АФОБАЗОЛ РЕТАРД применяется у взрослых при тревожных состояниях: генерализованные
тревожные расстройства, неврастения, расстройства адаптации, у пациентов с
различными соматическими заболеваниями (бронхиальная астма, синдром
раздраженного кишечника, системная красная волчанка, ишемическая болезнь
сердца, гипертоническая болезнь,...
Состав оболочки: Опадрай II 85 F18422 белый [поливиниловый спирт, частично гидролизованный, титана
диоксид, макрогол 4000, тальк] - 6,0 мг.
Описание
круглые
двояковыпуклые таблетки, покрытые пленочной оболочкой почти белого цвета. На
поперечном разрезе ядро почти белого или белого с желтовато-коричневатым
оттенком цвета.
Действуя на
сигма-1-рецепторы в нервных клетках головного мозга, фабомотизол стабилизирует
ГАМК/бензодиазепиновые рецепторы и восстанавливает их чувствительность к
эндогенным медиаторам торможения. фабомотизол
также повышает биоэнергетический потенциал нейронов и оказывает
нейропротективное действие: восстанавливает и защищает нервные клетки.
Действие препарата
реализуется преимущественно в виде сочетания анксиолитического
(противотревожного) и легкого стимулирующего (активирующего) эффектов. фабомотизол уменьшает или устраняет чувство тревоги
(озабоченность, плохие предчувствия, опасения), раздражительность,
напряженность (пугливость, плаксивость, чувство беспокойства, неспособность
расслабиться, бессонница, страх), депрессивное настроение, соматические
проявления тревоги (мышечные, сенсорные, сердечно-сосудистые, дыхательные,
желудочно-кишечные симптомы), вегетативные нарушения (сухость во рту,
потливость, головокружение), когнитивные расстройства (трудности при
концентрации внимания, ослабленная память), в т.ч. возникающие при стрессорных
расстройствах (расстройствах адаптации). Особенно показано применение препарата
у лиц с преимущественно астеническими личностными чертами в виде тревожной
мнительности, неуверенности, повышенной ранимости и эмоциональной лабильности,
склонности к эмоционально-стрессовым реакциям.
фабомотизол не вызывает мышечную
слабость, сонливость и не обладает негативным влиянием на концентрацию внимания
и память. При его применении не формируется привыкание, лекарственная
зависимость и не развивается синдром «отмены».
Фармакокинетика
После перорального приема фабомотизол
хорошо и быстро всасывается из желудочно-кишечного тракта. Прием пищи не
оказывает влияния на всасывание препарата и на параметры фармакокинетики.
Максимальная концентрация фабомотизол
в плазме (Сmax) после однократного приема препарата АФОБАЗОЛ РЕТАРД
составляет 47,740±43,252 нг/мл, после многократного - 27,668±13,770 нг/мл; время
достижения максимальной концентрации (Тmax) – 2,1±1,1 и 2,6±1,0 часа после
однократного и многократного приема соответственно.
Метаболизм: фабомотизол подвергается
«эффекту первого прохождения» через печень, основными направлениями метаболизма
являются гидроксилирование по ароматическому кольцу бензимидазольного цикла и
окисление по морфолиновому фрагменту.
Фабомотизолинтенсивно
распределяется по хорошо васкуляризированным органам, для него характерен
быстрый перенос из центрального пула (плазмы крови) в периферический (сильно
васкуляризованные органы и ткани).
Период полувыведения фабомотизола
при приеме внутрь составляет 8,41±5,01 часа после однократного приема и
6,05±3,54 часа после многократного приема препарата АФОБАЗОЛ РЕТАРД.
Фабомотизол выводится преимущественно в виде метаболитов и частично в
неизмененном виде почками и через кишечник.
Показания к применению
АФОБАЗОЛ РЕТАРД применяется у взрослых при тревожных состояниях: генерализованные
тревожные расстройства, неврастения, расстройства адаптации, у пациентов с
различными соматическими заболеваниями (бронхиальная астма, синдром
раздраженного кишечника, системная красная волчанка, ишемическая болезнь
сердца, гипертоническая болезнь, аритмии), дерматологических, онкологических и
др. заболеваниях; при лечении нарушений сна, связанных с тревогой.
Противопоказания
·
Гиперчувствительность
к фабомотизолу и/или любому вспомогательному веществу в составе препарата.
Если у Вас есть одно из перечисленных выше заболеваний, перед применением
препарата необходимо проконсультироваться с врачом.
