Эврин Раствор, 50 шт, 2 мл, 50 мг / мл, для внутривенного введения

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Препарат ингибирует перекисное окисление\nлипидов, повышает активность супероксидоксидазы, повышает соотношение\nлипид-белок, улучшает структуру и функцию мембраны клеток."}},{"type":"paragraph","data":{"text":"Этилметилгидроксипиридина\nсукцинат моделирует активность мембраносвязанных ферментов (кальций-независимой\nфосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы), рецепторных комплексов\n(бензодиазепинового, гамма-аминомасляного, ацетилхолинового), что усиливает их\nспособность связывания с лигандами, способствует сохранению структурно-функциональной\nорганизации биомембран, транспорта нейромедиаторов и улучшению синаптической\nпередачи. Этилметилгидроксипиридина сукцинат повышает содержание в головном\nмозге дофамина. Вызывает усиление компенсаторной активации аэробного гликолиза\nи снижение степени угнетения окислительных процессов в цикле Кребса в условиях\nгипоксии с увеличением содержания аденозинтрифосфата (АТФ) и креатинфосфата,\nактивацию энергосинтезирующих функций митохондрий. "}},{"type":"paragraph","data":{"text":"Повышает\nрезистентность организма к воздействию различных повреждающих факторов при\nпатологических состояниях (гипоксия и ишемия, нарушения мозгового\nкровообращения, интоксикация этанолом и антипсихотическими лекарственными\nсредствами). "}},{"type":"paragraph","data":{"text":"В условиях\nкритического снижения коронарного кровотока способствует сохранению\nструктурно-функциональной организации мембран кардиомиоцитов, стимулирует\nактивность мембранных ферментов – фосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы.\nПоддерживает развивающуюся при острой ишемии активацию ацетилхолинэстеразы.\nПоддерживает развивающуюся при острой ишемии активацию аэробного гликолиза и\nспособствует в условиях гипоксии восстановлению митохондриальных\nокислительно-восстановительных процессов, увеличивает синтез АТФ и\nкреатинфосфата. Обеспечивает целостность морфологических структур и\nфизиологических функций ишемизированного миокарда. Улучшает клиническое течение\nинфаркта миокарда, повышает эффективность проводимой терапии, снижает частоту\nвозникновения аритмий и нарушений внутрисердечной проводимости. "}},{"type":"paragraph","data":{"text":"Нормализует\nметаболические процессы в ишемизированном миокарде, повышает антиангинальную\nактивность нитратов, улучшает реологические свойства крови, уменьшает\nпоследствия реперфузионного синдрома при острой коронарной недостаточности. "}},{"type":"paragraph","data":{"text":"Способствует\nсохранению ганглиозных клеток сетчатки и волокон зрительного нерва при\nпрогрессирующей нейропатии, причинами которой являются хроническая ишемия и\nгипоксия. Улучшает функциональную активность сетчатки и зрительного нерва,\nувеличивая остроту зрения."}},{"type":"paragraph","data":{"text":"Уменьшает\nферментативную токсемию и эндогенную интоксикацию при остром панкреатите. "}},{"type":"paragraph","data":{"text":"Улучшает\nметаболизм и кровоснабжение головного мозга, микроциркуляцию и реологические\nсвойства крови, уменьшает агрегацию тромбоцитов. Стабилизирует мембраны клеток\nкрови (эритроцитов и тромбоцитов), снижая вероятность развития гемолиза. Обладает\nгиполипидемическим действием за счет уменьшения содержания общего холестерина и\nлипопротеидов низкой плотности."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eФармакокинетика\u003c/i\u003e\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Всасывание "}},{"type":"paragraph","data":{"text":"При однократном и курсовом приеме максимальная концентрация (Сmax) в плазме крови достигается через 0,58 ч. При введении в дозе 400-500\nмг Сmax в\nплазме крови –  3,5-4 мкг/мл.