Энцетрон-СОЛОфарм Раствор, 5 шт, 4 мл, 250 мг / мл, для внутривенного и внутримышечного введения

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В остром\nпериоде инсульта цитиколин уменьшает объем поражения ткани головного мозга, улучшает\nхолинергическую передачу. При черепно-мозговой травме уменьшает длительность\nпосттравматической комы и выраженность неврологических симптомов, кроме того,\nспособствует уменьшению продолжительности восстановительного периода. При\nхронической гипоксии головного мозга цитиколин эффективен в лечении когнитивных\nрасстройств, таких как ухудшение памяти, безынициативность, трудности при\nвыполнении повседневных действий и самообслуживания.  Повышает уровень внимания и сознания, а также\nуменьшает проявление амнезии. Эффективен в лечении чувствительных и\nдвигательных неврологических нарушений дегенеративной и сосудистой этиологии."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Всасывание"}},{"type":"paragraph","data":{"text":"Цитиколин хорошо абсорбируется при\nвнутривенном и внутримышечном введении."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При внутривенном и внутримышечном\nвведении цитиколин метаболизируется в печени с образованием холина и цитидина.\nПосле введения концентрация холина в плазме крови существенно повышается."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Цитиколин в значительной степени\nраспределяется в структурах головного мозга с быстрым внедрением фракции холина\nв структурные фосфолипиды и фракции цитидина – в цитидиновые нуклеотиды и\nнуклеиновые кислоты. Цитиколин проникает в головной мозг и активно встраивается\nв клеточные, цитоплазматические и митохондриальные мембраны, образуя часть\nфракции структурных фосфолипидов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Только 15 % введенной дозы цитиколина\nвыводится из организма человека: менее 3 % – почками и через кишечник и около\n12 % – с выдыхаемым СО\u003csub\u003e2\u003c/sub\u003e."}},{"type":"paragraph","data":{"text":"В экскреции цитиколина с мочой можно\nвыделить 2 фазы: первая фаза, длящаяся около 36 часов, в ходе которой скорость\nвыведения быстро снижается, и вторая фаза, в ходе которой скорость экскреции\nснижается намного медленнее. 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Хотя в исследованиях на животных отрицательного\nвлияния не выявлено, в период беременности препарат назначают только в тех\nслучаях, когда ожидаемая польза для матери превосходит потенциальный риск для\nплода."}},{"type":"paragraph","data":{"text":"При назначении препарата в период\nлактации женщинам следует прекратить грудное вскармливание, поскольку данные о\nвыделении цитиколина и его метаболитов с грудным молоком отсутствуют. Риск для\nребенка не может быть исключен."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат назначают внутривенно или\nвнутримышечно."}},{"type":"paragraph","data":{"text":"Внутривенно назначают в форме\nмедленной внутривенной инъекции (в течение 3-5 ми-нут, в зависимости от\nназначенной дозы) или капельного внутривенного вливания "}},{"type":"paragraph","data":{"text":"\n(40-60 капель в минуту)."}},{"type":"paragraph","data":{"text":"Внутривенный путь введения\nпредпочтительнее, чем внутримышечный. При внутримышечном введении следует\nизбегать повторного введения препарата в одно и то же место."}},{"type":"paragraph","data":{"text":"Рекомендуемый режим дозирования"}},{"type":"paragraph","data":{"text":"\u003ci\u003eОстрый период ишемического инсульта и черепно-мозговой травмы\n(ЧМТ): \u003c/i\u003e1000 мг\nкаждые 12 ч с первых суток после постановки диагноза, длительность лечения не\nменее 6 недель. Через 3-5 дней после начала лечения (если не нарушена\nфункция глотания) возможен переход на пероральные формы препарата.\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВосстановительный период ишемического и геморрагического инсультов,\nвосстановительный период ЧМТ, когнитивные и поведенческие нарушения при\nдегенеративных и сосудистых заболеваниях головного мозга: \u003c/i\u003e500-2000 мг в день. Дозировка и\nдлительность лечения в зависимости от тяжести симптомов заболевания.\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При подозрении на продолжающееся\nвнутричерепное кровотечение рекомендуется не превышать дозу 1000 мг в сутки,\nпрепарат вводят внутривенно капельно со скоростью "}},{"type":"paragraph","data":{"text":"\n30 капель в минуту."