Лечение и профилактика гриппа А и В и других острых респираторных вирусных
инфекций (аденовирусная инфекция, парагрипп, респираторно-синцитиальная
инфекция, риновирусная инфекция) у взрослых и детей от 3 лет.
Противопоказания
Повышенная чувствительность к действующему веществу или любому другому
компоненту препарата.
Прозрачная бесцветная слегка вязкая жидкость с характерным запахом.
Фармакотерапевтическая группа
Противовирусное средство.
Фармакологические свойства
Фармакодинамика
Противовирусный препарат.
В доклинических и клинических исследованиях показана эффективность
препарата Ингавирин в отношении вирусов гриппа типа A (A(H1N1), в
т.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В,
аденовируса, вируса парагриппа, респираторно-синцитиального вируса; в
доклинических исследованиях: коронавируса, метапневмовируса, энтеровирусов, в
том числе вируса Коксаки и риновируса.
Ингавирин снижает вирусную нагрузку, ускоряет элиминацию
вирусов, сокращает продолжительность болезни, снижает риск развития осложнений.
Механизм действия реализуется на уровне инфицированных клеток за счет активации
факторов врожденного иммунитета, подавляемых вирусными белками. В
экспериментальных исследованиях, в частности, показано, что препарат Ингавирин повышает экспрессию рецептора интерферона первого типа IFNAR на поверхности
эпителиальных и иммунокомпетентных клеток. Увеличение плотности интерфероновых
рецепторов приводит к повышению чувствительности клеток к сигналам эндогенного
интерферона. Процесс сопровождается активацией (фосфорилированием)
белка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза
противовирусных генов. Показано, что в условиях инфекции препарат активирует
синтез антивирусного эффекторного белка МхА (ранний фактор противовирусного
ответа, ингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов
различных вирусов) и фосфорилированной формы PKR, подавляющей трансляцию вирусных
белков, таким образом замедляя и останавливая процесс вирусной репродукции.
Действие препарата Ингавирин заключается в значительном уменьшении
признаков цитопатического и цитодеструктивного действия вируса, снижении
количества инфицированных клеток, ограничении патологического процесса,
нормализации состава и структуры клеток и морфологической картины тканей в зоне
инфекционного процесса, как на ранних, так и на поздних его стадиях. Противовоспалительное
действие обусловлено подавлением продукции ключевых провоспалительных цитокинов
(фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением активности миелопероксидазы.
В экспериментальных исследованиях показано, что совместное использование
препарата Ингавирин с антибиотиками повышает эффективность терапии
на модели бактериального сепсиса, в том числе вызванного
пенициллин-резистентными штаммами стафилококка.
Проведенные экспериментальные токсикологические исследования свидетельствуют
о низком уровне токсичности и высоком профиле безопасности препарата.
По параметрам острой токсичности препарат Ингавирин относится к
4 классу токсичности ‒ «Малотоксичные вещества» (при определении LD50 в экспериментах по острой токсичности летальные дозы
препарата определить не удалось).
Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и
канцерогенными свойствами, не оказывает местнораздражающего действия. Препарат
Ингавирин не влияет на репродуктивную функцию, не оказывает
эмбриотоксического и тератогенного действия.
Отсутствует влияние препарата Ингавирин на систему
кроветворения при приеме соответствующей возрасту дозы рекомендованными схемой
и курсом.
Фармакокинетика
Всасывание и распределение
В эксперименте с использованием радиоактивной метки установлено: действующее
вещество быстро поступает в кровь из желудочно-кишечного тракта, распределяясь
по внутренним органам. В исследовании у здоровых добровольцев при однократном
приеме препарата в дозе 90 мг максимальная
концентрация (Cmax) составила 441,45 ± 252,99 нг/мл; время ее
достижения (Tmax) – 1,30 ± 0,41 часа.
В доклинических исследованиях было установлено, что при курсовом приеме
препарата один раз в сутки происходит его накопление во внутренних органах и
тканях. При этом качественные характеристики фармакокинетических кривых после
каждого введения препарата тождественны: быстрое повышение концентрации
препарата после каждого введения через 0,5-1 час после приема и затем медленное снижение к 24 часам. Величины AUC (площадь под фармакокинетической кривой «концентрация‒время»)
почек, печени и легких незначительно превышают AUC крови. Величины AUC для
селезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови.
