Тералив 275 Таблетки, 12 шт, 275, в пленочной оболочке

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Механизм действия связан с неселективным ингибированием активности циклооксигеназы-1 и -2 (ЦОГ-1, ЦОГ-2)."}},{"type":"paragraph","data":{"text":"Препарат Тералив 275, таблетки, покрытые пленочной оболочкой, хорошо растворяется, быстро всасывается из желудочно-кишечного тракта и обеспечивает быстрое наступление обезболивающего эффекта."}},{"type":"paragraph","data":{"text":"Фармакокинетика"}},{"type":"paragraph","data":{"text":"Быстро и полностью всасывается из желудочно-кишечного тракта. Биодоступность – 95 % (прием пищи практически не влияет ни на полноту, ни на скорость всасывания). Время достижения максимальной концентрации – 1-2 часа. Связь с белками плазмы крови >99%. Период полувыведения – 12-15 часов. Метаболизм происходит в печени до диметилнапроксена с участием изофермента СУР2С9. Клиренс – 0,13 мл/мин/кг. Выводится на 98% почками, 10% выводится в неизмененном виде, с желчью – 0,5-2,5%. Равновесная концентрация в плазме крови определяется после приема 4-5 доз препарата (2-3 дня)."}},{"type":"paragraph","data":{"text":"При почечной недостаточности возможна кумуляция метаболитов.\n\n"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"\n\nЗаболевания опорно-двигательного аппарата (ревматическое поражение мягких тканей, остеоартроз периферических суставов и позвоночника, в том числе с радикулярным синдромом, тендовагинит, бурсит)."}},{"type":"paragraph","data":{"text":"Болевой синдром слабой или умеренной степени выраженности: невралгия, оссалгия, миалгия, люмбоишиалгия, посттравматический болевой синдром (растяжения и ушибы), сопровождающийся воспалением, головная боль, мигрень, альгодисменорея, зубная боль."}},{"type":"paragraph","data":{"text":"В составе комплексной терапии инфекционно-воспалительных заболеваний уха, горла, носа с выраженным болевым синдромом (фарингит, тонзиллит, отит)."}},{"type":"paragraph","data":{"text":"Лихорадочный синдром при «простудных» и инфекционных заболеваниях."}},{"type":"paragraph","data":{"text":"Препарат Тералив 275 применяется для симптоматической терапии (для уменьшения боли, воспаления и снижения повышенной температуры тела) и на прогрессирование основного заболевания не влияет.\n\n"}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"\n\nГиперчувствительность к напроксену или напроксену натрия."}},{"type":"paragraph","data":{"text":"Полное или неполное сочетание бронхиальной астмы, рецидивирующего полипоза носа или околоносовых пазух и непереносимости ацетилсалициловой кислоты и других нестероидных противовоспалительных препаратов (НПВП) (в том числе в анамнезе)."}},{"type":"paragraph","data":{"text":"Период после проведения аортокоронарного шунтирования."}},{"type":"paragraph","data":{"text":"Эрозивно-язвенные изменения слизистой желудка или 12-перстной кишки, активное желудочно-кишечное кровотечение."}},{"type":"paragraph","data":{"text":"Воспалительные заболевания кишечника (неспецифический язвенный колит, болезнь Крона) в фазе обострения."}},{"type":"paragraph","data":{"text":"Гемофилия и другие нарушения свертываемости крови и нарушения гемостаза."}},{"type":"paragraph","data":{"text":"Цереброваскулярное кровотечение или иные кровотечения."}},{"type":"paragraph","data":{"text":"Декомпенсированная сердечная недостаточность."}},{"type":"paragraph","data":{"text":"Выраженная печеночная недостаточность или активное заболевание печени."}},{"type":"paragraph","data":{"text":"Выраженная почечная недостаточность (клиренс креатинина (КК) менее 30 мл/мин), прогрессирующие заболевания почек, подтвержденная гиперкалиемия."}},{"type":"paragraph","data":{"text":"Беременность, период грудного вскармливания."}},{"type":"paragraph","data":{"text":"Детский возраст до 15 лет.