Пенталгин НЕО Таблетки, 20 шт, 50 + 220 + 325 мг + мг + мг, для взрослых, покрытые оболочкой

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На поперечном разрезе ядро белого или почти белого цвета."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"анальгезирующее средство комбинированное (нестероидное противовоспалительное средство + анальгезирующее ненаркотическое средство + психостимулирующее средство)."}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Комбинированное лекарственное средство."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНапроксен:\u003c/i\u003e НПВС, обладает обезболивающим, жаропонижающим и противовоспалительным действием. Механизм действия обусловлен неселективным ингибированием активности ЦОГ-1 и ЦОГ-2, регулирующей синтез простагландинов. Применение напроксена в виде соли напроксена натрия обеспечивает более быстрое всасывание и быстрое наступление обезболивающего эффекта."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПарацетамол:\u003c/i\u003e анальгетик-антипиретик, оказывает жаропонижающее и обезболивающее действие, обусловленное блокадой циклооксигеназы в центральной нервной системе и воздействием на центры боли и терморегуляции."}},{"type":"paragraph","data":{"text":"\u003ci\u003eКофеин:\u003c/i\u003e уменьшает сонливость, чувство усталости, повышает умственную и физическую работоспособность; расширяет кровеносные сосуды скелетных мышц, сердца, почек, снижает агрегацию тромбоцитов. В данной комбинации кофеин в малой дозе практически не оказывает симулирующего действия на ЦНС, повышает тонус сосудов головного мозга и способствует ускорению кровотока. Кофеин увеличивает проницаемость гистогематических барьеров и повышает биодоступность ненаркотических анальгетиков, а также снижает активность ЦОГ, т.к. является антагонистом аденозиновых А(2А) и А(2В) рецепторов, что способствует усилению обезболивающего действия анальгетиков."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nБолевой синдром различного генеза:"}},{"type":"paragraph","data":{"text":"• при заболеваниях опорно-двигательного аппарата (остеоартроз периферических суставов и позвоночника, в том числе с радикулярным синдромом, артрит, миалгия);"}},{"type":"paragraph","data":{"text":"• невралгия;"}},{"type":"paragraph","data":{"text":"• зубная боль;"}},{"type":"paragraph","data":{"text":"• головная боль, мигрень;"}},{"type":"paragraph","data":{"text":"• альгодисменорея;"}},{"type":"paragraph","data":{"text":"• посттравматический (растяжения и ушибы) и послеоперационный болевой синдром, сопровождающийся воспалением."}},{"type":"paragraph","data":{"text":"Препарат Пенталгин НЕО применяется для симптоматической терапии (для уменьшения боли и воспаления) и на прогрессирование основного заболевания не влияет.\n\n"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\n• Гиперчувствительность к напроксену, напроксену натрия, другим нестероидным противовоспалительным препаратам (НПВП), или ксантинам; повышенная чувствительность к другим компонентам препарата;"}},{"type":"paragraph","data":{"text":"• полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других НПВП (в том числе в анамнезе);"}},{"type":"paragraph","data":{"text":"• период после проведения аортокоронарного шунтирования;"}},{"type":"paragraph","data":{"text":"• эрозивно-язвенные поражения ЖКТ (в фазе обострения), активное желудочно-кишечное кровотечение;"}},{"type":"paragraph","data":{"text":"• гемофилия и другие нарушения свертываемости крови и нарушения гемостаза;"}},{"type":"paragraph","data":{"text":"• цереброваскулярное кровотечение или иные кровотечения;"}},{"type":"paragraph","data":{"text":"• декомпенсированная сердечная недостаточность;"}},{"type":"paragraph","data":{"text":"• органические заболевания сердечно-сосудистой системы (острый инфаркт миокарда, тяжелое течение ишемической болезни сердца, тяжелая артериальная гипертензия), пароксизмальная тахикардия, частая желудочковая экстрасистолия;"}},{"type":"paragraph","data":{"text":"• выраженная печеночная недостаточность или активное заболевание печени;"}},{"type":"paragraph","data":{"text":"• выраженная почечная недостаточность (клиренс креатинина (КК) менее 30 мл/мин), прогрессирующие заболевания почек, подтвержденная гиперкалиемия;"}},{"type":"paragraph","data":{"text":"• повышенная возбудимость, нарушение сна, тревожные расстройства (агорафобия, панические расстройства);"}},{"type":"paragraph","data":{"text":"• беременность, период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"• детский возраст до 18 лет.