Кагоцел применяют у взрослых и детей в возрасте от 3 лет в качестве профилактического и лечебного средства при гриппе и других острых респираторных вирусных инфекциях (ОРВИ), а также как лечебное средство при герпесе у взрослых.
Противопоказания
- Беременность и период лактации;
- Возраст до 3 лет;
- Повышенная чувствительность к компонентам препарата;
Основным механизмом действия Кагоцела является способность индуцировать продукцию интерферонов. Кагоцел вызывает образование в организме человека так называемых поздних интерферонов, являющихся смесью α- и β-интерферонов, обладающих высокой противовирусной активностью. Кагоцел вызывает продукцию интерферонов практически во всех популяциях клеток, принимающих участие в противовирусном ответе организма: Т- и В- лимфоцитах, макрофагах, гранулоцитах, фибробластах, эндотелиальных клетках. При приеме внутрь одной дозы Кагоцела титр интерферонов в сыворотке крови достигает максимальных значений через 48 часов. Интерфероновый ответ организма на введение Кагоцела характеризуется продолжительной (до 4-5 суток) циркуляцией интерферонов в кровотоке. Динамика накопления интерферонов в кишечнике при приеме внутрь Кагоцела не совпадает с динамикой титров циркулирующих интерферонов. В сыворотке крови продукция интерферонов достигает высоких значений лишь через 48 часов после приема Кагоцела, в то время как в кишечнике максимум продукции интерферонов отмечается уже через 4 часа.
Кагоцел, при назначении в терапевтических дозах, нетоксичен, не накапливается в организме. Препарат не обладает мутагенными и тератогенными свойствами, не канцерогенен и не обладает эмбриотоксическим действием.
ФАРМАКОКИНЕТИКА
Через 24 часа после введения в организм Кагоцел накапливается, в основном, в печени, в меньшей степени в легких, тимусе, селезенке, почках, лимфоузлах. Низкая концентрация отмечается в жировой ткани, сердце, мышцах, семенниках, мозге, плазме крови. Низкое содержание Кагоцела в головном мозге объясняется высокой молекулярной массой препарата, затрудняющей его проникновение через гематоэнцефалический барьер. В плазме крови препарат находится преимущественно в связанном виде.
При ежедневном многократном введении Кагоцела объем распределения колеблется в широких пределах во всех исследованных органах. Особенно выражено накопление препарата в селезенке и лимфатических узлах. При приеме внутрь в общий кровоток попадает около 20% введенной дозы препарата. Всосавшийся препарат циркулирует в крови, в основном, в связанной с макромолекулами форме: с липидами - 47%, с белками - 37%. Несвязанная часть препарата составляет около 16%.
Выведение: из организма препарат выводится, в основном, через кишечник: через 7 суток после введения из организма выводится 88% введенной дозы, в том числе 90% - через кишечник и 10% - почками. В выдыхаемом воздухе препарат не обнаружен.
Показания к применению
Кагоцел применяют у взрослых и детей в возрасте от 3 лет в качестве профилактического и лечебного средства при гриппе и других острых респираторных вирусных инфекциях (ОРВИ), а также как лечебное средство при герпесе у взрослых.
Противопоказания
- Беременность и период лактации;
- Возраст до 3 лет;
- Повышенная чувствительность к компонентам препарата;
Применение при беременности и в период грудного вскармливания
В связи с отсутствием необходимых клинических данных Кагоцел не рекомендуется принимать в период беременности и лактации.
Способ применения и дозы
Внутрь, независимо от приема пищи.
Для лечения гриппа и ОРВИ взрослым назначают в первые два дня – по 2 таблетки 3 раза в день, в последующие два дня – по одной таблетке 3 раза в день. Всего на курс – 18 таблеток, длительность курса – 4 дня.
Профилактика гриппа и ОРВИ у взрослых проводится 7-дневными циклами: два дня – по 2 таблетки 1 раз в день, 5 дней перерыв, затем цикл повторить. Длительность профилактического курса – от одной недели до нескольких месяцев.
Для лечения герпеса у взрослых назначают по 2 таблетки 3 раза в день в течение 5 дней. Всего на курс – 30 таблеток, длительность курса – 5 дней.
