Амбениум парентерал Раствор, 3 шт, 2 мл + 3.75 мг / 2 мл, для внутримышечного введения, для взрослых

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Неизбирательно ингибирует активность\nциклооксигеназ (ЦОГ-1 и ЦОГ-2), нарушает метаболизм арахидоновой кислоты,\nуменьшает количество простагландинов в очаге воспаления. Простагландины играют\nсущественную роль в развитии воспалительной реакции. Противовоспалительное и\nанальгезирующее действие фенилбутазона способствует уменьшению выраженности\nболи и воспалительного отека, утренней скованности, припухлости суставов,\nспособствует увеличению объема движений. Урикозурическое действие фенилбутазона\nсвязано со снижением тубулярной резорбции мочевой кислоты в почках.","level":4}},{"type":"header","data":{"text":"Лидокаина гидрохлорид обладает местноанестезирующим действием,\nблокирует потенциалзависимые натриевые каналы, что препятствует генерации\nимпульсов в окончаниях чувствительных нервов и проведению импульсов по нервным\nволокнам. Подавляет проведение не только болевых импульсов, но и импульсов\nдругой модальности. 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Главным метаболитом является фармакологически активный оксифенбутазон.\nПрочие метаболиты обладают меньшей противовоспалительной активностью."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение.\u003c/i\u003e\nЭлиминация неизмененного активного вещества, а также его метаболитов происходит\nкак через почки (около 70 %), так и с желчью через кишечник (около 30 %).\nПериод полувыведения составляет от 50 до 100 часов и может значительно\nувеличиваться при нарушенной функции печени и почек."}},{"type":"paragraph","data":{"text":"Связывание\nс белками плазмы крови составляет 99 %, что существенно при возможных\nлекарственных взаимодействиях фенилбутазона."}},{"type":"header","data":{"text":"Лидокаина гидрохлорид","level":4}},{"type":"header","data":{"text":"Всасывание. Системная абсорбция\nлидокаина определяется местом введения, дозой и его фармакологическим профилем.\nОсновным фактором, определяющим скорость абсорбции и концентрацию в крови,\nявляется общая введенная доза независимо от участка введения. Имеется линейная\nзависимость между количеством введенного лидокаина и результирующей максимальной\nконцентрацией анестетика в крови.","level":3}},{"type":"header","data":{"text":"Распределение. Лидокаин связывается с\nбелками плазмы, включая a\u003csub\u003e1\u003c/sub\u003e-кислый гликопротеин\n(АКГ) и альбумин. Степень связывания вариабельна, составляет приблизительно\n66 %. Лидокаин проникает через гематоэнцефалический и плацентарный\nбарьеры.","level":3}},{"type":"header","data":{"text":"Метаболизм. Лидокаин метаболизируется\nв печени, около 90 % введенной дозы подвергается N-дезалкилированию с\nобразованием моноэтилглицинксилидида (MEGX) и глицинксилидида (GX).","level":3}},{"type":"paragraph","data":{"text":"Выведение. Терминальный период\nполувыведения лидокаина после внутривенного болюсного введения здоровым\nвзрослым добровольцам составляет 1–2 часа."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Симптоматическое\nлечение болевого синдрома и воспаления при обострении:"}},{"type":"paragraph","data":{"text":"- анкилозирующего\nспондилита (болезнь Бехтерева);"}},{"type":"paragraph","data":{"text":"-\nревматоидного артрита;"}},{"type":"paragraph","data":{"text":"-\nподагры."}},{"type":"paragraph","data":{"text":"Препарат\nпредназначен для симптоматической терапии, уменьшения боли и воспаления на\nмомент использования. На прогрессирование заболевания не влияет."}},{"type":"paragraph","data":{"text":"Применение\nАмбениум парентерал в\nосновном должно производиться только в том случае, если другие терапевтические\nмероприятия, включая другие нестероидные противовоспалительные препараты, не\nоказали достаточного обезболивающего эффекта. "}},{"type":"paragraph","data":{"text":"Применение фенилбутазона в\nдозе, превышающей рекомендуемую (373,4 мг), или дополнительное применение других\nНПВП (исключение составляет ацетилсалициловая кислота в дозах не более 325 мг,\nприменяемая в качестве антиагреганта) не обеспечивает дополнительного\nобезболивающего эффекта, но существенно повышает риск развития нежелательных\nявлений и поэтому не рекомендуется."