Применение при беременности и в период грудного вскармливания
Применение препарата АФОБАЗОЛ РЕТАРД противопоказано при беременности.
При
необходимости применения препарата в период лактации грудное вскармливание
следует прекратить.
Перед применением препарата АФОБАЗОЛ РЕТАРД, если Вы
беременны или предполагаете, что Вы могли бы быть беременной, или планируете
беременность, необходимо проконсультироваться с врачом.
Способ применения и дозы
Внутрь.
По 1 таблетке 1 раз в сутки, утром, независимо
от приема пищи.
Длительность курсового применения
препарата составляет 2–4 недели.
Если после лечения
улучшения не наступает, или симптомы усугубляются, или появляются новые
симптомы, необходимо проконсультироваться с врачом.
Применяйте препарат
только согласно тем показаниям, тому способу применения и в тех дозах, которые
указаны в инструкции.
Побочное действие
Нежелательные эффекты, которые могут
развиваться во время лечения препаратом АФОБАЗОЛ РЕТАРД,
классифицированы в соответствии со следующей частотой встречаемости:
очень часто (≥ 1/10), часто (от ≥
1/100 до < 1/10), нечасто (от ≥ 1/1 000 до < 1/100), редко (от ≥ 1/10 000
до < 1/1 000), очень редко (< 1/10 000), частота неизвестна (не может
быть определена на основании имеющихся данных).
Со стороны иммунной системы: частота неизвестна - аллергические реакции.
Со стороны нервной системы: редко – головная боль, которая обычно
проходит самостоятельно и не требует отмены препарата.
Если у Вас отмечаются побочные эффекты, указанные в инструкции, или они
усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в
инструкции, сообщите об этом врачу.
Передозировка
Симптомы
При значительной передозировке и
интоксикации возможно развитие седативного эффекта и повышенной сонливости без
проявлений миорелаксации.
Лечение
В качестве неотложной помощи
применяется кофеин 20 % раствор в ампулах по 1,0 мл 2–3 раза в день подкожно.
При появлении симптомов передозировки следует прекратить прием препарата
и немедленно обратиться к врачу.
Взаимодействие с другими лекарственными средствами
Фабомотизол не взаимодействует с
этанолом и не оказывает влияния на гипнотическое действие тиопентала. Усиливает
противосудорожный эффект карбамазепина. Вызывает усиление анксиолитического
действия диазепама.
Если Вы применяете вышеперечисленные
или другие лекарственные препараты (в том числе безрецептурные), перед
применением препарата АФОБАЗОЛ РЕТАРД проконсультируйтесь с врачом.
Влияние на способность управлять автомобилем и движущимися механизмами
Препарат не оказывает
отрицательного влияния на вождение автотранспорта и выполнение потенциально
опасных видов деятельности, требующих повышенной концентрации внимания и
быстроты психомоторных реакций.
Форма выпуска
Таблетки с пролонгированным высвобождением,
покрытые пленочной оболочкой, 30 мг.
По 20 таблеток в контурную ячейковую упаковку из пленки
поливинилхлоридной и фольги алюминиевой печатной лакированной.
1 контурную ячейковую упаковку с инструкцией по применению
помещают в пачку из картона.
Условия хранения
При
температуре не выше 25 °С в оригинальной упаковке (блистер в пачке).
Хранить
в недоступном для детей месте.
Срок годности
2
года.
Не
применять по истечении срока годности.
Условия отпуска
Отпускают
без рецепта.
