Звездочка бронхо Раствор, флакон, 120 мл, 30/5 мг/мл, для приема внутрь

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Это\nотхаркивающее и муколитическое\nсредство, которое стимулирует секрецию слизи в дыхательных путях. Влияние препарата состоит в\nдеполимеризации мукополисахаридов и мукопротеиновых волокон в слизи. Амброксол снижает вязкость\nслизи, благодаря чему\nповышается цилиарная моторика, что обеспечивает отхождение мокроты при кашле и облегчает непродуктивный\nкашель."}},{"type":"paragraph","data":{"text":"\u003cb\u003eФармакокинетика\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВсасывание\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Для амброксола характерна быстрая и почти\nполная абсорбция из желудочно-кишечного тракта с линейной зависимостью от дозы\nв терапевтическом диапазоне концентраций"}},{"type":"paragraph","data":{"text":"Биодоступность составляет 70–80 %. Примерно\n30 % принятой дозы подвергается эффекту \"первого прохождения\" через\nпечень. Из-за пресистемного метаболизма абсолютная биодоступность амброксола\nпосле приема внутрь снижается приблизительно на 1/3. Образующиеся в связи с\nэтим метаболиты (такие как дибромоантраниловая кислота, глюкурониды) выводятся\nпочками."}},{"type":"paragraph","data":{"text":"Максимальная концентрация в плазме крови (C\u003csub\u003emax\u003c/sub\u003e)\nпри пероральном приеме достигается через 1 – 2,5 часа. В терапевтическом\nдиапазоне концентраций связывание с белками плазмы составляет около 90 %."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРаспределение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Объем распределения (V\u003csub\u003ed\u003c/sub\u003e)\nсоставляет 552 л. Переход амброксола из крови в ткани при пероральном\nприменении происходит быстро. Самые высокие концентрации активного компонента\nпрепарата наблюдаются в легких. Амброксол проникает в спинномозговую жидкость и\nчерез плацентарный барьер, а также выделяется с грудным молоком."}},{"type":"paragraph","data":{"text":"\u003ci\u003eМетаболизм\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Амброксол метаболизируется в печени. Исследования\nна микросомах печени человека показали, что CYP3A4 является преобладающей\nизоформой, ответственной за метаболизм амброксола до дибромантраниловой\nкислоты. Оставшаяся часть амброксола метаболизируется в печени, главным\nобразом, путем глюкуронизации и путем частичного расщепления до\nдибромантраниловой кислоты (приблизительно 10% от введенной дозы), а также\nнебольшого количества дополнительных метаболитов."}},{"type":"paragraph","data":{"text":"Общий клиренс находится в пределах 660\nмл/мин, на почечный клиренс (составляющий приблизительно 53 мл/мин) приходится около\n8 % от общего клиренса."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВыведение\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Амброксол выводится преимущественно\nпочками в виде метаболитов (90 %); приблизительно 5-6 % амброксола выводится\nпочками в неизменном виде. Терминальный\nпериод полувыведения (T1/2) составляет приблизительно 10 часов и состоит из\nдвух фаз (альфа-фаза - 1,3 часа, бета-фаза - 8,8 часов). Методом радиоактивной\nметки было подсчитано, что после приема единоразовой дозы препарата в течение\nпоследующих 5 дней с мочой выделяется около 83% принятой дозы."}},{"type":"paragraph","data":{"text":"Учитывая высокое связывание с белками\nплазмы, большой Vd и медленное перераспределение из тканей в кровь,\nсущественного выведения амброксола при диализе или форсированном диурезе не\nпроисходит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФармакокинетика\nв особых клинических случаях\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Не обнаружено клинически значимого влияния\nвозраста и пола на фармакокинетику амброксола, поэтому нет оснований для\nподбора дозы по этим признакам."}},{"type":"paragraph","data":{"text":"У пациентов с тяжелыми заболеваниями\nпечени клиренс амброксола уменьшается на 20-40%."}},{"type":"paragraph","data":{"text":"У пациентов с тяжелыми нарушениями функции\nпочек T\u003csub\u003e1/2\u003c/sub\u003e метаболитов амброксола увеличивается."