Максиколд Лор табс двойное действие Таблетки, 20 шт, 8,75+1 мг+мг, для рассасывания

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в\nрезультате чего снижается продукция простагландинов – медиаторов боли, воспаления\nи гипертермической реакции."}},{"type":"paragraph","data":{"text":"Препарат\nоказывает местное обезболивающее и противовоспалительное действие на слизистую\nоболочку полости рта и горла: уменьшает отек, затруднение при глотании, боль и\nощущение раздражения в горле."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЦетилпиридиния хлорид\u003c/i\u003e - антисептик из\nгруппы четвертичных аммониевых соединений, обладает противомикробным,\nпротивогрибковым и вирулицидным действием."}},{"type":"paragraph","data":{"text":"Комбинированное\nприменение \u003ci\u003eфлурбипрофена\u003c/i\u003e и \u003ci\u003eцетилпиридиния хлорида\u003c/i\u003e позволяет достичь\nболее высокой эффективности, в сравнении с цетилпиридиния хлоридом, при боли в\nгорле, вызванной инфекциями верхних дыхательных путей. Более выраженный эффект\nкомбинации проявляется в виде более быстрого уменьшения проявлений\nтонзиллофарингита, а также в виде более быстрого и выраженного снижения\nинтенсивности боли в горле, в\nтечение 1 часа и 2 часов после применения препарата. "}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика \u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eФлурбипрофен.\u003c/i\u003e Степень абсорбции –\nвысокая, флурбипрофен быстро и практически полностью всасывается,\nраспределяется по всему организму и в значительной степени связывается с\nбелками плазмы. Флурбипрофен обнаруживается в крови через 5 мин, максимальная\nконцентрация флурбипрофена в плазме крови (Cmax) достигается через 40–45 мин\nпосле рассасывания."}},{"type":"paragraph","data":{"text":"Флурбипрофен\nможет всасываться в полости рта путем пассивной диффузии. Скорость абсорбции\nзависит от лекарственной формы, при рассасывании Cmax флурбипрофена достигается\nбыстрее, чем при приеме внутрь эквивалентной дозы флурбипрофена. "}},{"type":"paragraph","data":{"text":"Период\nполувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) – 3-6 ч. Флурбипрофен выделяется с грудным\nмолоком в незначительных количествах (<0.05 мкг/мл). Подвергается\nметаболизму в печени путем гидроксилирования. Выводится почками и, в меньшей\nстепени, с желчью. Приблизительно 20–25% пероральной дозы флурбипрофена\nвыводится в неизмененном виде."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЦетилпиридиния\nхлорид\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Обладает местным\nдействием и практически не всасывается через слизистую оболочку полости рта."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- в качестве\nсимптоматического средства для облегчения боли в горле при инфекционно-воспалительных\nзаболеваниях полости рта и глотки."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"-  повышенная\nчувствительность к компонентам препарата;"}},{"type":"paragraph","data":{"text":"-  наличие в\nанамнезе реакций гиперчувствительности (бронхиальная астма, бронхоспазм, ринит,\nотек Квинке, крапивница, рецидивирующий полипоз носа или околоносовых пазух) в\nответ на применение ацетилсалициловой кислоты или других НПВП;"}},{"type":"paragraph","data":{"text":"-  эрозивно-язвенные\nзаболевания органов желудочно-кишечного тракта (ЖКТ) (в т.ч. язвенная болезнь\nжелудка и двенадцатиперстной кишки, болезнь Крона, язвенный колит) или язвенное\nкровотечение в фазе обострения или в анамнезе (два или более подтвержденных\nэпизода язвенной болезни или язвенного кровотечения);"}},{"type":"paragraph","data":{"text":"-  кровотечение\nили перфорация язвы ЖКТ в анамнезе, спровоцированные применением НПВП;"}},{"type":"paragraph","data":{"text":"-  гемофилия и\nдругие нарушения свертываемости крови (в т.ч. гипокоагуляция), геморрагические\nдиатезы;"}},{"type":"paragraph","data":{"text":"-  тяжелая\nпеченочная недостаточность или заболевание печени в активной фазе;"}},{"type":"paragraph","data":{"text":"-  почечная\nнедостаточность тяжелой степени тяжести (клиренс креатинина (КК)) "}},{"type":"paragraph","data":{"text":"\n< 30 мл/мин).;"}},{"type":"paragraph","data":{"text":"-  декомпенсированная\nсердечная недостаточность; "}},{"type":"paragraph","data":{"text":"-  период\nпосле проведения аортокоронарного шунтирования;"}},{"type":"paragraph","data":{"text":"-  беременность\n(III триместр);"}},{"type":"paragraph","data":{"text":"-  период\nгрудного вскармливания;"}},{"type":"paragraph","data":{"text":"-  подтвержденная\nгиперкалиемия"}},{"type":"paragraph","data":{"text":"-  дефицит\nглюкозо-6-фосфатдегидрогеназы;"}},{"type":"paragraph","data":{"text":"-  детский\nвозраст до 18 лет (в связи с отсутствием опыта медицинского применения у детей).