Лидамитол Раствор, 10 шт, 1 мл, 100+2.5 мг, для инъекций

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Оказывает\nмембраностабилизирующее, местноанестезирующее действие, тормозит проведение\nнервных импульсов в первичных афферентных волокнах и двигательных нейронах, что\nприводит к блокированию спинномозговых моно- и полисинаптических рефлексов.\nПредположительно, толперизон опосредует блокирование выделения медиаторов путем\nторможения поступления ионов кальция в синапсы. Тормозит проведение возбуждения\nпо ретикулоспинальному пути в стволе головного мозга. Независимо от влияния на\nцентральную нервную систему (ЦНС) усиливает периферическое кровоснабжение. 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Время достижения максимальной концентрации при внутримышечном\nвведении  ̶  30-45 мин. Связь с белками плазмы  ̶ \n50-80 %. Быстро распределяется в тканях и органах. Проникает через гематоэнцефалический барьер и плацентарный барьер, секретируется\nс материнским молоком (40 % от концентрации в плазме матери). Метаболизируется\nв печени (на 90-95 %) с участием микросомальных ферментов путем\nдезалкилирования аминогруппы и разрыва амидной связи с образованием активных\nметаболитов. Выводится с желчью (часть дозы подвергается реабсорбции в ЖКТ) и\nпочками (до 10 % в неизмененном виде)."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"-\n   Симптоматическое лечение спастичности у\nвзрослых, обусловленной инсультом."}},{"type":"paragraph","data":{"text":"-\n     Миофасциальный болевой синдром\nсредней и тяжелой степени (в том числе мышечный спазм при дорсопатиях)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная\nчувствительность к какому-либо из компонентов препарата (в т.ч. к лидокаину),\nтяжелая миастения, детский возраст до 18 лет, беременность, период лактации (в\nсвязи с отсутствием данных)."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью следует\nприменять препарат у пациентов с почечной и печеночной недостаточностью.\nКоррекция дозы не требуется."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Препарат противопоказан\nпри беременности и в период грудного вскармливания (в связи с отсутствием\nданных)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослым \u003c/i\u003eежедневно по 1 мл 2 раза в сутки внутримышечно или по 1 мл 1 раз в день\nвнутривенно."}},{"type":"paragraph","data":{"text":"Порядок\nработы с полимерной ампулой:"}},{"type":"paragraph","data":{"text":"1. Взять\nампулу и встряхнуть ее, удерживая за горлышко."}},{"type":"paragraph","data":{"text":"2. Вращающими движениями повернуть и отделить клапан от ампулы."}},{"type":"paragraph","data":{"text":"3. Через\nобразовавшееся отверстие немедленно соединить луер шприца с ампулой."}},{"type":"paragraph","data":{"text":"4. Набрать в\nшприц содержимое ампулы."}},{"type":"paragraph","data":{"text":"5. Надеть\nиглу на шприц."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Классификация частоты\nразвития побочных эффектов, рекомендуемая Всемирной организацией\nздравоохранения (ВОЗ): очень часто (≥ 1/10), часто (≥ 1/100 и < 1/10), нечасто\n(≥ 1/1000 и < 1/100), редко (≥ 1/10000 и < 1/1000), очень редко\n(< 1/10000), частота неизвестна (не может быть оценена на основе имеющихся\nданных)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны крови и лимфатической системы:\u003c/i\u003e очень редко – анемия,\nлимфаденопатия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны иммунной системы:\u003c/i\u003e редко – реакции гиперчувствительности,\nанафилактические реакции; очень редко – анафилактический шок."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны обмена веществ и питания:\u003c/i\u003e нечасто – анорексия; очень редко –\nполидипсия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения психики:\u003c/i\u003e нечасто – бессонница, расстройства сна; редко – потеря активности,\nдепрессия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны нервной системы:\u003c/i\u003e нечасто – головная боль,\nголовокружение, сонливость; редко – синдром дефицита внимания, тремор,\nсудороги, потеря чувствительности, расстройства чувствительности, вялость."