\n"}},{"type":"paragraph","data":{"text":"Распределение "}},{"type":"paragraph","data":{"text":"Быстро распределяется в органах и тканях. Среднее время удерживания\nэтилметилгидроксипиридина сукцината в организме – 0,7-1,3 ч. "}},{"type":"paragraph","data":{"text":"Метаболизм"}},{"type":"paragraph","data":{"text":"Метаболизируется в печени путем глюкуронирования. Идентифицировано 5\nметаболитов: 3-оксипиридина фосфат – образуется в печени и при участии щелочной\nфосфатазы распадается на фосфорную кислоту и 3-оксипиридин; 2-й метаболит –\nфармакологически активный, образуется в больших количествах и обнаруживается в\nмоче на 1-2 сутки после введения; 3-й – выводится в больших количествах с\nмочой; 4-й и 5-й – глюкуронконъюгаты."}},{"type":"paragraph","data":{"text":"Выведение "}},{"type":"paragraph","data":{"text":"Выводится из плазмы крови быстро и практически не определяется через 4\nчаса в ней. Быстро выводится с мочой, в основном в виде метаболитов (50 % за 12\nч), и в незначительном количестве – в неизменном виде (0,3 % за 12 ч).\nПоказатели выведения с мочой неизмененного этилметилгидроксипиридина сукцината\nи метаболитов имеют индивидуальную вариабельность. "}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"- острые нарушения мозгового\nкровообращения (в составе комплексной терапии);"}},{"type":"paragraph","data":{"text":"- черепно-мозговая травма,\nпоследствия черепно-мозговых травм;"}},{"type":"paragraph","data":{"text":"- дисциркуляторная энцефалопатия; "}},{"type":"paragraph","data":{"text":"- синдром вегетативной\n(нейроциркуляторной) дистонии;"}},{"type":"paragraph","data":{"text":"- легкие когнитивные расстройства\nатеросклеротического генеза;"}},{"type":"paragraph","data":{"text":"- тревожные расстройства при\nневротических и неврозоподобных состояниях;"}},{"type":"paragraph","data":{"text":"- острый инфаркт миокарда (с первых\nсуток) в составе комплексной терапии;"}},{"type":"paragraph","data":{"text":"- первичная\nоткрытоугольная глаукома различных стадий, в составе комплексной терапии;"}},{"type":"paragraph","data":{"text":"- купирование\nабстинентного синдрома при алкоголизме с преобладанием неврозоподобных и\nвегетативно-сосудистых расстройств;"}},{"type":"paragraph","data":{"text":"- острая интоксикация\nантипсихотическими лекарственными средствами;"}},{"type":"paragraph","data":{"text":"-\nострые гнойно-воспалительные процессы брюшной полости (острый некротический\nпанкреатит, перитонит) в составе комплексной терапии. "}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"- повышенная\nчувствительность к препарату;"}},{"type":"paragraph","data":{"text":"- острая печеночная и/или\nпочечная недостаточность;"}},{"type":"paragraph","data":{"text":"- детский возраст;"}},{"type":"paragraph","data":{"text":"- беременность;"}},{"type":"paragraph","data":{"text":"- период грудного\nвскармливания – в связи с отсутствием данных по эффективности и безопасности."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Аллергические заболевания в анамнезе."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"В\nэкспериментальных исследованиях не выявлено тератогенного, мутагенного,\nэмбриотоксического действия. Адекватных и строго контролируемых клинических\nисследований при беременности и в период лактации не проводилось. Препарат\nпротивопоказан при беременности и в период грудного вскармливания в связи с\nнедостаточностью данных по эффективности и безопасности препарата в данные\nпериоды. "}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутримышечно или внутривенно\n(струйно или капельно). При инфузионном способе введения препарат следует\nразводить в 0,9 % растворе натрия хлорида."}},{"type":"paragraph","data":{"text":"Дозы подбирают\nиндивидуально."}},{"type":"paragraph","data":{"text":"Струйно вводят медленно в\nтечение 5-7 минут, капельно – со скоростью 40-60 капель в минуту. Максимальная\nсуточная доза не должна превышать 1200 мг."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eострых нарушениях мозгового кровообращения\u003c/i\u003e применяют в комплексной\nтерапии в первые 10-14 дней – внутривенно капельно по 200-500 мг 2-4 раза в\nсутки, затем внутримышечно по 200-250 мг 2-3 раза в сутки в течение 2 недель."