Метаболизм
Препарат не метаболизируется в организме и выводится в неизмененном виде.
Выведение
В исследовании у здоровых добровольцев при однократном приеме препарата в
дозе 90 мг период полувыведения (Т1/2) составил 1,82 ± 0,23 часа. В
доклинических исследованиях было установлено, что основной процесс выведения
происходит в течение 24 часов. За этот период выводится 80 % принятой дозы:
34,8 % выводится во временном интервале от 0 до 5 часов и 45,2 % во временном
интервале от 5 до 24 часов. Из них 77 % выводится через кишечник и 23 % ‒ через почки.
Показания к применению
Лечение и профилактика гриппа А и В и других острых респираторных вирусных
инфекций (аденовирусная инфекция, парагрипп, респираторно-синцитиальная
инфекция, риновирусная инфекция) у взрослых и детей от 3 лет.
Противопоказания
Повышенная чувствительность к действующему веществу или любому другому
компоненту препарата.
Применение при беременности и в период грудного вскармливания
Применение препарата во время беременности не изучалось.
Применение препарата во время лактации не изучалось, поэтому при
необходимости применения препарата в период грудного вскармливания следует
прекратить грудное вскармливание.
Способ применения и дозы
Внутрь. Независимо от приема пищи.
Плотно вставьте
мерный шприц в горлышко флакона. Переверните флакон вверх дном и плавно
потяните поршень вниз, набирая сироп до нужной отметки. После употребления
промойте шприц в теплой воде и высушите его.
Для лечения и профилактики гриппа и острых респираторных вирусных инфекций
взрослым назначают по 90 мг (15 мл) 1 раз в день, детям от 7 лет ‒ по 60 мг (10
мл) 1 раз в день, детям от 3 до 6 лет ‒ по 30 мг (5 мл) 1 раз в день.
Длительность лечения гриппа и острых респираторных вирусных инфекций у
взрослых и детей от 7 лет ‒ 5-7 дней (в зависимости от тяжести
состояния). Длительность лечения гриппа и острых респираторных вирусных
инфекций у детей от 3 до 6 лет ‒ 5 дней.
Прием препарата начинают с момента появления первых симптомов заболевания,
желательно не позднее 2 суток от начала болезни.
Взрослым и детям при выраженных симптомах, а также при наличии сопутствующих
заболеваний (болезни дыхательной и сердечно-сосудистой систем, сахарный диабет,
ожирение), следует принимать двойную дозу препарата в первые 3 дня заболевания,
далее продолжить приём в обычной дозировке в течение 2-4 дней.
Для профилактики гриппа и острых респираторных вирусных инфекций после
контакта с больными лицами взрослым и детям от 7 лет препарат назначают в
течение 7 дней, детям от 3 до 6 лет ‒ в
течение 5 дней.
Если через 5 дней лечения улучшения не наступает или симптомы усугубляются,
или появляются новые симптомы, необходимо проконсультироваться с врачом.
Применяйте препарат только согласно тем показаниям, тому способу применения и в
тех дозах, которые указаны в инструкции.
Побочное действие
Аллергические реакции (редко).
Если любые из указанных в инструкции побочных эффектов усугубляются или Вы
заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об
этом врачу.
Передозировка
О случаях передозировки препарата Ингавирин до настоящего
времени не сообщалось.
Взаимодействие с другими лекарственными средствами
Лекарственное взаимодействие препарата Ингавирин не описано.
Особые указания
Не рекомендуется одновременный прием других противовирусных препаратов без
предварительной консультации врача.
Сохраняйте инструкцию. Она может
понадобиться вновь. Если у Вас возникли вопросы, обратитесь к врачу.
Влияние на способность управлять автомобилем и движущимися механизмами
Не изучалось, однако, учитывая механизм действия и профиль побочных
реакций, можно предположить, что препарат не оказывает влияния на способность
управлять транспортными средствами, механизмами.
Форма выпуска
Сироп 30 мг/5 мл.
Фасовка и упаковка на ABC Фармацойтичи С.п.А., Италия:
По 50 мл или по 90 мл
во флаконы коричневого цвета из полиэтилентерефталата, снабженные
кольцом-адаптером, укупоренные крышками винтовыми из полипропилена с контролем
первого вскрытия и защитой от вскрытия детьми.
