Цитрамон-мфф Таблетки, пачка, 6 шт, для приема внутрь, для взрослых, +15 лет, цвет серый

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Кислота ацетилсалициловая обладает антиоксидантными свойствами способствует повышению общей резистентности организма и хорошей переносимости препарата."}},{"type":"paragraph","data":{"text":"Парацетамол обладает анальгетическим жаропонижающим и крайне слабым противовоспалительным действием что связано с его влиянием на центр терморегуляции в гипоталамусе и слабовыраженной способностью ингибировать синтез Pg в периферических тканях."}},{"type":"paragraph","data":{"text":"Кофеин повышает рефлекторную возбудимость спинного мозга возбуждает дыхательный и сосудодвигательный центры расширяет кровеносные сосуды скелетных мышц головного мозга сердца почек снижает агрегацию тромбоцитов; уменьшает сонливость чувство усталости повышает умственную и физическую работоспособность. В данной комбинации кофеин в малой дозе практически не оказывает стимулирующего действия на ЦНС однако способствует нормализации тонуса сосудов мозга и ускорению кровотока."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Ацетилсалициловая кислота: после приема внутрь достаточно полно всасывается. Во время абсорбции подвергается пресистемной элиминации в стенке кишечника и в печени (деацетилируется). Резорбированная часть очень быстро гидролизуется эстеразами (Т1/2 составляет не более 15-20 мин). В организме циркулирует анион салициловой кислоты. Салицилаты легко проникают в ткани и жидкости организма диффузия ускоряется при наличии гиперемии и отека замедляется - в пролиферативной фазе воспаления. Салицилаты проникают через плаценту в небольших количествах выводятся с грудным молоком. 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Выводится почками главным образом в виде продуктов конъюгации менее 5% экскретируется в неизмененном виде."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Цитрамон-МФФ применяется у взрослых при. умеренно или слабо выраженном болевом синдроме (головная зубная боль боли в суставах невралгия миалгия дисменорея и др.) для снижения повышенной температуры тела при простудных и других инфекционно-воспалительных заболеваниях."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная индивидуальная чувствительность к компонентам препарата."}},{"type":"paragraph","data":{"text":"Язвенная болезнь желудка и двенадцатиперстной кишки желудочно-кишечные кровотечения выраженные нарушения функции печени или почек."}},{"type":"paragraph","data":{"text":"Генетическое отсутствие глюкозо-6-фосфатдегидрогеназы. Заболевания крови со склонностью к кровоизлияниям и кровотечениям."}},{"type":"paragraph","data":{"text":"Глаукома бронхиальная астма."}},{"type":"paragraph","data":{"text":"I и III триместр беременности и период грудного вскармливания."}},{"type":"paragraph","data":{"text":"Почечная недостаточность."}},{"type":"paragraph","data":{"text":"Приступ бронхообструкции крапивница или острый ринит в анамнезе спровоцированные приемом ацетилсалициловой кислоты или других нестероидных противовоспалительных средств; гемофилия геморрагический диатез гипопротромбинемия портальная гипертензия; авитаминоз витамина К. Подтвержденная гиперкалиемия."}},{"type":"paragraph","data":{"text":"Артериальная гипертензия тяжелое течение ИБС повышенная возбудимость нарушения сна; хирургические вмешательства сопровождающиеся кровотечением. Препарат не назначают детям до 15 лет с острыми респираторными заболеваниями вызванными вирусными инфекциями (ОРВИ грипп) из-за опасности развития синдрома Рейе."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью применяют у лиц пожилого возраста больных с нарушенной функцией печени или почек (клиренс креатинина менее 60 мл/мин) при подагре."}},{"type":"paragraph","data":{"text":"При ИБС цереброваскулярных заболеваниях застойной сердечной недостаточности дислипидемии/гиперлипидемии сахарном диабете заболевании периферических артерий курении."}},{"type":"paragraph","data":{"text":"Анамнестические данные о развитии язвенного поражения ЖКТ длительное использование НПВП сопутствующая терапия селективными ингибиторами обратного захвата серотонина."