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eчерепно-мозговой травме и последствиях травм\u003c/i\u003e препарат применяют в\nтечение     10-15 дней внутривенно\nкапельно по 200-500 мг 2-4 раза в сутки."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eдисциркуляторной энцефалопатии в фазе декомпенсации\u003c/i\u003e препарат\nприменяют внутривенно струйно или капельно в дозе 200-500 мг 1-2 раза в сутки\nна протяжении      14 дней. Затем\nвнутримышечно по 100-250 мг в сутки в течение последующих двух недель. "}},{"type":"paragraph","data":{"text":"Для \u003ci\u003eкурсовой профилактики дисциркуляторной энцефалопатии \u003c/i\u003eвводят\nвнутримышечно в дозе 200-250 мг 2 раза в сутки в течение 10-14 дней."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eнейроциркуляторной дистонии, невротических и неврозоподобных состояниях\n\u003c/i\u003eпрепарат вводят внутримышечно по 50-400 мг в сутки в течение 14 дней."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eлегких когнитивных нарушениях у пациентов пожилого возраста и при\nтревожных расстройствах\u003c/i\u003e препарат применяют внутримышечно в дозе 100-300 мг в\nсутки в течение 14-30 дней."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eостром инфаркте миокарда в составе комплексной терапии\u003c/i\u003e препарат\nвводят внутривенно или внутримышечно в течение 14 суток, на фоне стандартной\nтерапии инфаркта миокарда (включающей нитраты, бета-адреноблокаторы, ингибиторы\nангиотензинпревращающего фермента (АПФ), тромболитики, антикоагулянтные и\nантиагрегантные средства, а также симптоматические средства по показаниям). В\nпервые 5 суток для достижения максимального эффекта препарат вводят\nвнутривенно, в последующие 9 суток препарат может вводиться внутримышечно.\nВнутривенное введение препарата проводят путем капельной инфузии, медленно (во\nизбежание побочных эффектов) течение 30-90 минут (в 100-150 мл 0,9 % раствора\nнатрия хлорида или 5 % раствора декстрозы (глюкозы)), при необходимости\nвозможно медленное струйное введение препарата продолжительностью не менее 5\nминут. Введение препарата (внутривенно или внутримышечно) осуществляют 3 раза в\nсутки через каждые 8 часов. Суточная доза составляет 6-9 мг/кг массы тела,\nразовая доза – 2-3 мг/кг массы тела. Максимальная суточная доза не должна\nпревышать 800 мг, разовая – 250 мг.   "}},{"type":"paragraph","data":{"text":"При \u003ci\u003eоткрытоугольной глаукоме различных стадий в составе комплексной терапии\n\u003c/i\u003eвводят внутримышечно по 100-300 мг в сутки, 1-3 раза в сутки в течение 14\nдней.       "}},{"type":"paragraph","data":{"text":"При \u003ci\u003eабстинентном алкогольном синдроме \u003c/i\u003eпрепарат вводят внутримышечно или\nвнутривенно капельно в дозе 200-500 мг 2-3 раза в сутки в течение 5-7 дней."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eострой интоксикации антипсихотическими лекарственными средствами\u003c/i\u003e\nпрепарат вводят внутривенно в дозе 200-500 мг в сутки в течение 7-14 дней. "}},{"type":"paragraph","data":{"text":"При \u003ci\u003eострых гнойно-воспалительных процессах брюшной полости (острый\nнекротический панкреатит, перитонит\u003c/i\u003e) препарат назначают в первые сутки как\nв предоперационном, так и в послеоперационном периоде. Вводимые дозы зависят от\nформы и тяжести заболевания, распространенности процесса, вариантов\nклинического течения. Отмена препарата должна производиться только после\nустойчивого положительного клинико-лабораторного эффекта."}},{"type":"paragraph","data":{"text":"При \u003ci\u003eостром отечном (интерстициальном) панкреатите\u003c/i\u003e препарат назначают\nпо          200-500 мг 3 раза в день, внутривенно\nкапельно (в 0,9 % растворе натрия хлорида) и внутримышечно. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛегкая степень тяжести некротического панкреатита\u003c/i\u003e – по 100-200 мг 3 раза в\nдень, внутривенно капельно (в 0,9 % растворе натрия хлорида) и внутримышечно. \u003ci\u003eСредняя степень тяжести\u003c/i\u003e – по 200 мг 3\nраза в день, внутривенно капельно (в 0,9 % растворе натрия хлорида). \u003ci\u003eТяжелое течение\u003c/i\u003e – в дозировке 800 мг в\nпервые сутки, при двукратном режиме введения; далее по 200-500 мг 2 раза в день\nс постепенным снижением суточной дозы. \u003ci\u003eКрайне\nтяжелое течение\u003c/i\u003e в начальной дозировке 800 мг в сутки до стойкого\nкупирования проявлений панкреатогенного шока, по стабилизации состояния по          300-500 мг 2 раза в день внутривенно\nкапельно (в 0,9 % растворе натрия хлорида) с постепенным снижением суточной\nдозировки."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы: \u003c/i\u003eтошнота, сухость слизистой оболочки полости рта или\nметаллический привкус во рту, метеоризм, диарея."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны нервной системы: \u003c/i\u003eсонливость, нарушение засыпания. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы: \u003c/i\u003eпершение в горле, дискомфорт в грудной клетке, ощущение\nнехватки воздуха (как правило, связано с чрезмерно высокой скоростью введения и\nносит кратковременный характер). "}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны сердечно-сосудистой системы: \u003c/i\u003eкратковременное повышение\nартериального давления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e аллергические реакции, ощущение «разливающегося тепла» во всем теле,\nнеприятный запах.  \u003ci\u003e \u003c/i\u003e   \u003ci\u003e\u003c/i\u003e"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"В связи с низкой токсичностью\nпередозировка маловероятна. При случайной передозировке возможно нарушение сна\n(бессонница), в некоторых случаях сонливость и седация. При внутривенном\nвведении возможно повышение артериального давления."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение \u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Как правило, не требуется – симптомы\nисчезают самостоятельно в течение суток. В особо тяжелых случаях при бессоннице\nрекомендуется применение одного из снотворных и анксиолитических средств для\nприема внутрь (нитразепам 10 мг, оксазепам 10 мг или диазепам 5 мг). При\nчрезмерном повышении артериального давления – гипотензивные препараты под\nконтролем артериального давления."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Усиливает действие бензодиазепиновых\nанксиолитиков, противоэпилептических (карбамазепин), противопаркинсонических\n(леводопа) лекарственных средств."}},{"type":"paragraph","data":{"text":"Уменьшает токсическое действие\nэтанола.  "}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат не назначают детям до 18 лет\nв связи с недостаточной изученностью действия препарата."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения\nнеобходимо соблюдать осторожность при управлении транспортными средствами и\nзанятии другими потенциально опасными видами деятельности, требующими\nповышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного и\nвнутримышечного введения 50 мг/мл."}},{"type":"paragraph","data":{"text":"По 2 или 5 мл в ампулы из бесцветного\nили окрашенного стекла."}},{"type":"paragraph","data":{"text":"По 5 ампул объемом 2 или 5 мл или по\n10 ампул объемом 2 мл в контурной ячейковой упаковке из пленки\nполивинилхлоридной или полиэтилентерефталатной с пленкой полимерной или фольгой\nалюминиевой лакированной или без пленки полимерной и фольги алюминиевой\nлакированной или в форме из картона с ячейками для укладки ампул. "}},{"type":"paragraph","data":{"text":"По 1, 2, 4, 6, 10, 12, 20\nили 50 контурных ячейковых упаковок или форм из картона с 5 ампулами или\nпо 1, 2, 3, 5, 6, 10 или 25 контурных ячейковых упаковок или форм из картона с\n10 ампулами вместе с инструкцией по применению и скарификатором ампульным или\nбез него в пачке из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В потребительской\nупаковке при температуре не выше 25 ºС."