Один флакон вместе с
мерным шприцем и инструкцией по применению помещают в пачку из картона.
Упаковка на АО «Валента Фарм», Россия:
Один флакон вместе с
мерным шприцем и инструкцией по применению помещают в пачку из картона.
Условия хранения
В оригинальной упаковке при температуре не выше 25 °С.
После вскрытия флакона хранить не более 7 дней.
Хранить в недоступном для детей месте.
Срок годности
2 года
Не применять по истечении срока годности.
Условия отпуска
Отпускают без рецепта.
Производитель
АО «Валента Фарм»
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
Начните сравнивать цены и заказывать лекарства прямо в приложении
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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форма","slug":"","body":[{"type":"paragraph","data":{"text":"Сироп."}}]},{"id":26,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"5 мл сиропа содержит:"}},{"type":"paragraph","data":{"text":"\u003ci\u003eДействующее вещество: \u003c/i\u003eимидазолилэтанамид\nпентандиовой кислоты – 30 мг;\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВспомогательные вещества: \u003c/i\u003eмальтитол (мальтитол жидкий), глицерол, лимонной кислоты моногидрат, камедь\nксантановая, метилпарагидроксибензоат натрия, ароматизатор грушевый, вода\nочищенная."}}]},{"id":27,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Прозрачная бесцветная слегка вязкая жидкость с характерным запахом."}}]},{"id":28,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противовирусное средство.\u003cb\u003e\u003c/b\u003e"}}]},{"id":29,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакодинамика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Противовирусный препарат."}},{"type":"paragraph","data":{"text":"В доклинических и клинических исследованиях показана эффективность\nпрепарата Ингавирин в отношении вирусов гриппа типа A (A(H1N1), в\nт.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В,\nаденовируса, вируса парагриппа, респираторно-синцитиального вируса; в\nдоклинических исследованиях: коронавируса, метапневмовируса, энтеровирусов, в\nтом числе вируса Коксаки и риновируса."}},{"type":"paragraph","data":{"text":"Ингавирин снижает вирусную нагрузку, ускоряет элиминацию\nвирусов, сокращает продолжительность болезни, снижает риск развития осложнений.\nМеханизм действия реализуется на уровне инфицированных клеток за счет активации\nфакторов врожденного иммунитета, подавляемых вирусными белками. В\nэкспериментальных исследованиях, в частности, показано, что препарат Ингавирин повышает экспрессию рецептора интерферона первого типа IFNAR на поверхности\nэпителиальных и иммунокомпетентных клеток. Увеличение плотности интерфероновых\nрецепторов приводит к повышению чувствительности клеток к сигналам эндогенного\nинтерферона. Процесс сопровождается активацией (фосфорилированием)\nбелка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза\nпротивовирусных генов. Показано, что в условиях инфекции препарат активирует\nсинтез антивирусного эффекторного белка МхА (ранний фактор противовирусного\nответа, ингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов\nразличных вирусов) и фосфорилированной формы PKR, подавляющей трансляцию вирусных\nбелков, таким образом замедляя и останавливая процесс вирусной репродукции. "}},{"type":"paragraph","data":{"text":"\nДействие препарата Ингавирин заключается в значительном уменьшении\nпризнаков цитопатического и цитодеструктивного действия вируса, снижении\nколичества инфицированных клеток, ограничении патологического процесса,\nнормализации состава и структуры клеток и морфологической картины тканей в зоне\nинфекционного процесса, как на ранних, так и на поздних его стадиях. Противовоспалительное\nдействие обусловлено подавлением продукции ключевых провоспалительных цитокинов\n(фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением активности миелопероксидазы."}},{"type":"paragraph","data":{"text":"В экспериментальных исследованиях показано, что совместное использование\nпрепарата Ингавирин с антибиотиками повышает эффективность терапии\nна модели бактериального сепсиса, в том числе вызванного\nпенициллин-резистентными штаммами стафилококка."}},{"type":"paragraph","data":{"text":"Проведенные экспериментальные токсикологические исследования свидетельствуют\nо низком уровне токсичности и высоком профиле безопасности препарата."