\n"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли у Вас присутствует одно или несколько\nиз перечисленных выше заболеваний и состояний, то перед началом приема\nнеобходимо проконсультироваться с врачом.\u003c/i\u003e"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При\nодновременном приеме других НПВП; наличии в анамнезе однократного эпизода\nязвенной болезни желудка или язвенного кровотечения ЖКТ; заболеваниях ЖКТ в\nанамнезе (язвенный колит, болезнь Крона), гастрите, энтерите, колите, наличии\nинфекции \u003ci\u003eHelicobacter pylori\u003c/i\u003e;\nбронхиальной астме или аллергических заболевания в стадии обострения или в\nанамнезе (возможно развитие бронхоспазма); системной красной волчанке или\nсмешанном заболевании соединительной ткани (синдром Шарпа), т.к. повышен риск\nасептического менингита (при кратковременном применении флурбипрофена риск\nнезначительный); почечной недостаточности, в т.ч. при обезвоживании (КК менее\n30-60 мл/мин), нефротическом синдроме; печеночной недостаточности; циррозе\nпечени с портальной гипертензией; гипербилирубинемии; артериальной гипертензии\nи/или сердечной недостаточности, отеках; одновременном применении лекарственных\nсредств, которые могут увеличить риск возникновения язв или кровотечения, в\nчастности пероральных глюкокортикостероидов (в т.ч. преднизолона),\nантикоагулянтов (в т.ч. варфарина), антиагрегантов (в т.ч. ацетилсалициловой\nкислоты, клопидогрела), селективных ингибиторов обратного захвата серотонина (в\nт.ч. циталопрама, флуоксетина, пароксетина, сертралина); в I и II триместрах\nбеременности; пациентам пожилого возраста; при употреблении алкоголя. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли у Вас присутствует одно или несколько\nиз перечисленных выше заболеваний и состояний, то перед началом приема\nнеобходимо проконсультироваться с врачом.\u003c/i\u003e"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eБеременность\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Применение\nпрепаратов противопоказано в III\nтриместре беременности. Следует избегать применения препарата в I-II триместре беременности, при\nнеобходимости применения препарата следует проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eПериод\nгрудного вскармливания\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Применение\nпрепарата в период грудного вскармливания противопоказано. При необходимости\nприменения препарата в период грудного вскармливания следует прекратить\nкормление грудью."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПеред применением препарата, если Вы\nбеременны или предполагаете, что Вы могли бы быть беременной, или планируете\nбеременность, необходимо проконсультироваться с врачом.\u003c/i\u003e"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Взрослым – по 1\nтаблетке каждые 3-6 часов. Таблетки следует медленно рассасывать до полного\nрастворения. "}},{"type":"paragraph","data":{"text":"Не следует\nпринимать таблетки непосредственно перед или во время еды."}},{"type":"paragraph","data":{"text":"Максимальная\nсуточная доза – 5 таблеток."}},{"type":"paragraph","data":{"text":"Длительность\nприема составляет не более 3 дней."}},{"type":"paragraph","data":{"text":"В случае необходимости продолжения приема препарата более 3 дней (при\nсохранении болевого синдрома) необходимо проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрименяйте препарат только согласно тем\nпоказаниям, тому способу применения и в тех дозах, которые указаны в\nинструкции.\u003c/i\u003e"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Риск\nвозникновения побочных эффектов можно свести к минимуму, если принимать\nпрепарат коротким курсом в минимальной эффективной дозе, необходимой для\nустранения симптомов."}},{"type":"paragraph","data":{"text":"Частота\nвозникновения нежелательных лекарственных реакций определена в соответствии с\nклассификацией ВОЗ: очень часто (≥ 1/10), часто (от ≥ 1/100 до <1/10),\nнечасто (от ≥ 1/1000 до <  1/100), редко (от ≥ 1/10000 до  < 1/1000), очень редко (< 1/10000),\nчастота неизвестна (не может быть установлена по имеющимся данным)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны крови и\nлимфатической системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Частота неизвестна:\nнарушение кроветворения (анемия, тромбоцитопения)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны иммунной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко:\nанафилактические реакции."