Спазмалгон Эффект Таблетки, 10 шт

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Время достижения\nмаксимальной концентрации в плазме крови (ТC\u003csub\u003emax\u003c/sub\u003e) - "}},{"type":"paragraph","data":{"text":"\n0,5-1,5 часа после приема внутрь. Максимальная концентрация в плазме крови\n(С\u003csub\u003emax\u003c/sub\u003e) - "}},{"type":"paragraph","data":{"text":"\n5-20 мкг/мл. Связь с белками плазмы незначительная - 15%. Парацетамол\nравномерно распределяется и проникает через гематоэнцефалический барьер, а\nтакже в большинство тканей организма. Предполагаемый объем распределения\nсоставляет 0,95 л/кг. Метаболизируется в печени (90-95%): 80% вступает в\nреакции конъюгации с глюкуроновой кислотой и сульфатами с образованием\nнеактивных метаболитов; 17% подвергается гидроксилированию с образованием 8\nактивных метаболитов, которые конъюгируют с глутатионом с образованием уже\nнеактивных метаболитов. При недостатке глутатиона эти метаболиты могут\nблокировать ферментные системы гепатоцитов и вызывать их некроз. В метаболизме\nпрепарата также участвует изофермент CYP2E1. Период полувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) - 1,5-2,5 часа. Выводится почками в виде\nметаболитов, преимущественно конъюгатов, только 3% в неизмененном виде. У\nпожилых пациентов снижается клиренс препарата и увеличивается Т\u003csub\u003e1/2\u003c/sub\u003e."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНапроксен\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Абсорбция из ЖКТ напроксена быстрая и полная.\nБиодоступность - 95%. Прием пищи практически не влияет ни на полноту, ни на\nскорость всасывания. ТC\u003csub\u003emax\u003c/sub\u003e - 1-2 часа. Связывание с белками плазмы –\nболее 99%. Равновесная концентрация достигается к приему 4-5 доз препарата (2-3\nдня). Метаболизируется в печени до диметилнапроксена с участием изофермента\nCYP2C9. Т\u003csub\u003e1/2\u003c/sub\u003e - 12-15 часов. Клиренс – 0,13 мл/мин/кг. Выводится\nпочками (98%), 10% из которых - в неизмененном виде; с желчью выводится 0,5-2,5%\nпринятой дозы. При почечной недостаточности возможна кумуляция метаболитов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eКофеин\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Кофеин, входящий в состав\nпрепарата, почти полностью и быстро всасывается, максимальная концентрация в\nплазме крови достигается через 1 час. Быстро проходит через\nгематоэнцефалический и плацентарный барьеры, поступает в грудное молоко,\nвыводится (в т.ч. в виде метаболитов) в основном почками около 65-80%. Основные\nметаболиты - "}},{"type":"paragraph","data":{"text":"\n1-метилксантин, 1-метилмочевая кислота и ацетилированные производные урацила,\nнебольшое количество кофеина превращается в теофиллин и теобромин. Т\u003csub\u003e1/2\u003c/sub\u003e\n– 3,5 часа. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eДротаверин\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"При пероральном приеме абсорбция\nдротаверина высокая и быстрая.\nБиодоступность - 100%. После пресистемного метаболизма в системный кровоток\nпоступает 65% принятой дозы дротаверина. Время достижения C\u003csub\u003emax\u003c/sub\u003e в\nкрови – 45-60 минут. Связывание с белками плазмы – 95-97%, преимущественно с\nальбумином, гамма- и бета-глобулинами, а также липопротеинами высокой\nплотности. Равномерно распределяется в тканях, проникает в гладкомышечные\nклетки. Не проникает через гематоэнцефалический барьер. Дротаверин и/или его\nметаболиты могут незначительно проникать через плацентарный барьер. Т\u003csub\u003e1/2\u003c/sub\u003e\n- "}},{"type":"paragraph","data":{"text":"\n8-10 часов. Почти полностью метаболизируется в печени путем\nО-дезэтилирования. Метаболиты быстро конъюгируют с глюкуроновой кислотой.\nГлавный метаболит - "}},{"type":"paragraph","data":{"text":"\n4´-дезэтилдротаверин, другие метаболиты – 6-дезэтилдротаверин и\n4´-дезэтилдротавералдин. Т\u003csub\u003e1/2\u003c/sub\u003e – 8-10 часов. За 72 часа практически\nполностью выводится из организма. В основном (более 50% дротаверина) выводится\nпочками, преимущественно в виде метаболитов, в меньшей степени (около 30%) – с\nжелчью. Неизмененный дротаверин в моче не обнаруживается."