\n\n"}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Ишемическая болезнь сердца, цереброваскулярные заболевания, застойная сердечная недостаточность, дислипидемия/гиперлипидемия, сахарный диабет, заболевания периферических артерий, курение, нарушение функции почек (КК 30-60 мл/мин), анамнестические данные о развитии язвенного поражения желудочно-кишечного тракта (ЖКТ), наличие инфекции Helicobacter pylori, применение у пациентов пожилого возраста, системная красная волчанка или смешанные заболевания соединительной ткани (синдром Шарпа), длительное применение НПВП, частое употребление алкоголя, тяжелые соматические заболевания, сопутствующая терапия следующими препаратами: антикоагулянты (например, варфарин), антиагреганты (например, ацетилсалициловая кислота, клопидогрел), пероральные глюкокортикоиды (например, преднизолон), селективные ингибиторы обратного захвата серотонина (например, циталопрам, флуоксетин, пароксетин, сертралин)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Препарат Тералив 275 не рекомендуется применять при беременности и в период грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\n\nВнутрь. Таблетки следует принимать с достаточным количеством воды."}},{"type":"paragraph","data":{"text":"Взрослые и дети от 15 лет и старше"}},{"type":"paragraph","data":{"text":"Обычно суточная доза, применяемая для облегчения боли, составляет 2-3 таблетки (550-825 мг). Максимальная суточная доза – 3 таблетки (825 мг). Длительность применения – не более 5 дней."}},{"type":"paragraph","data":{"text":"При применении препарата Тералив 275 в качестве жаропонижающего средства начальная доза составляет 2 таблетки, далее принимается по 1 таблетке (275 мг) каждые 8 часов."}},{"type":"paragraph","data":{"text":"Для предупреждения и лечения приступов мигрени начальная рекомендуемая доза составляет 2 таблетки (550 мг), при необходимости можно принимать по 1 таблетке (275 мг) каждые 8-12 часов. Максимальная суточная доза – 3 таблетки (825 мг)."}},{"type":"paragraph","data":{"text":"Для облегчения менструальных болей и спазмов, болей после введения внутриматочных спиралей и других гинекологических болей рекомендуется назначение препарата в начальной дозе, составляющей 2 таблетки (550 мг), далее по 1 таблетке (275 мг) каждые 8 часов."}},{"type":"paragraph","data":{"text":"Дети"}},{"type":"paragraph","data":{"text":"Препарат Тералив 275 противопоказан для применения у детей до 15 лет."}},{"type":"paragraph","data":{"text":"Пациенты пожилого возраста (≥65 лет)"}},{"type":"paragraph","data":{"text":"Пациентам старше 65 лет следует принимать препарат по мере необходимости каждые 12 часов."}},{"type":"paragraph","data":{"text":"Для снижения риска развития нежелательных явлений со стороны ЖКТ препарат следует принимать в минимальной эффективной дозе минимально возможным коротким курсом."}},{"type":"paragraph","data":{"text":"Если у Вас создается впечатление, что эффект препарата очень сильный или слабый, проинформируйте лечащего врача или фармацевта.\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nНежелательные эффекты, которые могут развиваться во время лечения напроксеном, классифицированы в соответствии со следующей частотой встречаемости: очень часто (>1/10), часто (от ≥1/100 до <1/10), нечасто (от ≥1/1000 до <1/100), редко (от ≥1/10000 до <1/1000), очень редко (<1/10000), частота неизвестна (не может быть определена на основании имеющихся данных)."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта: наиболее часто наблюдались нежелательные явления со стороны ЖКТ. Возможно развитие пептической язвы, перфорации или желудочно-кишечного кровотечения, иногда со смертельным исходом, особенно у пациентов пожилого возраста (см. раздел «Особые указания»)."}},{"type":"paragraph","data":{"text":"В каждой группе нежелательные явления перечислены в порядке убывания серьезности."}},{"type":"paragraph","data":{"text":"Нарушения со стороны крови и лимфатической системы"}},{"type":"paragraph","data":{"text":"Нечасто: эозинофилия, гранулоцитопения, лейкопения, громбоцитопения."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы"}},{"type":"paragraph","data":{"text":"Часто: головная боль, вертиго, головокружение, сонливость."