Твердые желатиновые непрозрачные капсулы № 1 коричневого цвета, содержащие маслянистую пастообразную массу желтовато-коричневого цвета.
Фармакологические свойства
Фармакодинамика.
Эссенциальные фосфолипиды являются основными элементами структуры оболочки клеток
и клеточных органелл. При болезнях печени всегда имеется повреждение оболочек
печеночных клеток и их органелл, которое приводит к нарушениям активности связанных с
ними ферментов и систем рецепторов, ухудшению функциональной активности печеночных
клеток и снижению способности к регенерации.
Фосфолипиды, входящие в состав препарата Эссенциале® форте Н, соответствуют по своей
химической структуре эндогенным фосфолипидам, но превосходят эндогенные фосфолипиды
по активности за счет более высокого содержания в них полиненасыщенных (эссенциальных)
жирных кислот. Встраивание этих высоко энергетических молекул в поврежденные участки
клеточных мембран гепатоцитов восстанавливает целостность печеночных клеток,
способствует их регенерации. Цис-двойные связи их полиненасыщенных жирных кислот
предотвращают параллельное расположение углеводородных цепей в фосфолипидах
клеточных оболочек, фосфолипидная структура клеточных оболочек гепатоцитов
«разрыхляется», что обусловливает повышение их текучести и эластичности, улучшает обмен
веществ. Образующиеся функциональные блоки повышают активность фиксированных на
мембранах ферментов и способствуют нормальному, физиологическому пути протекания
важнейших метаболических процессов.
Фосфолипиды, входящие в состав препарата Эссенциале® форте, регулируют метаболизм
липопротеинов, перенося нейтральные жиры и холестерин к местам окисления, главным
образом это происходит за счет повышения способности липопротеинов высокой плотности
связываться с холестерином.
Таким образом, оказывается нормализующее действие на метаболизм липидов и белков; на
дезинтоксикационную функцию печени; на восстановление и сохранение клеточной
структуры печени и фосфолипидозависимых ферментных систем; что в конечном итоге
препятствует формированию соединительной ткани в печени и способствует естественному
восстановлению клеток печени.
При экскреции фосфолипидов в желчь происходит снижение литогенного индекса и
стабилизация желчи.
Фармакокинетика.
Более 90% принятых внутрь фосфолипидов всасывается в тонком кишечнике. Большая часть их расщепляется фосфолипазой А до 1-ацил-лизофосфатидилхолина, 50% которого немедленно подвергается обратному ацетилированию в полиненасыщенный фосфатидилхолин ещё в ходе процесса всасывания в слизистой оболочке кишечника. Этот полиненасыщенный фосфатидилхолин с током лимфы попадает в кровь и оттуда, главным образом, в связанном с липопротеинами высокой плотности виде поступает в печень. Исследования фармакокинетики у людей проводились с помощью дилинолеил фосфатидилхолина с радиоактивной меткой (3H и 14C). Холиновая часть была мечена 3H, а остаток линолевой кислоты имел в качестве метки 14C. Максимальная концентрация 3H достигается через 6-24 часа после введения и составляет 19,9% от назначенной дозы. Период полувыведения холинового компонента составляет 66 часов. Максимальная концентрация 14C достигается через 4-12 часов после введения и составляет до 27,9% от назначенной дозы. Период полувыведения этого компонента составляет 32 часа. В кале обнаруживается 2% от введенной дозы 3H и 4,5% от введенной дозы 14C, в моче – 6% от 3H и лишь минимальное количество 14C. Оба изотопа более чем на 90% всасываются в кишечнике.
токсические поражения печени, алкогольный гепатит, нарушения функции печени при
других соматических заболеваниях.
Токсикоз беременности.
Профилактика рецидивов образования желчных камней.
Псориаз (в качестве средства вспомогательной терапии).
Радиационный синдром.
Противопоказания
Повышенная чувствительность к фосфатидилхолину, сое, соевым бобам или другим
ингредиентам препарата.
Детский возраст до 12 лет (отсутствие достаточной доказательной базы).
Применение при беременности и в период грудного вскармливания
Применение препарата Эссенциале® форте Н при беременности не рекомендуется без
наблюдения у врача. Отсутствует достаточное количество исследований.
Побочное действие
Препарат Эссенциале® форте Н обычно хорошо переносится пациентами.