Производитель
Открытое акционерное общество "Фармстандарт-Лексредства"
(ОАО "Фармстандарт-Лексредства"), Россия
Курская обл., г. Курск, ул. 2-я Агрегатная, д. 1а/18
тел./факс: (4712) 34-03-13
www.pharmstd.ru
Организация, принимающая претензии потребителей
Акционерное Общество «Отисифарм»
(АО «Отисифарм»), Россия
123112, г. Москва, ул. Тестовская, д. 10, эт. 12, пом. II, ком. 29
Тел.: +7 (800) 775-98-19
Факс: +7 (495) 221-18-02
www.otcpharm.ru
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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форма","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки\nс пролонгированным высвобождением, покрытые пленочной оболочкой"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eна одну таблетку:\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eДействующее вещество: \u003c/i\u003eфабомотизола дигидрохлорид – 30,0 мг.\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества: \u003c/i\u003eКоллидон SR [поливинилацетат, повидон, натрия лаурилсульфат, кремния диоксид] - 120,0 мг,\u003ci\u003e \u003c/i\u003eгипромеллоза - 25,0 мг, лактоза - 23,0 мг, магния стеарат – 2,0 мг."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСостав оболочки:\u003c/i\u003e Опадрай II 85 F18422 белый [поливиниловый спирт, частично гидролизованный, титана\nдиоксид, макрогол 4000, тальк] - 6,0 мг."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"круглые\nдвояковыпуклые таблетки, покрытые пленочной оболочкой почти белого цвета. На\nпоперечном разрезе ядро почти белого или белого с желтовато-коричневатым\nоттенком цвета."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"анксиолитическое средство (транквилизатор).\n"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"header","data":{"text":"\u003cb\u003e\u003ci\u003eФармакодинамика\u003c/i\u003e\u003c/b\u003e","level":4}},{"type":"paragraph","data":{"text":"фабомотизол – селективный\nнебензодиазепиновый анксиолитик."}},{"type":"paragraph","data":{"text":"Действуя на\nсигма-1-рецепторы в нервных клетках головного мозга, фабомотизол стабилизирует\nГАМК/бензодиазепиновые рецепторы и восстанавливает их чувствительность к\nэндогенным медиаторам торможения. фабомотизол\nтакже повышает биоэнергетический потенциал нейронов и оказывает\nнейропротективное действие: восстанавливает и защищает нервные клетки. "}},{"type":"paragraph","data":{"text":"Действие препарата\nреализуется преимущественно в виде сочетания анксиолитического\n(противотревожного) и легкого стимулирующего (активирующего) эффектов. фабомотизол уменьшает или устраняет чувство тревоги\n(озабоченность, плохие предчувствия, опасения), раздражительность,\nнапряженность (пугливость, плаксивость, чувство беспокойства, неспособность\nрасслабиться, бессонница, страх), депрессивное настроение, соматические\nпроявления тревоги (мышечные, сенсорные, сердечно-сосудистые, дыхательные,\nжелудочно-кишечные симптомы), вегетативные нарушения (сухость во рту,\nпотливость, головокружение), когнитивные расстройства (трудности при\nконцентрации внимания, ослабленная память), в т.ч. возникающие при стрессорных\nрасстройствах (расстройствах адаптации). Особенно показано применение препарата\nу лиц с преимущественно астеническими личностными чертами в виде тревожной\nмнительности, неуверенности, повышенной ранимости и эмоциональной лабильности,\nсклонности к эмоционально-стрессовым реакциям."}},{"type":"paragraph","data":{"text":"фабомотизол не вызывает мышечную\nслабость, сонливость и не обладает негативным влиянием на концентрацию внимания\nи память. При его применении не формируется привыкание, лекарственная\nзависимость и не развивается синдром «отмены»."}},{"type":"header","data":{"text":"\u003ci\u003eФармакокинетика\u003c/i\u003e","level":4}},{"type":"paragraph","data":{"text":"После перорального приема фабомотизол\nхорошо и быстро всасывается из желудочно-кишечного тракта. Прием пищи не\nоказывает влияния на всасывание препарата и на параметры фармакокинетики."}},{"type":"paragraph","data":{"text":"Максимальная концентрация фабомотизол\nв плазме (Сmax) после однократного приема препарата АФОБАЗОЛ РЕТАРД\nсоставляет 47,740±43,252 нг/мл, после многократного - 27,668±13,770 нг/мл; время\nдостижения максимальной концентрации (Тmax) – 2,1±1,1 и 2,6±1,0 часа после\nоднократного и многократного приема соответственно. "}},{"type":"paragraph","data":{"text":"Метаболизм: фабомотизол подвергается\n«эффекту первого прохождения» через печень, основными направлениями метаболизма\nявляются гидроксилирование по ароматическому кольцу бензимидазольного цикла и\nокисление по морфолиновому фрагменту."}},{"type":"paragraph","data":{"text":"Фабомотизол\u003csup\u003e \u003c/sup\u003eинтенсивно\nраспределяется по хорошо васкуляризированным органам, для него характерен\nбыстрый перенос из центрального пула (плазмы крови) в периферический (сильно\nваскуляризованные органы и ткани)."