Токсические поражения печени, в т.ч. алкогольного, вирусного и лекарственного происхождения (антибиотики, противоопухолевые, противотуберкулезные, противовирусные ЛС, трициклические антидепрессанты, пероральные контрацептивы и т.д.).
Противопоказания
Повышенная чувствительность к компонентам препарата Тиотриазолин;
раствор для внутривенного и внутримышечного введения 25 мг/мл; ампула 4 мл с ножом ампульным или скарификатором, если необходим для ампул данного типа, коробка (коробочка) картонная 10; код EAN: 4823000801967; № ЛСР-002170/10, 2010-03-17 от Фармацеутикал Балканс д.о.о. Нови Бечей (Сербия); производитель: Галичфарм АО (Украина); переоформлено
Раствор для в/в и в/м введения прозрачный, бесцветный или со слегка желтоватым оттенком.
Фармакотерапевтическая группа
Антиоксидантное средство
Фармакологические свойства
Антиоксидантный препарат. Фармакологический эффект обусловлен противоишемическими, антиоксидантными, мембраностабилизирующими и иммуномодулирующими свойствами. Предупреждает гибель гепатоцитов, снижает степень их жировой инфильтрации и распространение центролобулярных некрозов печени, способствует процессам регенерации гепатоцитов, нормализует белковый, углеводный, липидный и пигментный обмены. Увеличивает количество синтеза и выделения желчи, нормализует ее химический состав.
Тиотриазолин® усиливает компенсаторную активацию анаэробного гликолиза, снижает угнетение процессов окисления в цикле Кребса с сохранением внутриклеточного фонда АТФ. Препарат активирует антиоксидантную систему и тормозит процессы окисления липидов в ишемизированных участках. Улучшает реологические свойства крови (активирует фибринолитическую систему).
Показания к применению
Хронический алкогольный гепатит минимальной и умеренной активности.
Токсические поражения печени, в т.ч. алкогольного, вирусного и лекарственного происхождения (антибиотики, противоопухолевые, противотуберкулезные, противовирусные ЛС, трициклические антидепрессанты, пероральные контрацептивы и т.д.).
Противопоказания
Повышенная чувствительность к компонентам препарата Тиотриазолин;
детский возраст;
почечная недостаточность;
период беременности и лактации.
Применение при беременности и в период грудного вскармливания
Противопоказано при беременности и кормлении грудью.
Способ применения и дозы
Парентерально.
При хроническом гепатите Тиотриазолин в первые пять дней заболевания вводят внутримышечно по 2 мл 2,5% раствора 2-3- раза в день (2-3 раза по 50 мг), или внутривенно медленно, со скоростью 2 мл/мин по 4 мл 2,5% раствора (100 мг) или капельно со скоростью 20-30 капель в минуту (2 ампулы 2,5% раствора растворяют в 150-250 мл физиологического раствора).
С пятого по двадцатый день лечения назначают Тиотриазолин в таблетках (100 мг 3 раза в день).
Курс лечения – 20-30 дней.
Побочное действие
Тиотриазолин®, как правило, хорошо переносится. При клиническом применении Тиотриазолина® крайне редко возможно развитие следующих побочных реакций:
Со стороны желудочно-кишечного тракта: тошнота, сухость во рту, вздутие живота.
Со стороны центральной и периферической нервной системы: общая слабость, головокружение, шум в ушах.
Со стороны сердечно-сосудистой системы: тахикардия, повышение артериального давления, боль в области сердца, аритмии.
Со стороны дыхательной системы: очень редко - одышка, приступы удушья. аллергические реакции: реакции гиперчувствительности, лихорадка, очень редко - отек Квинке.
Со стороны кожных покровов: зуд, гиперемия кожи, крапивница; местные реакции: в редких случаях чувство покалывания и покраснение в месте введения.
Передозировка
Случаи передозировки неизвестны.
Взаимодействие с другими лекарственными средствами
Тиотриазолин как кардиопротекторный препарат можно применять в комбинации с базисными средствами терапии ишемической болезни сердца.
Как гепатопротекторное средство, может сочетатся с назначением традиционных методов лечения гепатитов соответствующей этиологии.
Особые указания
Отсутствуют.
Форма выпуска
Раствор для инъекций
Условия хранения
В защищенном от света месте, при температуре 15–25 °C
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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