Повышенная индивидуальная чувствительность к компонентам препарата, острый инфаркт миокарда, детский возраст.
С осторожностью
Применять у больных с тяжелым кардиосклерозом, перенесших инфаркт миокарда, при повышенном риске развития тромбоэмболий; гипопротромбинемии, вызванной недостаточностью витамина К.
Обладает антиоксидантной активностью, участвует в биосинтезе гема и белков, пролиферации клеток, тканевом дыхании, других важнейших процессах тканевого метаболизма; защищает ткани от повреждающего действия избыточных количеств свободных радикалов и перекисных продуктов; стимулирует синтез белков и коллагена.
Фармакокинетика:
Абсорбция из 12-перстной кишки (необходимо присутствие солей желчных кислот, жиров, нормальное функционирование поджелудочной железы) – 20-40%. При повышении дозы степень абсорбции снижается. Время достижения максимальной концентрации – 4 часа. Депонируется во всех органах и тканях, особенно в жировой ткани. Проникает через плаценту, проникает в грудное молоко. Экскреция в основном через желудочно-кишечный тракт, с желчью – более 90%, менее чем 6% выделяется почками в виде глюкуронидов и других метаболитов.
Показания к применению
Лечение и профилактика гиповитаминоза витамина Е.
Противопоказания
Повышенная индивидуальная чувствительность к компонентам препарата, острый инфаркт миокарда, детский возраст.
С осторожностью
Применять у больных с тяжелым кардиосклерозом, перенесших инфаркт миокарда, при повышенном риске развития тромбоэмболий; гипопротромбинемии, вызванной недостаточностью витамина К.
Передозировка
При приеме витамина Е в течение длительного периода в дозах 400-800 МЕ/сут: нечеткость зрительного восприятия, головокружение, головная боль, тошнота, повышенная утомляемость, диарея, гастралгия, астения.
При приеме более 800 МЕ/сут в течение длительного периода – увеличение риска развития кровотечений у больных с гиповитаминозом витамина К, нарушение метаболизма тиреоидных гормонов, расстройства сексуальной функции, тромбофлебит, тромбоэмболия, некротический колит, сепсис, почечная недостаточность, кровоизлияние в сетчатую оболочку глаза, гемморагический инсульт, асцит.
Лечение: симптоматическое; отмена препарата; назначение глюкокортикостероидов, ускоряющих метаболизм витамина Е в печени.
Взаимодействие с другими лекарственными средствами
Одновременный прием больших доз витамина Е с витамином К или с непрямыми антикоагулянтами (производными кумарина и индандиона), увеличивает время свертывания крови. Витамин Е усиливает эффект глюкокортикостероидов, нестероидных противовоспалительных препаратов, сердечных гликозидов. При одновременном приеме с другими витаминно-минеральными препаратами, содержащими жирорастворимые витамины A, D и Е, следует посоветоваться с врачом.
Особые указания
Не превышать рекомендованную дозировку. Не следует принимать удвоенную дозу, если вы пропустили предыдущий прием препарата.
Влияние на способность к вождению транспортных средств и управлению механизмами
Прием препарата не влияет на способность человека управлять транспортными средствами или механизмами.
Для описания товара использована информация от партнера 36.6
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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