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность\nк фенилбутазону, лидокаину, анестетикам амидного типа или вспомогательным\nкомпонентам препарата;"}},{"type":"paragraph","data":{"text":"-\nтяжелые нарушения проводимости сердца, острый инфаркт миокарда в период после\nпроведения аортокоронарного шунтирования; \n"}},{"type":"paragraph","data":{"text":"-  декомпенсированная сердечная недостаточность;"}},{"type":"paragraph","data":{"text":"-\nполное или неполное сочетание бронхиальной астмы, рецидивирующего полиноза носа\nи околоносовых пазух и непереносимости ацетилсалициловой кислоты или других\nНПВП (в том числе в анамнезе); "}},{"type":"paragraph","data":{"text":"-\nзаболевания крови и системы свертывания (лейкопения, в том числе в анамнезе,\nтромбоцитопения, гемофилия);"}},{"type":"paragraph","data":{"text":"-\nактивные эрозивно-язвенные поражения желудка или двенадцатиперстной кишки, или\nязвенная болезнь желудка и двенадцатиперстной кишки, язвенный колит, болезнь\nКрона;"}},{"type":"paragraph","data":{"text":"-\nжелудочно-кишечное кровотечение, в т. ч. в анамнезе, спровоцированное\nприемом НПВП;"}},{"type":"paragraph","data":{"text":"-\nвнутричерепные кровотечения, острые нарушения мозгового кровообращения;"}},{"type":"paragraph","data":{"text":"-\nпочечная или печеночная недостаточность; "}},{"type":"paragraph","data":{"text":"-\nподтвержденная гиперкалиемия;"}},{"type":"paragraph","data":{"text":"- беременность, период грудного\nвскармливания, детский возраст (до 18 лет)."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Заболевания печени в анамнезе, печеночная порфирия, хроническая сердечная недостаточность, артериальная гипертензия, значительное снижение объема циркулирующей крови (в том числе после хирургического вмешательства); пожилые пациенты (в т. ч. получающие диуретики, ослабленные пациенты и с низкой массой тела); бронхиальная астма; одновременный прием глюкокортикостероидов (в том числе преднизолона), антикоагулянтов (в том числе варфарина), антиагрегантов (в том числе ацетилсалициловой кислоты, клопидогрела), селективных ингибиторов обратного захвата серотонина (в т. ч. циталопрама, флуоксетина, пароксетина, сертралина); ишемическая болезнь сердца, цереброваскулярные заболевания, дислипидемия/гиперлипидемия, сахарный диабет, заболевания периферических артерий, курение, наличие инфекции Нelicobacter pylori, длительное использование НПВП, заболевания щитовидной железы, туберкулез, алкоголизм, тяжёлые соматические заболевания. Следует избегать совместного применения с иными НПВП, в т. ч. ЦОГ-2 селективными."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Безопасность\nприменения во время беременности данного препарата не доказана. Влияние\nзадержки синтеза простагландинов на эмбриогенез во время первых двух триместров\nбеременности неясно. В последний триместр беременности механизм действия фенилбутазона\nхарактеризуется торможением родовой деятельности, преждевременным закрытием Ductus arteriosus Botalli у плода, повышается\nпредрасположенность к кровотечениям у матери и ребенка, повышается риск\nобразования отеков у матери."}},{"type":"paragraph","data":{"text":"Фенилбутазон\nв небольших количествах проникает в материнское молоко, и в случае грудного\nвскармливания фенилбутазон можно обнаружить в плазме крови младенца. "}},{"type":"paragraph","data":{"text":"На основании приведенной\nинформации препарат противопоказан в период беременности и при грудном\nвскармливании."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Для\nснижения риска развития нежелательных явлений со стороны желудочно-кишечного\nтракта следует использовать минимальную эффективную дозу минимально возможным\nкоротким курсом."}},{"type":"paragraph","data":{"text":"Для лечения острых состояний или\nкупирования обострения хронического заболевания препарат вводится однократно,\nмедленно, глубоко в мышцу, в дозе 373,4 мг (2 мл)."}},{"type":"paragraph","data":{"text":"Суточная доза: 373,4 мг (2 мл). Не\nследует превышать указанную дозу."