Круглые таблетки белого или белого с желтоватым оттенком цвета плоскоцилиндрической формы с риской на одной стороне и фаской.
Фармакотерапевтическая группа
Антибиотик
Фармакологические свойства
Антибиотик широкого спектра действия. Механизм противомикробного действия связан с нарушением синтеза белка в микробной клетке на стадии переноса аминокислот т-РНК на рибосомы. Оказывает бактериостатическое действие. Активен в отношении грамположительных бактерий: Staphylococcus spp., Streptococcus spp.; грамотрицательных бактерий: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; активен также в отношении Spirochaetaceae, некоторых крупных вирусов.
Хлорамфеникол активен в отношении штаммов, устойчивых к пенициллину, стрептомицину, сульфаниламидам.
Устойчивость микроорганизмов к хлорамфениколу развивается относительно медленно.
Показания к применению
Инфекции мочевыводящих и желчевыводящих путей вызванные чувствительными микроорганизмами.
Противопоказания
Гиперчувствительность угнетение костномозгового кроветворения острая интермиттирующая порфирия дефицит глюкозо-6-фосфатдегидрогеназы печёночная и/или почечная недостаточность беременность период лактации детский возраст.
С осторожностью
Пациентам получавшим ранее лечение цитостатическими препаратами или лучевую терапию
Применение при беременности и в период грудного вскармливания
Хлорамфеникол противопоказан к применению при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Внутрь (за 30 мин до еды а при развитии тошноты и рвоты - через 1 ч после еды) 3-4 раза в сутки.
Разовая доза для взрослых - 250-500 мг суточная - 2 г. При тяжёлых формах инфекций (в условиях стационара) возможно повышение дозы до 3-4 г/сут (под контролем состояния крови функции почек и печени).
Средняя продолжительность лечения - 8-10 дней.
Побочное действие
Со стороны пищеварительной системы: диспепсия тошнота рвота (вероятность развития снижается при приёме через 1 ч после еды) диарея раздражение слизистой оболочки полости рта и зева дерматит дисбактериоз (подавление нормальной микрофлоры).
Со стороны органов кроветворения: ретикулоцитопения лейкопения гранулоцнтопения тромбоцитопення эритроцитопения; редко - апластическая анемия агранулоцитоз.
Со стороны нервной системы: психомоторные расстройства депрессия спутанность сознания периферический неврит неврит зрительного нерва зрительные и слуховые галлюцинации снижение остроты зрения и слуха головная боль.
Аллергические реакции: кожная сыпь ангионевротический отёк.
Прочие: вторичная грибковая инфекция.
Передозировка
Симптомы: угнетение костномозгового кроветворения желудочно-кишечные расстройства поражение печени и почек нейропатия (в том числе зрительного нерва) и ретинопатия.
Лечение: симптоматическая терапия гемосорбция.
Взаимодействие с другими лекарственными средствами
Ингибирует микросомальные ферменты печени поэтому при одновременном применении с фенобарбиталом фенитоином непрямыми антикоагулянтами отмечается ослабление метаболизма этих лекарственных средств (ЛС) замедление выведения и повышение их концентрации в плазме.
Снижает антибактериальный эффект пенициллинов и цефалоспоринов. При одновременном применении с эритромицином клиндамицином линкомицином отмечается взаимное ослабление действия за счет того что хлорамфеникол может вытеснять эти ЛС из связанного состояния или препятствовать их связыванию с субъединицей 50S бактериальных рибосом.
Одновременное назначение с ЛС угнетающими кроветворение (сульфаниламиды цитостатикн) влияющими на обмен веществ в печени с лучевой терапией увеличивает риск развития побочного действия.
При назначении с пероральными гипогликемическими ЛС отмечается усиление их действия (за счет подавления метаболизма в печени и повышения их концентрации в плазме).
Тяжелые осложнения со стороны кроветворной системы как правило связаны с применением высоких доз Левомицетина (более 4 r/сут) длительное время.
В процессе лечения необходим систематический контроль картины периферической крови.
При одновременном приёме этанола возможно развитие дисульфирамоподобной реакции (гиперемия кожных покровов тахикардия тошнота рвота рефлекторный кашель судороги).
Форма выпуска
Таблетки 500 мг.
Условия хранения
Список Б. В защищённом от света месте при температуре не выше 25 °С. Хранить в местах недоступных для детей.
Срок годности
5 лет. Не использовать по истечении срока годности.
Условия отпуска
По рецепту
Производитель
Открытое акционерное общество "Акционерное Курганское общество медицинских препаратов и изделий "Синтез" (ОАО "Синтез")
Организация, принимающая претензии потребителей
ОАО "Синтез"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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