}},{"type":"paragraph","data":{"text":"Период полувыведения фабомотизола\nпри приеме внутрь составляет 8,41±5,01 часа после однократного приема и\n6,05±3,54 часа после многократного приема препарата АФОБАЗОЛ РЕТАРД.\nФабомотизол выводится преимущественно в виде метаболитов и частично в\nнеизмененном виде почками и через кишечник."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"АФОБАЗОЛ РЕТАРД применяется у взрослых при тревожных состояниях: генерализованные\nтревожные расстройства, неврастения, расстройства адаптации, у пациентов с\nразличными соматическими заболеваниями (бронхиальная астма, синдром\nраздраженного кишечника, системная красная волчанка, ишемическая болезнь\nсердца, гипертоническая болезнь, аритмии), дерматологических, онкологических и\nдр. заболеваниях; при лечении нарушений сна, связанных с тревогой."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"· \nГиперчувствительность\nк фабомотизолу и/или любому вспомогательному веществу в составе препарата. "}},{"type":"paragraph","data":{"text":"· \nНепереносимость\nгалактозы, недостаточность лактазы, глюкозо-галактозная мальабсорбция. "}},{"type":"paragraph","data":{"text":"· \nБеременность,\nпериод грудного вскармливания."}},{"type":"paragraph","data":{"text":"· \nДетский\nвозраст до 18 лет."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли у Вас есть одно из перечисленных выше заболеваний, перед применением\nпрепарата необходимо проконсультироваться с врачом.\u003c/i\u003e"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата АФОБАЗОЛ РЕТАРД противопоказано при беременности. "}},{"type":"paragraph","data":{"text":"При\nнеобходимости применения препарата в период лактации грудное вскармливание\nследует прекратить."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПеред применением препарата АФОБАЗОЛ РЕТАРД, если Вы\nбеременны или предполагаете, что Вы могли бы быть беременной, или планируете\nбеременность, необходимо проконсультироваться с врачом.\u003c/i\u003e"}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"По 1 таблетке 1 раз в сутки, утром, независимо\nот приема пищи."}},{"type":"paragraph","data":{"text":"Длительность курсового применения\nпрепарата составляет 2–4 недели."}},{"type":"paragraph","data":{"text":"Если после лечения\nулучшения не наступает, или симптомы усугубляются, или появляются новые\nсимптомы, необходимо проконсультироваться с врачом. "}},{"type":"paragraph","data":{"text":"Применяйте препарат\nтолько согласно тем показаниям, тому способу применения и в тех дозах, которые\nуказаны в инструкции."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Нежелательные эффекты, которые могут\nразвиваться во время лечения препаратом АФОБАЗОЛ РЕТАРД,\nклассифицированы в соответствии со следующей частотой встречаемости: "}},{"type":"paragraph","data":{"text":"очень часто (≥ 1/10), часто (от ≥\n1/100 до < 1/10), нечасто (от ≥ 1/1 000 до < 1/100), редко (от ≥ 1/10 000\nдо < 1/1 000), очень редко (< 1/10 000), частота неизвестна (не может\nбыть определена на основании имеющихся данных)."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eСо стороны иммунной системы: \u003c/i\u003e\u003c/b\u003eчастота неизвестна - аллергические реакции."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eСо стороны нервной системы: \u003c/i\u003e\u003c/b\u003eредко – головная боль, которая обычно\nпроходит самостоятельно и не требует отмены препарата."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли у Вас отмечаются побочные эффекты, указанные в инструкции, или они\nусугубляются, или Вы заметили любые другие побочные эффекты, не указанные в\nинструкции, сообщите об этом врачу.\u003c/i\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eСимптомы\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"При значительной передозировке и\nинтоксикации возможно развитие седативного эффекта и повышенной сонливости без\nпроявлений миорелаксации. "}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eЛечение\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"В качестве неотложной помощи\nприменяется кофеин 20 % раствор в ампулах по 1,0 мл 2–3 раза в день подкожно."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри появлении симптомов передозировки следует прекратить прием препарата\nи немедленно обратиться к врачу.\u003c/i\u003e"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Фабомотизол не взаимодействует с\nэтанолом и не оказывает влияния на гипнотическое действие тиопентала. Усиливает\nпротивосудорожный эффект карбамазепина. Вызывает усиление анксиолитического\nдействия диазепама. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли Вы применяете вышеперечисленные\nили другие лекарственные препараты (в том числе безрецептурные), перед\nприменением препарата АФОБАЗОЛ РЕТАРД проконсультируйтесь с врачом.