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны психики\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто:\nбессонница."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны нервной системы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто:\nголовокружение, головная боль, парестезия."}},{"type":"paragraph","data":{"text":"Нечасто:\nсонливость."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сердца\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Частота\nнеизвестна: сердечная недостаточность, отеки."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сосудов\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Частота\nнеизвестна: повышение артериального давления"}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны дыхательной системы,\nорганов грудной клетки и средостения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: чувство\nраздражения в горле."}},{"type":"paragraph","data":{"text":"Нечасто:\nобострение астмы и бронхоспазм, одышка, свистящее дыхание, волдыри в полости\nрта и глотки, фарингеальная гипестезия (снижение чувствительности в полости рта\nи глотки)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного\nтракта\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: диарея, изъязвление полости рта, тошнота, боль в ротовой полости,\nпарестезия ротовой полости, боль в полости рта и глотки, дискомфорт в полости\nрта (ощущение тепла, чувство жжения или покалывания во рту)."}},{"type":"paragraph","data":{"text":"Нечасто: вздутие живота, боль в животе, запор, сухость во рту, диспепсия,\nметеоризм, глоссалгия (синдром жжения полости рта), дисгевзия (изменение\nвосприятия вкуса), дизестезия полости рта, рвота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны печени и\nжелчевыводящих путей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Частота\nнеизвестна: гепатит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны кожи и подкожных\nтканей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: кожная\nсыпь, зуд."}},{"type":"paragraph","data":{"text":"Очень редко:\nреакции гиперчувствительности, включая раздражение и кожную сыпь."}},{"type":"paragraph","data":{"text":"Частота\nнеизвестна: тяжелые кожные реакции, такие как буллезные реакции, включая\nсиндром Стивенса-Джонсона и токсический эпидермальный некролиз (Синдром\nЛайелла)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочее\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто:\nлихорадка, боль."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли любые из указанных в инструкции\nпобочных эффектов усугубляются или Вы заметили любые другие побочные эффекты,\nне указанные в инструкции, сообщите об этом врачу. \u003c/i\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Учитывая\nколичество действующего вещества, содержащегося в одной пастилке, возможность\nпередозировки минимальная."}},{"type":"paragraph","data":{"text":"Флурбипрофен"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: тошнота, рвота, боль в\nэпигастральной области или, реже, диарея, шум в ушах, головная боль и\nжелудочно-кишечное кровотечение. В тяжелых случаях наблюдаются проявления со\nстороны центральной нервной системы: сонливость, редко – возбуждение, судороги,\nдезориентация, кома. В случаях тяжелого отравления может развиваться\nметаболический ацидоз и увеличение протромбинового времени, острая почечная\nнедостаточность, повреждение ткани печени, снижение артериального давления,\nугнетение дыхания и ацидоз. У пациентов с бронхиальной астмой возможно\nобострение этого заболевания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Симптоматическое, с обязательным обеспечением проходимости дыхательных\nпутей, мониторингом ЭКГ и основных показателей жизнедеятельности вплоть до\nнормализации состояния пациента. Рекомендуется пероральное применение\nактивированного угля или промывание желудка в течение одного часа после приема\nпотенциально токсической дозы флурбипрофена. Частые или продолжительные\nсудороги следует купировать внутривенным введением диазепама или лоразепама.\nПри усугублении бронхиальной астмы рекомендуется применение бронходилататоров.\nСпецифического антидота к флурбипрофену не существует."