Для таблеток 120 мг: каждая таблетка, покрытая оболочкой, содержит фексофенадина гидрохлорида 126,00 мг, что эквивалентно содержанию фексофенадина 120 мг.
Для таблеток 180 мг: каждая таблетка, покрытая оболочкой, содержит фексофенадина гидрохлорида 189,00 мг, что эквивалентно содержанию фексофенадина 180 мг.
Таблетки 120 мг: Таблетки белого цвета, круглые двояковыпуклые, покрытые пленочной оболочкой.
Таблетки 180 мг: Таблетки оранжевого цвета продолговатой формы, покрытые пленочной оболочкой.
Фармакотерапевтическая группа
противоаллергическое средство - H1-гистаминовых рецепторов блокатор АТХ :
Фармакологические свойства
Фексофенадина гидрохлорид является неседативным блокатором H1 - гистаминовых рецепторов, представляет собой фармакологически активный метаболит терфенадина.
Антигистаминный эффект проявляется через 1 час после приема, достигает максимума через 6 часов и продолжается в течение 24 часов.
При повторном применении не отмечено развития толерантности.
Не оказывает холино- и адренолитического, седативного действия.
Не вызывает изменений функции кальциевых и калиевых каналов, интервала QT в терапевтических дозах.
Фармакокинетика:
После приема внутрь быстро абсорбируется из желудочно-кишечного тракта, время после достижения максимальной концентрации (ТСmах) - 1-3 ч. Среднее значение максимальной концентрации (Сmах) после приема 180 мг - приблизительно 494 нг/мл, после приема 120 мг - 427 нг/мл. Связь с белками плазмы - 60-70% (преимущественно с альбумином и альфа1-гликопротеином). Не проникает через гематоэнцефалический барьер.
Период полувыведения (Т1/2) после многократного приема - 14,4 ч. У пациентов с умеренной (клиренс креатинина 41-80 мл/мии) и тяжелой (11-40 мл/мин) почечной недостаточностью Т1/2 увеличивается на 59 и 72% соответственно; у пациентов, находящихся на гемодиализе, Т1/2 увеличивается на 31%.
Подвергается (5% от дозы) частичному внепеченочному метаболизму. Выводится преимущественно (80%) с желчью, 11% - почками в неизменном виде.
Гиперчувствительность, беременность, период лактации, детский возраст (до 12 лет).
С осторожностью
Хроническая почечная недостаточность (рекомендуемая суточная доза у таких пациентов 60 мг однократно).
Применение при беременности и в период грудного вскармливания
Внутрь.
При сезонном аллергическом рините взрослым и детям старше 12 лет по 120 мг 1 раз в день.
При хронической крапивнице по 180 мг 1 раз в день.
Способ применения и дозы
Способ применения и режим дозирования конкретного препарата зависят от его формы выпуска и других факторов. Оптимальный режим дозирования определяет врач. Следует строго соблюдать соответствие используемой лекарственной формы конкретного препарата показаниям к применению и режиму дозирования.Для взрослых и детей старше 12 лет суточная доза составляет 120-180 мг (1 раз/сут).
Редко (менее 1 случая на 1000 назначений): чувство усталости, бессонница, нервозность, нарушение сна.
В отдельных случаях: кожная сыпь, крапивница, кожный зуд, другие реакции гиперчувствительности (ангионевротический отек, одышка).
Передозировка
Симптомы: головокружение, сонливость и сухость во рту. В случае передозировки рекомендуется проведение стандартных мер по удалению из желудочно-кишечного тракта неабсорбированного препарата.
Рекомендуется симптоматическая и поддерживающая терапия. Гемодиализ не эффективен.
Взаимодействие с другими лекарственными средствами
При совместном применении с эритромицином или кетоконазолом концентрация фексофенадина в плазме увеличивается в 2-3 раза.
Прием алюминий- или магнийсодержащих антацидов за 15 мин до приема фексофенадина приводит к снижению биодоступности последнего (интервал времени между их приемом должен быть не менее 2 ч.).
Не взаимодействует с омепразолом, с препаратами, метаболизирующимися в печени.
