По 10 таблеток покрытых пленочной оболочкой в блистер из ПВХ/АЛ. 2 или 3 блистера с инструкцией по применению в пачку картонную.
Описание
Таблетки покрытые пленочной оболочкой 40 мг: круглые, двояковыпуклые таблетки, покрытые пленочной оболочкой, бледно-коричневого со слегка розоватым оттенком цвета, на изломе белого цвета.
Характеристика
Таблетки покрытые пленочной оболочкой 20 мг: круглые, двояковыпуклые таблетки, покрытые пленочной оболочкой, бледно-розового с сероватым оттенком цвета, на изломе белого цвета.
Таблетки покрытые пленочной оболочкой 40 мг: круглые, двояковыпуклые таблетки, покрытые пленочной оболочкой, бледно-коричневого со слегка розоватым оттенком цвета, на изломе белого цвета.
Фармакологические свойства
После приема внутрь быстро абсорбируется из ЖКТ. После приема внутрь максимальная концентрация в плазме крови достигается в течение 1-3,5 часов. Связывание с белками плазмы 15-20%. 30-35% фамотидина метаболизируется в печени (с образованием S-оксида). Элиминация, в основном, происходит через почки: 27-40% препарата экскретируется с мочой в неизмененном виде. Период полувыведения - 2,5-4 часа, у пациентов с клиренсом креатинина ниже 30 мл/мин увеличивается до 10-12 часов. Проникает через плацентарный барьер и выделяется с грудным молоком.
Фармакодинамика
Фамотидин является конкурентным антагонистом гистамина. Действуя на гистаминовые Н2 – рецепторы париетальных клеток значительно уменьшает вызванную различными раздражителями секрецию хлористоводородной кислоты. Снижается и базальная секреция хлористоводородной кислоты. В меньшей степени угнетается вызванная секреция пепсиногена. Вызывает дозозависимое подавление продукции соляной кислоты и уменьшение активности пепсина. Существенно не изменяет уровень гастрина в плазме. Продолжительность действия препарата при однократном приеме зависит от дозы и составляет от 12 до 24 часов.
Клиническая фармакология
Желез желудка секрецию понижающее средство - Н2-гистаминовых рецепторов блокатор
Показания к применению
Язвенная болезнь желудка и 12-перстной кишки, профилактика рецидивов;
- Эрозивный гастродуоденит;
- Функциональная диспепсия, ассоциированная с повышенной секреторной функцией;
- Симптоматические и стрессовые язвы ЖКТ;
- Рефлюкс-эзофагит;
- профилактика рецидивов, связанных с длительным приемом нестероидных противовоспалительных средств;
- Синдром Золлингера-Эллисона;
- Системный мастоцитоз;
- Полиэндокринный аденоматоз,
- Профилактика рецидивов кровотечений в послеоперационном периоде.
- Профилактика аспирации желудочного сока у больных, которым проводятся операции под общей анестезией (синдром Мендельсона);
- Профилактика аспирационного пневмонита;
- Диспепсия с эпигастральными или загрудинными болями, возникающими в ночное время или связанными с приемом пищи.
Противопоказания
Повышенная чувствительность к фамотидину и другим блокаторам Н2-гистаминовых рецепторов, детский возраст.
С осторожностью: печеночная и/или почечная недостаточность, цирроз печени с портосистемной энцефалопатией (в анамнезе), иммунодефицит.
Применение при беременности и в период грудного вскармливания
Во время беременности и в период лактации — применение препарата противопоказано.
Способ применения и дозы
Внутрь, не разжевывая, запивая достаточным количеством воды.
Взрослые:
При язвенной болезни желудка и 12-перстной кишки в фазе обострения, симптоматических язвах, эрозивном гастродуодените обычно назначают по 20 мг 2 раза в сутки или по 40 мг 1 раз в сутки на ночь. При необходимости суточная доза может быть увеличена до 80 - 160 мг. Курс лечения 4-8 недель.
При диспепсии, связанной с повышенной секреторной функцией желудка, назначают по 20 мг 1-2 раза в сутки.
С целью профилактики рецидивов язвенной болезни назначают по 20 мг 1 раз в сутки перед сном.
При рефлюкс-эзофагите 20-40 мг два раза в сутки в течение 6-12 недель.
При синдроме Золлингера-Эллисона дозу препарата и продолжительность курса лечения устанавливают индивидуально. Начальная доза обычно составляет 20 мг каждые 6 часов и может быть увеличена до 160 мг каждые 6 часов.
Для профилактики аспирации желудочного сока при общей анестезии назначают по 40 мг вечером и/или утром перед операцией. Таблетки Фамотидина следует проглатывать не разжевывая, запивая достаточным количеством воды.
