Трифтазин Таблетки, банка, 50 шт, 5 мг, для приема внутрь, для взрослых, покрытые оболочкой +6 лет, цвет синий

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Проникает через гематоэнцефалический барьер, плаценту и в грудное молоко. Интенсивно метаболизируется в печени, метаболиты фармакологически неактивны. Период полувыведения - 15 - 30 ч. Выводится в основном почками (в виде метаболитов) и с желчью. При проведении гемодиализа диализируется слабо (высокая связь с белками плазмы)."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Шизофрения (с продуктивной и негативной симптоматикой) и другие психотические заболевания, протекающие с психомоторным возбуждением, галлюцинаторными и бредовыми расстройствами."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к компонентам препарата (в т.ч. другим производным фенотиазина), тяжелые сердечно-сосудистые заболевания (декомпенсированная хроническая сердечная недостаточность, артериальная гипотензия), выраженное угнетение функции центральной нервной системы (в т.ч. на фоне лекарственных средств) и коматозные состояния любой этиологии, черепно-мозговые травмы, прогрессирующие заболевания головного и спинного мозга, угнетение костномозгового кроветворения, нарушение кроветворения, тяжелая печеночная недостаточность, детский возраст."}},{"type":"paragraph","data":{"text":"С осторожностью:"}},{"type":"paragraph","data":{"text":"Алкоголизм (повышенная предрасположенность к гепатотоксическим реакциям), стенокардия, клапанные поражения сердца, лимитирующие величину минутного обращения крови (возможно развитие тяжелой артериальной гипотензии), рак молочной железы (в результате индуцированной фенотиазином секреции пролактина возрастает потенциальный риск прогрессирования болезни и резистентности к лечению эндокринными и цито- статическими лекарственными средствами), закрытоугольная глаукома, гиперплазия предстательной железы с клиническими проявлениями, печеночная недостаточность легкой и средней степени, почечная недостаточность, язвенная болезнь желудка и двенадцатиперстной кишки в период обострения; заболевания, сопровождающиеся повышенным риском тромбоэмболических осложнений; болезнь Паркинсона (усиливаются экстрапирамидные эффекты); эпилепсия; микседема; хронические заболевания, сопровождающиеся нарушением дыхания (особенно у детей); синдром Рейе (повышен риск развития проявлений гепатотоксичности у детей и подростков); кахексия, рвота (противорвотное действие фенотиазинов может маскировать рвоту, связанную с передозировкой других лекарственных средств), пожилой возраст. Во время приема препарата следует избегать воздействия высоких температур (возможно нарушение терморегуляции)."}},{"type":"paragraph","data":{"text":"Злокачественный нейролептический синдром может возникнуть в любое время в процессе лечения нейролептиками и привести к летальному исходу."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Алкоголизм (повышенная предрасположенность к гепатотоксическим реакциям), стенокардия, клапанные поражения сердца, лимитирующие величину минутного обращения крови (возможно развитие тяжелой артериальной гипотензии), рак молочной железы (в результате индуцированной фенотиазином секреции пролактина возрастает потенциальный риск прогрессирования болезни и резистентности к лечению эндокринными и цито- статическими лекарственными средствами), закрытоугольная глаукома, гиперплазия предстательной железы с клиническими проявлениями, печеночная недостаточность легкой и средней степени, почечная недостаточность, язвенная болезнь желудка и двенадцатиперстной кишки в период обострения; заболевания, сопровождающиеся повышенным риском тромбоэмболических осложнений; болезнь Паркинсона (усиливаются экстрапирамидные эффекты); эпилепсия; микседема; хронические заболевания, сопровождающиеся нарушением дыхания (особенно у детей); синдром Рейе (повышен риск развития проявлений гепатотоксичности у детей и подростков); кахексия, рвота (противорвотное действие фенотиазинов может маскировать рвоту, связанную с передозировкой других лекарственных средств), пожилой возраст. Во время приема препарата следует избегать воздействия высоких температур (возможно нарушение терморегуляции)."}},{"type":"paragraph","data":{"text":"Злокачественный нейролептический синдром может возникнуть в любое время в процессе лечения нейролептиками и привести к летальному исходу."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Препарат противопоказан в период беременности и в период грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Принимают внутрь после еды. Дозы подбирают индивидуально в соответствии с тяжестью состояния. При достижении максимального терапевтического эффекта дозу постепенно снижают до поддерживающей дозы."}},{"type":"paragraph","data":{"text":"При психотических заболеваниях обычно назначают по 5 мг 2 раза в сутки, далее в течение 2-3 недель дозу постепенно увеличивают до 15 - 20 мг в сутки, деленные на 2 - 3 приема. Для получения желаемого терапевтического эффекта и улучшения состояния пациента обычно необходимо 2-3 недели. Максимальная суточная доза - 40 мг."