}},{"type":"paragraph","data":{"text":"Пожилые пациенты"}},{"type":"paragraph","data":{"text":"При назначении препарата пожилым\nпациентам коррекции дозы не требуется."}},{"type":"paragraph","data":{"text":"Раствор в ампуле предназначен для\nоднократного применения. Он должен быть немедленно использован после вскрытия\nампулы."}},{"type":"paragraph","data":{"text":"Препарат совместим со всеми видами\nвнутривенных изотонических растворов и растворов декстрозы."}},{"type":"paragraph","data":{"text":"Порядок работы с\nполимерной ампулой:"}},{"type":"paragraph","data":{"text":"1. Взять ампулу и\nвстряхнуть ее, удерживая за горлышко."}},{"type":"paragraph","data":{"text":"2. Сдавить ампулу рукой, при\nэтом не должно происходить выделение препарата, и вращающими движениями\nповернуть и отделить клапан."}},{"type":"paragraph","data":{"text":"3. Через образовавшееся\nотверстие немедленно соединить шприц с ампулой."}},{"type":"paragraph","data":{"text":"4. Перевернуть ампулу и\nмедленно набрать в шприц ее содержимое."}},{"type":"paragraph","data":{"text":"5. Надеть иглу на шприц."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты\nразвития побочных эффектов согласно Всемирной организации здравоохранения\n(ВОЗ): очень часто (≥\n1/10); часто (от ≥ 1/100 до < 1/10); нечасто          (от ≥ 1/1000 до < 1/100); редко\n(от ≥ 1/10000 до < 1/1000); очень редко (от < 1/10000, включая единичные\nслучаи); частота неизвестна (частота не может быть оценена\nна основе имеющихся данных)."}},{"type":"paragraph","data":{"text":"Частота неблагоприятных\nпобочных реакций – очень редко:"}},{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e сыпь, кожный зуд, анафилактический шок."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e чувство жара, отеки, одышка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны центральной и периферической нервной\nсистемы:\u003c/i\u003e\nбессонница, головная боль, головокружение, тремор, онемение в парализованных\nконечностях, стимуляция парасимпатической нервной системы."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нарушения психики:\u003c/i\u003e галлюцинации,\nвозбуждение."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы:\u003c/i\u003e кратковременное\nизменение артериального давления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e тошнота, снижение\nаппетита, рвота, диарея, изменение активности печеночных ферментов."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"С учетом низкой токсичности препарата\nслучаи передозировки не описаны."}},{"type":"paragraph","data":{"text":"При случайной\nпередозировке – лечение симптоматическое."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Цитиколин усиливает эффект леводопы.\nНе следует назначать одновременно с лекарственными средствами, содержащими\nмеклофеноксат."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат вводится внутривенно струйно\nмедленно (3-5 мин в зависимости от дозы). При внутривенном капельном введении\nскорость инфузии должна быть 40-60 капель в минуту."}},{"type":"paragraph","data":{"text":"При персистирующем\nвнутривенном кровоизлиянии рекомендуется не превышать дозу препарата 1000\nмг/сут, препарат вводят внутривенно капельно со скоростью 30 капель в минуту."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения следует\nсоблюдать осторожность при выполнении потенциально опасных видов деятельности,\nтребующих особого внимания и быстроты реакций (управление автомобилем и другими\nтранспортными средствами, работа с движущимися механизмами, работа диспетчера и\nоператора и т.п.).\u003cb\u003e\u003c/b\u003e"}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного и\nвнутримышечного введения 125 мг/мл и 250 мг/мл."}},{"type":"paragraph","data":{"text":"По\n4 мл в ампулы из полиэтилена низкой плотности (Политвист) со\nскручивающимся колпачком для безыгольного забора препарата или в ампулы из бесцветного стекла. "}},{"type":"paragraph","data":{"text":"По\n3, 5 или 10 ампул из полиэтилена низкой плотности вместе с инструкцией по\nприменению в пачке из картона."