Доксазозин является селективным конкурентным блокатором пост... Инструкция
Показания к применению
Артериальная гипертензия:
в качестве монотерапии или в комбинации с другими антигипертензивными средствами (тиазидные диуретики, бета-адреноблокаторы, блокаторы медленных кальциевых каналов, ингибиторы АПФ).
как при наличии артериальной гипертензии, так и при нормальном АД.
Противопоказания
повышение чувствительности к доксазозину, к любому из вспомогательных компонентов препарата, другим производным хиназолона.
Инструкция
Фармакологические свойства
Доксазозин является селективным конкурентным блокатором постсинаптических α1-адренорецепторов. За счет снижения тонуса мышц сосудов доксазозин уменьшает ОПСС, что приводит к снижению АД. После однократного приема препарата максимум гипотензивного действия наблюдается в период от 2 до 6 ч, а в целом гипотензивный эффект сохраняется в течение 24 ч. В период лечения доксазозином у пациентов с артериальной гипертензией отсутствуют различия величин АД в положении стоя и лежа.
Эффективен при артериальной гипертензии, в т.ч. сопровождающейся метаболическими нарушениями (ожирение, снижение толерантности к глюкозе). Снижает риск развития ИБС.
Прием препарата у нормотоников не сопровождается снижением АД.
При длительном применении доксазозина у пациентов не наблюдается изменения толерантности к терапевтическому антигипертензивному эффекту.
В период лечения доксазозином наблюдается снижение уровня концентрации в плазме крови триглицеридов, общего холестерина.
Одновременно отмечается некоторый (на 4-13%) рост коэффициента ЛПВП/общий холестерин.
При длительном лечении доксазозином наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена.
В связи с тем, что доксазозин блокирует α1-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшение сопротивления внутреннего сфинктера. Поэтому назначение доксазозина пациентам с симптомами доброкачественной гиперплазии предстательной железы приводит к значительному улучшению показателей уродинамики и уменьшению проявлений симптомов заболевания.
Оказывает эффект у 66-71% больных, начало действия - через 1-2 недели лечения, максимум - после 14 недель, эффект сохраняется в течение длительного времени.
Фармакокинетика
Всасывание
После приема внутрь в терапевтических дозах доксазозин хорошо всасывается из ЖКТ, абсорбция - 80-90% (одновременный прием пищи замедляет всасывание на 1 ч), время достижения Cmax - 3 ч, при вечернем приеме - 5 ч. Биодоступность - 60-70% (пресистемный метаболизм).
Распределение
Связывание с белками плазмы крови - около 98%. Выведение из плазмы крови происходит в 2 фазы, с конечным T1/2 - 19-22 ч, что позволяет назначать препарат 1 раз/сут.
Метаболизм и выведение
Быстро метаболизируется в печени путем о-деметилирования и гидроксилирования.
Выводится через кишечник, преимущественно в виде метаболитов до 65%, лишь 5% выводится с мочой в неизмененном виде.
Исследования фармакокинетики доксазозина у пациентов пожилого возраста и у пациентов с заболеваниями почек не выявили существенных фармакокинетических различий.
Показания к применению
Артериальная гипертензия:
в качестве монотерапии или в комбинации с другими антигипертензивными средствами (тиазидные диуретики, бета-адреноблокаторы, блокаторы медленных кальциевых каналов, ингибиторы АПФ).
как при наличии артериальной гипертензии, так и при нормальном АД.
Противопоказания
повышение чувствительности к доксазозину, к любому из вспомогательных компонентов препарата, другим производным хиназолона.
С осторожностью
С осторожностью следует применять у пациентов с нарушением функции печени, аортальным и митральным стенозом, ортостатической гипотензией, в возрасте до 18 лет (эффективность и безопасность не установлены).
Способ применения и дозы
Препарат принимают внутрь 1 раз/сут (утром или вечером), независимо от приема пищи. Таблетки принимают не разжевывая и запивая достаточным количеством воды.
При лечении артериальной гипертензии начальная доза составляет 1 мг/сут перед сном.
После приема первой дозы пациент должен находиться в постели в течение 6-8 ч. Это требуется в связи с возможностью развития "феномена первой дозы", особенно выраженной на фоне предшествующего приема диуретиков. При недостаточном терапевтическом эффекте суточную дозу можно увеличить до 2 мг через 1-2 недели. В последующем через каждые 1-2 недели дозу можно увеличить на 2 мг. У подавляющего большинства пациентов оптимальный терапевтический эффект достигается при дозе 8 мг/сут. Максимальная доза - 16 мг/сут.