\n\n"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"\n\nИшемическая болезнь сердца, цереброваскулярные заболевания, застойная сердечная недостаточность, дислипидемия/гиперлипидемия, сахарный диабет, печеночная недостаточность легкой и средней степени тяжести с повышением уровня трансаминаз, доброкачественные гипербилирубинемии (в т.ч. синдром Жильбера, алкогольное поражение печени), заболевания периферических артерий, курение, глаукома, нарушение функции почек (КК 30–60 мл/мин), язвенное поражение ЖКТ в анамнезе, наличие инфекции Helicobacter pylori, дефицит глюкозо-6-фосфатдегидрогеназы; эпилепсия и склонность к судорожным припадкам, пожилой возраст, системная красная волчанка или смешанные заболевания соединительной ткани (синдром Шарпа), длительное применение НПВП, частое употребление алкоголя, тяжелые соматические заболевания, сопутствующая терапия следующими препаратами: антикоагулянты, антиагреганты, пероральные глюкокортикоиды, селективные ингибиторы обратного захвата серотонина."}},{"type":"paragraph","data":{"text":"Если у Вас одно из перечисленных заболеваний/состояний, перед приемом препарата обязательно проконсультируйтесь с врачом.\n\n"}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Применение препарата Пенталгин®НЕО противопоказано при беременности и в период грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nВнутрь. Таблетки следует принимать с достаточным количеством воды."}},{"type":"paragraph","data":{"text":"Разовая доза – 1 таблетка."}},{"type":"paragraph","data":{"text":"Частота приема – 1–3 раза в день, с интервалом не менее 4 часов."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза – 3 таблетки."}},{"type":"paragraph","data":{"text":"Длительность применения препарата – не более 5 дней.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nНежелательные эффекты, которые могут развиваться во время лечения препаратом Пенталгин® НЕО, классифицированы в соответствии со следующей частотой встречаемости:"}},{"type":"paragraph","data":{"text":"очень часто (> 1/10), часто (от ≥ 1/100 до < 1/10), нечасто (от ≥ 1/1 000 до < 1/100), редко (от ≥ 1/10 000 до < 1/1 000), очень редко (< 1/10 000), частота неизвестна (не может быть определена на основании имеющихся данных)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны крови и лимфатической системы: нечасто: эозинофилия, гранулоцитопения, лейкопения, тромбоцитопения; очень редко – метгемоглобинемия, гемолитическая анемия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы: часто: головная боль, вертиго, головокружение, сонливость; нечасто: тремор, парестезии, головная боль, депрессия, нарушения сна, расстройство внимания, бессонница, недомогание."}},{"type":"paragraph","data":{"text":"Психические расстройства: часто: нервозность; нечасто: бессонница; редко: тревога, эйфорическое настроение, внутреннее напряжение."}},{"type":"paragraph","data":{"text":"Нарушения со стороны органа зрения: часто: нарушение зрения."}},{"type":"paragraph","data":{"text":"Нарушения со стороны органа слуха и лабиринтные нарушения: часто: шум в ушах, нарушение слуха; нечасто: снижение слуха."}},{"type":"paragraph","data":{"text":"Нарушения со стороны сердца: часто: отечность, ощущение сердцебиения; нечасто: застойная сердечная недостаточность, тахикардия, аритмия; частота неизвестна – повышение артериального давления."}},{"type":"paragraph","data":{"text":"Нарушения со стороны дыхательной системы, органов грудной клетки и средостения: часто: одышка; нечасто: эозинофильные пневмонии; очень редко: бронхоспазм (у пациентов с гиперчувствительностью к ацетилсалициловой кислоте и другим НПВП)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта: часто: запор, боль в животе, диспепсия, тошнота, диарея, стоматит, метеоризм; нечасто: желудочно-кишечное кровотечение и/или перфорация желудка, кровавая рвота, мелена, рвота; сухость во рту; очень редко: рецидив или обострение язвенного колита или болезни Крона; частота неизвестна: гастрит."