Для лечения гриппа и ОРВИ детям в возрасте от 3 до 6 лет назначают в первые два дня – по 1 таблетке 2 раза в день, в последующие два дня – по одной таблетке 1 раз в день. Всего на курс – 6 таблеток, длительность курса – 4 дня.
Для лечения гриппа и ОРВИ детям в возрасте от 6 лет назначают в первые два дня – по 1 таблетке 3 раза в день, в последующие два дня – по одной таблетке 2 раза в день. Всего на курс – 10 таблеток, длительность курса – 4 дня.
Профилактика гриппа и ОРВИ у детей в возрасте от 3 лет проводится 7-дневными циклами: два дня – по 1 таблетке 1 раз в день, 5 дней перерыв, затем цикл повторить. Длительность профилактического курса – от одной недели до нескольких месяцев.
Побочное действие
Возможно развитие аллергических реакций.
Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, сообщите об этом врачу.
Передозировка
При случайной передозировке рекомендуется назначить обильное питье, вызвать рвоту.
Взаимодействие с другими лекарственными средствами
Кагоцел хорошо сочетается с другими противовирусными препаратами, иммуномодуляторами и антибиотиками (аддитивный эффект).
Особые указания
Для достижения лечебного эффекта прием Кагоцела следует начинать не позднее четвертого дня от начала заболевания.
Влияние на способность управлять автомобилем и движущимися механизмами
Влияние препарата на способность к управлению транспортными средствами, механизмами не изучено.
Форма выпуска
Таблетки, 12 мг.
По 10 таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной/ поливинилиденхлоридной и фольги алюминиевой с термосвариваемым покрытием.
1, 2 или 3 контурные ячейковые упаковки вместе с инструкцией по применению помещают в пачку.
Условия хранения
В защищенном от света месте при температуре не выше 25 С.
Хранить в недоступном для детей месте.
Срок годности
4 года.
По истечении срока годности, указанного на упаковке, препарат не должен применяться.
Условия отпуска
Без рецепта врача.
Производитель
Производитель 1: ООО “НИАРМЕДИК ПЛЮС”, Россия, 125252, г. Москва, ул. Авиаконструктора Микояна, д. 12.
Адрес места производства: Россия, 123098, г. Москва, ул. Гамалеи, д. 18, стр. 4, 10, 11, 18, 33.
Производитель 2: ООО “Хемофарм”, Россия, 249030, Калужская область, г. Обнинск, Киевское шоссе, д. 62.
Производитель 3: ООО “НИАРМЕДИК ФАРМА”, Россия, 249030, Калужская область, г. Обнинск, ул. Королева, д. 4, оф. 402.
Адрес места производства: Россия, 249008, Калужская область, Боровский район, в районе дер. Маланьино, Киевское шоссе, стр. 6.
Организация, принимающая претензии потребителей
ООО “НИАРМЕДИК ПЛЮС”, Россия, 125252, г. Москва, ул. Авиаконструктора Микояна, д. 12, телефон/факс: +7 (495) 385-80-08, электронная почта: safety@nearmedic.ru.
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форма","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки"}}]},{"id":1,"name":"Состав","slug":"ingredients","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Активное вещество: \u003cb\u003eКагоцел\u003c/b\u003e 12 мг. Вспомогательные вещества: крахмал картофельный — 10мг, кальций стеарат — 0.65мг, Лудипресс (состав: лактозы моногидрат, повидон (Коллидон 30), кросповидон (Коллидон CL)) – до получения таблетки массой 100 мг. "}}]},{"id":13,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Противовирусное средство."}}]},{"id":2,"name":"Фармакологические свойства","slug":"pharmacologic_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003cb\u003eФАРМАКОДИНАМИКА\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Основным механизмом действия \u003cb\u003eКагоцела\u003c/b\u003e является способность индуцировать продукцию интерферонов. \u003cb\u003eКагоцел\u003c/b\u003e вызывает образование в организме человека так называемых поздних интерферонов, являющихся смесью α- и β-интерферонов, обладающих высокой противовирусной активностью. \u003cb\u003eКагоцел\u003c/b\u003e вызывает продукцию интерферонов практически во всех популяциях клеток, принимающих участие в противовирусном ответе организма: Т- и В- лимфоцитах, макрофагах, гранулоцитах, фибробластах, эндотелиальных клетках. При приеме внутрь одной дозы \u003cb\u003eКагоцела\u003c/b\u003e титр интерферонов в сыворотке крови достигает максимальных значений через 48 часов. Интерфероновый ответ организма на введение \u003cb\u003eКагоцела\u003c/b\u003e характеризуется продолжительной (до 4-5 суток) циркуляцией интерферонов в кровотоке. Динамика накопления интерферонов в кишечнике при приеме внутрь \u003cb\u003eКагоцела\u003c/b\u003e не совпадает с динамикой титров циркулирующих интерферонов. В сыворотке крови продукция интерферонов достигает высоких значений лишь через 48 часов после приема \u003cb\u003eКагоцела\u003c/b\u003e, в то время как в кишечнике максимум продукции интерферонов отмечается уже через 4 часа."