}},{"type":"paragraph","data":{"text":"По 3 или 5 ампул из бесцветного стекла в\nконтурной ячейковой упаковке из пленки поливинилхлоридной или полиэтилентерефталатной с пленкой полимерной\nили с фольгой алюминиевой лакированной, или без пленки полимерной и фольги\nалюминиевой лакированной, или в форме из картона с ячейками для укладки ампул. "}},{"type":"paragraph","data":{"text":"По 1\nконтурной ячейковой упаковке или форме из картона с 3 или 5 ампулами или по 2 контурные\nячейковые упаковки или формы из картона с 5 ампулами вместе с инструкцией по\nприменению и скарификатором ампульным или без него в пачке из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в защищенном от света месте, при температуре не выше 30 ºС. "}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей\nместе."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. "}},{"type":"paragraph","data":{"text":"Не применять после окончания\nсрока годности!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по\nрецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «Гротекс»"}},{"type":"paragraph","data":{"text":"Россия, 195279, Санкт-Петербург"}},{"type":"paragraph","data":{"text":"Индустриальный пр., д. 71, к. 2, лит. А"}},{"type":"paragraph","data":{"text":"Тел.: +7 812 385 47 87"}},{"type":"paragraph","data":{"text":"Факс: +7 812 385 47 88"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.solopharm.com\"\u003ewww.solopharm.com\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"www.encetron.ru"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаЦитиколин, являясь предшественником ключевых ультраструктурных компонентов клеточной мембраны (преимущественно фосфолипидов), обладает широким спектром действия – способствует восстановлению поврежденных мембран клеток, ингибирует действие фосфолипаз, препятствует избыточному образованию свободных радикалов, а также предотвращает гибель клеток, воздействуя на механизмы апоптоза. В остром периоде инсульта цитиколин уменьшает объем поражения ткани головного мозга, улучшает холинергическую передачу. При черепно-мозговой травме уменьшает длительность посттравматической комы и выраженность неврологических симптомов, кроме того, способствует уменьшению продолжительности восстановительного периода. При хронической гипоксии головного мозга цитиколин эффективен в лечении когнитивных расстройств, таких как ухудшение памяти, безынициативность, трудности при выполнении повседневных действий и самообслуживания. Повышает уровень внимания и сознания, а также уменьшает проявление амнезии. Эффективен в лечении чувствительных и двигательных неврологических нарушений дегенеративной и сосудистой этиологии.ФармакокинетикаВсасывание Цитиколин хорошо абсорбируется при внутривенном и внутримышечном введении.МетаболизмПри внутривенном и внутримышечном введении цитиколин метаболизируется в печени с образованием холина и цитидина. После введения концентрация холина в плазме крови существенно повышается.РаспределениеЦитиколин в значительной степени распределяется в структурах головного мозга с быстрым внедрением фракции холина в структурные фосфолипиды и фракции цитидина – в цитидиновые нуклеотиды и нуклеиновые кислоты. Цитиколин проникает в головной мозг и активно встраивается в клеточные, цитоплазматические и митохондриальные мембраны, образуя часть фракции структурных фосфолипидов.ВыведениеТолько 15 % введенной дозы цитиколина выводится из организма человека: менее 3 % – почками и через кишечник и около 12 % – с выдыхаемым СО2. В экскреции цитиколина с мочой можно выделить 2 фазы: первая фаза, длящаяся около 36 часов, в ходе которой скорость выведения быстро снижается, и вторая фаза, в ходе которой скорость экскреции снижается намного медленнее. То же самое наблюдается в выдыхаемом СО2– скорость выведения быстро снижается приблизительно через 15 ч, а затем снижается намного медленнее.","substance":[],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Энцетрон-СОЛОфарм - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62335/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62335/share_default/"}},"diseases":[],"other_packages":[{"id":152971,"title":"Энцетрон-СОЛОфарм","subtitle":{"full":"Раствор, 10 шт, 10 мл, 100 мг / мл, для приема внутрь","short":"Раствор, 10 шт, 10 мл, 100 мг / мл","package":"10 шт, 10 мл, 100 мг / 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