этамзилат равномерно распределяется в различных органах и тканях (зависит от степени их кровоснабжения). Препарат выводится из организма главным образом почками (в неизменном виде) в незначительном количестве с желчью. Период полувыведения препарата после внутривенного введения составляет 19 часа после внутримышечного введения - 21 часа. 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