}},{"type":"paragraph","data":{"text":"Данную\nлекарственную форму следует применять однократно. Дальнейшее лечение при\nнеобходимости следует проводить препаратами фенилбутазона в таблетированной\nформе, при этом следует соблюдать все соответствующие указания в отношении\nприменения. "}},{"type":"paragraph","data":{"text":"Из-за возможного возникновения\nанафилактических реакций вплоть до анафилактического шока при применении\nпрепарата необходимо обеспечить доступность функционального набора для оказания\nнеотложной медицинской помощи. После введения препарата следует наблюдать\nпациента не менее 1 часа. Пациенту следует разъяснить важность данной меры."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Часто\n– 1–10 %; нечасто – 0,1–1 %; редко – 0,01–0,1 %; очень редко –\nменее 0,001 %, включая отдельные случаи."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы\u003c/i\u003e: \u003ci\u003eчасто –\u003c/i\u003e тошнота, диарея и\nкровотечения из желудочно-кишечного тракта, которые в некоторых случаях могут\nвызвать анемию; \u003ci\u003eнечасто –\u003c/i\u003e\nповышение активности трансаминаз, холестатический синдром, гепатит; \u003ci\u003eредко\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e язва желудка и двенадцатиперстной кишки, желудочно-кишечное\nкровотечение (обычно сопровождается сильными болями\nв верхней части живота и/или окрашиванием кала в черный цвет), функциональные\nнарушения работы поджелудочной железы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы:\u003c/i\u003e \u003ci\u003eнечасто\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e головная боль, возбуждение, раздражительность, бессонница,\nголовокружение и усталость; \u003ci\u003eочень\nредко \u003c/i\u003eмогут возникнуть местные реакции: периферический неврит\nседалищного нерва. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны мочевыделительной системы: нечасто\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e генерализированные и/или\nпериферические отеки; \u003ci\u003eочень редко\u003c/i\u003e\n\u003ci\u003e–\u003c/i\u003e уменьшение количества выделенной\nмочи, отеки, нереагирующие на терапию с применением диуретиков, острая почечная\nнедостаточность."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны органов кроветворения:\u003c/i\u003e \u003ci\u003eр\u003c/i\u003e\u003ci\u003eедко\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e анемия, лейкопения, тромбоцитопения, панцитопения, агранулоцитоз."}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции: часто – \u003c/i\u003eреакции\nгиперчувствительности; \u003ci\u003eочень редко\u003c/i\u003e\n\u003ci\u003e–\u003c/i\u003e опухание лица, языка и гортани.\nОтеки, одышка, учащенное сердцебиение, анафилактический шок."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы: редко\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e снижение или повышение артериального\nдавления; \u003ci\u003eочень редко\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e острое нарушение кровообращения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы: редко\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e бронхиальная астма, отек легких."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны кожных покровов и\nподкожно-жировой клетчатки: часто\u003c/i\u003e \u003ci\u003e–\u003c/i\u003e кожная сыпь и зуд; \u003ci\u003eочень\nредко – \u003c/i\u003eнекрозы жировой ткани при неправильно проведенных инъекциях в\nжировую ткань, синдром Стивенса – Джонсона, синдром Лайелла, дискоидная красная волчанка."}},{"type":"paragraph","data":{"text":"Нежелательные реакции на\nлидокаин рдки и, как правило, обусловлены повышенной плазменной концентрацией\nвследствие случайного внутрисосудистого введения, превышения дозы или быстрой\nабсорбции из участков с обильным кровоснабжением, либо вследствие\nгиперчувствительности, идиосинкразии или сниженной переносимости пациента."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Наряду\nс желудочно-кишечными нарушениями (тошнота, рвота, абдоминальные боли,\nкровотечения) и нарушениями работы центральной нервной системы (спутанность\nсознания, повышенная возбудимость, начальная гипервентиляция, дыхательная\nдепрессия, повышенная судорожная готовность, нарушения сознания вплоть до комы)\nмогут возникать нарушения почечной функции (вплоть до полного отказа работы\nпочек), а также нарушения функции печени."