}},{"type":"paragraph","data":{"text":"На первом этапе подбора дозы у пожилых, истощенных, ослабленных пациентов и детей- целесообразно использовать лекарственные формы с меньшей дозировкой трифлуоперазина. Пожилым, а также истощенным и ослабленным больным требуется меньшая первоначальная доза, которую при необходимости с учетом переносимости постепенно увеличивают."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны нервной системы: сонливость, головокружение, бессонница (в начале лечения), при длительном применении в высоких дозах (0,5 -1,5 г/сут) - акатизия, дистонические экстрапирамидные реакции (спазмы мышц лица, шеи и спины, тикоподобные движения или подергивания, изгибающиеся движения туловища, невозможность двигать глазами, слабость в руках и ногах), паркинсонизм (затруднение при разговоре и глотании, потеря контроля равновесия, маскообразное лицо, шаркающая походка, тугоподвижность рук и ног, дрожание кистей и пальцев), поздняя дискинезия (причмокивание и сморщивание губ, надувание щек, быстрые или червеобразные движения языка, неконтролируемые жевательные движения, неконтролируемые движения рук и ног), злокачественный нейролептический синдром (судороги, затрудненное или учащенное дыхание, учащенное сердцебиение или неритмичный пульс, гипертермия, нестабильное артериальное давление, повышенное потоотделение, утрата контроля за мочеиспусканием, выраженная ригидность мышц, необычно бледная кожа, чрезмерная утомляемость и слабость), явления психической индифферентности, запоздалой реакции на внешние раздражения и другие изменения психики,судороги."}},{"type":"paragraph","data":{"text":"Со стороны мочеполовой системы: задержка мочи, снижение потенции, фригидность (в начале лечения), снижение либидо, нарушения эякуляции, приапизм, олигурия."}},{"type":"paragraph","data":{"text":"Со стороны эндокринной системы: гипо- или гипергликемия, гиперпролактинемия, галакторея, набухание или боль в молочных железах, гинекомастия, аменорея, дисменорея, увеличение массы тела."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: снижение аппетита, сухость во рту, запор (в начале лечения), булимия или анорексия, тошнота, рвота, диарея, гастралгия, холестатическая желтуха, гепатит, парез кишечника."}},{"type":"paragraph","data":{"text":"Со стороны органов чувств: нарушения зрения - парез аккомодации (в начале лечения), ретинопатия, помутнение хрусталика и роговицы, нечеткость зрительного восприятия."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: угнетение костномозгового кроветворения (тромбоцитопения, лейкопения, агранулоцитоз (на 4-10 нед. лечения), панцитопения, эозинофилия), гемолитическая анемия."}},{"type":"paragraph","data":{"text":"Лабораторные показатели: ложноположительные тесты на беременность и фенилкетонурию."}},{"type":"paragraph","data":{"text":"Со стороны сердечно-сосудистой системы: тахикардия, снижение артериального давления (в т.ч. ортостатическая гипотензия) особенно у пожилых больных и лиц с алкоголизмом (в начале лечения), нарушения сердечного ритма, удлинение интервала Q-T, снижение или инверсия зубца Т, учащение приступов стенокардии (на фоне увеличения физической активности)."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь, крапивница, эксфолиативный дерматит, ангионевротический отек."}},{"type":"paragraph","data":{"text":"Прочие: окрашивание кожи от сине-фиолетового до коричневого цвета, фотосенсибилизация, обесцвечивание склер и роговицы, снижение переносимости воздействия высоких температур (вплоть до развития теплового удара - горячая сухая кожа, утрата способности к потоотделению, спутанность сознания), миастения."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: арефлексия или гиперрефлексия, нечеткость зрительного восприятия, кардиотоксическое (аритмия, сердечная недостаточность, снижение артериального давления, шок, тахикардия, изменение комплекса QRS, фибрилляция желудочков, остановка сердца), нейротоксическое действие, включая ажитацию, спутанность сознания, судороги, дезориентацию, сонливость, ступор или кому; мидриаз, сухость во рту, гиперпирексия или гипотермия, ригидность мышц, рвота, отек легких или угнетение дыхания."}},{"type":"paragraph","data":{"text":"Лечение: симптоматическое: для устранения экстрапирамидных нарушений используют противопаркинсонические препараты из группы центральных м-холиноблокаторов, барбитураты или дифенгидрамин. При необходимости назначения стимуляторов лучше использовать амфетамин, декстроамфетамин или кофеин. Следует избегать назначения стимуляторов, которые могут вызвать судороги (пикротоксин, пентилентетразол). При развитии артериальной гипотензии показаны норадреналин и фенилэфрин. Применение других вазопрессорных средств (в т.ч. адреналина) не рекомендуется, т.к. метаболиты трифтазина могут изменять их действие, что приводит к еще большему снижению артериального давления. Контроль функции сердечно-сосудистой системы в течение не менее 5 суток, функции центральной нервной системы, дыхания, измерение температуры тела, консультация психиатра. Диализ малоэффективен. Не допускается вызывать рвоту с целью опорожнения желудка."