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФенирамин\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Максимальная\nконцентрация фенирамина в плазме крови достигается примерно через "}},{"type":"paragraph","data":{"text":"\n1-2,5 часа. Т\u003csub\u003e1/2\u003c/sub\u003e – 16-19 часов. 70-83% принятой дозы выводится\nиз организма через почки в виде метаболитов или в неизмененном виде. "}}]},{"id":2,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"-   болевой синдром различного генеза, включая\nболи в суставах, мышцах; при радикулите, альгодисменорее (менструальных болях),\nневралгиях, зубной боли, головной боли (в том числе при головной боли,\nобусловленной спазмом сосудов головного мозга);"}},{"type":"paragraph","data":{"text":"-   болевой синдром, связанный со спазмом гладкой\nмускулатуры, в том числе при хроническом холецистите, желчекаменной болезни,\nпостхолецистэктомическом синдроме, почечной колике;"}},{"type":"paragraph","data":{"text":"-   посттравматический и послеоперационный\nболевой синдром, в том числе сопровождающийся воспалением;"}},{"type":"paragraph","data":{"text":"-   простудные заболевания, сопровождающиеся\nлихорадочным синдромом (в качестве симптоматической терапии)."}}]},{"id":3,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"-   повышенная чувствительность к компонентам препарата;"}},{"type":"paragraph","data":{"text":"-   эрозивно-язвенные поражения ЖКТ (в фазе\nобострения);"}},{"type":"paragraph","data":{"text":"-   желудочно-кишечное кровотечение;"}},{"type":"paragraph","data":{"text":"-   полное\nили неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа и\nоколоносовых пазух и непереносимости ацетилсалициловой кислоты или других НПВП\n(в том числе в анамнезе);"}},{"type":"paragraph","data":{"text":"-   тяжелая печеночная недостаточность;"}},{"type":"paragraph","data":{"text":"-   тяжелая почечная недостаточность;"}},{"type":"paragraph","data":{"text":"-   угнетение костномозгового кроветворения;"}},{"type":"paragraph","data":{"text":"-   состояние после проведения аортокоронарного\nшунтирования;"}},{"type":"paragraph","data":{"text":"-   тяжелые органические заболевания сердечно-сосудистой\nсистемы (в том числе острый инфаркт миокарда);"}},{"type":"paragraph","data":{"text":"-   пароксизмальная тахикардия;"}},{"type":"paragraph","data":{"text":"-   частая желудочковая экстрасистолия;"}},{"type":"paragraph","data":{"text":"-   тяжелая артериальная гипертензия;"}},{"type":"paragraph","data":{"text":"-   гиперкалиемия;"}},{"type":"paragraph","data":{"text":"-   беременность и период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"-   детский и подростковый возраст до 18 лет."}}]},{"id":13,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью\nследует применять препарат у пациентов с цереброваскулярными заболеваниями,\nсахарным диабетом, заболеваниями периферических артерий, язвенными поражениями\nЖКТ в анамнезе, при почечной и печеночной недостаточности легкой или средней\nстепени тяжести, вирусном гепатите, алкогольном поражении печени,\nдоброкачественной гипербилирубинемии (синдромы Жильбера, Дубина-Джонсона и\nРотора), эпилепсии, при склонности к судорожным припадкам, дефиците\nглюкозо-6-фосфатдегидрогеназы, у пациентов пожилого возраста. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eПри\nналичии любого из перечисленных заболеваний/состояний пациент перед применением\nпрепарата должен обраться за консультацией к врачу.\u003c/i\u003e"}}]},{"id":4,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Противопоказано применение препарата при\nбеременности и в период грудного вскармливания."}}]},{"id":14,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Препарат принимают \u003ci\u003eвнутрь\u003c/i\u003e по 1 таблетке 1-3 раза в\nдень. Максимальная суточная доза - "}},{"type":"paragraph","data":{"text":"\n4 таблетки."}},{"type":"paragraph","data":{"text":"Длительность лечения составляет не более 3\nдней в качестве жаропонижающего средства и не более 5 дней - в качестве\nобезболивающего. Продолжение лечения препаратом возможно только после\nконсультации с врачом."}},{"type":"paragraph","data":{"text":"\u003cb\u003eНе\nследует превышать указанные дозы препарата!