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны органа зрения:\u003c/i\u003e редко – нарушения зрительного\nвосприятия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны органа слуха и лабиринтные нарушения:\u003c/i\u003e редко – звон в ушах, вертиго."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сердца:\u003c/i\u003e редко – стенокардия, тахикардия,\nучащенное сердцебиение; очень редко – брадикардия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сосудов:\u003c/i\u003e нечасто – артериальная гипотензия;\nредко – приливы крови."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны дыхательной системы, органов грудной\nклетки и средостения:\u003c/i\u003e\nредко – одышка, носовое кровотечение, учащенное дыхание."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны желудочно-кишечного тракта:\u003c/i\u003e нечасто – желудочно-кишечный\nдискомфорт, диарея, сухость во рту, диспепсия, тошнота; редко – боль в\nэпигастрии, запор, метеоризм, рвота."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны печени и желчевыводящих путей:\u003c/i\u003e редко – нарушения функции печени."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны кожи и подкожных тканей:\u003c/i\u003e редко – аллергический дерматит,\nпотливость, кожный зуд, крапивница, кожная сыпь."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны скелетно-мышечной и соединительной\nткани:\u003c/i\u003e нечасто –\nмышечная слабость, миалгия, боль в конечностях; редко – дискомфорт в\nконечностях; очень редко – остеопения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны почек и мочевыводящих путей:\u003c/i\u003e редко – энурез, протеинурия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие расстройства и нарушения в месте введения:\u003c/i\u003e часто – покраснение места инъекции;\nнечасто – астения (слабость), недомогание, усталость; редко – чувство\nопьянения, ощущение жара, раздражительность, жажда; очень редко – чувство\nдискомфорта в груди."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛабораторные и инструментальные данные:\u003c/i\u003e редко – снижение артериального\nдавления, повышение концентрации билирубина, нарушение функциональных проб\nпечени, снижение количества тромбоцитов, повышение количества лейкоцитов; очень\nредко – повышение уровня креатинина."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы\u003c/i\u003e: атаксия, тонические и клонические судороги, диспноэ и остановка\nдыхания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e: рекомендуется проведение симптоматической и поддерживающий терапии.\nСпецифического антидота нет."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Нет данных о\nвзаимодействии с лекарственными средствами, ограничивающими применение\nпрепарата. Хотя толперизон и оказывает влияние на ЦНС, он не вызывает\nседативного эффекта и поэтому может применяться в комбинации с седативными,\nснотворными средствами и препаратами, содержащими этанол. Не усиливает действие\nэтанола на ЦНС. "}},{"type":"paragraph","data":{"text":"Усиливает действие\nнестероидных противовоспалительных препаратов, поэтому при одновременном\nназначении может потребоваться снижение дозы последних."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Необходимо соблюдать\nосторожность при вождении автотранспорта и при занятии другими потенциально\nопасными видами деятельности, требующими повышенной концентрации внимания и\nбыстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного\nи внутримышечного введения 100 мг/мл + 2,5 мг/мл."}},{"type":"paragraph","data":{"text":"По 1 мл в ампулы (Политвист) из полиэтилена низкой плотности, соответствующего требованиям Европейской\nФармакопеи к полиэтилену для парентеральных препаратов,\u003ci\u003e \u003c/i\u003eсо\nскручивающимся колпачком для безыгольного забора препарата или в ампулы из окрашенного стекла. "}},{"type":"paragraph","data":{"text":"По 5 или 10 ампул из полиэтилена низкой плотности\nвместе с инструкцией по применению в пачке из картона."