}},{"type":"paragraph","data":{"text":"\u003cb\u003eКагоцел\u003c/b\u003e, при назначении в терапевтических дозах, нетоксичен, не накапливается в организме. Препарат не обладает мутагенными и тератогенными свойствами, не канцерогенен и не обладает эмбриотоксическим действием."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФАРМАКОКИНЕТИКА\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"Через 24 часа после введения в организм \u003cb\u003eКагоцел\u003c/b\u003e накапливается, в основном, в печени, в меньшей степени в легких, тимусе, селезенке, почках, лимфоузлах. Низкая концентрация отмечается в жировой ткани, сердце, мышцах, семенниках, мозге, плазме крови. Низкое содержание \u003cb\u003eКагоцела\u003c/b\u003e в головном мозге объясняется высокой молекулярной массой препарата, затрудняющей его проникновение через гематоэнцефалический барьер. В плазме крови препарат находится преимущественно в связанном виде."}},{"type":"paragraph","data":{"text":"При ежедневном многократном введении \u003cb\u003eКагоцела\u003c/b\u003e объем распределения колеблется в широких пределах во всех исследованных органах. Особенно выражено накопление препарата в селезенке и лимфатических узлах. При приеме внутрь в общий кровоток попадает около 20% введенной дозы препарата. Всосавшийся препарат циркулирует в крови, в основном, в связанной с макромолекулами форме: с липидами - 47%, с белками - 37%. Несвязанная часть препарата составляет около 16%."}},{"type":"paragraph","data":{"text":"Выведение: из организма препарат выводится, в основном, через кишечник: через 7 суток после введения из организма выводится 88% введенной дозы, в том числе 90% - через кишечник и 10% - почками. В выдыхаемом воздухе препарат не обнаружен."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003cb\u003eКагоцел\u003c/b\u003e применяют у взрослых и детей в возрасте от 3 лет в качестве профилактического и лечебного средства при гриппе и других острых респираторных вирусных инфекциях (ОРВИ), а также как лечебное средство при герпесе у взрослых. "}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\n\n- Беременность и период лактации;"}},{"type":"paragraph","data":{"text":"- Возраст до 3 лет;"}},{"type":"paragraph","data":{"text":"- Повышенная чувствительность к компонентам препарата;"}},{"type":"paragraph","data":{"text":"- Дефицит лактазы, непереносимость лактозы, глюкозо-галактозная мальабсорбция.\n\n"}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":" В связи с отсутствием необходимых клинических данных \u003cb\u003eКагоцел\u003c/b\u003e не рекомендуется принимать в период беременности и лактации. "}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\n\nВнутрь, независимо от приема пищи."}},{"type":"paragraph","data":{"text":"Для лечения гриппа и ОРВИ взрослым назначают в первые два дня – по 2 таблетки 3 раза в день, в последующие два дня – по одной таблетке 3 раза в день. Всего на курс – 18 таблеток, длительность курса – 4 дня."}},{"type":"paragraph","data":{"text":"Профилактика гриппа и ОРВИ у взрослых проводится 7-дневными циклами: два дня – по 2 таблетки 1 раз в день, 5 дней перерыв, затем цикл повторить. Длительность профилактического курса – от одной недели до нескольких месяцев."}},{"type":"paragraph","data":{"text":"Для лечения герпеса у взрослых назначают по 2 таблетки 3 раза в день в течение 5 дней. Всего на курс – 30 таблеток, длительность курса – 5 дней."}},{"type":"paragraph","data":{"text":"Для лечения гриппа и ОРВИ детям в возрасте от 3 до 6 лет назначают в первые два дня – по 1 таблетке 2 раза в день, в последующие два дня – по одной таблетке 1 раз в день. Всего на курс – 6 таблеток, длительность курса – 4 дня."