После достижения стойкого терапевтического эффекта дозу обычно несколько снижают (средняя терапевтическая доза при поддерживающей терапии обычно равна 2-4 мг/сут).
При лечении доброкачественной гиперплазии предстательной железы без артериальной гипертензии препарат, как правило, назначают в дозе 2-4 мг/сут. Максимальная допустимая доза составляет 8 мг/сут.
Препарат применяют длительно. Продолжительность лечения определяет лечащий врач.
Побочное действие
Артериальная гипертензия
В клинических исследованиях наиболее часто наблюдалась, особенно в начале лечения, ортостатическая гипотензия, которая в редких случаях может привести к обморокам.
Со стороны сердечно-сосудистой системы: отеки, обморок.
Со стороны нервной системы: головокружение, головная боль, сонливость.
У пациентов с ДГПЖ встречаются те же побочные эффекты, что и у пациентов с артериальной гипертензией, а также перечисленные ниже.
Со стороны сердечно-сосудистой системы: снижение АД, ортостатическая гипотензия.
Со стороны нервной системы: сухость во рту, приапизм, гипестезия, парастезия, тремор, импотенция, бессонница, повышенная возбудимость.
Со стороны эндокринной системы: гинекомастия.
Со стороны пищеварительной системы: боль в животе, запор, диарея, диспепсия, метеоризм, тошнота, потеря аппетита, повышение активности печеночных трансаминаз, холестаз, гепатит, желтуха.
Со стороны системы кроветворения: лейкопения, пурпура, тромбоцитопения.
Со стороны костно-мышечной системы: артралгия, мышечные судороги, слабость в мышцах, миалгии.
Со стороны дыхательной системы: бронхоспазм, кашель, одышка, носовое кровотечение.
Со стороны кожных покровов: алопеция.
Со стороны органов чувств: нечеткость зрительного восприятия, шум в ушах.
Со стороны мочевыделительной системы: дизурия, гематурия, нарушение мочеиспускания, никтурия, полиурия, недержание мочи.
Аллергические реакции: кожная сыпь, крапивница.
Общие реакции: боль в спине, ощущение жара ("приливы").
Кроме того, у пациентов с артериальной гипертензией отмечались следующие побочные реакции (причинно-следственная связь не установлена): брадикардия, тахикардия, сердцебиение, боль в груди, стенокардия, инфаркт миокарда, нарушение мозгового кровообращения и аритмии.
Взаимодействие с другими лекарственными средствами
Доксазозин усиливает гипотензивный эффект антигипертензивных средств (при использовании комбинации требуется коррекция доз).
Не отмечено неблагоприятного взаимодействия при одновременном применении доксазозина и тиазидных диуретиков, фуросемида, бета-адреноблокаторов, антибиотиков, пероральных гипогликемических средств, непрямых антикоагулянтов и урикозурических средств.
Не влияет на степень связывания с белками плазмы дигоксина, фенитоина.
При одновременном применении с индукторами микросомального окисления в печени возможно повышение эффективности доксазозина, с ингибиторами - понижение.
НПВС (особенно индометацин), эстрогены и симпатомиметические средства могут уменьшать гипотензивное действие доксазозина.
Устраняя альфа-адреностимулирующие эффекты эпинефрина, может приводить к развитию тахикардии и артериальной гипотензии.
Особые указания
С особой осторожностью следует назначать препарат пациентам с нарушением функции печени, особенно в тех случаях, когда одновременно применяются препараты, способные отрицательно повлиять на функцию печени. В случаях ухудшения показателей функционального состояния печени препарат немедленно отменяют.
С целью предотвращения ортостатических реакций пациенты должны избегать неожиданных и резких смен положения тела (переход из положения лежа в положение стоя).
При одновременном употреблении алкоголя возможно усиление нежелательных реакций.
Эффект первого приема препарата особенно выражен на фоне предшествующей диуретической терапии и соблюдения диеты с ограничением потребления натрия.
Перед началом терапии необходимо исключить злокачественное перерождение предстательной железы.
Влияние на способность к управлению транспортными средствами и механизмами
В период лечения пациентам следует соблюдать осторожность при управлении транспортными средствами и занятиях другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций (риск развития головокружения, слабости).
В связи с тем, что доксазозин способен вызывать ортостатические реакции в начале лечения или в период повышения доз, пациентам целесообразно воздерживаться от всех потенциально опасных видов деятельности, в частности от управления автотранспортом и другими транспортными средствами и механизмами.
