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Гемореологические эффекты пирацетама связаны с его влиянием на эритроциты, тромбоциты и стенку сосудов."}},{"type":"paragraph","data":{"text":"Тиотриазолин реагирует с активными формами кислорода и липидными радикалами за счет выраженных восстановительных свойств тиоловой группы и предупреждает возникновение активных форм кислорода путем реактивации антирадикальных ферментов: супероксиддисмутазы, каталазы и глутатионпероксидазы."}},{"type":"paragraph","data":{"text":"Тиоцетам улучшает интегративную и когнитивную деятельность мозга, способствует процессу обучения, устраняет амнезию, повышает показатели кратковременной и долговременной памяти."}},{"type":"paragraph","data":{"text":"Препарат, улучшающий метаболизм головного мозга."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"list","data":{"style":"ordered","items":["Хроническая ишемия головного мозга;","восстановительный период ишемического инсульта (в том числе у пациентов, имеющих недементное когнитивное нарушение);","диабетическая энцефалопатия;"]}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"list","data":{"style":"ordered","items":["Гиперчувствительность к пирацетаму или тиотриазолину, а также к другим компонентам препарата;","хорея Гентингтона;","острое нарушение мозгового кровообращения (геморрагический инсульт);","тяжелая хроническая почечная недостаточность (клиренс креатинина менее 20 мл/мин);","психомоторное возбуждение на момент назначения препарата;","детский возраст;","беременность и период лактации;","наследственная непереносимость лактозы, дефицит лактазы;","дефицит сахаразы/изомальтазы, непереносимость фруктозы;","глюкозо-галактозная мальабсорбция."]}},{"type":"paragraph","data":{"text":"С осторожностью препарат назначают больным c хронической почечной недостаточностью (клиренс креатинина 20-80 мл/мин). Тиоцетам влияет на агрегацию тромбоцитов, поэтому его необходимо применять с осторожностью больным с нарушением гемостаза, при хирургических вмешательствах, тяжелых кровотечениях."}},{"type":"paragraph","data":{"text":"С осторожностью следует применять препарат лицам пожилого возраста с сердечно-сосудистой патологией в связи с тем, что у данной группы больных отмечаются чаще побочные реакции."}},{"type":"paragraph","data":{"text":"Опыта применения препарата для лечения детей нет, поэтому препарат противопоказан для лечения детей до 18 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"При длительной терапии у пациентов пожилого возраста рекомендуется регулярный контроль функции почек, при необходимости проводят коррекцию дозы в зависимости от клиренса креатинина."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Опыт применения препарата в период беременности или кормления грудью отсутствует, поэтому препарат не следует назначать этой категории женщин."}},{"type":"paragraph","data":{"text":"Опыта применения препарата для лечения детей нет, поэтому препарат противопоказан для лечения детей до 18 лет."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"При хронических нарушениях мозгового кровообращения и в восстановительный период после ишемического инсульта по 2 таблетки 3 раза/сут в течение 25-30 дней. Курс лечения может быть продлен до 3-4 месяцев."}},{"type":"paragraph","data":{"text":"Для лечения диабетической энцефалопатии назначают по 2 таблетки 3 раза/сут на протяжении 45 дней."}},{"type":"paragraph","data":{"text":"Последнюю дозу принимают не позднее 17 ч (для предотвращения нарушения сна)."}},{"type":"paragraph","data":{"text":"Внутрь, за 30 мин до еды."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны нервной системы: двигательная расторможенность, раздражительность, сонливость, депрессия, астения, головная боль, головокружение, шум в ушах, бессонница, психическое возбуждение, нарушение равновесия, атаксия, обострение течения эпилепсии, тревога, галлюцинации, спутанность сознания."}},{"type":"paragraph","data":{"text":"Со стороны ЖКТ: тошнота, рвота, диарея, боль в области живота (в том числе гастралгия) и вздутие, сухость во рту."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: тахикардия, повышение АД, боль в области сердца, аритмии, у лиц пожилого возраста возможно обострение коронарной недостаточности."}},{"type":"paragraph","data":{"text":"Аллергические реакции: гиперчувствительность, анафилактические реакции, включая дерматит, зуд крапивницу и ангионевротичёский отек, лихорадка."}},{"type":"paragraph","data":{"text":"Со стороны органов дыхания: одышка, приступы удушья."}},{"type":"paragraph","data":{"text":"Со стороны обмена веществ: увеличение массы тела."}},{"type":"paragraph","data":{"text":"Со стороны органов слуха: вертиго."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: возникновение или усиление выраженности - дозозависимых побочных эффектов препарата."}},{"type":"paragraph","data":{"text":"Лечение: отмена препарата, индукция рвоты, промывание желудка, симптоматическая терапия."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Тиоцетам нельзя одновременно назначать с препаратами, имеющими кислое значение рН. За счет наличия пирацетама усиливается эффект антидепрессантов и антиангинальных препаратов. При одновременном назначении с гормонами щитовидной железы возможна спутанность сознания, раздражительность и нарушение сна."}},{"type":"paragraph","data":{"text":"Пирацетам не угнетает изоферменты цитохрома Р450. Метаболическое взаимодействие с другими препаратами маловероятно."}},{"type":"paragraph","data":{"text":"Совместный прием с алкоголем не влиял на уровень концентрации пирацетама в сыворотке концентрация этанола в сыворотке крови, не изменялась при приеме 1.6 г пирацетама."