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Ослабляет эффекты леводопы и производных фенамина, последние снижают антипсихотическую активность трифлуоперазина. Усиливает действие этанола и других лекарственных средств, угнетающих центральную нервную систему (средства для общей анестезии, наркотические анальгетики, опиоиды, барбитураты), а также атропина."}},{"type":"paragraph","data":{"text":"При одновременном приеме с противоэпилептическими лекарственными средствами (в т.ч. барбитуратами) трифлуоперазин уменьшает их эффект (снижает эпилептический порог)."}},{"type":"paragraph","data":{"text":"Уменьшает эффект анорексигенных лекарственных средств (за исключением фенфлурамина)."}},{"type":"paragraph","data":{"text":"Снижает эффективность рвотного действия апоморфина, усиливает его угнетающее действие на центральную нервную систему."}},{"type":"paragraph","data":{"text":"Повышает концентрацию в плазме пролактина и препятствует действию бромокриптина. При совместном применении с трициклическими антидепрессантами, мапротилином, ингибиторами моноаминоксидазы возможно удлинение и усиление седативного и антихоли- нергического эффектов, с тиазидными диуретиками - возникновение электролитного дисбаланса, с препаратами лития - снижение всасывания в желудочно-кишечном тракте, увеличение скорости выведения лития почками, усиление выраженности экстрапирамидных нарушений, ранние признаки интоксикации литием (тошнота и рвота) могут маскироваться противорвотным эффектом трифлуоперазина."}},{"type":"paragraph","data":{"text":"При сочетании с бета-адреноблокаторами способствует усилению гипотензивного эффекта, повышается риск развития необратимой ретинопатии, аритмий и поздней дискинезии. Снижает эффект непрямых антикоагулянтов."}},{"type":"paragraph","data":{"text":"Применение альфа- и бета-адреностимуляторов (эпинефрин) и симпатомиметиков (эфедрин) может привести к парадоксальному снижению артериального давления. Амитриптилин, амантадин, блокаторы Н1-гистаминовых рецепторов и другие лекарственные средства с м-холиноблокирующим эффектом повышают м-холиноблокирующую активность. Алюминий и магний-содержащие антацидные лекарственные средства или противодиарейные адсорбенты снижают всасывание."}},{"type":"paragraph","data":{"text":"Антитиреоидные лекарственные средства увеличивают риск развития агранулоцитоза. Пробукол, астемизол, цизаприд, дизопирамид, эритромицин, пимозид, прокаинамид, хинидин способствуют дополнительному удлинению интервала Q-T, что увеличивает риск развития желудочковой тахикардии."}},{"type":"paragraph","data":{"text":"При одновременном применении фенотиазидов с пропранололом отмечается увеличение концентрации обоих лекарственных средств."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Для коррекции экстрапирамидных расстройств применяют противопаркинсонические лекарственные средства - \u003ca target=\"_blank\" href=\"http://www.lsgeotar.ru/pharma_mnn/2294.html?XFrom=www.lsgeotar.ru\"\u003eтригексифенидил\u003c/a\u003e и другие; дискинезии купируются подкожно введением 2 мл 20 % раствора кофеина и 1 мл 0,1 % раствора атропина)."}},{"type":"paragraph","data":{"text":"Препарат, обладая кардиотоксическим эффектом, может вызвать артериальную гипотензию, ухудшение сердечной гемодинамики (отек легких, фибрилляцию желудочков и как следствие последней внезапную смерть) у пожилых больных с психозами."}},{"type":"paragraph","data":{"text":"У пожилых больных возможно развитие необратимых дискинезий. При появлении признаков поздней дискинезии, нейролептического злокачественного синдрома лечение следует отменить."}},{"type":"paragraph","data":{"text":"На фоне терапии фенотиазинами возможно получение ложноположительных тестов на фенилкетонурию."}},{"type":"paragraph","data":{"text":"Назначение фенотиазинов должно быть прекращено не менее чем за 48 ч до предполагаемого проведения миелографии (возобновление возможно через 24 ч)."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Во время лечения не рекомендуется управление транспортными средствами, а также занятие видами деятельности, требующими быстроты психомоторных реакции и точных движений."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки, покрытые оболочкой, 5 мг или 10 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток покрытых оболочкой в контурную ячейковую упаковку из пленки поливинилхлоридной и фольги алюминиевой печатной лакированной."}},{"type":"paragraph","data":{"text":"По 50 или 100 таблеток покрытых оболочкой в банку стеклянную, укупоренную крышкой пластмассовой или в банку полимерную."}},{"type":"paragraph","data":{"text":"Каждую банку или 5 контурных ячейковых упаковок вместе с инструкцией по применению помещают в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте при температуре от 5 до 30 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не использовать по истечении срока годности, указанного на упаковке"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://apteka.ru/vendor/%D0%94%D0%B0%D0%BB%D1%8C%D1%85%D0%B8%D0%BC%D1%84%D0%B0%D1%80%D0%BC%20%D0%9E%D0%90%D0%9E/\"\u003eДальхимфарм ОАО \u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Антипсихотическое средство (нейролептик), пиперазиновое производное фенотиазина. 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