}},{"type":"paragraph","data":{"text":"Цетилпиридиния\nхлорид"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Признаки и\nсимптомы интоксикации могут развиваться в результате приема внутрь\nзначительного количества цетилпиридиния хлорида, включают: тошноту, рвоту, одышку,\nцианоз, асфиксию с возможным последующим развитием паралича дыхательных мышц,\nугнетение центральной нервной системы (ЦНС), гипотензию и кому. Смертельная\nдоза у человека составляет примерно 1-3 г."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Ввиду отсутствия\nспецифического антидота к цетилпиридиния хлориду, лечение острой передозировки\nцетилпиридиния хлоридом является симптоматическим."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри появлении симптомов передозировки\nследует прекратить прием препарата и немедленно обратиться к врачу.\u003c/i\u003e"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФлурбипрофен\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСледует избегать одновременного\nприменения со следующими лекарственными средствами:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"·    \nАцетилсалициловая кислота: за исключением низких\nдоз ацетилсалициловой кислоты (не более 75 мг в сутки), назначенных врачом,\nпоскольку совместное применение может повысить риск возникновения побочных\nэффектов."}},{"type":"paragraph","data":{"text":"·    \nДругие НПВП, в том числе ибупрофен и селективные\nингибиторы циклооксигеназы-2: следует избегать одновременного применения двух и\nболее препаратов из группы НПВП из-за возможного увеличения риска возникновения\nпобочных эффектов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eС осторожностью применять одновременно со\nследующими лекарственным и средствам:\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"·    \nАнтикоагулянты: НПВП могут усиливать эффект\nантикоагулянтов, в частности, варфарина."}},{"type":"paragraph","data":{"text":"·    \nАнтиагреганты и селективные ингибиторы обратного\nзахвата серотонина: повышенный риск возникновения желудочно-кишечного\nкровотечения."}},{"type":"paragraph","data":{"text":"·    \nГипотензивные средства (ингибиторы АПФ и\nантагонисты ангиотензина II) и диуретики: НПВП могут снижать эффективность\nпрепаратов этих групп и могут повышать нефротоксичность вследствие\nингибирования циклооксигеназы, особенно у пациентов с нарушением почечной\nфункции (необходимо обеспечить адекватное возмещение жидкости у таких\nпациентов)."}},{"type":"paragraph","data":{"text":"·    \nАлкоголь: возможно увеличение риска\nвозникновения побочных реакций, в особенности, кровотечения в ЖКТ."}},{"type":"paragraph","data":{"text":"·    \nСердечные гликозиды: одновременное применение с\nНПВП может привести к усугублению сердечной недостаточности, снижению скорости\nклубочковой фильтрации и увеличению концентрации сердечных гликозидов в плазме\nкрови."}},{"type":"paragraph","data":{"text":"·    \nЦиклоспорин: увеличение риска нефротоксичности\nпри одновременном применении с НПВП."}},{"type":"paragraph","data":{"text":"·    \nГлюкокортикостероиды: повышенный риск\nобразования язв ЖКТ и желудочно-кишечного кровотечения."}},{"type":"paragraph","data":{"text":"·    \nПрепараты лития: существуют данные о вероятности\nувеличения концентрации лития в плазме крови на фоне применения НПВП. "}},{"type":"paragraph","data":{"text":"·    \nМетотрексат: существуют данные о вероятности\nувеличения концентрации метотрексата в плазме крови на фоне применения НПВП.\nНеобходимо принимать НПВП за 24 часа до или после приёма метотрексата."}},{"type":"paragraph","data":{"text":"·    \nМифепристон: применение НПВП следует начинать не\nранее, чем через 8-12 дней после окончания применения мифепристона, поскольку\nНПВП могут снижать эффективность мифепристона."}},{"type":"paragraph","data":{"text":"·    \nАнтибиотики хинолонового ряда: при совместном\nприменении с НПВП возможно увеличение риска возникновения судорог."}},{"type":"paragraph","data":{"text":"·    \nТакролимус: при одновременном применении с НПВП\nвозможно увеличение риска нефротоксичности."}},{"type":"paragraph","data":{"text":"·    \nЗидовудин: одновременное применение с НПВП может\nпривести к повышению гематотоксичности."}},{"type":"paragraph","data":{"text":"·    \nПероральные гипогликемические препараты:\nвозможно изменение уровня глюкозы в крови (рекомендуется увеличить частоту\nконтроля уровня глюкозы в крови)."}},{"type":"paragraph","data":{"text":"·    \nФенитоин: возможно повышение сывороточного\nуровня фенитоина (рекомендуется контроль сывороточного уровня фенитоина и, при\nнеобходимости, коррекция дозы)."