}},{"type":"paragraph","data":{"text":"Для лечения гриппа и ОРВИ детям в возрасте от 6 лет назначают в первые два дня – по 1 таблетке 3 раза в день, в последующие два дня – по одной таблетке 2 раза в день. Всего на курс – 10 таблеток, длительность курса – 4 дня."}},{"type":"paragraph","data":{"text":"Профилактика гриппа и ОРВИ у детей в возрасте от 3 лет проводится 7-дневными циклами: два дня – по 1 таблетке 1 раз в день, 5 дней перерыв, затем цикл повторить. Длительность профилактического курса – от одной недели до нескольких месяцев.\n\n"}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\n\nВозможно развитие аллергических реакций."}},{"type":"paragraph","data":{"text":"Если любые из указанных в инструкции побочных эффектов усугубляются, или Вы заметили любые другие побочные эффекты, не указанные в инструкции, \u003cb\u003eсообщите об этом врачу.\u003c/b\u003e"}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При случайной передозировке рекомендуется назначить обильное питье, вызвать рвоту."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\u003cb\u003eКагоцел\u003c/b\u003e хорошо сочетается с другими противовирусными препаратами, иммуномодуляторами и антибиотиками (аддитивный эффект). "}}]},{"id":9,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Для достижения лечебного эффекта прием \u003cb\u003eКагоцела\u003c/b\u003e следует начинать не позднее четвертого дня от начала заболевания. "}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Влияние препарата на способность к управлению транспортными средствами, механизмами не изучено."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nТаблетки, 12 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток в контурную ячейковую упаковку из пленки поливинилхлоридной/ поливинилиденхлоридной и фольги алюминиевой с термосвариваемым покрытием."}},{"type":"paragraph","data":{"text":"1, 2 или 3 контурные ячейковые упаковки вместе с инструкцией по применению помещают в пачку.\n\n"}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nВ защищенном от света месте при температуре не выше 25 С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n4 года."}},{"type":"paragraph","data":{"text":"По истечении срока годности, указанного на упаковке, препарат не должен применяться.\n\n"}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта врача."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nПроизводитель 1: ООО “НИАРМЕДИК ПЛЮС”, Россия, 125252, г. Москва, ул. Авиаконструктора Микояна, д. 12."}},{"type":"paragraph","data":{"text":"Адрес места производства: Россия, 123098, г. Москва, ул. Гамалеи, д. 18, стр. 4, 10, 11, 18, 33."}},{"type":"paragraph","data":{"text":"Производитель 2: ООО “Хемофарм”, Россия, 249030, Калужская область, г. Обнинск, Киевское шоссе, д. 62."}},{"type":"paragraph","data":{"text":"Производитель 3: ООО “НИАРМЕДИК ФАРМА”, Россия, 249030, Калужская область, г. Обнинск, ул. Королева, д. 4, оф. 402."}},{"type":"paragraph","data":{"text":"Адрес места производства: Россия, 249008, Калужская область, Боровский район, в районе дер. Маланьино, Киевское шоссе, стр. 6.\n\n"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО “НИАРМЕДИК ПЛЮС”, Россия, 125252, г. Москва, ул. Авиаконструктора Микояна, д. 12, телефон/факс: +7 (495) 385-80-08, электронная почта: safety@nearmedic.ru."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФАРМАКОДИНАМИКАОсновным механизмом действияКагоцелаявляется способность индуцировать продукцию интерферонов.Кагоцелвызывает образование в организме человека так называемых поздних интерферонов, являющихся смесью α- и β-интерферонов, обладающих высокой противовирусной активностью.Кагоцелвызывает продукцию интерферонов практически во всех популяциях клеток, принимающих участие в противовирусном ответе организма: Т- и В- лимфоцитах, макрофагах, гранулоцитах, фибробластах, эндотелиальных клетках. При приеме внутрь одной дозыКагоцелатитр интерферонов в сыворотке крови достигает максимальных значений через 48 часов. Интерфероновый ответ организма на введениеКагоцелахарактеризуется продолжительной (до 4-5 суток) циркуляцией интерферонов в кровотоке. 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