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За счет снижения тонуса мышц сосудов доксазозин уменьшает ОПСС, что приводит к снижению АД. После однократного приема препарата максимум гипотензивного действия наблюдается в период от 2 до 6 ч, а в целом гипотензивный эффект сохраняется в течение 24 ч. В период лечения доксазозином у пациентов с артериальной гипертензией отсутствуют различия величин АД в положении стоя и лежа."}},{"type":"paragraph","data":{"text":"Эффективен при артериальной гипертензии, в т.ч. сопровождающейся метаболическими нарушениями (ожирение, снижение толерантности к глюкозе). Снижает риск развития ИБС."}},{"type":"paragraph","data":{"text":"Прием препарата у нормотоников не сопровождается снижением АД."}},{"type":"paragraph","data":{"text":"При длительном применении доксазозина у пациентов не наблюдается изменения толерантности к терапевтическому антигипертензивному эффекту."}},{"type":"paragraph","data":{"text":"В период лечения доксазозином наблюдается снижение уровня концентрации в плазме крови триглицеридов, общего холестерина."}},{"type":"paragraph","data":{"text":"Одновременно отмечается некоторый (на 4-13%) рост коэффициента ЛПВП/общий холестерин."}},{"type":"paragraph","data":{"text":"При длительном лечении доксазозином наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена."}},{"type":"paragraph","data":{"text":"В связи с тем, что доксазозин блокирует α\u003csub\u003e1\u003c/sub\u003e-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшение сопротивления внутреннего сфинктера. Поэтому назначение доксазозина пациентам с симптомами доброкачественной гиперплазии предстательной железы приводит к значительному улучшению показателей уродинамики и уменьшению проявлений симптомов заболевания."}},{"type":"paragraph","data":{"text":"Оказывает эффект у 66-71% больных, начало действия - через 1-2 недели лечения, максимум - после 14 недель, эффект сохраняется в течение длительного времени."}},{"type":"header","data":{"text":"Фармакокинетика","level":4}},{"type":"paragraph","data":{"text":"\u003ci\u003eВсасывание\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"После приема внутрь в терапевтических дозах доксазозин хорошо всасывается из ЖКТ, абсорбция - 80-90% (одновременный прием пищи замедляет всасывание на 1 ч), время достижения C\u003csub\u003emax\u003c/sub\u003e - 3 ч, при вечернем приеме - 5 ч. Биодоступность - 60-70% (пресистемный метаболизм)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Связывание с белками плазмы крови - около 98%. Выведение из плазмы крови происходит в 2 фазы, с конечным T\u003csub\u003e1/2\u003c/sub\u003e - 19-22 ч, что позволяет назначать препарат 1 раз/сут."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм и выведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Быстро метаболизируется в печени путем о-деметилирования и гидроксилирования."}},{"type":"paragraph","data":{"text":"Выводится через кишечник, преимущественно в виде метаболитов до 65%, лишь 5% выводится с мочой в неизмененном виде."}},{"type":"paragraph","data":{"text":"Исследования фармакокинетики доксазозина у пациентов пожилого возраста и у пациентов с заболеваниями почек не выявили существенных фармакокинетических различий."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Артериальная гипертензия:"}},{"type":"list","data":{"style":"ordered","items":["в качестве монотерапии или в комбинации с другими антигипертензивными средствами (тиазидные диуретики, бета-адреноблокаторы, блокаторы медленных кальциевых каналов, ингибиторы АПФ)."]}},{"type":"paragraph","data":{"text":"Доброкачественная гиперплазия предстательной железы:"}},{"type":"list","data":{"style":"ordered","items":["как при наличии артериальной гипертензии, так и при нормальном АД."]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["повышение чувствительности к доксазозину, к любому из вспомогательных компонентов препарата, другим производным хиназолона."]}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью\u003c/i\u003e следует применять у пациентов с нарушением функции печени, аортальным и митральным стенозом, ортостатической гипотензией, в возрасте до 18 лет (эффективность и безопасность не установлены). "}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат принимают внутрь 1 раз/сут (утром или вечером), независимо от приема пищи. Таблетки принимают не разжевывая и запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eлечении артериальной гипертензии\u003c/i\u003e начальная доза составляет 1 мг/сут перед сном."}},{"type":"paragraph","data":{"text":"После приема первой дозы пациент должен находиться в постели в течение 6-8 ч. Это требуется в связи с возможностью развития \"феномена первой дозы\", особенно выраженной на фоне предшествующего приема диуретиков. При недостаточном терапевтическом эффекте суточную дозу можно увеличить до 2 мг через 1-2 недели. В последующем через каждые 1-2 недели дозу можно увеличить на 2 мг. У подавляющего большинства пациентов оптимальный терапевтический эффект достигается при дозе 8 мг/сут. Максимальная доза - 16 мг/сут."