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Ацетилсалициловая кислота при применении в I триместре беременности обладает тератогенным влиянием; в III триместре - может привести к торможению родовой деятельности. Выделяется с грудным молоком поэтому применения в период лактации противопоказано."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Цитрамон-МФФ применяют внутрь после еды по 1-2 таблетки 2-3 раза в день максимальная суточная доза -6 таблеток. Перерыв между приемами не менее 6 часов. При нарушениях функции почек или печени перерыв между приемами препарата должен быть не менее 8 часов."}},{"type":"paragraph","data":{"text":"Препарат не следует применять более 5 дней как обезболивающее средство и более 3-х дней как жаропонижающее без назначения и наблюдения врача. Другие дозировки и схемы применения устанавливает врач."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Редко возможны кожные аллергические реакции (сыпь зуд крапивница) сердцебиение головокружение тошнота боли в области желудка. При длительном приеме в высоких дозах могут возникнуть нарушения функции печени и почек. Гастралгия тошнота рвота гепатотоксичность нефротоксичность эрозивно-язвенные поражения ЖКТ аллергические реакции (в т.ч. синдром Стивенса-Джонсона Лайелла) тахикардия повышение АД бронхоспазм."}},{"type":"paragraph","data":{"text":"При длительном применении - головокружение головная боль нарушения зрения шум в ушах снижение агрегации тромбоцитов гипокоагуляция геморрагический синдром (носовое кровотечение кровоточивость десен пурпура и др.) поражение почек с папиллярным некрозом; глухота; синдром Рейе у детей (гиперпирексия метаболический ацидоз нарушения со стороны нервной системы и психики рвота нарушения функции печени)."}},{"type":"paragraph","data":{"text":"О побочных эффектах препарата в том числе не указанных в инструкции необходимо сообщать лечащему врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Не следует превышать рекомендуемую дозу и длительность применения!"}},{"type":"paragraph","data":{"text":"Симптомы (обусловлены ацетилсалициловой кислотой): при легких интоксикациях - тошнота рвота гастралгия головокружение звон в ушах; тяжелая интоксикация - заторможенность сонливость коллапс судороги бронхоспазм затрудненное дыхание анурия кровотечения."}},{"type":"paragraph","data":{"text":"Первоначально центральная гипервентиляция легких приводит к дыхательному алкалозу (одышка удушье цианоз испарина). По мере усиления интоксикации прогрессирующий паралич дыхания и разобщение окислительного фосфорилирования вызывают респираторный ацидоз."}},{"type":"paragraph","data":{"text":"Лечение: При подозрении на отравление необходимо немедленно обратиться за врачебной помощью. Пострадавшему следует сделать промывание желудка с использованием активированного угля.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Препарат усиливает действие средств снижающих свертывание крови и агрегацию тромбоцитов а также побочные действия глюкокортикоидов производных сульфонилмочевины метотрексата ненаркотических анальгетиков и нестероидных противовоспалительных средств."}},{"type":"paragraph","data":{"text":"Усиливает действие резерпина и гипогликемических средств."}},{"type":"paragraph","data":{"text":"Уменьшает эффективность спиронолактона фуросемида гипотензивных ЛС а также противоподагрических ЛС способствующих выведению мочевой кислоты. Барбитураты рифампицин салициламид противоэпилептические ЛС и др. стимуляторы микросомального окисления способствуют образованию токсичных метаболитов парацетамола влияющих на функцию печени. Метоклопрамид ускоряет всасывание парацетамола. Под воздействием парацетамола Т1/2 хлорамфеникола увеличивается в 5 раз. При повторном приеме парацетамол может усилить действие антикоагулянтов (производных дикумарина). Одновременный прием парацетамола и этанола повышает риск развития гепатотоксических эффектов. Кофеин ускоряет всасывание эрготамина."}},{"type":"paragraph","data":{"text":"Использование других лекарственных средств должно быть согласовано с врачом."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не назначать препарат детям до 15 лет из-за высокого риска возникновения синдрома Рейе. Синдром Рейе проявляется продолжительной рвотой острой энцефалопатией увеличением печени."