}},{"type":"paragraph","data":{"text":"·    \nКалийсберегающие диуретики: совместное\nприменение с флурбипрофеном может привести к гиперкалиемии."}},{"type":"paragraph","data":{"text":"·    \nПробенецид и сульфинпиразон: могут задерживать\nвыведение флурбипрофена."}},{"type":"paragraph","data":{"text":"·    \nТолбутамид и антациды: к настоящему времени\nисследования не выявили взаимодействия между флурбипрофеном и толбутамидом или\nантацидами."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЦетилпиридиния\nхлорид\u003c/i\u003e\u003c/b\u003e\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Не следует применять одновременно с молоком, поскольку при этом снижается\nпротивомикробная активность цетилпиридиния хлорида."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли Вы применяете выше перечисленные или\nдругие лекарственные препараты (в том числе безрецептурные) перед применением\nпрепарата МАКСИКОЛД ЛОР ТАБС ДВОЙНОЕ ДЕЙСТВИЕ проконсультируйтесь с\nврачом.\u003c/i\u003e"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eВнимательно прочитайте эту\nинструкцию перед тем, как начать применение этого препарата, так как она\nсодержит важную для Вас информацию.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eСохраняйте инструкцию, она может\nпонадобиться вновь.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли у Вас возникли вопросы,\nобратитесь к врачу.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛекарственное средство, которым\nВы лечитесь, предназначено лично Вам, и его не следует передавать другим лицам,\nпоскольку оно может причинить им вред даже при наличии тех же симптомов, что и\nу Вас.\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Рекомендуется принимать препарат максимально возможным\nкоротким курсом и в минимальной эффективной дозе, необходимой для устранения\nсимптомов."}},{"type":"paragraph","data":{"text":"При появлении\nсимптомов гастропатии показан тщательный контроль, включающий проведение\nэзофагогастродуоденоскопии, общий анализ крови (определение гемоглобина),\nанализ кала на скрытую кровь."}},{"type":"paragraph","data":{"text":"При\nнеобходимости определения 17-кетостероидов препарат следует отменить за 48\nчасов до исследования."}},{"type":"paragraph","data":{"text":"В период лечения\nне рекомендуется прием этанола."}},{"type":"paragraph","data":{"text":"Пациентам с\nпочечной или печеночной недостаточностью, а также пожилым пациентам и пациентам,\nпринимающим диуретики, необходимо проконсультироваться с врачом перед\nприменением препарата, поскольку существует\nриск ухудшения функционального состояния почек. При кратковременном применении\nпрепарата риск является незначительным. "}},{"type":"paragraph","data":{"text":"Пациентам с артериальной гипертензией, в том числе\nв анамнезе и/или хронической сердечной недостаточностью, необходимо\nпроконсультироваться с врачом перед применением препарата, поскольку препарат\nможет вызывать задержку жидкости, повышение артериального давления и отеки."}},{"type":"paragraph","data":{"text":"Информация для\nженщин, планирующих беременность: препарат подавляет циклооксигеназу и синтез\nпростагландинов и может воздействовать на овуляцию, нарушая женскую\nрепродуктивную функцию (обратимо после отмены лечения)."}},{"type":"paragraph","data":{"text":"При появлении\nраздражения в полости рта, кожной сыпи, поражения слизистой оболочки и других\nпроявлениях аллергической реакции, следует прекратить применение препарата и\nобратиться к врачу."}},{"type":"paragraph","data":{"text":"При отсутствии\nэффекта после 3 дней терапии, а также в случае ухудшения существующих симптомов\nили появления новых, в том числе при появлении признаков бактериальной\nинфекции, необходимо незамедлительно обратиться к врачу для пересмотра терапии."}},{"type":"paragraph","data":{"text":"При необходимости применения препарата\nодновременно с жаропонижающими средствами, следует избегать приема НПВП из-за\nвозможного увеличения риска возникновения побочных эффектов и выбирать\nпрепараты других фармакологических групп (например, парацетамол)."}},{"type":"paragraph","data":{"text":"Препарат МАКСИКОЛД ЛОР ТАБС ДВОЙНОЕ\nДЕЙСТВИЕ не следует применять при наличии\nоткрытых ран в полости рта, поскольку цетилпиридиния хлорид замедляет\nзаживление ран."}},{"type":"paragraph","data":{"text":"Цетилпиридиния\nхлорид не является антимикробным (антибактериальным) средством – а относится к антисептикам,\nрезистентность к нему не формируется."