}},{"type":"paragraph","data":{"text":"Нарушения со стороны печени и желчевыводящих путей: нечасто: повышение активности «печеночных» ферментов, желтуха; очень редко: нарушение функции печени."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей: часто: кожный зуд, кожная сыпь, экхимозы, пурпура; нечасто: алопеция, фотодерматозы; очень редко: буллезные реакции, включая синдром Стивенса-Джонсона и токсический эпидермальный некролиз."}},{"type":"paragraph","data":{"text":"Нарушения со стороны скелетно-мышечной и соединительной ткани: нечасто: миалгия и мышечная слабость."}},{"type":"paragraph","data":{"text":"Нарушения со стороны почек и мочевыводящих путей: нечасто: гломерулонефрит, гематурия, интерстициальный нефрит, нефротический синдром, почечная недостаточность, почечный папиллярный некроз."}},{"type":"paragraph","data":{"text":"Общие расстройства и нарушения в месте введения: часто: жажда, повышенное потоотделение; нечасто: реакции повышенной чувствительности, нарушения менструального цикла, гипертермия (озноб и лихорадка)."}},{"type":"paragraph","data":{"text":"Данные об усилении или расширении спектра нежелательных явлений отдельных компонентов при применении их в составе комбинации в соответствии с инструкцией по медицинскому применению отсутствуют."}},{"type":"paragraph","data":{"text":"При возникновении побочных эффектов следует обратиться к врачу.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы: сонливость, диспептические расстройства (изжога, тошнота, рвота, боль в животе), головная боль, шум в ушах, слабость, потливость, бледность кожных покровов, тревога, возбуждение, двигательное беспокойство, анорексия, спутанность сознания, тахикардия, аритмия, гипертермия, тремор или мышечные подергивания; в тяжелых случаях – кровавая рвота, мелена, нарушение сознания, судороги, почечная и/или печеночная недостаточность."}},{"type":"paragraph","data":{"text":"При подозрении на передозировку препарата необходимо немедленно обратиться за врачебной помощью."}},{"type":"paragraph","data":{"text":"Лечение. Пострадавшему следует сделать промывание желудка и назначить энтеросорбенты (активированный уголь). Необходимость в проведении дополнительных терапевтических мероприятий определяется в зависимости от тяжести состояния и выраженности симптомов интоксикации.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nДругие НПВП, включая селективные ингибиторы циклооксигеназы-2, кортикостероиды: возрастание риска развития побочных эффектов напроксена со стороны ЖКТ."}},{"type":"paragraph","data":{"text":"Пропранолол и другие бета-адреноблокаторы: напроксен может снижать антигипертензивное действие препаратов. Кофеин может подавлять терапевтические эффекты бета-адреноблокаторов."}},{"type":"paragraph","data":{"text":"Сердечные гликозиды: кофеин ускоряет всасывание и усиливает действие сердечных гликозидов, повышает их токсичность."}},{"type":"paragraph","data":{"text":"Диуретики: напроксен может уменьшать мочегонное действие диуретиков, ингибировать натрийуретическое действие фуросемида. Диуретики могут повышать риск нефротоксичности НПВП."}},{"type":"paragraph","data":{"text":"Литий: напроксен снижает выведение лития, что приводит к увеличению концентрации лития в плазме крови."}},{"type":"paragraph","data":{"text":"Миелотоксические препараты: усиление гематоксичности напроксена."}},{"type":"paragraph","data":{"text":"Циклоспорин: увеличение риска развития почечной недостаточности."}},{"type":"paragraph","data":{"text":"Пробенецид: увеличивает концентрацию напроксена в плазме крови."}},{"type":"paragraph","data":{"text":"Метотрексат, фенитион, сульфаниламид: напроксен замедляет их экскрецию, что увеличивает риск развития их токсического действия."}},{"type":"paragraph","data":{"text":"Антацидные препараты, содержащие магний и алюминий: уменьшение абсорбции напроксена."}},{"type":"paragraph","data":{"text":"Антикоагулянты: напроксен может усиливать действие антикоагулянтов, парацетамол при длительном применении усиливает действие непрямых антикоагулянтов."}},{"type":"paragraph","data":{"text":"Антитромбоцитарные препараты, селективные ингибиторы обратного захвата серотонина: повышение риска развития желудочно-кишечного кровотечения."