}}]},{"id":3,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Острые и хронические заболевания\nдыхательных путей, сопровождающиеся выделением вязкой мокроты:"}},{"type":"paragraph","data":{"text":"– острый и хронический бронхит;"}},{"type":"paragraph","data":{"text":"– пневмония;"}},{"type":"paragraph","data":{"text":"– хроническая обструктивная болезнь легких;"}},{"type":"paragraph","data":{"text":"– бронхиальная астма с затрудненным\nотхождением мокроты;"}},{"type":"paragraph","data":{"text":"– бронхоэктатическая болезнь;"}}]},{"id":4,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"· повышенная чувствительность\nк амброксолу, бромгексину или другим компонентам препарата;"}},{"type":"paragraph","data":{"text":"· наследственная\nнепереносимость фруктозы (в связи с тем, что препарат содержит сорбитол);"}},{"type":"paragraph","data":{"text":"· Беременность (I триместр);"}},{"type":"paragraph","data":{"text":"· период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"· детский возраст до 6 лет (для дозы 30\nмг/5 мл);"}},{"type":"paragraph","data":{"text":"· у детей до 2-х лет препарат может\nприменяться только по назначению врача."}}]},{"id":14,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"· \nбеременность (II-III триместр);"}},{"type":"paragraph","data":{"text":"· \nпеченочная недостаточность;"}},{"type":"paragraph","data":{"text":"· \nпочечная недостаточность;"}},{"type":"paragraph","data":{"text":"· язвенная болезнь желудка\nи 12-перстной кишки в стадии обострения;"}},{"type":"paragraph","data":{"text":"· нарушение моторной функции бронхов и\nповышенное образование мокроты (при синдроме неподвижных ресничек)."}}]},{"id":5,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Амброксол проникает через плацентарный\nбарьер. Данные клинических исследований применении амброксола у беременных\n(особенно в течение первых 28 недель беременности) отсутствуют. Доклинические\nисследования не выявили прямого или косвенного неблагоприятного влияния на\nбеременность, эмбриональное/фетальное, постнатальное развитие и на родовую\nдеятельность. Имеющийся ограниченный клинический опыт применения препаратов амброксола\nпосле 28 недели беременности не выявил отрицательного влияния на плод."}},{"type":"paragraph","data":{"text":"Применение амброксола в I триместре\nбеременности противопоказано. Во II и III триместрах беременности применение\nпрепарата возможно только в том случае, когда предполагаемая польза для матери\nпревосходит потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"В доклинических исследованиях было\nустановлено, что амброксол экскретируется в грудное молоко. Данные в отношении\nэкскреции амброксола в грудное молоко у человека отсутствуют. Несмотря на то, что нежелательные эффекты у\nдетей, находящихся на грудном вскармливании, не наблюдались, применение\nамброксола в период грудного вскармливания противопоказано."}},{"type":"paragraph","data":{"text":"Доклинические исследования амброксола не\nвыявили отрицательного воздействия на фертильность животных."}}]},{"id":6,"name":"Способ применения и дозы","slug":"dosage","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Внутрь, после еды."}},{"type":"paragraph","data":{"text":"Муколитический эффект препарата проявляется\nпри приеме большого количества жидкости. Поэтому во время лечения рекомендуется\nобильное питье. Препарат не следует принимать непосредственно перед сном."}},{"type":"paragraph","data":{"text":"Для дозирования используют чайную ложку."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eРаствор для\nприема внутрь 15\u003c/i\u003e\u003c/b\u003e\u003ci\u003e \u003cb\u003eмг/5\u003c/b\u003e \u003cb\u003eмл\u003c/b\u003e\u003c/i\u003e\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослые\u003c/i\u003e \u003ci\u003eи\u003c/i\u003e \u003ci\u003eдети\u003c/i\u003e \u003ci\u003eстарше 12\u003c/i\u003e \u003ci\u003eлет\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В течение первых 2-3 дней принимают по 10\nмл (30 мг) раствора\nдля приема внутрь 3 раза в день, затем дозу следует\nуменьшить до 10 мл (30 мг) раствора для приема внутрь 2 раза в день."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети\u003c/i\u003e \u003ci\u003eот 6\u003c/i\u003e \u003ci\u003eдо 12\u003c/i\u003e \u003ci\u003eлет\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По 5 мл (15 мг) раствора для приема внутрь\n2-3 раза в день."