По данным Всемирной организации здравоохранения (ВОЗ) побочные эффекты
классифицированы в соответствии с их частотой развития следующим образом: очень часто
(≥ 1/10), часто (≥1/100, 1/10), нечасто (≥1/1000, 1/100), редко (≥1/10000, 1/1000) и очень
редко (≥ 1/10000); частота неизвестна (частота не может быть определена на основании
имеющихся данных).
Передозировка
Применение препарата Эссенциале® форте Н в дозах, превышающих рекомендованные,
может вести к усилению побочных эффектов.
Взаимодействие с другими лекарственными средствами
Взаимодействие препарата Эссенциале® форте Н с антикоагулянтами не может быть
исключено. Необходимо скорректировать дозу антикоагулянтов при совместном применении
с препаратом Эссенциале® форте Н.
Особые указания
Препарат Эссенциале® форте Н может быть причиной тяжелых аллергических реакций, так
как содержит соевых бобов масло.
Пациентов следует информировать о том, что прием препарата Эссенциале® форте Н не
заменяет необходимость избегать повреждающего влияния некоторых веществ на печень
(например, алкоголя).
Поддерживающая терапия фосфолипидами оправдана только при улучшении субъективных
признаков состояния во время лечения. Пациентов следует информировать о необходимости
консультации с врачом при ухудшении симптомов или появлении других неясных
симптомов.
Условия хранения
Хранить при температуре не выше 21 °С. Хранить в недоступном для детей месте.
Срок годности
Для капсул, упакованных в блистер из ПВХ и алюминиевой фольги - 3 года.
Для капсул, упакованных в блистер из ПВХ/ПТФХЭ и алюминиевой фольги или ПВХ/ПЭ/ПВДХ и алюминиевой фольги – 30 месяцев.
Не применять препарат по истечении срока годности, указанного на упаковке.
Условия отпуска
Без рецепта.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
Наведите камеру на QR-код, чтобы скачать
Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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1 капсуле содержится:\u003cbr /\u003e\nактивный ингредиент: фосфолипиды из соевых бобов, содержащие 76% (3-sn-фосфатидил)-\nхолина (синонимы: EPL, эссенциальные фосфолипиды) – 300 мг;\nвспомогательные ингредиенты: жир твердый – 57,000 мг, соевых бобов масло – 36,000 мг,\nкасторовое масло гидрированное – 1,600 мг, этанол 96% – 8,100 мг, этилванилин – 1,500 мг,\n4-метоксиацетофенон – 0,800 мг, α-токоферол – 0,750 мг.\u003cbr /\u003e\nСостав капсулы: желатин – 67,945 мг, вода очищенная – 11,495 мг, титана диоксид (Е 171) –\n0,830 мг, краситель железа оксид желтый (Е 172) – 2,075 мг, краситель железа оксид черный\n(Е 172) – 0,332 мг, краситель железа оксид красный (Е 172) – 0,198 мг, натрия лаурилсульфат\n– 0,125 мг.\u003cbr /\u003e"}}]},{"id":2,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Твердые желатиновые непрозрачные капсулы № 1 коричневого цвета, содержащие маслянистую пастообразную массу желтовато-коричневого цвета.\u003cbr /\u003e"}}]},{"id":3,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Фармакодинамика.\u003cbr /\u003e\nЭссенциальные фосфолипиды являются основными элементами структуры оболочки клеток\nи клеточных органелл. При болезнях печени всегда имеется повреждение оболочек\nпеченочных клеток и их органелл, которое приводит к нарушениям активности связанных с\nними ферментов и систем рецепторов, ухудшению функциональной активности печеночных\nклеток и снижению способности к регенерации.\u003cbr /\u003e\nФосфолипиды, входящие в состав препарата Эссенциале® форте Н, соответствуют по своей\nхимической структуре эндогенным фосфолипидам, но превосходят эндогенные фосфолипиды\nпо активности за счет более высокого содержания в них полиненасыщенных (эссенциальных)\nжирных кислот. Встраивание этих высоко энергетических молекул в поврежденные участки \nклеточных мембран гепатоцитов восстанавливает целостность печеночных клеток,\nспособствует их регенерации. Цис-двойные связи их полиненасыщенных жирных кислот\nпредотвращают параллельное расположение углеводородных цепей в фосфолипидах\nклеточных оболочек, фосфолипидная структура клеточных оболочек гепатоцитов\n«разрыхляется», что обусловливает повышение их текучести и эластичности, улучшает обмен\nвеществ. Образующиеся функциональные блоки повышают активность фиксированных на\nмембранах ферментов и способствуют нормальному, физиологическому пути протекания\nважнейших метаболических процессов.