}},{"type":"paragraph","data":{"text":"По параметрам острой токсичности препарат Ингавирин относится к\n4 классу токсичности ‒ «Малотоксичные вещества» (при определении LD\u003csub\u003e50\u003c/sub\u003e в экспериментах по острой токсичности летальные дозы\nпрепарата определить не удалось)."}},{"type":"paragraph","data":{"text":"Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и\nканцерогенными свойствами, не оказывает местнораздражающего действия. Препарат\nИнгавирин не влияет на репродуктивную функцию, не оказывает\nэмбриотоксического и тератогенного действия."}},{"type":"paragraph","data":{"text":"Отсутствует влияние препарата Ингавирин на систему\nкроветворения при приеме соответствующей возрасту дозы рекомендованными схемой\nи курсом."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Всасывание и распределение"}},{"type":"paragraph","data":{"text":"В эксперименте с использованием радиоактивной метки установлено: действующее\nвещество быстро поступает в кровь из желудочно-кишечного тракта, распределяясь\nпо внутренним органам. В исследовании у здоровых добровольцев при однократном\nприеме препарата в дозе 90 мг максимальная\nконцентрация (C\u003csub\u003emax\u003c/sub\u003e) составила 441,45 ± 252,99 нг/мл; время ее\nдостижения (T\u003csub\u003emax\u003c/sub\u003e) – 1,30 ± 0,41 часа."}},{"type":"paragraph","data":{"text":"В доклинических исследованиях было установлено, что при курсовом приеме\nпрепарата один раз в сутки происходит его накопление во внутренних органах и\nтканях. При этом качественные характеристики фармакокинетических кривых после\nкаждого введения препарата тождественны: быстрое повышение концентрации\nпрепарата после каждого введения через 0,5-1 час после приема и затем медленное снижение к 24 часам. Величины AUC (площадь под фармакокинетической кривой «концентрация‒время»)\nпочек, печени и легких незначительно превышают AUC крови. Величины AUC для\nселезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови."}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Препарат не метаболизируется в организме и выводится в неизмененном виде."}},{"type":"paragraph","data":{"text":"Выведение"}},{"type":"paragraph","data":{"text":"В исследовании у здоровых добровольцев при однократном приеме препарата в\nдозе 90 мг период полувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) составил 1,82 ± 0,23 часа. В\nдоклинических исследованиях было установлено, что основной процесс выведения\nпроисходит в течение 24 часов. За этот период выводится 80 % принятой дозы:\n34,8 % выводится во временном интервале от 0 до 5 часов и 45,2 % во временном\nинтервале от 5 до 24 часов. Из них 77 % выводится через кишечник и 23 % ‒ через почки."}}]},{"id":30,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Лечение и профилактика гриппа А и В и других острых респираторных вирусных\nинфекций (аденовирусная инфекция, парагрипп, респираторно-синцитиальная\nинфекция, риновирусная инфекция) у взрослых и детей от 3 лет."}}]},{"id":31,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к действующему веществу или любому другому\nкомпоненту препарата."}},{"type":"paragraph","data":{"text":"Дефицит сахаразы/изомальтазы, непереносимость фруктозы, глюкозо-галактозная\nмальаб-сорбция."}},{"type":"paragraph","data":{"text":"Беременность."}},{"type":"paragraph","data":{"text":"Период грудного вскармливания."}},{"type":"paragraph","data":{"text":"Детский возраст до 3 лет."}}]},{"id":33,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата во время беременности не изучалось."}},{"type":"paragraph","data":{"text":"Применение препарата во время лактации не изучалось, поэтому при\nнеобходимости применения препарата в период грудного вскармливания следует\nпрекратить грудное вскармливание."}}]},{"id":34,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь. Независимо от приема пищи."}},{"type":"paragraph","data":{"text":"Плотно вставьте\nмерный шприц в горлышко флакона. Переверните флакон вверх дном и плавно\nпотяните поршень вниз, набирая сироп до нужной отметки. После употребления\nпромойте шприц в теплой воде и высушите его."}},{"type":"paragraph","data":{"text":"Для лечения и профилактики гриппа и острых респираторных вирусных инфекций\nвзрослым назначают по 90 мг (15 мл) 1 раз в день, детям от 7 лет ‒ по 60 мг (10\nмл) 1 раз в день, детям от 3 до 6 лет ‒ по 30 мг (5 мл) 1 раз в день."