Особые указания
При приеме препарата Фексофаст возможно выполнение работ, требующих высокой концентрации внимания и быстроты психомоторных реакций (за исключением людей, обладающих нестандартной реакцией на лекарственные средства). Таким образом, прежде чем приступать к выполнению данных работ (вождение автотранспорта, управление механизмами), необходимо сначала проверить индивидуальную реакцию на препарат.
Влияние на способность управлять автомобилем и движущимися механизмами
При проведении объективных исследований было показано, что фексофенадин не оказывает существенного влияния на функции ЦНС. Тем не менее, рекомендуется проверить индивидуальную реакцию до того, как приступать к вождению автотранспорта или к другим потенциально опасным видам деятельности.
Форма выпуска
Таблетки, покрытые пленочной оболочкой, 120 мг и 180 мг.
Условия хранения
В сухом, защищенном от света месте, недоступном для детей, при температуре не выше 25°С.
Срок годности
3 года.
Не использовать позже срока, указанного на упаковке.
Условия отпуска
Без рецепта
Производитель
MICRO LABS, Limited Индия
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Среднее значение максимальной концентрации (С\u003csub\u003emах\u003c/sub\u003e) после приема 180 мг - приблизительно 494 нг/мл, после приема 120 мг - 427 нг/мл. Связь с белками плазмы - 60-70% (преимущественно с альбумином и альфа1-гликопротеином). Не проникает через гематоэнцефалический барьер."}},{"type":"paragraph","data":{"text":"Период полувыведения (Т\u003csub\u003e1/2\u003c/sub\u003e) после многократного приема - 14,4 ч. У пациентов с умеренной (клиренс креатинина 41-80 мл/мии) и тяжелой (11-40 мл/мин) почечной недостаточностью Т\u003csub\u003e1/2\u003c/sub\u003e увеличивается на 59 и 72% соответственно; у пациентов, находящихся на гемодиализе, Т\u003csub\u003e1/2\u003c/sub\u003e увеличивается на 31%."}},{"type":"paragraph","data":{"text":"Подвергается (5% от дозы) частичному внепеченочному метаболизму. Выводится преимущественно (80%) с желчью, 11% - почками в неизменном виде."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Сезонный аллергический ринит, хроническая крапивница."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность, беременность, период лактации, детский возраст (до 12 лет)."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Хроническая почечная недостаточность (рекомендуемая суточная доза у таких пациентов 60 мг однократно)."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"При сезонном аллергическом рините взрослым и детям старше 12 лет по 120 мг 1 раз в день."}},{"type":"paragraph","data":{"text":"При хронической крапивнице по 180 мг 1 раз в день."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСпособ применения и режим дозирования конкретного препарата зависят от его формы выпуска и других факторов. Оптимальный режим дозирования определяет врач. Следует строго соблюдать соответствие используемой лекарственной формы конкретного препарата показаниям к применению и режиму дозирования.\u003c/i\u003eДля взрослых и детей старше 12 лет суточная доза составляет 120-180 мг (1 раз/сут). "}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Головная боль, сонливость, тошнота, головокружение."}},{"type":"paragraph","data":{"text":"Редко (менее 1 случая на 1000 назначений): чувство усталости, бессонница, нервозность, нарушение сна."}},{"type":"paragraph","data":{"text":"В отдельных случаях: кожная сыпь, крапивница, кожный зуд, другие реакции гиперчувствительности (ангионевротический отек, одышка)."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: головокружение, сонливость и сухость во рту. 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Таким образом, прежде чем приступать к выполнению данных работ (вождение автотранспорта, управление механизмами), необходимо сначала проверить индивидуальную реакцию на препарат."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"При проведении объективных исследований было показано, что фексофенадин не оказывает существенного влияния на функции ЦНС. Тем не менее, рекомендуется проверить индивидуальную реакцию до того, как приступать к вождению автотранспорта или к другим потенциально опасным видам деятельности."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые пленочной оболочкой, 120 мг и 180 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, недоступном для детей, при температуре не выше 25°С."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не использовать позже срока, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Без рецепта"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"MICRO LABS, Limited Индия"}}]}],"source":null},"description_toggle":false,"short_description":"Фексофенадина гидрохлорид является неседативным блокатором H1- гистаминовых рецепторов, представляет собой фармакологически активный метаболит терфенадина. 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