\u003cbr /\u003e\nФосфолипиды, входящие в состав препарата Эссенциале® форте, регулируют метаболизм\nлипопротеинов, перенося нейтральные жиры и холестерин к местам окисления, главным\nобразом это происходит за счет повышения способности липопротеинов высокой плотности\nсвязываться с холестерином.\u003cbr /\u003e\nТаким образом, оказывается нормализующее действие на метаболизм липидов и белков; на\nдезинтоксикационную функцию печени; на восстановление и сохранение клеточной\nструктуры печени и фосфолипидозависимых ферментных систем; что в конечном итоге\nпрепятствует формированию соединительной ткани в печени и способствует естественному\nвосстановлению клеток печени.\u003cbr /\u003e\nПри экскреции фосфолипидов в желчь происходит снижение литогенного индекса и\nстабилизация желчи. \u003cbr /\u003e\n\u003cbr /\u003e\nФармакокинетика.\u003cbr /\u003e\nБолее 90% принятых внутрь фосфолипидов всасывается в тонком кишечнике. Большая часть их расщепляется фосфолипазой А до 1-ацил-лизофосфатидилхолина, 50% которого немедленно подвергается обратному ацетилированию в полиненасыщенный фосфатидилхолин ещё в ходе процесса всасывания в слизистой оболочке кишечника. Этот полиненасыщенный фосфатидилхолин с током лимфы попадает в кровь и оттуда, главным образом, в связанном с липопротеинами высокой плотности виде поступает в печень. Исследования фармакокинетики у людей проводились с помощью дилинолеил фосфатидилхолина с радиоактивной меткой (3H и 14C). Холиновая часть была мечена 3H, а остаток линолевой кислоты имел в качестве метки 14C. Максимальная концентрация 3H достигается через 6-24 часа после введения и составляет 19,9% от назначенной дозы. Период полувыведения холинового компонента составляет 66 часов. Максимальная концентрация 14C достигается через 4-12 часов после введения и составляет до 27,9% от назначенной дозы. Период полувыведения этого компонента составляет 32 часа. В кале обнаруживается 2% от введенной дозы 3H и 4,5% от введенной дозы 14C, в моче – 6% от 3H и лишь минимальное количество 14C. Оба изотопа более чем на 90% всасываются в кишечнике."}}]},{"id":4,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Хронические гепатиты, цирроз печени, жировая дистрофия печени различной этиологии,"]}},{"type":"paragraph","data":{"text":"токсические поражения печени, алкогольный гепатит, нарушения функции печени при\nдругих соматических заболеваниях.\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["Токсикоз беременности.\u003cbr /\u003e","Профилактика рецидивов образования желчных камней.\u003cbr /\u003e","Псориаз (в качестве средства вспомогательной терапии).\u003cbr /\u003e","Радиационный синдром.\u003cbr /\u003e"]}}]},{"id":5,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"list","data":{"style":"unordered","items":["Повышенная чувствительность к фосфатидилхолину, сое, соевым бобам или другим"]}},{"type":"paragraph","data":{"text":"ингредиентам препарата.\u003cbr /\u003e"}},{"type":"list","data":{"style":"unordered","items":["Детский возраст до 12 лет (отсутствие достаточной доказательной базы).\u003cbr /\u003e"]}}]},{"id":6,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение препарата Эссенциале® форте Н при беременности не рекомендуется без\nнаблюдения у врача. Отсутствует достаточное количество исследований.\u003cbr /\u003e"}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат Эссенциале® форте Н обычно хорошо переносится пациентами.\u003cbr /\u003e\nПо данным Всемирной организации здравоохранения (ВОЗ) побочные эффекты\nклассифицированы в соответствии с их частотой развития следующим образом: очень часто\n(≥ 1/10), часто (≥1/100, 1/10), нечасто (≥1/1000, 1/100), редко (≥1/10000, 1/1000) и очень\nредко (≥ 1/10000); частота неизвестна (частота не может быть определена на основании\nимеющихся данных).\u003cbr /\u003e"}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Применение препарата Эссенциале® форте Н в дозах, превышающих рекомендованные,\nможет вести к усилению побочных эффектов."