}},{"type":"paragraph","data":{"text":"Наряду\nс респираторными нарушениями или метаболическим ацидозом могут наблюдаться и такие\nизменения биохимических показателей, как повышение активности трансаминаз (АЛТ,\nАСТ); повышение уровня щелочной фосфатазы; изменения картины крови (лейкопения,\nтромбопения)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМеры по\nоказанию помощи при передозировке\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Специфический антидот\nнеизвестен. В качестве основной меры необходимо проведение симптоматической\nтерапии (поддержание артериального давления, нормализация кислотно-основного\nравновесия, искусственная вентиляция легких), показаны меры для снижения\nрезорбции и ускоряющие элиминацию (активированный уголь, форсированный диурез,\nгемодиализ)."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременный\nприем фенилбутазона и глюкокортикостероидов или нестероидных\nпротивовоспалительных средств и анальгетиков повышает риск возникновения\nпобочных явлений со стороны желудочно-кишечного тракта."}},{"type":"paragraph","data":{"text":"Одновременный\nприем барбитуратов (например, фенобарбитал), хлорфенамина, рифампицина, прометазина\nи колестирамина ведет к снижению концентрации фенилбутазона в сыворотке крови и\nтем самым к снижению обезболивающего эффекта."}},{"type":"paragraph","data":{"text":"Одновременный\nприем метилфенидата или анаболических стероидов (метандростенолон) может\nпривести к повышению концентрации фенилбутазона в сыворотке крови и тем самым\nусилить эффект."}},{"type":"paragraph","data":{"text":"Одновременный\nприем фенилбутазона и фенитоина или лития может повысить уровень этих\nлекарственных средств в плазме, что потребует контроля их концентрации в крови."}},{"type":"paragraph","data":{"text":"Одновременное\nприменение фенилбутазона и калийсберегающих диуретиков может привести к\nповышению уровня калия в плазме, что потребует контроля концентрации калия в\nкрови."}},{"type":"paragraph","data":{"text":"Фенилбутазон\nможет ослабить действие дигоксина, кортизона, диуретиков и гипотензивных\nпрепаратов."}},{"type":"paragraph","data":{"text":"Введение\nфенилбутазона в течение 24 часов до или после приема метотрексата может\nпривести к повышенной концентрации метотрексата в плазме крови и к\nпотенцированию его нежелательных реакций."}},{"type":"paragraph","data":{"text":"Одновременное\nприменение фенилбутазона и антикоагулянтов (например, препараты кумарина,\nсульфаниламиды) может привести к усилению тромболитического эффекта."}},{"type":"paragraph","data":{"text":"Фенилбутазон может усилить\nдействие таблетированных гипогликемических средств, тем самым имеется опасность\nвозникновения гипогликемии."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Из-за\nважной роли простагландинов в поддержании почечного кровотока следует проявлять\nособую осторожность при назначении пациентам с сердечной недостаточностью, а\nтакже при терапии пожилых пациентов, принимающих диуретики, и больных, у\nкоторых по какой-либо причине наблюдается снижение объема циркулирующей крови\n(в т.ч. после обширного хирургического вмешательства). Если в таких случаях\nназначают фенилбутазон, рекомендуют в качестве меры предосторожности контролировать\nфункцию почек."}},{"type":"paragraph","data":{"text":"Если\nпосле применения препарата наблюдается повышение активности\n\"печеночных\" трансаминаз или отмечаются клинические симптомы\nгепатотоксичности (в т. ч. тошнота, усталость, сонливость, диарея, кожный\nзуд, желтуха), лечение в дальнейшем не следует повторять."}},{"type":"paragraph","data":{"text":"Фенилбутазон\n(как и другие нестероидные противовоспалительные препараты) может вызвать\nгиперкалиемию."}},{"type":"paragraph","data":{"text":"При\nпроведении длительной терапии препаратами фенилбутазона необходимо\nконтролировать функцию печени, картину периферической крови, анализ кала на\nскрытую кровь."