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети\u003c/i\u003e \u003ci\u003eот 2\u003c/i\u003e \u003ci\u003eдо 6\u003c/i\u003e \u003ci\u003eлет\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По 2,5 мл (7,5 мг) раствора для приема\nвнутрь 3 раза в день."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети\u003c/i\u003e \u003ci\u003eв\u003c/i\u003e \u003ci\u003eвозрасте\u003c/i\u003e \u003ci\u003eдо 2\u003c/i\u003e \u003ci\u003eлет\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По 2,5 мл (7,5 мг) раствора для приема внутрь 2 раза в\nдень."}},{"type":"paragraph","data":{"text":"\u003cb\u003e\u003ci\u003eРаствор для\nприема внутрь 30\u003c/i\u003e\u003c/b\u003e\u003ci\u003e \u003cb\u003eмг/5\u003c/b\u003e \u003cb\u003eмл\u003c/b\u003e\u003c/i\u003e\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eВзрослые\u003c/i\u003e \u003ci\u003eи\u003c/i\u003e \u003ci\u003eдети\u003c/i\u003e \u003ci\u003eстарше 12\u003c/i\u003e \u003ci\u003eлет\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В течение первых 2-3 дней принимают по 5\nмл (30 мг) раствора\nдля приема внутрь 3 раза в день, затем дозу следует\nуменьшить до 5 мл (30 мг) раствора для приема внутрь 2 раза в день."}},{"type":"paragraph","data":{"text":"\u003ci\u003eДети\u003c/i\u003e \u003ci\u003eот 6\u003c/i\u003e \u003ci\u003eдо 12\u003c/i\u003e\n\u003ci\u003eлет\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"По 2,5 мл (15 мг) раствора для приема внутрь 2-3 раза в день."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза для взрослых –\n120 мг амброксола; максимальная суточная доза для детей от 6 до 12 лет – 45 мг\nамброксола; максимальная суточная доза для детей от 2 до 6 лет – 22,5 мг\nамброксола; максимальная суточная доза для детей до 2 лет – 15 мг амброксола."}},{"type":"paragraph","data":{"text":"Продолжительность лечения определяется\nиндивидуально в зависимости от течения заболевания. Не рекомендуется принимать\nамброксол более 4-5 дней без консультации с врачом."}}]},{"id":7,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Частота развития побочных реакций,\nразвивающихся при приеме амброксола, классифицирована согласно\nрекомендациям ВОЗ: очень часто - не менее 10 %; часто - не менее 1 % и менее 10%; нечасто - не\nменее 0,1 % и менее 1 %; редко – не менее 0,01 % и менее 0,1 %;\nочень редко - менее"}},{"type":"paragraph","data":{"text":"\n0,01 %, включая единичные случаи; частота неизвестна."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со\u003c/i\u003e \u003ci\u003eстороны иммунной\nсистемы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Редко: реакции гиперчувствительности, кожная\nсыпь, крапивница."}},{"type":"paragraph","data":{"text":"Частота неизвестна: анафилактические\nреакции (включая анафилактический шок), ангионевротический отек, кожный зуд."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со\u003c/i\u003e \u003ci\u003eстороны нервной\nсистемы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: дисгевзия (нарушение вкусовых\nощущений)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со\u003c/i\u003e \u003ci\u003eстороны\u003c/i\u003e \u003ci\u003eдыхательной\u003c/i\u003e\n\u003ci\u003eсистемы\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: одышка (как признак реакции\nгиперчувствительности)."}},{"type":"paragraph","data":{"text":"Частота неизвестна: снижение\nчувствительности в горле (онемение)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со\u003c/i\u003e \u003ci\u003eстороны\u003c/i\u003e \u003ci\u003eжелудочно-кишечного\nтракта\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Часто: тошнота, снижение чувствительности\nв полости рта (онемение)."}},{"type":"paragraph","data":{"text":"Нечасто: диспепсия, рвота, диарея, боль в\nживоте, сухость слизистой оболочки полости рта и глотки."}},{"type":"paragraph","data":{"text":"Очень редко: гиперсаливация (обильное\nслюноотделение)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со\u003c/i\u003e \u003ci\u003eстороны кожи и\nподкожных тканей\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Частота неизвестна: многоформная\nэкссудативная эритема, синдром Стивенса-Джонсона, токсический эпидермальный\nнекролиз (синдром Лайелла), острый генерализованный экзантематозный пустулез.\u003ci\u003e\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003eОбщие расстройства и нарушения\nв месте введения\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Нечасто: лихорадка."