}}]},{"id":9,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Взаимодействие препарата Эссенциале® форте Н с антикоагулянтами не может быть\nисключено. Необходимо скорректировать дозу антикоагулянтов при совместном применении\nс препаратом Эссенциале® форте Н."}}]},{"id":10,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Препарат Эссенциале® форте Н может быть причиной тяжелых аллергических реакций, так\nкак содержит соевых бобов масло.\u003cbr /\u003e\nПациентов следует информировать о том, что прием препарата Эссенциале® форте Н не\nзаменяет необходимость избегать повреждающего влияния некоторых веществ на печень\n(например, алкоголя).\u003cbr /\u003e\nПоддерживающая терапия фосфолипидами оправдана только при улучшении субъективных\nпризнаков состояния во время лечения. Пациентов следует информировать о необходимости\nконсультации с врачом при ухудшении симптомов или появлении других неясных\nсимптомов.\u003cbr /\u003e"}}]},{"id":11,"name":"Условия хранения","slug":"storage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 21 °С. Хранить в недоступном для детей месте."}}]},{"id":12,"name":"Срок годности","slug":"expiry_date","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Для капсул, упакованных в блистер из ПВХ и алюминиевой фольги - 3 года.\u003cbr /\u003e\nДля капсул, упакованных в блистер из ПВХ/ПТФХЭ и алюминиевой фольги или ПВХ/ПЭ/ПВДХ и алюминиевой фольги – 30 месяцев.\u003cbr /\u003e\nНе применять препарат по истечении срока годности, указанного на упаковке.\u003cbr /\u003e"}}]},{"id":13,"name":"Условия отпуска","slug":"release_condition","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Без рецепта."}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика. Эссенциальные фосфолипиды являются основными элементами структуры оболочки клеток и клеточных органелл. При болезнях печени всегда имеется повреждение оболочек печеночных клеток и их органелл, которое приводит к нарушениям активности связанных с ними ферментов и систем рецепторов, ухудшению функциональной активности печеночных клеток и снижению способности к регенерации. Фосфолипиды, входящие в состав препарата Эссенциале® форте Н, соответствуют по своей химической структуре эндогенным фосфолипидам, но превосходят эндогенные фосфолипиды по активности за счет более высокого содержания в них полиненасыщенных (эссенциальных) жирных кислот. Встраивание этих высоко энергетических молекул в поврежденные участки клеточных мембран гепатоцитов восстанавливает целостность печеночных клеток, способствует их регенерации. Цис-двойные связи их полиненасыщенных жирных кислот предотвращают параллельное расположение углеводородных цепей в фосфолипидах клеточных оболочек, фосфолипидная структура клеточных оболочек гепатоцитов «разрыхляется», что обусловливает повышение их текучести и эластичности, улучшает обмен веществ. Образующиеся функциональные блоки повышают активность фиксированных на мембранах ферментов и способствуют нормальному, физиологическому пути протекания важнейших метаболических процессов. Фосфолипиды, входящие в состав препарата Эссенциале® форте, регулируют метаболизм липопротеинов, перенося нейтральные жиры и холестерин к местам окисления, главным образом это происходит за счет повышения способности липопротеинов высокой плотности связываться с холестерином. Таким образом, оказывается нормализующее действие на метаболизм липидов и белков; на дезинтоксикационную функцию печени; на восстановление и сохранение клеточной структуры печени и фосфолипидозависимых ферментных систем; что в конечном итоге препятствует формированию соединительной ткани в печени и способствует естественному восстановлению клеток печени. При экскреции фосфолипидов в желчь происходит снижение литогенного индекса и стабилизация желчи. Фармакокинетика. Более 90% принятых внутрь фосфолипидов всасывается в тонком кишечнике. Большая часть их расщепляется фосфолипазой А до 1-ацил-лизофосфатидилхолина, 50% которого немедленно подвергается обратному ацетилированию в полиненасыщенный фосфатидилхолин ещё в ходе процесса всасывания в слизистой оболочке кишечника. Этот полиненасыщенный фосфатидилхолин с током лимфы попадает в кровь и оттуда, главным образом, в связанном с липопротеинами высокой плотности виде поступает в печень. 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