\u003c/b\u003e"}}]},{"id":5,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003ca\u003e\u003ci\u003eАллергические реакции:\u003c/i\u003e\u003c/a\u003e кожная сыпь, зуд, крапивница, ангионевротический отек."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо\nстороны органов кроветворения:\u003c/i\u003e тромбоцитопения,\nлейкопения, агранулоцитоз, анемия, метгемоглобинемия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо\nстороны ЦНС:\u003c/i\u003e возбуждение,\nтревожность, усиление рефлексов, тремор, головная боль, нарушения сна,\nголовокружение, снижение концентрации внимания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо\nстороны сердечно-сосудистой системы:\u003c/i\u003e ощущение\nсердцебиения, аритмии, повышение артериального давления (АД)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо\nстороны пищеварительной системы:\u003c/i\u003e\nэрозивно-язвенные поражения ЖКТ, тошнота, рвота, дискомфорт в эпигастрии, боли\nв животе, запор, нарушение функции печени."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо\nстороны мочевыделительной системы:\u003c/i\u003e\nнарушение функции почек."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо\nстороны органов чувств:\u003c/i\u003e снижение слуха, шум в\nушах, повышение внутриглазного давления у пациентов с закрытоугольной\nглаукомой."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПрочие:\u003c/i\u003e дерматит, тахипноэ (учащение дыхания). "}},{"type":"paragraph","data":{"text":"\u003ci\u003eЕсли любые указанные побочные эффекты усугубляются, или пациент\nотмечает какие-либо другие побочные эффекты, не указанные в инструкции, он\nдолжен сообщить об этом врачу.\u003c/i\u003e"}}]},{"id":6,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e бледность кожных\nпокровов, анорексия (отсутствие аппетита), боль в животе, тошнота, рвота,\nжелудочно-кишечное кровотечение, возбуждение, двигательное беспокойство,\nспутанность сознания, тахикардия, аритмия, гипертермия (повышение температуры\nтела), учащенное мочеиспускание, головная боль, тремор или мышечные\nподергивания; эпилептические припадки, повышение активности «печеночных»\nтрансаминаз, гепатонекроз, увеличение протромбинового времени. "}},{"type":"paragraph","data":{"text":"Симптомы нарушения функции печени могут\nпоявиться через 12-48 ч после передозировки. При тяжелой передозировке\nразвивается печеночная недостаточность с прогрессирующей энцефалопатией, кома, смерть;\nострая почечная недостаточность с тубулярным некрозом; аритмия, панкреатит. При\nподозрении на передозировку необходимо немедленно обратиться за медицинской\nпомощью к врачу."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e промывание желудка с\nпоследующим приемом активированного угля. Специфическим антидотом при\nотравлении парацетамолом является ацетилцистеин. Введение ацетилцистеина\nактуально в течение 8 ч после приема парацетамола. При желудочно-кишечном\nкровотечении необходимо введение антацидных средств и промывание желудка\nледяным 0,9% раствором хлорида натрия; поддержание вентиляции легких и\nоксигенации; при эпилептических припадках - внутривенное введение диазепама;\nподдержание баланса жидкости и солей в организме."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\u003ca\u003eПри одновременном приеме\nпрепарата \u003c/a\u003eСПАЗМАЛГОН\u003csup\u003e®\u003c/sup\u003e\u003csup\u003e \u003c/sup\u003eЭффект с \u003ci\u003eбарбитуратами,\nтрициклическими антидепрессантами, рифампицином, алкогольсодержащими напитками\u003c/i\u003e\nувеличивается риск гепатотоксического действия (данных комбинаций следует\nизбегать)."}},{"type":"paragraph","data":{"text":"Парацетамол\nусиливает действие \u003ci\u003eантикоагулянтов\nнепрямого действия\u003c/i\u003e и снижает эффективность \u003ci\u003eурикозурических препаратов\u003c/i\u003e."}},{"type":"paragraph","data":{"text":"Длительное\nприменение \u003ci\u003eбарбитуратов\u003c/i\u003e снижает\nэффективность парацетамола."}},{"type":"paragraph","data":{"text":"При\nодновременном применении парацетамола с \u003ci\u003eэтанолом\u003c/i\u003e\n(напитки и лекарственные препараты, содержащие алкоголь) повышается риск\nвозникновения острого панкреатита. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eИнгибиторы микросомального окисления\u003c/i\u003e (в том числе циметидин) снижают риск гепатотоксического действия\nпарацетамола. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eДифлунисал\u003c/i\u003e повышает плазменную\nконцентрацию парацетамола на 50%, что повышает риск развития гепатотоксичности.\n"}},{"type":"paragraph","data":{"text":"Напроксен\nспособен вызывать уменьшение диуретического эффекта \u003ci\u003eфуросемида\u003c/i\u003e, усиление эффекта \u003ci\u003eнепрямых\nантикоагулянтов\u003c/i\u003e, повышает токсичность \u003ci\u003eсульфаниламидов\n\u003c/i\u003eи \u003ci\u003eметотрексата\u003c/i\u003e, снижает выведение\n\u003ci\u003eлития\u003c/i\u003e и повышает его концентрацию в\nплазме крови. "}},{"type":"paragraph","data":{"text":"При\nсовместном применении кофеина и \u003ci\u003eбарбитуратов,\nпримидона, противосудорожных средств (производные гидантоина, особенно\nфенитоин)\u003c/i\u003e возможно усиление метаболизма и увеличение клиренса кофеина; при\nодновременном приеме кофеина и \u003ci\u003eциметидина,\nпероральных контрацептивных средств, дисульфирама, ципрофлоксацина,\nнорфлоксацина \u003c/i\u003e- снижение метаболизма кофеина в печени (замедление его\nвыведения и увеличение концентрации в крови)."}},{"type":"paragraph","data":{"text":"Одновременное\nупотребление \u003ci\u003eкофеинсодержащих напитков и\nдругих средств, стимулирующих ЦНС,\u003c/i\u003e может приводить к чрезмерной стимуляции\nЦНС."}},{"type":"paragraph","data":{"text":"При\nодновременном применении дротаверин может ослабить противопаркинсонический\nэффект \u003ci\u003eлеводопы\u003c/i\u003e."}},{"type":"paragraph","data":{"text":"При\nодновременном применении фенирамина с \u003ci\u003eтранквилизаторами,\nснотворными средствами, ингибиторами моноаминоксидазы, алкоголем\u003c/i\u003e возможно\nусиление угнетающего влияния на ЦНС."}}]},{"id":7,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Следует избегать одновременного применения\nпрепарата СПАЗМАЛГОН\u003csup\u003e®\u003c/sup\u003e\u003csup\u003e \u003c/sup\u003eЭффект с другими средствами, содержащими парацетамол и/или другие НПВП, в\nтом числе со средствами для облегчения симптомов «простуды», гриппа и\nзаложенности носа. "}},{"type":"paragraph","data":{"text":"При применении препарата СПАЗМАЛГОН\u003csup\u003e®\u003c/sup\u003e\u003csup\u003e \u003c/sup\u003eЭффект более 5-7 дней следует\nконтролировать показатели периферической крови и функциональное состояние\nпечени."}},{"type":"paragraph","data":{"text":"Парацетамол искажает результаты\nлабораторных исследований содержания глюкозы и мочевой кислоты в плазме крови."}},{"type":"paragraph","data":{"text":"При необходимости определения\n17-кетостероидов СПАЗМАЛГОН\u003csup\u003e®\u003c/sup\u003e\u003csup\u003e \u003c/sup\u003eЭффект следует отменить за 48 ч до исследования. Следует учитывать, что\nнапроксен увеличивает время кровотечения."}},{"type":"paragraph","data":{"text":"Влияние кофеина на ЦНС зависит от типа\nнервной системы и может проявляться как возбуждением, так и торможением высшей\nнервной деятельности."}},{"type":"paragraph","data":{"text":"В период лечения пациент должен избегать\nупотребления алкоголя."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В отдельных случаях возможно снижение\nконцентрации внимания и скорости психомоторных реакций, поэтому в период\nлечения пациент должен соблюдать осторожность при вождении автотранспорта и\nзанятии другими потенциально опасными видами деятельности, требующими\nповышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой. По 10 таблеток\nв блистер из трехслойной\nПВХ/ПВДХ/ПВХ пленки или двухслойной ПВХ/ПВДХ пленки и алюминиевой фольги. По 1, 2 или 3\nблистера вместе с инструкцией по применению в картонной пачке с контролем\nпервого вскрытия."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 25\u003csup\u003e \u003c/sup\u003e°С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для\nдетей месте."}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года. Не применять по\nистечении срока годности."