}},{"type":"paragraph","data":{"text":"После достижения стойкого терапевтического эффекта дозу обычно несколько снижают (средняя терапевтическая доза при поддерживающей терапии обычно равна 2-4 мг/сут)."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eлечении доброкачественной гиперплазии предстательной железы\u003c/i\u003e без артериальной гипертензии препарат, как правило, назначают в дозе 2-4 мг/сут. Максимальная допустимая доза составляет 8 мг/сут."}},{"type":"paragraph","data":{"text":"Препарат применяют длительно. Продолжительность лечения определяет лечащий врач."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eАртериальная гипертензия\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В клинических исследованиях \u003ci\u003eнаиболее часто\u003c/i\u003e наблюдалась, особенно в начале лечения, ортостатическая гипотензия, которая в редких случаях может привести к обморокам."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы: \u003c/i\u003eотеки, обморок."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы: \u003c/i\u003eголовокружение, головная боль, сонливость."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы: \u003c/i\u003eтошнота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы: \u003c/i\u003eринит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие реакции: \u003c/i\u003eастения, утомляемость, недомогание."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДоброкачественная гиперплазия предстательной железы (ДГПЖ)\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"У пациентов с ДГПЖ встречаются те же побочные эффекты, что и у пациентов с артериальной гипертензией, а также перечисленные ниже."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e снижение АД, ортостатическая гипотензия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e сухость во рту, приапизм, гипестезия, парастезия, тремор, импотенция, бессонница, повышенная возбудимость."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны эндокринной системы:\u003c/i\u003e гинекомастия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e боль в животе, запор, диарея, диспепсия, метеоризм, тошнота, потеря аппетита, повышение активности печеночных трансаминаз, холестаз, гепатит, желтуха."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны системы кроветворения:\u003c/i\u003e лейкопения, пурпура, тромбоцитопения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны костно-мышечной системы:\u003c/i\u003e артралгия, мышечные судороги, слабость в мышцах, миалгии."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы:\u003c/i\u003e бронхоспазм, кашель, одышка, носовое кровотечение."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны кожных покровов: \u003c/i\u003eалопеция."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов чувств:\u003c/i\u003e нечеткость зрительного восприятия, шум в ушах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны мочевыделительной системы:\u003c/i\u003e дизурия, гематурия, нарушение мочеиспускания, никтурия, полиурия, недержание мочи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции: \u003c/i\u003eкожная сыпь, крапивница."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие реакции:\u003c/i\u003e боль в спине, ощущение жара (\"приливы\")."}},{"type":"paragraph","data":{"text":"Кроме того, у пациентов с артериальной гипертензией отмечались следующие побочные реакции (причинно-следственная связь не установлена): брадикардия, тахикардия, сердцебиение, боль в груди, стенокардия, инфаркт миокарда, нарушение мозгового кровообращения и аритмии."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Доксазозин усиливает гипотензивный эффект антигипертензивных средств (при использовании комбинации требуется коррекция доз)."}},{"type":"paragraph","data":{"text":"Не отмечено неблагоприятного взаимодействия при одновременном применении доксазозина и тиазидных диуретиков, фуросемида, бета-адреноблокаторов, антибиотиков, пероральных гипогликемических средств, непрямых антикоагулянтов и урикозурических средств."}},{"type":"paragraph","data":{"text":"Не влияет на степень связывания с белками плазмы дигоксина, фенитоина."}},{"type":"paragraph","data":{"text":"При одновременном применении с индукторами микросомального окисления в печени возможно повышение эффективности доксазозина, с ингибиторами - понижение."}},{"type":"paragraph","data":{"text":"НПВС (особенно индометацин), эстрогены и симпатомиметические средства могут уменьшать гипотензивное действие доксазозина."}},{"type":"paragraph","data":{"text":"Устраняя альфа-адреностимулирующие эффекты эпинефрина, может приводить к развитию тахикардии и артериальной гипотензии."