}},{"type":"paragraph","data":{"text":"Ацетилсалициловая кислота замедляет свертывание крови. Если пациенту предстоит хирургическое вмешательство следует заранее предупредить врача о приеме препарата"}},{"type":"paragraph","data":{"text":"У пациентов с предрасположенностью к накоплению мочевой кислоты прием препарата может спровоцировать приступ подагры."}},{"type":"paragraph","data":{"text":"Во время приема следует воздерживаться от употребления алкоголя (повышение риска желудочно-кишечного кровотечения и токсического поражения печени)."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"не описано"}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки."}},{"type":"header","data":{"text":"Упаковка:","level":3}},{"type":"paragraph","data":{"text":"По 6 или 10 штук в контурную безъячейковую упаковку или по 10 таблеток в контурную ячейковую упаковку."}},{"type":"paragraph","data":{"text":"По 2 или 3 контурных ячейковых упаковок по 10 таблеток или по 2 или 3 контурных безъячейковых упаковок по 6 или 10 таблеток вместе с инструкцией по применению помещают в картонную пачку."}},{"type":"paragraph","data":{"text":"Допускается контурные ячейковые и безъячейковые упаковки вместе с равным количеством инструкций по применению упаковывать в коробку из картона."}},{"type":"break","data":{}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом месте при температуре не выше +25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года."}},{"type":"paragraph","data":{"text":"Не использовать по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Закрытое акционерное общество \"Московская фармацевтическая фабрика\" (ЗАО \"Московская фармацевтическая фабрика\"), 125239, г. Москва, Фармацевтический проезд, д. 1, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО \"Московская фармацевтическая фабрика\""}}]}],"source":null},"description_toggle":false,"short_description":"Цитрамон-МФФ оказывает обезболивающее жаропонижающее и противовоспалительное действие. Комбинированное действие компонентов препарата обеспечивает его эффективность при низкой токсичности. Ацетилсалициловая кислота обладает обезболивающим жаропонижающим и противовоспалительным действием. Кислота ацетилсалициловая обладает антиоксидантными свойствами способствует повышению общей резистентности организма и хорошей переносимости препарата. Парацетамол обладает анальгетическим жаропонижающим и крайне слабым противовоспалительным действием что связано с его влиянием на центр терморегуляции в гипоталамусе и слабовыраженной способностью ингибировать синтез Pg в периферических тканях. Кофеин повышает рефлекторную возбудимость спинного мозга возбуждает дыхательный и сосудодвигательный центры расширяет кровеносные сосуды скелетных мышц головного мозга сердца почек снижает агрегацию тромбоцитов; уменьшает сонливость чувство усталости повышает умственную и физическую работоспособность. В данной комбинации кофеин в малой дозе практически не оказывает стимулирующего действия на ЦНС однако способствует нормализации тонуса сосудов мозга и ускорению кровотока. Ацетилсалициловая кислота: после приема внутрь достаточно полно всасывается. Во время абсорбции подвергается пресистемной элиминации в стенке кишечника и в печени (деацетилируется). Резорбированная часть очень быстро гидролизуется эстеразами (Т1/2 составляет не более 15-20 мин). В организме циркулирует анион салициловой кислоты. Салицилаты легко проникают в ткани и жидкости организма диффузия ускоряется при наличии гиперемии и отека замедляется - в пролиферативной фазе воспаления. Салицилаты проникают через плаценту в небольших количествах выводятся с грудным молоком. Биотрансформируются в печени с образованием 4 метаболитов; экскретируются почками (при подщелачивании мочи экскреция значительно увеличивается). Кофеин: хорошо всасывается в кишечнике период полувыведения - 5 ч (иногда - до 10 ч). Выводится преимущественно почками в виде метаболитов около 10% - в неизмененном виде. Парацетамол: быстро всасывается из желудочно-кишечного тракта. Период полувыведения из плазмы составляет 1-4 часа. Максимальная концентрация в плазме определяется обычно через 30-60 минут после приёма внутрь. Метаболизируется в печени с образованием глюкуронида и сульфата парацетамола. 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