Фамотидин-Акос Таблетки, коробка, 20 шт, 40 мг, для приема внутрь, цвет белый

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Начальная доза — обычно 20 мг каждые 6 ч и возможно ее увеличение до 160 мг каждые 6 ч."}},{"type":"paragraph","data":{"text":"Для профилактики аспирации желудочного сока при общей анестезии — по 40 мг вечером и/или утром перед операцией."}},{"type":"paragraph","data":{"text":"При почечной недостаточности (при Cl креатинина <30 мл/мин или содержании креатинина в сыворотке крови >3 мг/100 мл) суточную дозу препарата необходимо уменьшить до 20 мг."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Редко — головная боль, головокружение, усталость, сухость во рту, отсутствие аппетита, диарея или запор, кожная сыпь."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы: рвота, двигательное возбуждение, тремор, снижение АД, тахикардия, коллапс."}},{"type":"paragraph","data":{"text":"Лечение: при пероральном приеме показана индукция рвоты или/и промывание желудка. Симптоматическая и поддерживающая терапия: при судорогах - в/в диазепам; при брадикардии - атропин; при желудочковых аритмиях - лидокаин. Гемодиализ эффективен.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Антациды нарушают абсорбцию (рекомендуется перерыв между приемом антацидов и фамотидина не менее 1–2 ч)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"С осторожностью применяют у пациентов с нарушениями функции почек и печени."}},{"type":"paragraph","data":{"text":"Перед началом лечения необходимо исключить возможность наличия злокачественного заболевания пищевода, желудка или двенадцатиперстной кишки."}},{"type":"paragraph","data":{"text":"Не изменяет активность микросомальных ферментов печени."}},{"type":"paragraph","data":{"text":"Следует соблюдать интервал между приемом антацидов и фамотидина не менее 1-2 ч."}},{"type":"paragraph","data":{"text":"Клинический опыт применения фамотидина у детей ограничен."}},{"type":"header","data":{"text":"Применение при нарушениях функции почек","level":4}},{"type":"paragraph","data":{"text":"С осторожностью применяют у пациентов с нарушениями функции почек."}},{"type":"header","data":{"text":"Применение при нарушениях функции печени","level":4}},{"type":"paragraph","data":{"text":"С осторожностью применяют у пациентов с нарушениями функции печени."}},{"type":"header","data":{"text":"Применение у детей","level":4}},{"type":"paragraph","data":{"text":"Клинический опыт применения фамотидина у детей ограничен."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nТаблетки, покрытые пленочной оболочкой бледно-коричневого цвета, круглые, двояковыпуклые."}},{"type":"paragraph","data":{"text":"1 таб. Активное вещество: фамотидин 20 мг;"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: крахмал кукурузный, целлюлоза микрокристаллическая, кремния диоксид, тальк, магния стеарат, натрия кроскармеллоза."}},{"type":"paragraph","data":{"text":"Состав оболочки: гипромеллоза, макрогол 6000, титана диоксид (Е171), тальк, краситель железа оксид коричневый."}},{"type":"paragraph","data":{"text":"10 шт. - блистеры (2) - пачки картонные."}},{"type":"paragraph","data":{"text":"10 шт. - блистеры (3) - пачки картонные.\n\n"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре от 15 до 25° С."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное общество \"Акционерное Курганское общество медицинских препаратов и изделий \"Синтез\" (ОАО \"Синтез\"), 640008, Курганская обл., г. Курган, проспект Конституции, д. 7, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ОАО \"Синтез\""}},{"type":"paragraph","data":{"text":"23 сентября 2015 г."}}]}],"source":null},"description_toggle":false,"short_description":"Фамотидин оказывает противоязвенное действие. Блокатор Н2-гистаминовых рецепторов III поколения. Подавляет базальную и стимулированную гистамином, гастрином и ацетилхолином продукцию соляной кислоты. Уменьшает активность пепсина. Усиливает защитные механизмы слизистой оболочки желудка, способствует заживлению связанных с воздействием соляной кислоты ее повреждений (в т. ч. рубцеванию стрессовых язв) и прекращению желудочно-кишечных кровотечений путем увеличения образования желудочной слизи, содержания в ней гликопротеидов, стимуляции секреции гидрокарбоната слизистой оболочкой желудка, эндогенного синтеза в ней простагландинов и скорости регенерации. Существенно не изменяет уровень гастрина в плазме. Слабо ингибирует оксидазную систему цитохрома Р450 в печени. После приема внутрь действие начинается через 1 час, достигает максимума в течение 3 часов. Продолжительность действия препарата при однократном приеме зависит от дозы и составляет от 12 до 24 часов. Фармакокинетика После приема внутрь быстро абсорбируется из желудочно-кишечного тракта, максимальная концентрация в плазме крови достигается в течение 1-3,5 часов. Биодоступность – 40-45%, увеличивается при приеме с пищей и снижается на фоне приема антацидов. Связь с белками плазмы – 15-20%. 30-35% фамотидина метаболизируется в печени (с образованием S-оксида). Проникает в спинномозговую жидкость, через плацентарный барьер, выделяется с грудным молоком. Элиминация, в основном, происходит через почки: 27-40% препарата выводится с мочой в неизмененном виде. Период полувыведения – 2,5-4 часа, у пациентов с клиренсом креатинина ниже 30 мл в минуту увеличивается до 10-12 часов. 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