}},{"type":"paragraph","data":{"text":"Нечасто: депрессия, нарушения сна, невозможность концентрироваться, бессонница, недомогание."}},{"type":"paragraph","data":{"text":"Нарушения со стороны органа зрения"}},{"type":"paragraph","data":{"text":"Часто: нарушение зрения."}},{"type":"paragraph","data":{"text":"Нарушения со стороны органа слуха и лабиринтные нарушения"}},{"type":"paragraph","data":{"text":"Часто: шум в ушах, нарушение слуха."}},{"type":"paragraph","data":{"text":"Нечасто: снижение слуха."}},{"type":"paragraph","data":{"text":"Нарушения со стороны сердца"}},{"type":"paragraph","data":{"text":"Часто: отечность, ощущение сердцебиения."}},{"type":"paragraph","data":{"text":"Нечасто: застойная сердечная недостаточность."}},{"type":"paragraph","data":{"text":"Нарушения со стороны дыхательной системы, органов грудной клетки и средостения"}},{"type":"paragraph","data":{"text":"Часто: одышка."}},{"type":"paragraph","data":{"text":"Нечасто: эозинофильные пневмонии."}},{"type":"paragraph","data":{"text":"Нарушения со стороны желудочно-кишечного тракта"}},{"type":"paragraph","data":{"text":"Часто: запор, боль в животе, диспепсия, тошнота, диарея, стоматит, метеоризм."}},{"type":"paragraph","data":{"text":"Нечасто: желудочно-кишечное кровотечение и/или перфорация желудка, кровавая рвота, мелена, рвота."}},{"type":"paragraph","data":{"text":"Очень редко: рецидив или обострение язвенного колита или болезни Крона."}},{"type":"paragraph","data":{"text":"Частота неизвестна: гастрит."}},{"type":"paragraph","data":{"text":"Нарушения со стороны печени и желчевыводящих путей"}},{"type":"paragraph","data":{"text":"Нечасто: повышение активности «печеночных» ферментов, желтуха."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей"}},{"type":"paragraph","data":{"text":"Часто: кожный зуд, кожная сыпь, экхимозы, пурпура."}},{"type":"paragraph","data":{"text":"Нечасто: алопеция, фотодерматозы."}},{"type":"paragraph","data":{"text":"Очень редко: буллезные реакции, включая синдром Стивенса-Джонсона и токсический эпидермальный некролиз."}},{"type":"paragraph","data":{"text":"Нарушения со стороны скелетно-мышечной и соединительной ткани"}},{"type":"paragraph","data":{"text":"Нечасто: миалгия и мышечная слабость."}},{"type":"paragraph","data":{"text":"Нарушения со стороны почек и мочевыводящих путей"}},{"type":"paragraph","data":{"text":"Нечасто: гломерулонефрит, гематурия, интерстициальный нефрит, нефротический синдром, почечная недостаточность, почечный папиллярный некроз."}},{"type":"paragraph","data":{"text":"Общие расстройства и нарушения в месте введения"}},{"type":"paragraph","data":{"text":"Часто: жажда, повышенное потоотделение."}},{"type":"paragraph","data":{"text":"Нечасто: реакции повышенной чувствительности, нарушения менструального цикла, гипертермия (озноб и лихорадка)."}},{"type":"paragraph","data":{"text":"При терапии НПВП сообщалось о появлении отеков и симптомов сердечной недостаточности, повышении артериального давления."}},{"type":"paragraph","data":{"text":"Клинические исследования и эпидемиологические данные свидетельствуют о том, что применение некоторых НПВП (особенно высоких доз и при длительной терапии) может быть связано с небольшим увеличением риска возникновения артериальных тромбозов (например, инфаркт миокарда или инсульт)."}},{"type":"paragraph","data":{"text":"Нежелательные эффекты, причинно-следственная связь которых с применением напроксена не установлена"}},{"type":"paragraph","data":{"text":"Нарушения со стороны крови и лимфатической системы: апластическая анемия, гемолитическая анемия."}},{"type":"paragraph","data":{"text":"Нарушения со стороны нервной системы: асептический менингит, когнитивная дисфункция."}},{"type":"paragraph","data":{"text":"Нарушения со стороны кожи и подкожных тканей: мультиформная эритема, реакции фоточувствительности, подобные поздней кожной порфирии и буллезному эпидермолизу, крапивница."