}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Балканфарма-Дупница АД, ул. Самоковское\nшоссе, 3, Дупница 2600, Болгария"}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «Тева», 115054, Москва, ул. Валовая, 35,"}},{"type":"paragraph","data":{"text":"тел.: +7 (495) 644 22 34,\nфакс: +7 (495) 644 22 35"}},{"type":"paragraph","data":{"text":"Адрес в интернете: www.teva.ru\u003cb\u003e\u003c/b\u003e"}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаКомбинированный препарат, оказывает анальгезирующее, противовоспалительное, спазмолитическое, жаропонижающее действие.Парацетамол– ненаркотический анальгетик, оказывает жаропонижающее и обезболивающее действие, обусловленное блокадой циклооксигеназы (ЦОГ) в центральной нервной системе (ЦНС) и воздействием на центры боли и терморегуляции.Напроксен– нестероидный противовоспалительный препарат (НПВП), оказывает противовоспалительное, анальгезирующее и жаропонижающее действие, связанное с неселективным подавлением активности ЦОГ, регулирующей синтез простагландинов.Кофеин– вызывает расширение кровеносных сосудов скелетных мышц, сердца, почек; повышает умственную и физическую работоспособность, способствует устранению утомления и сонливости; увеличивает проницаемость гистогематических барьеров и повышает биодоступность ненаркотических анальгетиков, способствуя тем самым усилению терапевтического эффекта. Оказывает тонизирующее действие на сосуды головного мозга.Дротаверин– оказывает миотропное спазмолитическое действие, обусловленное ингибированием фосфодиэстеразы IV, действует на гладкие мышцы желудочно-кишечного тракта (ЖКТ), желчевыводящих путей, мочеполовой системы, сосудов.Фенирамин– H1-гистаминовых рецепторов блокатор. Оказывает спазмолитическое и легкое седативное действие, уменьшает явления экссудации, а также усиливает анальгезирующее действие парацетамола и напроксена.ФармакокинетикаПарацетамолХарактеризуется высокой и быстрой абсорбцией из ЖКТ, преимущественно в тонком кишечнике. Время достижения максимальной концентрации в плазме крови (ТCmax) - 0,5-1,5 часа после приема внутрь. Максимальная концентрация в плазме крови (Сmax) - 5-20 мкг/мл. Связь с белками плазмы незначительная - 15%. Парацетамол равномерно распределяется и проникает через гематоэнцефалический барьер, а также в большинство тканей организма. Предполагаемый объем распределения составляет 0,95 л/кг. Метаболизируется в печени (90-95%): 80% вступает в реакции конъюгации с глюкуроновой кислотой и сульфатами с образованием неактивных метаболитов; 17% подвергается гидроксилированию с образованием 8 активных метаболитов, которые конъюгируют с глутатионом с образованием уже неактивных метаболитов. При недостатке глутатиона эти метаболиты могут блокировать ферментные системы гепатоцитов и вызывать их некроз. В метаболизме препарата также участвует изофермент CYP2E1. Период полувыведения (Т1/2) - 1,5-2,5 часа. Выводится почками в виде метаболитов, преимущественно конъюгатов, только 3% в неизмененном виде. У пожилых пациентов снижается клиренс препарата и увеличивается Т1/2.НапроксенАбсорбция из ЖКТ напроксена быстрая и полная. Биодоступность - 95%. Прием пищи практически не влияет ни на полноту, ни на скорость всасывания. ТCmax- 1-2 часа. Связывание с белками плазмы – более 99%. Равновесная концентрация достигается к приему 4-5 доз препарата (2-3 дня). Метаболизируется в печени до диметилнапроксена с участием изофермента CYP2C9. Т1/2- 12-15 часов. Клиренс – 0,13 мл/мин/кг. Выводится почками (98%), 10% из которых - в неизмененном виде; с желчью выводится 0,5-2,5% принятой дозы. При почечной недостаточности возможна кумуляция метаболитов.КофеинКофеин, входящий в состав препарата, почти полностью и быстро всасывается, максимальная концентрация в плазме крови достигается через 1 час. Быстро проходит через гематоэнцефалический и плацентарный барьеры, поступает в грудное молоко, выводится (в т.ч. в виде метаболитов) в основном почками около 65-80%. Основные метаболиты - 1-метилксантин, 1-метилмочевая кислота и ацетилированные производные урацила, небольшое количество кофеина превращается в теофиллин и теобромин. Т1/2– 3,5 часа.ДротаверинПри пероральном приеме абсорбция дротаверина высокая и быстрая. Биодоступность - 100%. После пресистемного метаболизма в системный кровоток поступает 65% принятой дозы дротаверина. 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