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"С особой осторожностью следует назначать препарат пациентам с нарушением функции печени, особенно в тех случаях, когда одновременно применяются препараты, способные отрицательно повлиять на функцию печени. В случаях ухудшения показателей функционального состояния печени препарат немедленно отменяют."}},{"type":"paragraph","data":{"text":"С целью предотвращения ортостатических реакций пациенты должны избегать неожиданных и резких смен положения тела (переход из положения лежа в положение стоя)."}},{"type":"paragraph","data":{"text":"При одновременном употреблении алкоголя возможно усиление нежелательных реакций."}},{"type":"paragraph","data":{"text":"Эффект первого приема препарата особенно выражен на фоне предшествующей диуретической терапии и соблюдения диеты с ограничением потребления натрия."}},{"type":"paragraph","data":{"text":"Перед началом терапии необходимо исключить злокачественное перерождение предстательной железы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В период лечения пациентам следует соблюдать осторожность при управлении транспортными средствами и занятиях другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций (риск развития головокружения, слабости)."}},{"type":"paragraph","data":{"text":"В связи с тем, что доксазозин способен вызывать ортостатические реакции в начале лечения или в период повышения доз, пациентам целесообразно воздерживаться от всех потенциально опасных видов деятельности, в частности от управления автотранспортом и другими транспортными средствами и механизмами."}}]}],"source":null},"description_toggle":false,"short_description":"Доксазозин является селективным конкурентным блокатором постсинаптических α1-адренорецепторов. За счет снижения тонуса мышц сосудов доксазозин уменьшает ОПСС, что приводит к снижению АД. После однократного приема препарата максимум гипотензивного действия наблюдается в период от 2 до 6 ч, а в целом гипотензивный эффект сохраняется в течение 24 ч. В период лечения доксазозином у пациентов с артериальной гипертензией отсутствуют различия величин АД в положении стоя и лежа. Эффективен при артериальной гипертензии, в т.ч. сопровождающейся метаболическими нарушениями (ожирение, снижение толерантности к глюкозе). Снижает риск развития ИБС. Прием препарата у нормотоников не сопровождается снижением АД. При длительном применении доксазозина у пациентов не наблюдается изменения толерантности к терапевтическому антигипертензивному эффекту. В период лечения доксазозином наблюдается снижение уровня концентрации в плазме крови триглицеридов, общего холестерина. Одновременно отмечается некоторый (на 4-13%) рост коэффициента ЛПВП/общий холестерин. При длительном лечении доксазозином наблюдается регрессия гипертрофии левого желудочка, подавление агрегации тромбоцитов и повышение содержания в тканях активного плазминогена. В связи с тем, что доксазозин блокирует α1-адренорецепторы, расположенные в строме и капсуле предстательной железы и в шейке мочевого пузыря, происходит снижение сопротивления и давления в мочеиспускательном канале, уменьшение сопротивления внутреннего сфинктера. Поэтому назначение доксазозина пациентам с симптомами доброкачественной гиперплазии предстательной железы приводит к значительному улучшению показателей уродинамики и уменьшению проявлений симптомов заболевания. Оказывает эффект у 66-71% больных, начало действия - через 1-2 недели лечения, максимум - после 14 недель, эффект сохраняется в течение длительного времени.ВсасываниеПосле приема внутрь в терапевтических дозах доксазозин хорошо всасывается из ЖКТ, абсорбция - 80-90% (одновременный прием пищи замедляет всасывание на 1 ч), время достижения Cmax- 3 ч, при вечернем приеме - 5 ч. Биодоступность - 60-70% (пресистемный метаболизм).РаспределениеСвязывание с белками плазмы крови - около 98%. Выведение из плазмы крови происходит в 2 фазы, с конечным T1/2- 19-22 ч, что позволяет назначать препарат 1 раз/сут.Метаболизм и выведениеБыстро метаболизируется в печени путем о-деметилирования и гидроксилирования. Выводится через кишечник, преимущественно в виде метаболитов до 65%, лишь 5% выводится с мочой в неизмененном виде. Исследования фармакокинетики доксазозина у пациентов пожилого возраста и у пациентов с заболеваниями почек не выявили существенных фармакокинетических различий.","substance":[{"id":223,"title":"Доксазозин","title_latin":"Doxazosinum","slug":"doksazozin_223"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Доксазозин-ФПО - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/82147/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/82147/share_default/"}},"diseases":[],"other_packages":[{"id":200318,"title":"Доксазозин-ФПО","subtitle":{"full":"Таблетки, 30 шт, 2 мг","short":"Таблетки, 30 шт, 2 мг","package":"30 шт, 2 мг"},"prescription":true,"catalog_section_id":99,"manufacturer":{"id":2702,"title":"Оболенское 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