}}]},{"id":8,"name":"Передозировка","slug":"overdose","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Специфических\nсимптомов передозировки у человека не описано. Имеются сообщения о случайной\nпередозировке, в результате которых наблюдались симптомы известных побочных\nэффектов амброксола: тошнота, диспепсия, диарея, рвота, боль в животе."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e: искусственная рвота,\nпромывание желудка в первые 1-2 часа после приема препарата, симптоматическая\nтерапия. Вследствие высокой степени связывания амброксола с белками плазмы\nкрови и большого объема распределения, проведение гемодиализа или\nфорсированного диуреза нецелесообразно."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Амброксол не следует принимать\nодновременно с противокашлевыми средствами, из-за возможного подавления кашлевого\nрефлекса и задержки секрета в дыхательных путях."}},{"type":"paragraph","data":{"text":"Амброксол не следует одновременно принимать со средствами,\nподавляющими бронхиальную секрецию."}},{"type":"paragraph","data":{"text":"Амброксол увеличивает проникновение\nнекоторых антибиотиков (например, амоксициллин, цефуроксим,\nэритромицин, доксициклин) в легочную ткань и, следовательно,\nувеличивает их концентрацию в легочной паренхиме."}}]},{"id":9,"name":"Особые указания","slug":"cautions","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"У детей и пациентов с пониженным кашлевым\nрефлексом (пожилые пациенты, пациенты в бессознательном состоянии, или в\nсостоянии иммобилизации) следует обеспечить эвакуацию\nбронхиального секрета. Снижение вязкости большого количества секрета должно\nсочетаться с его аспирацией."}},{"type":"paragraph","data":{"text":"В начале терапии амброксолом возможно\nусиление кашля у больных с бронхиальной астмой."}},{"type":"paragraph","data":{"text":"Детям младше 2-х лет амброксол следует\nприменять только по назначению врача."}},{"type":"paragraph","data":{"text":"Пациентам, принимающим амброксол, не\nрекомендуется выполнение дыхательной гимнастики вследствие затруднения\nотхождения мокроты."}},{"type":"paragraph","data":{"text":"При тяжелых заболеваниях печени и почек\nпрепарат Звездочка Бронхо следует применять с осторожностью, уменьшая дозу и\nувеличивая интервалы между приемами препарата. В таких случаях рекомендуется\nпроводить лечение под наблюдением врача."}},{"type":"paragraph","data":{"text":"При применении препаратов амброксола\nкрайне редко наблюдались тяжелые кожные реакции, такие как синдром\nСтивенса-Джонсона и синдром Лайелла (токсический эпидермальный некролиз). Поэтому\nпри появлении любых изменений кожи и слизистых оболочек необходимо срочно\nобратиться к врачу и прекратить прием препарата."}},{"type":"paragraph","data":{"text":"При применении препаратов амброксола в форме раствора\nдля приема внутрь следует учитывать, что калорийность составляет 2.6 ккал/г\nсорбитола."}},{"type":"paragraph","data":{"text":"Препарат Звездочка Бронхо можно\nназначать пациентам с сахарным диабетом. 5 мл раствора для приема внутрь содержат 2,1 мг сорбитола, что\nсоответствует 0.18 ХЕ."}},{"type":"paragraph","data":{"text":"Препарат Звездочка Бронхо может вызывать аллергические реакции\n(возможно, замедленного типа) и бронхоспазм, в связи с наличием в составе метилпарагидроксибензоата и\nпропилпарагидроксибензоата."}},{"type":"paragraph","data":{"text":"Прием препарата Звездочка Бронхо может\nсопровождаться незначительным слабительным эффектом в связи с наличием в\nсоставе сорбитола."}},{"type":"paragraph","data":{"text":"Муколитические средства могут оказывать\nраздражающее действие на слизистую оболочку желудочно-кишечного тракта, поэтому\nамброксол следует применять с осторожностью у пациентов с язвенной болезнью\nжелудка и двенадцатиперстной кишки."}}]},{"id":16,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Исследования о влиянии препарата на\nспособность к вождению транспорта и управлению другими\nмеханизмами не проводились."}},{"type":"paragraph","data":{"text":"Не было выявлено случаев влияния\nпрепарата на способность управлять транспортными средствами и механизмами.\nИсследования по влиянию препарата на способность управлять автотранспортом и\nзаниматься другими потенциально опасными видами деятельности, требующими\nповышенной концентрации внимания и быстроты психомоторных реакций не\nпроводились."