}},{"type":"paragraph","data":{"text":"Нарушения со стороны сосудов: васкулит."}},{"type":"paragraph","data":{"text":"Общие расстройства и нарушения в месте введения: ангионевротический отек, гипергликемия, гипогликемия."}},{"type":"paragraph","data":{"text":"Если Вы заметили подобные явления, прекратите прием препарата и, по возможности, обратитесь к врачу.\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы"}},{"type":"paragraph","data":{"text":"Значительная передозировка напроксена может характеризоваться сонливостью, диспептическими расстройствами (изжогой, тошнотой, рвотой, болью в животе), слабостью, шумом в ушах, раздражительностью, в тяжелых случаях – кровавая рвота, мелена, нарушение сознания, судороги и почечная недостаточность."}},{"type":"paragraph","data":{"text":"Лечение"}},{"type":"paragraph","data":{"text":"Пациенту, принявшему случайно или преднамеренно большое количество препарата Тералив 275, необходимо промыть желудок, принять активированный уголь и проводить симптоматическую терапию: антациды, блокаторы Н\u003csub\u003e2\u003c/sub\u003e-рецепторов, ингибиторы протонной помпы. Гемодиализ неэффективен.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nПри лечении антикоагулянтами следует иметь в виду, что напроксен может увеличивать время кровотечения. Не следует применять препарат Тералив 275 одновременно с ацетилсалициловой кислотой, другими НПВП, включая селективные ингибиторы циклооксигеназы-2 (возрастание риска развития побочных эффектов)."}},{"type":"paragraph","data":{"text":"Пациенты, одновременно получающие гидантоины, антикоагулянты или другие лекарственные препараты, связывающиеся в значительной степени с белками плазмы крови, должны следить за признаками потенцирования действия или передозировкой этих препаратов."}},{"type":"paragraph","data":{"text":"Препарат Тералив 275 может снижать антигипертензивное действие пропранолола и других бета-адреноблокаторов, а также может увеличивать риск почечной недостаточности, связанной с применением ингибиторов ангиотензинпревращающего фермента (АПФ)."}},{"type":"paragraph","data":{"text":"НПВП могут уменьшать мочегонное действие диуретиков. Под действием напроксена ингибируется натрийуретическое действие фуросемида. Диуретики могут повышать риск нефротоксичности НПВП."}},{"type":"paragraph","data":{"text":"Ингибирование почечного клиренса лития приводит к увеличению концентрации лития в плазме крови. Прием пробенецида увеличивает концентрацию напроксена в плазме крови. Циклоспорин увеличивает риск развития почечной недостаточности."}},{"type":"paragraph","data":{"text":"Напроксен замедляет экскрецию метотрексата, фенитоина, сульфаниламидов, увеличивая риск развития их токсического действия."}},{"type":"paragraph","data":{"text":"Антацидные препараты, содержащие магний и алюминий, уменьшают абсорбцию напроксена."}},{"type":"paragraph","data":{"text":"Миелотоксические лекарственные средства усиливают проявления гематоксичности препарата."}},{"type":"paragraph","data":{"text":"По данным исследований in vitro одновременное применение напроксена и зидовудина увеличивает концентрацию зидовудина в плазме крови."}},{"type":"paragraph","data":{"text":"Одновременное применение кортикостероидов может увеличивать риск образования язвы или кровотечения ЖКТ."}},{"type":"paragraph","data":{"text":"НПВП могут усиливать действие антикоагулянтов, таких как варфарин."}},{"type":"paragraph","data":{"text":"Одновременное применение напроксена и антитромбоцитарных препаратов, селективных ингибиторов обратного захвата серотонина повышает риск развития желудочно-кишечного кровотечения."}},{"type":"paragraph","data":{"text":"Не рекомендуется одновременный прием НПВП в течение 8-12 дней после применения мифепристона."}},{"type":"paragraph","data":{"text":"Одновременное применение НПВП и такролимуса повышает риск нефротоксичности.\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nНе превышайте доз, указанных в инструкции. Для снижения риска развития нежелательных явлений со стороны ЖКТ следует использовать минимальную эффективную дозу минимально возможным коротким курсом."