При почечной недостаточности, если клиренс креатинина составляет менее 30 мл/мин или содержание креатинина в сыворотке крови более 3 мг/100 мл, суточную дозу препарата необходимо уменьшить до 20 мг.
Побочное действие
Сухость во рту, тошнота, рвота, боль в животе, метеоризм, запор, диарея, нарушение аппетита;
- Повышение активности "печеночных" ферментов, гепатит, острый панкреатит;
- Головная боль, головокружение, бессонница, беспокойство, шум в ушах;
- Брадикардия, аритмия, васкулит, снижение артериального давления, антриовентрикулярная блокада;
- Мышечные боли, боли в суставах;
- Сухость кожи, алопеция, обыкновенные угри, кожная сыпь, зуд, бронхоспазм, ангионевротический отек, анафилактический шок, другие проявления гиперсенсибилизации;
- Увеличение уровня мочевины в крови, лейкопения, тромбоцитопения, агранулоцитоз, панцитопения, гипоплазия, аплазия костного мозга.
- При длительном приеме больших доз – гиперпролактинемия, гинекомастия, аменорея, снижение либидо, импотенция.
Передозировка
Симптомы: рвота, двигательное возбуждение, тремор, снижение АД, тахикардия, коллапс.
Лечение: при пероральном приеме показана индукция рвоты или/и промывание желудка.
Симптоматическая и поддерживающая терапия: при судорогах – в/в диазепам; при брадикардии – атропин; при желудочковых аритмиях – лидокаин. Гемодиализ эффективен.
Взаимодействие с другими лекарственными средствами
Увеличивает всасывание амоксициллина и клавулановой кислоты. Совместим с 0.18 и 0.9% раствором NaCl, 4 и 5% раствором декстрозы, 4.2% раствором натрия гидрокарбоната.
При одновременном применении с антацидными средствами, содержащими магний и алюминий, сукральфатом происходит снижение интенсивности абсорбции фамотидина, поэтому перерыв между приемом этих препаратов должен составлять не менее 1-2 часов. Вследствие повышения рН содержимого желудка при одновременном приеме может уменьшиться всасывание кетоконазола и итраконазола.
Лекарственные средства, угнетающие костный мозг, увеличивают риск развития нейтропении.
Перед началом терапии, или, если такой возможности нет, перед переходом на пероральное лечение необходимо исключить наличие злокачественного новообразования желудка.
При почечной и/или печеночной недостаточности фамотидин следует использовать с осторожностью в сниженной дозе.
Поскольку в случае использования блокаторов Н2-гистаминовых рецепторов была описана перекрестная аллергия, применение фамотидина у пациентов, имеющих в анамнезе гиперчувствительность к другим блокаторам Н2-гистаминовых рецепторов, требует осторожности.
Влияние на способность управлять автомобилем и движущимися механизмами
Влияние на способность управлять трансп. ср. и мех.:
Пациентам следует соблюдать осторожность при выполнении работ, требующих быстроты психомоторных реакций (в т.ч. при управлении автотранспорта и работе с техникой), поскольку во время лечения может возникать головокружение и наблюдаться повышенная утомляемость.
Форма выпуска
Таблетки, покрытые пленочной оболочкой бледно-коричневого цвета, круглые, двояковыпуклые.
10 шт. - блистеры (3) - пачки картонные.
Условия хранения
В защищенном от света месте, при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
3 года.