}},{"type":"paragraph","data":{"text":"Длительность лечения гриппа и острых респираторных вирусных инфекций у\nвзрослых и детей от 7 лет ‒ 5\u003cb\u003e-\u003c/b\u003e7 дней (в зависимости от тяжести\nсостояния). Длительность лечения гриппа и острых респираторных вирусных\nинфекций у детей от 3 до 6 лет ‒ 5 дней. "}},{"type":"paragraph","data":{"text":"Прием препарата начинают с момента появления первых симптомов заболевания,\nжелательно не позднее 2 суток от начала болезни."}},{"type":"paragraph","data":{"text":"Взрослым и детям при выраженных симптомах, а также при наличии сопутствующих\nзаболеваний (болезни дыхательной и сердечно-сосудистой систем, сахарный диабет,\nожирение), следует принимать двойную дозу препарата в первые 3 дня заболевания,\nдалее продолжить приём в обычной дозировке в течение 2-4 дней."}},{"type":"paragraph","data":{"text":"Для профилактики гриппа и острых респираторных вирусных инфекций после\nконтакта с больными лицами взрослым и детям от 7 лет препарат назначают в\nтечение 7 дней, детям от 3 до 6 лет ‒ в\nтечение 5 дней."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли через 5 дней лечения улучшения не наступает или симптомы усугубляются,\nили появляются новые симптомы, необходимо проконсультироваться с врачом.\nПрименяйте препарат только согласно тем показаниям, тому способу применения и в\nтех дозах, которые указаны в инструкции.\u003c/i\u003e"}}]},{"id":35,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции (редко)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли любые из указанных в инструкции побочных эффектов усугубляются или Вы\nзаметили любые другие побочные эффекты, не указанные в инструкции, сообщите об\nэтом врачу.\u003c/i\u003e"}}]},{"id":36,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"О случаях передозировки препарата Ингавирин до настоящего\nвремени не сообщалось."}}]},{"id":37,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Лекарственное взаимодействие препарата Ингавирин не описано."}}]},{"id":38,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Не рекомендуется одновременный прием других противовирусных препаратов без\nпредварительной консультации врача."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСохраняйте инструкцию. Она может\nпонадобиться вновь. Если у Вас возникли вопросы, обратитесь к врачу.\u003c/i\u003e"}}]},{"id":39,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не изучалось, однако, учитывая механизм действия и профиль побочных\nреакций, можно предположить, что препарат не оказывает влияния на способность\nуправлять транспортными средствами, механизмами."}}]},{"id":40,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Сироп 30 мг/5 мл."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФасовка и упаковка на \u003c/i\u003e\u003ci\u003eABC\u003c/i\u003e\u003ci\u003e Фармацойтичи С.п.А., Италия: \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По 50 мл или по 90 мл\nво флаконы коричневого цвета из полиэтилентерефталата, снабженные\nкольцом-адаптером, укупоренные крышками винтовыми из полипропилена с контролем\nпервого вскрытия и защитой от вскрытия детьми."}},{"type":"paragraph","data":{"text":"Один флакон вместе с\nмерным шприцем и инструкцией по применению помещают в пачку из картона."}},{"type":"paragraph","data":{"text":"\u003ci\u003eУпаковка на АО «Валента Фарм», Россия: \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Один флакон вместе с\nмерным шприцем и инструкцией по применению помещают в пачку из картона."}}]},{"id":41,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В оригинальной упаковке при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"После вскрытия флакона хранить не более 7 дней."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":42,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года"}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности."}}]},{"id":43,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":44,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"АО «Валента Фарм»"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаПротивовирусный препарат. В доклинических и клинических исследованиях показана эффективность препарата Ингавирин в отношении вирусов гриппа типа A (A(H1N1), в т.