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Препарат можно назначать при цереброваскулярной недостаточности с появлением нарушения речи, памяти, внимания, снижением интеллектуальной функции мозга и нарушением эмоциональной сферы для повышения возможности обучаться при цефалгиях, в том числе вызванных нейроциркуляторной дистонией. Тиоцетам можно использовать для лечения вышеперечисленных заболеваний на фоне имеющейся патологии сердца (стенокардия напряжения, инфаркт миокарда), печени (гепатит, цирроз) и вирусных инфекций."}},{"type":"paragraph","data":{"text":"С осторожностью следует применять препарат лицам пожилого возраста с сердечно-сосудистыми патологиями, так как описанные выше побочные реакции у данной группы больных отмечаются чаще."}},{"type":"paragraph","data":{"text":"Аллергические реакции чаще встречаются у лиц, склонных к аллергии."}},{"type":"paragraph","data":{"text":"В связи с тем, что пирацетам снижает агрегацию тромбоцитов, необходимо с осторожностью назначать больным с нарушением гемостаза, состояниями, которые могут сопровождаться кровоизлияниями (язвы желудочно-кишечного тракта), при больших хирургических операций (включая стоматологические вмешательства), больным с симптомами тяжелого кровотечения или больным, имеющим в анамнезе геморрагический инсульт; пациентам, которые применяют антикоагулянты, тромбоцитарные антиагреганты, включая низкие дозы ацетилсалициловой кислоты."}},{"type":"paragraph","data":{"text":"При длительной терапии у больных пожилого возраста рекомендуется регулярный контроль за показателями функции почек."}},{"type":"paragraph","data":{"text":"Препарат содержит лактозу, как вспомогательное вещество, что следует учесть пациентам с непереносимостью галактозы, дефицитом лактазы или нарушениями всасывания глюкозы/галактозы."}},{"type":"paragraph","data":{"text":"1 таблетка Тиоцетама содержит 3,5 мг сахара-пудры, что следует учесть пациентам с сахарным диабетом."}},{"type":"paragraph","data":{"text":"Применение в период беременности или кормления грудью. Опыт применения препарата в период беременности или кормления грудью отсутствует, поэтому препарат не следует назначать этой категории женщин."}},{"type":"paragraph","data":{"text":"Дети. Опыта применения препарата для лечения детей нет, поэтому препарат противопоказан для применения этой категорией пациентов."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Способность влиять на скорость реакции при управлении автотранспортом или другими механизмами. Не рекомендовано применение препарата при управлении автотранспортом или работе с механизмами, требующими повышенного внимания, в связи с риском развития возможных нежелательных реакций со стороны нервной системы."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"По 10 таблеток в контурной ячейковой упаковке из пленки поливинилхлоридной и фольги алюминиевой с печатью лакированной."}},{"type":"paragraph","data":{"text":"По 6 контурных ячейковых упаковок вместе с инструкций по медицинскому применению на государственном и русском языках помещают в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить в оригинальной упаковке при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года"}},{"type":"paragraph","data":{"text":"Не применять после истечения срока годности, указанного на упаковке!"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"по рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ПАО «Киевмедпрепарат»"}},{"type":"paragraph","data":{"text":"Украина, 01032, г. Киев, ул. Саксаганского, 139;"}},{"type":"paragraph","data":{"text":"Наименование и страна владельца регистрационного удостоверения"}},{"type":"paragraph","data":{"text":"ПАО «Галичфарм», Украина"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Адрес организации, принимающей на территории Республики Казахстан претензии от потребителей по качеству продукции:"}},{"type":"paragraph","data":{"text":"Представительство корпорации «Артериум» в Республике Казахстан"}},{"type":"paragraph","data":{"text":"050060, г. Алматы, проспект Аль-Фараби д. 97, 3 подъезд, офис «54»"}},{"type":"paragraph","data":{"text":"Тел/факс: 8(727)315-82-09; 8(727)315-82-10;"}},{"type":"paragraph","data":{"text":"Е-mail: Almaty@arterium.ua"}}]}],"source":null},"description_toggle":false,"short_description":"Тиоцетам относится к группе цереброактивных средств, проявляет ноотропные противоишемические и антиоксидантные свойства. Фармакологический эффект препарата обусловлен взаимопотенциирующим действием тиотриазолина и пирацетама. Пирацетам - циклическое, производное ГАМК, ноотропное средство; воздействует непосредственно на головной мозг, улучшая такие функции как обучение, память, внимание и сознание, не оказывая седативного или психостимулирующего воздействия. На нейрональном уровне пирацетам облегчает различные типы синаптической передачи, оказывая преимущественное воздействие на плотность и активность постсинаптических рецепторов. Гемореологические эффекты пирацетама связаны с его влиянием на эритроциты, тромбоциты и стенку сосудов. Тиотриазолин реагирует с активными формами кислорода и липидными радикалами за счет выраженных восстановительных свойств тиоловой группы и предупреждает возникновение активных форм кислорода путем реактивации антирадикальных ферментов: супероксиддисмутазы, каталазы и глутатионпероксидазы. Тиоцетам улучшает интегративную и когнитивную деятельность мозга, способствует процессу обучения, устраняет амнезию, повышает показатели кратковременной и долговременной памяти. 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