Не применять препарат после истечения срока годности, указанного на упаковке.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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форма","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"1 таблетка покрытая пленочной оболочкой 20 мг, содержит активное вещество фамотидин 20 мг."}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: крахмал кукурузный – 16,0 мг, целлюлоза микрокристаллическая – 78,35 мг, кремния диоксид – 1,4 мг, тальк – 5,625 мг, магния стеарат – 1,125 мг, кроскармеллоза натрия – 2,5 мг."}},{"type":"paragraph","data":{"text":"Оболочка: гипромеллоза – 2,5 мг, титана диоксид – 1,53 мг, лактозы моногидрат – 1,313 мг, макрогол-4000 – 0,5 мг, триацетин – 0,375 мг, краситель железа оксид желтый [Е172] – 0,021 мг, краситель железа оксид красный [Е172] – 0,006 мг, краситель железа оксид черный [Е172] – 0,005 мг."}},{"type":"paragraph","data":{"text":"1 таблетка покрытая пленочной оболочкой 40 мг, содержит активное вещество фамотидин 40 мг."}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: крахмал кукурузный – 32,0 мг, целлюлоза микрокристаллическая – 156,7 мг, кремния диоксид – 2,8 мг, тальк – 11,25 мг, магния стеарат – 2,25 мг, кроскармеллоза натрия – 5,0 мг."}},{"type":"paragraph","data":{"text":"Оболочка: гипромеллоза – 5,0 мг, титана диоксид – 2,61 мг, лактозы моногидрат – 2,625 мг, макрогол-4000 – 1,0 мг, триацетин – 0,75 мг, краситель железа оксид желтый [Е172] – 0,375 мг, краситель железа оксид красный [Е172] – 0,125 мг, краситель железа оксид черный [Е172] – 0,015 мг. Таблетки покрытые пленочной оболочкой 20 мг и 40 мг."}},{"type":"paragraph","data":{"text":"По 10 таблеток покрытых пленочной оболочкой в блистер из ПВХ/АЛ. 2 или 3 блистера с инструкцией по применению в пачку картонную."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Таблетки покрытые пленочной оболочкой 40 мг: круглые, двояковыпуклые таблетки, покрытые пленочной оболочкой, бледно-коричневого со слегка розоватым оттенком цвета, на изломе белого цвета."}},{"type":"header","data":{"text":"Характеристика","level":3}},{"type":"paragraph","data":{"text":"Таблетки покрытые пленочной оболочкой 20 мг: круглые, двояковыпуклые таблетки, покрытые пленочной оболочкой, бледно-розового с сероватым оттенком цвета, на изломе белого цвета."}},{"type":"paragraph","data":{"text":"Таблетки покрытые пленочной оболочкой 40 мг: круглые, двояковыпуклые таблетки, покрытые пленочной оболочкой, бледно-коричневого со слегка розоватым оттенком цвета, на изломе белого цвета."}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"После приема внутрь быстро абсорбируется из ЖКТ. После приема внутрь максимальная концентрация в плазме крови достигается в течение 1-3,5 часов. Связывание с белками плазмы 15-20%. 30-35% фамотидина метаболизируется в печени (с образованием S-оксида). Элиминация, в основном, происходит через почки: 27-40% препарата экскретируется с мочой в неизмененном виде. Период полувыведения - 2,5-4 часа, у пациентов с клиренсом креатинина ниже 30 мл/мин увеличивается до 10-12 часов. Проникает через плацентарный барьер и выделяется с грудным молоком."}},{"type":"header","data":{"text":"Фармакодинамика","level":3}},{"type":"paragraph","data":{"text":"Фамотидин является конкурентным антагонистом гистамина. Действуя на гистаминовые Н2 – рецепторы париетальных клеток значительно уменьшает вызванную различными раздражителями секрецию хлористоводородной кислоты. Снижается и базальная секреция хлористоводородной кислоты. В меньшей степени угнетается вызванная секреция пепсиногена. Вызывает дозозависимое подавление продукции соляной кислоты и уменьшение активности пепсина. Существенно не изменяет уровень гастрина в плазме. Продолжительность действия препарата при однократном приеме зависит от дозы и составляет от 12 до 24 часов."}},{"type":"header","data":{"text":"Клиническая фармакология","level":3}},{"type":"paragraph","data":{"text":"Желез желудка секрецию понижающее средство - Н2-гистаминовых рецепторов блокатор"}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Язвенная болезнь желудка и 12-перстной кишки, профилактика рецидивов;"}},{"type":"paragraph","data":{"text":"- Эрозивный гастродуоденит;"}},{"type":"paragraph","data":{"text":"- Функциональная диспепсия, ассоциированная с повышенной секреторной функцией;"}},{"type":"paragraph","data":{"text":"- Симптоматические и стрессовые язвы ЖКТ;"}},{"type":"paragraph","data":{"text":"- Рефлюкс-эзофагит;"}},{"type":"paragraph","data":{"text":"- профилактика рецидивов, связанных с длительным приемом нестероидных противовоспалительных средств;"}},{"type":"paragraph","data":{"text":"- Синдром Золлингера-Эллисона;"}},{"type":"paragraph","data":{"text":"- Системный мастоцитоз;"}},{"type":"paragraph","data":{"text":"- Полиэндокринный аденоматоз,"}},{"type":"paragraph","data":{"text":"- Профилактика рецидивов кровотечений в послеоперационном периоде."