ч. пандемический штамм A(H1N1)pdm09 («свиной»), A(H3N2), A(H5N1)) и типа В, аденовируса, вируса парагриппа, респираторно-синцитиального вируса; в доклинических исследованиях: коронавируса, метапневмовируса, энтеровирусов, в том числе вируса Коксаки и риновируса. Ингавирин снижает вирусную нагрузку, ускоряет элиминацию вирусов, сокращает продолжительность болезни, снижает риск развития осложнений. Механизм действия реализуется на уровне инфицированных клеток за счет активации факторов врожденного иммунитета, подавляемых вирусными белками. В экспериментальных исследованиях, в частности, показано, что препарат Ингавирин повышает экспрессию рецептора интерферона первого типа IFNAR на поверхности эпителиальных и иммунокомпетентных клеток. Увеличение плотности интерфероновых рецепторов приводит к повышению чувствительности клеток к сигналам эндогенного интерферона. Процесс сопровождается активацией (фосфорилированием) белка-трансмиттера STAT1, передающего сигнал в ядро клетки для индукции синтеза противовирусных генов. Показано, что в условиях инфекции препарат активирует синтез антивирусного эффекторного белка МхА (ранний фактор противовирусного ответа, ингибирующий внутриклеточный транспорт рибонуклеопротеиновых комплексов различных вирусов) и фосфорилированной формы PKR, подавляющей трансляцию вирусных белков, таким образом замедляя и останавливая процесс вирусной репродукции. Действие препарата Ингавирин заключается в значительном уменьшении признаков цитопатического и цитодеструктивного действия вируса, снижении количества инфицированных клеток, ограничении патологического процесса, нормализации состава и структуры клеток и морфологической картины тканей в зоне инфекционного процесса, как на ранних, так и на поздних его стадиях. Противовоспалительное действие обусловлено подавлением продукции ключевых провоспалительных цитокинов (фактора некроза опухоли (TNF-α), интерлейкинов (IL-1β и IL-6)), снижением активности миелопероксидазы. В экспериментальных исследованиях показано, что совместное использование препарата Ингавирин с антибиотиками повышает эффективность терапии на модели бактериального сепсиса, в том числе вызванного пенициллин-резистентными штаммами стафилококка. Проведенные экспериментальные токсикологические исследования свидетельствуют о низком уровне токсичности и высоком профиле безопасности препарата. По параметрам острой токсичности препарат Ингавирин относится к 4 классу токсичности ‒ «Малотоксичные вещества» (при определении LD50в экспериментах по острой токсичности летальные дозы препарата определить не удалось). Препарат не обладает мутагенными, иммунотоксическими, аллергизирующими и канцерогенными свойствами, не оказывает местнораздражающего действия. Препарат Ингавирин не влияет на репродуктивную функцию, не оказывает эмбриотоксического и тератогенного действия. Отсутствует влияние препарата Ингавирин на систему кроветворения при приеме соответствующей возрасту дозы рекомендованными схемой и курсом.ФармакокинетикаВсасывание и распределение В эксперименте с использованием радиоактивной метки установлено: действующее вещество быстро поступает в кровь из желудочно-кишечного тракта, распределяясь по внутренним органам. В исследовании у здоровых добровольцев при однократном приеме препарата в дозе 90 мг максимальная концентрация (Cmax) составила 441,45 ± 252,99 нг/мл; время ее достижения (Tmax) – 1,30 ± 0,41 часа. В доклинических исследованиях было установлено, что при курсовом приеме препарата один раз в сутки происходит его накопление во внутренних органах и тканях. При этом качественные характеристики фармакокинетических кривых после каждого введения препарата тождественны: быстрое повышение концентрации препарата после каждого введения через 0,5-1 час после приема и затем медленное снижение к 24 часам. Величины AUC (площадь под фармакокинетической кривой «концентрация‒время») почек, печени и легких незначительно превышают AUC крови. Величины AUC для селезенки, надпочечников, лимфатических узлов и тимуса ниже AUC крови. Метаболизм Препарат не метаболизируется в организме и выводится в неизмененном виде. Выведение В исследовании у здоровых добровольцев при однократном приеме препарата в дозе 90 мг период полувыведения (Т1/2) составил 1,82 ± 0,23 часа. В доклинических исследованиях было установлено, что основной процесс выведения происходит в течение 24 часов. За этот период выводится 80 % принятой дозы: 34,8 % выводится во временном интервале от 0 до 5 часов и 45,2 % во временном интервале от 5 до 24 часов. 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