}},{"type":"paragraph","data":{"text":"В\nсвязи с отрицательным действием на фертильность женщинам, желающим\nзабеременеть, препарат применять не рекомендуется. Пациенткам с бесплодием (в\nтом числе проходящих обследование) рекомендуется отменить препарат."}},{"type":"paragraph","data":{"text":"Фенилбутазон\nзатрудняет интерпретацию лабораторных тестов для оценки функции щитовидной\nжелезы, меняя их показатели."}},{"type":"paragraph","data":{"text":"Существует значимый риск развития анафилактических реакций, включая\nанафилактический шок. При возникновении сразу после введения головокружения,\nрвоты, помрачения сознания, нарушения ритма сердечной деятельности, брадикардии,\nартериальной гипотензии – требуется неотложная медицинская помощь."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения возможно снижение скорости психических и двигательных реакций, поэтому необходимо воздерживаться от вождения транспорта и занятий другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для\nвнутримышечного введения 373,4 мг/2 мл + 3,75 мг/2 мл."}},{"type":"paragraph","data":{"text":"По 2 мл в ампулы темного стекла 1-го\nгидролитического класса с точкой надлома или кольцом излома."}},{"type":"paragraph","data":{"text":"По 1 или 3 ампулы в\nконтурный пластиковый поддон или контурную ячейковую упаковку из пленки\nполивинилхлоридной или ленты полистирольной. "}},{"type":"paragraph","data":{"text":"\nПо 1 контурному пластиковому поддону или по 1 контурной ячейковой упаковке\nвместе с инструкцией по применению в пачку из картона. По 5\nампул в контурный пластиковый поддон или контурную ячейковую упаковку из пленки\nполивинилхлоридной или ленты полистирольной. По 1 или 2 контурных пластиковых\nподдона или по 1 или 2 контурные ячейковые упаковки вместе с инструкцией по\nприменению в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В\nзащищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для\nдетей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3\nгода."}},{"type":"paragraph","data":{"text":"Не использовать по истечении\nсрока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускается по рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Федеральное\nказенное предприятие «Армавирская биологическая фабрика»"}},{"type":"paragraph","data":{"text":"(ФКП «Армавирская биофабрика»)"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО\n«Тривиум-XXI»"}}]}],"source":null},"description_toggle":false,"short_description":"ФенилбутазонВсасывание.После внутримышечной инъекции препарата фенилбутазон быстро высвобождается на протяжении двух часов. Далее на протяжении нескольких часов концентрация фенилбутазона в системном кровотоке поддерживается на высоком уровне, составляя 80–90 % от максимальной.Метаболизм.Метаболизм фенилбутазона происходит в результате окисления и глюкуронизации в печени. Главным метаболитом является фармакологически активный оксифенбутазон. Прочие метаболиты обладают меньшей противовоспалительной активностью.Выведение.Элиминация неизмененного активного вещества, а также его метаболитов происходит как через почки (около 70 %), так и с желчью через кишечник (около 30 %). Период полувыведения составляет от 50 до 100 часов и может значительно увеличиваться при нарушенной функции печени и почек. Связывание с белками плазмы крови составляет 99 %, что существенно при возможных лекарственных взаимодействиях фенилбутазона. Выведение. Терминальный период полувыведения лидокаина после внутривенного болюсного введения здоровым взрослым добровольцам составляет 1–2 часа.","substance":[{"id":542,"title":"Лидокаин","title_latin":"Lidocainum","slug":"lidokain_542"},{"id":692,"title":"Фенилбутазон","title_latin":"Phenylbutazonum","slug":"fenilbutazon_692"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Амбениум парентерал - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81705/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/81705/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"similar","products":[{"id":94039,"title":"Мильгамма","subtitle":{"full":"Раствор, 5 шт, 2 мл","short":"Раствор, 5 шт, 2 мл","package":"5 шт, 2 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