}},{"type":"paragraph","data":{"text":"По 5 или 10 ампул из\nокрашенного стекла в контурной ячейковой упаковке из пленки поливинилхлоридной или полиэтилентерефталатной с пленкой полимерной\nили с фольгой алюминиевой лакированной, или без пленки полимерной и фольги\nалюминиевой лакированной, или в форме из картона с ячейками для укладки ампул. "}},{"type":"paragraph","data":{"text":"По 1 контурной ячейковой упаковке или форме из\nкартона с 5 или 10 ампулами или по 2 контурные ячейковые упаковки или\nформы из картона с 5 ампулами вместе с инструкцией по применению и\nскарификатором ампульным или без него в пачке из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не\nвыше 15 ºС. "}},{"type":"paragraph","data":{"text":"Хранить в недоступном для\nдетей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. "}},{"type":"paragraph","data":{"text":"Не\nприменять после окончания срока годности!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают по рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ООО «Гротекс»"}},{"type":"paragraph","data":{"text":"Россия, 195279, Санкт-Петербург "}},{"type":"paragraph","data":{"text":"Индустриальный пр., д. 71, к. 2, лит. А"}},{"type":"paragraph","data":{"text":"Тел.: +7 812 385 47 87"}},{"type":"paragraph","data":{"text":"Факс: +7 812 385 47 88"}},{"type":"paragraph","data":{"text":"\u003ca href=\"http://www.solopharm.com\"\u003ewww.solopharm.com\u003c/a\u003e"}},{"type":"paragraph","data":{"text":"www.lidamitol.ru"}}]}],"source":null},"description_toggle":false,"short_description":"ФармакодинамикаТолперизона гидрохлорид– миорелаксант центрального действия. Оказывает мембраностабилизирующее, местноанестезирующее действие, тормозит проведение нервных импульсов в первичных афферентных волокнах и двигательных нейронах, что приводит к блокированию спинномозговых моно- и полисинаптических рефлексов. Предположительно, толперизон опосредует блокирование выделения медиаторов путем торможения поступления ионов кальция в синапсы. Тормозит проведение возбуждения по ретикулоспинальному пути в стволе головного мозга. Независимо от влияния на центральную нервную систему (ЦНС) усиливает периферическое кровоснабжение. Это действие не связано с воздействием препарата на ЦНС и может быть обусловлено слабым спазмолитическим и антиадренергическим действием толперизона.Лидокаина гидрохлоридобладает местноанестезирующим действием и при дозировании Лидамитола согласно инструкции системного действия не оказывает.ФармакокинетикаТолперизона гидрохлоридподвергается интенсивному метаболизму в печени и почках. Выводится почками, почти исключительно (\u003e 99 %) в виде метаболитов, фармакологическая активность которых неизвестна. При внутривенном введении период полувыведения около 1,5 ч.Лидокаина гидрохлоридабсорбируется полностью (скорость абсорбции зависит от места введения и дозы). Время достижения максимальной концентрации при внутримышечном введении ̶ 30-45 мин. Связь с белками плазмы ̶ 50-80 %. Быстро распределяется в тканях и органах. Проникает через гематоэнцефалический барьер и плацентарный барьер, секретируется с материнским молоком (40 % от концентрации в плазме матери). Метаболизируется в печени (на 90-95 %) с участием микросомальных ферментов путем дезалкилирования аминогруппы и разрыва амидной связи с образованием активных метаболитов. Выводится с желчью (часть дозы подвергается реабсорбции в ЖКТ) и почками (до 10 % в неизмененном виде).","substance":[],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Лидамитол - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62212/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/62212/share_default/"}},"diseases":[],"other_packages":[{"id":152927,"title":"Лидамитол","subtitle":{"full":"Раствор, 5 шт, 1 мл, 100+2.5 мг, для инъекций","short":"Раствор, 5 шт, 1 мл, 100+2.5 мг","package":"5 шт, 1 мл, 100+2.5 мг"},"prescription":true,"catalog_section_id":77,"manufacturer":{"id":2347,"title":"Гротекс","slug":"groteks_2347","logo":{"isTouch":{"retina":null,"default":null},"isFromTablet":{"retina":null,"default":null}}},"is_advert":false,"product_form":"Раствор","slug":"152927-lidamitol","attributes":{"count":"5 шт","dose":"100+2.5 мг","volume":"1 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