Повышенная чувствительность к компонентам препарата
Детский возраст (эффективность и безопасность применения препарата не изучены)
Тяжелые и острые формы декомпрепенсированной хронической сердечной недостаточности (ХСН); период беременности и грудного вскармливания; детский возраст
По 10 или 20 таблеток в контурной ячейковой упаковке
По 1, 2 или 6 контурных ячейковых упаковок по 10 таблеток вместе с инструкцией по применению в пачке из картона
По 1 или 3 контурных ячейковых упаковок по 20 таблеток вместе с инструкцией по применению в пачке из картона
Описание
Круглые, двояковыпуклые таблетки, покрытые пленочной оболочкой белого или почти белого цвета. На поперечном разрезе ядро от белого до светло-розового цвета с вкраплениями от светло-розового до темно-розового цвета
Фармакологические свойства
Комбинированный препарат. Нейротропные витамины группы В (тиамин, пиридоксин, цианокобаламин) оказывают благоприятное воздействие на воспалительные и дегенеративные заболевания нервов и двигательного аппарата. Они применяются не для устранения гиповитаминозных состояний, а в высоких дозах обладают анальгетическими свойствами, способствуют усилению кровотока и нормализуют работу нервной системы, процесс кроветворения (цианокобаламин (витамин В12)). Витамины тиамин (В1), пиридоксин (В6,) и цианокобаламин (B12) регулируют белковый, углеводный и жировой обмен, способствуют их нормализации, улучшают функцию двигательных, чувствительных и вегетативных нервов. Фармакологическое действие определяется свойствами витаминов, входящих в состав препарата. Препарат содержит витамины B1 (тиамин), В6 (пиридоксин) и В12 (цианокобаламин), дефицит которых может приводить к неврологическим расстройствам, главным образом, со стороны периферической нервной системыНейротропные витамины группы В оказывают благоприятное воздействие на воспалительные и дегенеративные заболевания нервов и двигательного аппарата, способствуют усилению кровотока и улучшают работу нервной системыТиамин является кофактором ферментов, переносящих двухуглеродные группы в реакциях декарбоксилирования, играет ключевую роль в метаболизме углеводов, а также в цикле Кребса с последующим участием в синтезе тиамина пирофосфата (ТПФ) и аденозина трифосфата (АТФ)Пиридоксин является кофактором трансаминаз, участвует в метаболизме протеина и, частично, в метаболизме углеводов и жировФизиологической функцией обоих витаминов является потенцирование действия друг друга, проявляющееся в положительном влиянии на нервную, нейромышечную и сердечно-сосудистую системыЦианокобаламин является кофактором в реакциях переноса одноуглеродных групп, участвует в синтезе миелиновой оболочки, стимулирует гемопоэз, уменьшает болевые ощущения, связанные с поражением периферической нервной системы, стимулирует нуклеиновый обмен через активацию фолиевой кислотыПрепарат быстро восполняет дефицит указанных витаминов
Показания к применению
В комплексной терапии следующих неврологических заболеваний сопровождающихся дефицитом витаминов группы В:Полинейропатии (диабетической, алкогольной);Межреберная невралгия;Невралгия тройничного нерва;Неврит лицевого нерва;Корешковый синдром, вызванный дегенеративными изменениями позвоночника;Шейный синдром;Плече-лопаточный синдром;Поясничный синдром;Люмбоишалгия
Противопоказания
Повышенная чувствительность к компонентам препарата
Детский возраст (эффективность и безопасность применения препарата не изучены)
Тяжелые и острые формы декомпрепенсированной хронической сердечной недостаточности (ХСН); период беременности и грудного вскармливания; детский возраст
Побочное действие
Частота проявления нежелательных явлений приведена в соответствии с классификацией ВОЗ: очень часто (≥ 1/10); часто (≥ 1/100, < 1/10); нечасто (≥ 1/1000, < 1/100); редко (≥ 1/10000, < 1/1000); очень редко (< 1/10000), включая отдельные случаи; частота неизвестна (невозможно оценить на основании имеющихся данных)Со стороны иммунной системы:Очень редко: аллергические реакции - крапивница, зудСо стороны желудочно-кишечного тракта:Частота неизвестна: тошнотаСо стороны сердечно-сосудистой системы:Очень редко: тахикардия
Взаимодействие с другими лекарственными средствами
При одновременном применении с леводопой пиридоксин может уменьшать противопаркинсоническое действие леводопы
Одновременное применение антагонистов пиридоксина (например, изониазида, гидралазина, пеницилламина или циклосерина) может увеличивать потребность в пиридоксине
Тиамин инактивируется фторурацилом. Фторурацил конкурентно ингибирует фосфорилирование тиамина до тиаминпирофосфата
Антациды снижают всасывание тиамина
"Петлевые" диуретики, например, фуросемид, могут блокировать канальцевую резорбцию, таким образом усиливая экскрецию тиамина при длительном применении, что приводит к снижению содержания тиамина в крови
Этанол и черный чай приводят к снижению всасывания тиамина
Напитки, содержащие сульфиты (например, вино), усиливают деградацию тиамина
Особые указания
При длительном применении (более 6-12 мес.) витамина В6 в суточной дозе 50 мг может возникать периферическая сенсорная нейропатия. Поэтому при длительной терапии рекомендуется регулярно контролировать состояние пациента
При появлении признаков периферической сенсорной нейропатии (парестезии) необходимо скорректировать дозу и, при необходимости, прекратить прием препарата
При приеме витамина В12 клиническая картина, а также лабораторные показатели при фуникулярном миелозе или пернициозной анемии, могут терять свою специфичность. Витамин В12 может маскировать симптомы дефицита фолиевой кислоты
Во время приема препарата Бинавит форте не рекомендуется прием поливитаминных комплексов, включающих в состав витамины группы В
Влияние на способность к вождению автотранспорта и управлению механизмами: Бинавит форте не оказывает влияние на способность управления транспортными средствами и механизмами
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