\u003c/i\u003e"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не оказывает\nотрицательного влияния на вождение автотранспорта и выполнение потенциально\nопасных видов деятельности, требующих повышенной концентрации внимания и\nбыстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки с пролонгированным высвобождением,\nпокрытые пленочной оболочкой, 30 мг."}},{"type":"paragraph","data":{"text":"По 20 таблеток в контурную ячейковую упаковку из пленки\nполивинилхлоридной и фольги алюминиевой печатной лакированной."}},{"type":"paragraph","data":{"text":"1 контурную ячейковую упаковку с инструкцией по применению\nпомещают в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При\nтемпературе не выше 25 °С в оригинальной упаковке (блистер в пачке)."}},{"type":"paragraph","data":{"text":"Хранить\nв недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2\nгода. "}},{"type":"paragraph","data":{"text":"Не\nприменять по истечении срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают\nбез рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное общество \"Фармстандарт-Лексредства\""}},{"type":"paragraph","data":{"text":"(ОАО \"Фармстандарт-Лексредства\"), Россия"}},{"type":"paragraph","data":{"text":"Курская обл., г. Курск, ул. 2-я Агрегатная, д. 1а/18"}},{"type":"paragraph","data":{"text":"тел./факс: (4712) 34-03-13"}},{"type":"paragraph","data":{"text":"www.pharmstd.ru"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Акционерное Общество «Отисифарм» "}},{"type":"paragraph","data":{"text":"(АО «Отисифарм»), Россия"}},{"type":"paragraph","data":{"text":"123112, г. Москва, ул. Тестовская, д. 10, эт. 12, пом. II, ком. 29"}},{"type":"paragraph","data":{"text":"Тел.: +7 (800) 775-98-19"}},{"type":"paragraph","data":{"text":"Факс: +7 (495) 221-18-02"}},{"type":"paragraph","data":{"text":"www.otcpharm.ru"}}]}],"source":null},"description_toggle":false,"short_description":"фабомотизол – селективный небензодиазепиновый анксиолитик. Действуя на сигма-1-рецепторы в нервных клетках головного мозга, фабомотизол стабилизирует ГАМК/бензодиазепиновые рецепторы и восстанавливает их чувствительность к эндогенным медиаторам торможения. фабомотизол также повышает биоэнергетический потенциал нейронов и оказывает нейропротективное действие: восстанавливает и защищает нервные клетки. Действие препарата реализуется преимущественно в виде сочетания анксиолитического (противотревожного) и легкого стимулирующего (активирующего) эффектов. фабомотизол уменьшает или устраняет чувство тревоги (озабоченность, плохие предчувствия, опасения), раздражительность, напряженность (пугливость, плаксивость, чувство беспокойства, неспособность расслабиться, бессонница, страх), депрессивное настроение, соматические проявления тревоги (мышечные, сенсорные, сердечно-сосудистые, дыхательные, желудочно-кишечные симптомы), вегетативные нарушения (сухость во рту, потливость, головокружение), когнитивные расстройства (трудности при концентрации внимания, ослабленная память), в т.ч. возникающие при стрессорных расстройствах (расстройствах адаптации). Особенно показано применение препарата у лиц с преимущественно астеническими личностными чертами в виде тревожной мнительности, неуверенности, повышенной ранимости и эмоциональной лабильности, склонности к эмоционально-стрессовым реакциям. фабомотизол не вызывает мышечную слабость, сонливость и не обладает негативным влиянием на концентрацию внимания и память. При его применении не формируется привыкание, лекарственная зависимость и не развивается синдром «отмены». После перорального приема фабомотизол хорошо и быстро всасывается из желудочно-кишечного тракта. Прием пищи не оказывает влияния на всасывание препарата и на параметры фармакокинетики. Максимальная концентрация фабомотизол в плазме (Сmax) после однократного приема препарата АФОБАЗОЛ РЕТАРД составляет 47,740±43,252 нг/мл, после многократного - 27,668±13,770 нг/мл; время достижения максимальной концентрации (Тmax) – 2,1±1,1 и 2,6±1,0 часа после однократного и многократного приема соответственно. Метаболизм: фабомотизол подвергается «эффекту первого прохождения» через печень, основными направлениями метаболизма являются гидроксилирование по ароматическому кольцу бензимидазольного цикла и окисление по морфолиновому фрагменту. Фабомотизолинтенсивно распределяется по хорошо васкуляризированным органам, для него характерен быстрый перенос из центрального пула (плазмы крови) в периферический (сильно васкуляризованные органы и ткани). Период полувыведения фабомотизола при приеме внутрь составляет 8,41±5,01 часа после однократного приема и 6,05±3,54 часа после многократного приема препарата АФОБАЗОЛ РЕТАРД. 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