}},{"type":"paragraph","data":{"text":"- Профилактика аспирации желудочного сока у больных, которым проводятся операции под общей анестезией (синдром Мендельсона);"}},{"type":"paragraph","data":{"text":"- Профилактика аспирационного пневмонита;"}},{"type":"paragraph","data":{"text":"- Диспепсия с эпигастральными или загрудинными болями, возникающими в ночное время или связанными с приемом пищи."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":" Повышенная чувствительность к фамотидину и другим блокаторам Н2-гистаминовых рецепторов, детский возраст."}},{"type":"paragraph","data":{"text":"С осторожностью: печеночная и/или почечная недостаточность, цирроз печени с портосистемной энцефалопатией (в анамнезе), иммунодефицит."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Во время беременности и в период лактации — применение препарата противопоказано."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь, не разжевывая, запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"Взрослые:"}},{"type":"paragraph","data":{"text":"При язвенной болезни желудка и 12-перстной кишки в фазе обострения, симптоматических язвах, эрозивном гастродуодените обычно назначают по 20 мг 2 раза в сутки или по 40 мг 1 раз в сутки на ночь. При необходимости суточная доза может быть увеличена до 80 - 160 мг. Курс лечения 4-8 недель."}},{"type":"paragraph","data":{"text":"При диспепсии, связанной с повышенной секреторной функцией желудка, назначают по 20 мг 1-2 раза в сутки."}},{"type":"paragraph","data":{"text":"С целью профилактики рецидивов язвенной болезни назначают по 20 мг 1 раз в сутки перед сном."}},{"type":"paragraph","data":{"text":"При рефлюкс-эзофагите 20-40 мг два раза в сутки в течение 6-12 недель."}},{"type":"paragraph","data":{"text":"При синдроме Золлингера-Эллисона дозу препарата и продолжительность курса лечения устанавливают индивидуально. Начальная доза обычно составляет 20 мг каждые 6 часов и может быть увеличена до 160 мг каждые 6 часов."}},{"type":"paragraph","data":{"text":"Для профилактики аспирации желудочного сока при общей анестезии назначают по 40 мг вечером и/или утром перед операцией. Таблетки Фамотидина следует проглатывать не разжевывая, запивая достаточным количеством воды."}},{"type":"paragraph","data":{"text":"При почечной недостаточности, если клиренс креатинина составляет менее 30 мл/мин или содержание креатинина в сыворотке крови более 3 мг/100 мл, суточную дозу препарата необходимо уменьшить до 20 мг."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Сухость во рту, тошнота, рвота, боль в животе, метеоризм, запор, диарея, нарушение аппетита;"}},{"type":"paragraph","data":{"text":"- Повышение активности \"печеночных\" ферментов, гепатит, острый панкреатит;"}},{"type":"paragraph","data":{"text":"- Головная боль, головокружение, бессонница, беспокойство, шум в ушах;"}},{"type":"paragraph","data":{"text":"- Повышенная утомляемость, сонливость, депрессия, нервозность, психоз;"}},{"type":"paragraph","data":{"text":"- Нечеткость зрительного восприятия, парез аккомодации;"}},{"type":"paragraph","data":{"text":"- Спутанность сознания, галлюцинации, гипертермия;"}},{"type":"paragraph","data":{"text":"- Лихорадка;"}},{"type":"paragraph","data":{"text":"- Брадикардия, аритмия, васкулит, снижение артериального давления, антриовентрикулярная блокада;"}},{"type":"paragraph","data":{"text":"- Мышечные боли, боли в суставах;"}},{"type":"paragraph","data":{"text":"- Сухость кожи, алопеция, обыкновенные угри, кожная сыпь, зуд, бронхоспазм, ангионевротический отек, анафилактический шок, другие проявления гиперсенсибилизации;"}},{"type":"paragraph","data":{"text":"- Увеличение уровня мочевины в крови, лейкопения, тромбоцитопения, агранулоцитоз, панцитопения, гипоплазия, аплазия костного мозга."}},{"type":"paragraph","data":{"text":"- При длительном приеме больших доз – гиперпролактинемия, гинекомастия, аменорея, снижение либидо, импотенция."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: рвота, двигательное возбуждение, тремор, снижение АД, тахикардия, коллапс."}},{"type":"paragraph","data":{"text":"Лечение: при пероральном приеме показана индукция рвоты или/и промывание желудка."}},{"type":"paragraph","data":{"text":"Симптоматическая и поддерживающая терапия: при судорогах – в/в диазепам; при брадикардии – атропин; при желудочковых аритмиях – лидокаин. Гемодиализ эффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Увеличивает всасывание амоксициллина и клавулановой кислоты. Совместим с 0.18 и 0.9% раствором NaCl, 4 и 5% раствором декстрозы, 4.2% раствором натрия гидрокарбоната."}},{"type":"paragraph","data":{"text":"При одновременном применении с антацидными средствами, содержащими магний и алюминий, сукральфатом происходит снижение интенсивности абсорбции фамотидина, поэтому перерыв между приемом этих препаратов должен составлять не менее 1-2 часов. 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