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В случае\nвозникновения головокружения, сонливости, заторможенности или нарушения зрения\nпри приеме препарата следует избегать вождения автотранспорта или управления\nмеханизмами."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки для\nрассасывания, 8,75 мг + 1,0 мг. "}},{"type":"paragraph","data":{"text":"По 6 или 10\nтаблеток в контурную ячейковую упаковку из пленки ПВХ/ПВДХ и фольги алюминиевой\nпечатной лакированной. "}},{"type":"paragraph","data":{"text":"1 или 2\nконтурные ячейковые упаковки с инструкцией по применению помещают в пачку из\nкартона. "}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 ºС в оригинальной упаковке (блистер в\nпачке)."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей\nместе."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. "}},{"type":"paragraph","data":{"text":"Не применять по истечении срока\nгодности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"Фармстандарт-Лексредства\",\nРоссия,"}},{"type":"paragraph","data":{"text":"305022, г. Курск, ул. 2-я\nАгрегатная, 1а/18, "}},{"type":"paragraph","data":{"text":"тел./факс: (4712) 34-03-13"}},{"type":"paragraph","data":{"text":"www.pharmstd.ru"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"АО \"Отисифарм\", Россия, "}},{"type":"paragraph","data":{"text":"123112, г. Москва, ул. Тестовская,\nд. 10, эт. 12, пом. II,\nком.29."}},{"type":"paragraph","data":{"text":"Тел.: +7 (800) 775-98-19"}},{"type":"paragraph","data":{"text":"Факс: +7 (495) 221-18-02"}},{"type":"paragraph","data":{"text":"www.otcpharm.ru"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаФлурбипрофенявляется производным пропионовой кислоты из группы нестероидных противовоспалительных препаратов (НПВП) и обладает значительным обезболивающим, противовоспалительным и жаропонижающим эффектом за счет подавления циклооксигеназы-1 (ЦОГ-1) и циклооксигеназы-2 (ЦОГ-2), с некоторой селективностью по отношению к ЦОГ-1, в результате чего снижается продукция простагландинов – медиаторов боли, воспаления и гипертермической реакции. Препарат оказывает местное обезболивающее и противовоспалительное действие на слизистую оболочку полости рта и горла: уменьшает отек, затруднение при глотании, боль и ощущение раздражения в горле.Цетилпиридиния хлорид- антисептик из группы четвертичных аммониевых соединений, обладает противомикробным, противогрибковым и вирулицидным действием. Комбинированное применениефлурбипрофенаицетилпиридиния хлоридапозволяет достичь более высокой эффективности, в сравнении с цетилпиридиния хлоридом, при боли в горле, вызванной инфекциями верхних дыхательных путей. Более выраженный эффект комбинации проявляется в виде более быстрого уменьшения проявлений тонзиллофарингита, а также в виде более быстрого и выраженного снижения интенсивности боли в горле, в течение 1 часа и 2 часов после применения препарата.ФармакокинетикаФлурбипрофен.Степень абсорбции – высокая, флурбипрофен быстро и практически полностью всасывается, распределяется по всему организму и в значительной степени связывается с белками плазмы. Флурбипрофен обнаруживается в крови через 5 мин, максимальная концентрация флурбипрофена в плазме крови (Cmax) достигается через 40–45 мин после рассасывания. Флурбипрофен может всасываться в полости рта путем пассивной диффузии. Скорость абсорбции зависит от лекарственной формы, при рассасывании Cmax флурбипрофена достигается быстрее, чем при приеме внутрь эквивалентной дозы флурбипрофена. Период полувыведения (Т1/2) – 3-6 ч. Флурбипрофен выделяется с грудным молоком в незначительных количествах (\u003c0.05 мкг/мл). Подвергается метаболизму в печени путем гидроксилирования. Выводится почками и, в меньшей степени, с желчью. Приблизительно 20–25% пероральной дозы флурбипрофена выводится в неизмененном виде.Цетилпиридиния хлоридОбладает местным действием и практически не всасывается через слизистую оболочку полости рта.","substance":[{"id":473,"title":"Флурбипрофен","title_latin":null,"slug":"flurbiprofen_473"},{"id":775,"title":"Цетилпиридиния хлорид","title_latin":"Cetylpyridinii chloridum","slug":"tsetilpiridiniya_hlorid_775"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":true,"comments":null,"image_alt":"Максиколд Лор табс двойное действие - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/71835/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/71835/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"similar","products":[{"id":108461,"title":"Граммидин детский","subtitle":{"full":"Таблетки, 18 шт, для рассасывания, 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