}},{"type":"paragraph","data":{"text":"Если боль и лихорадка сохраняются или становятся сильнее, следует обратиться к врачу. Пациентам с бронхиальной астмой, с нарушениями свертываемости крови, а также пациентам с повышенной чувствительностью к другим анальгетикам перед приемом препарата Тералив 275 следует проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"С осторожностью следует назначать пациентам с заболеваниями печени и почечной недостаточностью. У пациентов с почечной недостаточностью необходимо контролировать клиренс креатинина. При КК менее 30 мл/мин применять напроксен не рекомендуется. При хроническом алкогольном и других формах цирроза печени концентрация несвязанного напроксена повышается, поэтому таким пациентам рекомендуются более низкие дозы. После двух недель применения препарата необходим контроль показателей функции печени."}},{"type":"paragraph","data":{"text":"Препарат Тералив 275 не следует принимать вместе с другими противовоспалительными и болеутоляющими препаратами, за исключением назначений врача."}},{"type":"paragraph","data":{"text":"Пациентам пожилого возраста также рекомендуются более низкие дозы."}},{"type":"paragraph","data":{"text":"Следует избегать приема напроксена в течение 48 часов до хирургического вмешательства. При необходимости определения 17-кортикостероидов препарат следует отменить за 48 часов до исследования. Аналогично напроксен может оказывать влияние на определение 5-гидроксииндолуксусной кислоты в моче."}},{"type":"paragraph","data":{"text":"Применение напроксена, как и других препаратов, блокирующих синтез простагландинов, может влиять на фертильность, поэтому не рекомендуется женщинам, планирующим беременность."}},{"type":"paragraph","data":{"text":"Каждая таблетка препарата Тералив 275 содержит приблизительно 25 мг натрия. При ограничении потребления соли это необходимо учитывать.\n\n"}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Напроксен замедляет скорость реакции у пациентов. Это следует учитывать при управлении автомобилем и выполнении задач, требующих повышенного внимания."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nТаблетки, покрытые пленочной оболочкой, 275 мг."}},{"type":"paragraph","data":{"text":"По 12 таблеток в ПВХ/Ал блистер. По 1 или 2 блистера вместе с инструкцией по применению в пачку картонную.\n\n"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nПри температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n5 лет."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nВладелец регистрационного удостоверения: АО «БАЙЕР», Россия"}},{"type":"paragraph","data":{"text":"Произведено: Байер Биттерфельд ГмбХ, Ортштейл Греппин, Салегастер шоссе 1, 06803 Биттерфельд-Вольфен, Германия.\n\n"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"\n\nАО «БАЙЕР», Россия"}},{"type":"paragraph","data":{"text":"107113, г. Москва, ул. 3-я Рыбинская, д. 18, стр. 2.\n\n"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодииамика Препарат Тералив 275 представляет собой напроксен, обладает обезболивающим, жаропонижающим и противовоспалительным действием. Механизм действия связан с неселективным ингибированием активности циклооксигеназы-1 и -2 (ЦОГ-1, ЦОГ-2). Препарат Тералив 275, таблетки, покрытые пленочной оболочкой, хорошо растворяется, быстро всасывается из желудочно-кишечного тракта и обеспечивает быстрое наступление обезболивающего эффекта. Фармакокинетика Быстро и полностью всасывается из желудочно-кишечного тракта. Биодоступность – 95 % (прием пищи практически не влияет ни на полноту, ни на скорость всасывания). Время достижения максимальной концентрации – 1-2 часа. Связь с белками плазмы крови \u003e99%. Период полувыведения – 12-15 часов. Метаболизм происходит в печени до диметилнапроксена с участием изофермента СУР2С9. Клиренс – 0,13 мл/мин/кг. 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