}},{"type":"paragraph","data":{"text":"Мифепристон: не рекомендуется одновременный прием НПВП в течение 8-12 дней после применения мифепристона."}},{"type":"paragraph","data":{"text":"Такролимус: одновременное применение НПВП повышает риск нефротоксичности."}},{"type":"paragraph","data":{"text":"Дифлунисал: повышение концентрации парацетамола в плазме крови, что повышает риск развития гепатотоксичности."}},{"type":"paragraph","data":{"text":"Индукторы микросомальных ферментов печени: возможно повышение гепатотоксического действия парацетамола."}},{"type":"paragraph","data":{"text":"Ингибиторы микросомальных ферментов печени: снижение риска гепатотоксического действия парацетамола."}},{"type":"paragraph","data":{"text":"Хлорамфеникол: парацетамол увеличивает время выведения хлорамфеникола."}},{"type":"paragraph","data":{"text":"Метоклопрамид, домперидон: увеличение скорости всасывания парацетамола."}},{"type":"paragraph","data":{"text":"Колестирамин: снижение скорости всасывания парацетамола."}},{"type":"paragraph","data":{"text":"Теофиллин: кофеин снижает экскрецию теофиллина."}},{"type":"paragraph","data":{"text":"Барбитураты, примидон, противосудорожные средства: возможно усиление метаболизма и увеличение клиренса кофеина."}},{"type":"paragraph","data":{"text":"Циметидин, пероральные контрацептивы, дисульфирам, ципрофлоксацин, норфлоксацин: возможно снижение метаболизма кофеина в печени (замедление его выведения и увеличение концентрации в крови)."}},{"type":"paragraph","data":{"text":"Препараты кальция: кофеин снижает их всасывание в ЖКТ."}},{"type":"paragraph","data":{"text":"Наркотические и снотворные лекарственные средства: кофеин снижает их эффективность."}},{"type":"paragraph","data":{"text":"Алкоголь: увеличение риска поражения печени и острого панкреатита.\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nОбщие"}},{"type":"paragraph","data":{"text":"Не превышайте доз, указанных в инструкции. Для снижения риска развития нежелательных явлений следует использовать минимальную эффективную дозу минимально возможным коротким курсом."}},{"type":"paragraph","data":{"text":"При сохранении или усилении болевого синдрома на фоне терапии следует обратиться к врачу."}},{"type":"paragraph","data":{"text":"При продолжительном применении препарата необходим контроль периферической крови и функционального состояния печени."}},{"type":"paragraph","data":{"text":"Препарат не следует принимать вместе с другими противовоспалительными и болеутоляющими препаратами, за исключением назначений врача."}},{"type":"paragraph","data":{"text":"Следует избегать приема препарата в течение 48 часов до хирургического вмешательства. При необходимости определения 17-кортикостероидов препарат следует отменить за"}},{"type":"paragraph","data":{"text":"48 часов до исследования. Аналогично напроксен может оказывать влияние на определение 5-гидроксииндолуксусной кислоты в моче."}},{"type":"paragraph","data":{"text":"Применение напроксена, как и других препаратов, блокирующих синтез простагландинов, может влиять на фертильность, поэтому не рекомендуется женщинам, планирующим беременность."}},{"type":"paragraph","data":{"text":"Во время лечения следует отказаться от употребления алкогольсодержащих напитков"}},{"type":"paragraph","data":{"text":"(см. Раздел «Лекарственные взаимодействия»)."}},{"type":"paragraph","data":{"text":"При применении препарата следует ограничить потребление продуктов, содержащих кофеин, поскольку избыточное поступление кофеина может привести к нервозности, раздражительности, бессоннице и, в некоторых случаях, учащению сердцебиения."}},{"type":"paragraph","data":{"text":"Влияние на лабораторные показатели"}},{"type":"paragraph","data":{"text":"Применение парацетамола может повлиять на результаты определения мочевой кислоты по методу фосфорновольфрамовой кислоты и гликемии глюкозооксидазным/пероксидазным методом."}},{"type":"paragraph","data":{"text":"Кофеин может искажать результаты пробы с дипиридамолом; при проведении исследования необходимо в течение 8–12 ч воздержаться от приема кофеина."}},{"type":"paragraph","data":{"text":"Каждая таблетка препарата содержит приблизительно 20 мг натрия. 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