}}]},{"id":17,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для приема внутрь 15 мг/5 мл и 30 мг/5 мл."}},{"type":"paragraph","data":{"text":"По 120 мл во\nфлаконы из полиэтилентерефталата."}},{"type":"paragraph","data":{"text":"По 1 флакону с инструкцией по применению в\nкартонной пачке."}}]},{"id":18,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 25 ºС."}},{"type":"paragraph","data":{"text":"Хранить в\nнедоступном для детей месте!"}}]},{"id":19,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Открытый флакон – 28\nдней."}},{"type":"paragraph","data":{"text":"Не применять по истечении\nсрока годности!"}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Ветпром АД, Болгария,"}},{"type":"paragraph","data":{"text":"ул. “Отец Паисий” № 26, г. Радомир 2400."}},{"type":"paragraph","data":{"text":"Тел.: + 359/777/82493, факс: + 359/777/82391, е-mail: office@vetprom.bg."}}]},{"id":22,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ООО «ДАНСОН-РУ»"}},{"type":"paragraph","data":{"text":"142100, Московская область, г.\nПодольск, ул. Комсомольская, д. 1, литера Щ, офис 220."}}]}],"source":{"title":"36.6","url":"https://366.ru"}},"description_toggle":false,"short_description":"ФармакодинамикаАмброксол является метаболитом бромгексина. Это отхаркивающее и муколитическое средство, которое стимулирует секрецию слизи в дыхательных путях. Влияние препарата состоит в деполимеризации мукополисахаридов и мукопротеиновых волокон в слизи. Амброксол снижает вязкость слизи, благодаря чему повышается цилиарная моторика, что обеспечивает отхождение мокроты при кашле и облегчает непродуктивный кашель.ФармакокинетикаВсасываниеДля амброксола характерна быстрая и почти полная абсорбция из желудочно-кишечного тракта с линейной зависимостью от дозы в терапевтическом диапазоне концентраций Биодоступность составляет 70–80 %. Примерно 30 % принятой дозы подвергается эффекту \"первого прохождения\" через печень. Из-за пресистемного метаболизма абсолютная биодоступность амброксола после приема внутрь снижается приблизительно на 1/3. Образующиеся в связи с этим метаболиты (такие как дибромоантраниловая кислота, глюкурониды) выводятся почками. Максимальная концентрация в плазме крови (Cmax) при пероральном приеме достигается через 1 – 2,5 часа. В терапевтическом диапазоне концентраций связывание с белками плазмы составляет около 90 %.РаспределениеОбъем распределения (Vd) составляет 552 л. Переход амброксола из крови в ткани при пероральном применении происходит быстро. Самые высокие концентрации активного компонента препарата наблюдаются в легких. Амброксол проникает в спинномозговую жидкость и через плацентарный барьер, а также выделяется с грудным молоком.МетаболизмАмброксол метаболизируется в печени. Исследования на микросомах печени человека показали, что CYP3A4 является преобладающей изоформой, ответственной за метаболизм амброксола до дибромантраниловой кислоты. Оставшаяся часть амброксола метаболизируется в печени, главным образом, путем глюкуронизации и путем частичного расщепления до дибромантраниловой кислоты (приблизительно 10% от введенной дозы), а также небольшого количества дополнительных метаболитов. Общий клиренс находится в пределах 660 мл/мин, на почечный клиренс (составляющий приблизительно 53 мл/мин) приходится около 8 % от общего клиренса.ВыведениеАмброксол выводится преимущественно почками в виде метаболитов (90 %); приблизительно 5-6 % амброксола выводится почками в неизменном виде. Терминальный период полувыведения (T1/2) составляет приблизительно 10 часов и состоит из двух фаз (альфа-фаза - 1,3 часа, бета-фаза - 8,8 часов). Методом радиоактивной метки было подсчитано, что после приема единоразовой дозы препарата в течение последующих 5 дней с мочой выделяется около 83% принятой дозы. Учитывая высокое связывание с белками плазмы, большой Vd и медленное перераспределение из тканей в кровь, существенного выведения амброксола при диализе или форсированном диурезе не происходит.Фармакокинетика в особых клинических случаяхНе обнаружено клинически значимого влияния возраста и пола на фармакокинетику амброксола, поэтому нет оснований для подбора дозы по этим признакам. У пациентов с тяжелыми заболеваниями печени клиренс амброксола уменьшается на 20-40%. 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