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для\nдетей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять\nпосле окончания срока годности!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «Гротекс»"}},{"type":"paragraph","data":{"text":"Россия, 195279, Санкт-Петербург"}},{"type":"paragraph","data":{"text":"Индустриальный пр., д. 71, к. 2, лит. А"}},{"type":"paragraph","data":{"text":"Тел.: +7 812 385 47 87"}},{"type":"paragraph","data":{"text":"Факс: +7 812 385 47 88"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.solopharm.com\"\u003ewww.solopharm.com\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"www.evrin.ru"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаЭтилметилгидроксипиридина сукцинат относится к классу 3-оксипиридинов, является ингибитором свободнорадикальных процессов, мембранопротектором. Обладает также антигипоксическим действием, повышает устойчивость организма к стрессу. Механизм действия этилметилгидроксипиридина сукцината обусловлен его антиоксидантным и мембранопротекторным действием. Препарат ингибирует перекисное окисление липидов, повышает активность супероксидоксидазы, повышает соотношение липид-белок, улучшает структуру и функцию мембраны клеток. Этилметилгидроксипиридина сукцинат моделирует активность мембраносвязанных ферментов (кальций-независимой фосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы), рецепторных комплексов (бензодиазепинового, гамма-аминомасляного, ацетилхолинового), что усиливает их способность связывания с лигандами, способствует сохранению структурно-функциональной организации биомембран, транспорта нейромедиаторов и улучшению синаптической передачи. Этилметилгидроксипиридина сукцинат повышает содержание в головном мозге дофамина. Вызывает усиление компенсаторной активации аэробного гликолиза и снижение степени угнетения окислительных процессов в цикле Кребса в условиях гипоксии с увеличением содержания аденозинтрифосфата (АТФ) и креатинфосфата, активацию энергосинтезирующих функций митохондрий. Повышает резистентность организма к воздействию различных повреждающих факторов при патологических состояниях (гипоксия и ишемия, нарушения мозгового кровообращения, интоксикация этанолом и антипсихотическими лекарственными средствами). В условиях критического снижения коронарного кровотока способствует сохранению структурно-функциональной организации мембран кардиомиоцитов, стимулирует активность мембранных ферментов – фосфодиэстеразы, аденилатциклазы, ацетилхолинэстеразы. Поддерживает развивающуюся при острой ишемии активацию ацетилхолинэстеразы. Поддерживает развивающуюся при острой ишемии активацию аэробного гликолиза и способствует в условиях гипоксии восстановлению митохондриальных окислительно-восстановительных процессов, увеличивает синтез АТФ и креатинфосфата. Обеспечивает целостность морфологических структур и физиологических функций ишемизированного миокарда. Улучшает клиническое течение инфаркта миокарда, повышает эффективность проводимой терапии, снижает частоту возникновения аритмий и нарушений внутрисердечной проводимости. Нормализует метаболические процессы в ишемизированном миокарде, повышает антиангинальную активность нитратов, улучшает реологические свойства крови, уменьшает последствия реперфузионного синдрома при острой коронарной недостаточности. Способствует сохранению ганглиозных клеток сетчатки и волокон зрительного нерва при прогрессирующей нейропатии, причинами которой являются хроническая ишемия и гипоксия. Улучшает функциональную активность сетчатки и зрительного нерва, увеличивая остроту зрения. Уменьшает ферментативную токсемию и эндогенную интоксикацию при остром панкреатите. Улучшает метаболизм и кровоснабжение головного мозга, микроциркуляцию и реологические свойства крови, уменьшает агрегацию тромбоцитов. Стабилизирует мембраны клеток крови (эритроцитов и тромбоцитов), снижая вероятность развития гемолиза. 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