Лоперамид связываясь с опиоидными рецепторами кишечной стенк... Инструкция
Показания к применению
Симптоматическое лечение острой и хронической диареи различного генеза (аллергического эмоционального лекарственного лучевого; при изменении режима питания и качественного состава пищи при нарушении метаболизма и всасывания; как вспомогательное средство при диарее инфекционного генеза). Регуляция стула у пациентов с илеостомой.
Противопоказания
Повышенная чувствительность к препарату непереносимость лактозы дефицит лактазы или глюкозо-галактозная мальабсорбция дивертикулез кишечная непроходимость язвенный колит в стадии обострения диарея на фоне острого псевдомембранозного энтероколита в виде монотерапии - дизентерия и другие инфекции желудочно-кишечного тракта; беременность (I триместр) период ...
Твердые желатиновые капсулы №3, корпус капсулы серого цвета, крышечка капсулы зеленого цвета.
Содержимое капсул - порошок белого или почти белого цвета.
Фармакотерапевтическая группа
Противодиарейное средство
Фармакологические свойства
Фармакодинамика:
Лоперамид связываясь с опиоидными рецепторами кишечной стенки (стимуляция холин- и адренергических нейронов через гуанин-нуклеотиды) снижает тонус и моторику гладкой мускулатуры кишечника замедляет пассаж содержимого кишечника уменьшает выделение жидкости и электролитов с фекалиями. Повышает тонус анального сфинктера способствует удержанию каловых масс и урежению позывов к дефекации. Действие наступает быстро и продолжается 4-6 часов.
Фармакокинетика:
Абсорбция - 40 %. Время необходимое для достижения максимальной концентрации (ТСcmах) - 25 часа. Связь с белками плазмы - 97 %. Период полувыведения - 9-14 ч. Не проникает через гематоэнцефалический барьер. Практически полностью метаболизируется в печени путем конъюгации. Выводится преимущественно кишечником; незначительная часть выводится почками (в виде конъюгированных метаболитов).
Показания к применению
Симптоматическое лечение острой и хронической диареи различного генеза (аллергического эмоционального лекарственного лучевого; при изменении режима питания и качественного состава пищи при нарушении метаболизма и всасывания; как вспомогательное средство при диарее инфекционного генеза). Регуляция стула у пациентов с илеостомой.
Противопоказания
Повышенная чувствительность к препарату непереносимость лактозы дефицит лактазы или глюкозо-галактозная мальабсорбция дивертикулез кишечная непроходимость язвенный колит в стадии обострения диарея на фоне острого псевдомембранозного энтероколита в виде монотерапии - дизентерия и другие инфекции желудочно-кишечного тракта; беременность (I триместр) период лактации лоперамид в капсулах не назначают детям до 6 лет.
С осторожностью
Печеночная недостаточность.
Применение при беременности и в период грудного вскармливания
Во II и III триместрах беременности Лоперамид можно назначать в случаях когда ожидаемая польза терапии для матери превышает потенциальный риск для плода. Поскольку небольшое количество Лоперамида обнаруживается в грудном молоке прием в период грудного вскармливания не рекомендуется.
Способ применения и дозы
Внутрь не разжевывая запивая водой.
Взрослым при острой и хронической диарее первоначально назначают 2 капсулы (0004 г) затем по 1 капсуле (0002 г) после каждого акта дефекации в случае жидкого стула.
При острой диарее детям старше 6 лет назначают по 1 капсуле (0002 г) после каждого акта дефекации в случае жидкого стула.
Максимальная суточная доза. При острой и хронической диарее у взрослых - 8 капсул (0016 г); у детей - 3 капсулы (0006 г).
После нормализации стула или при отсутствии стула более 12 часов лечение Лоперамидом следует прекратить.
Побочное действие
Аллергические реакции (кожная сыпь) сонливость или бессонница головокружение гиповолемия электролитные нарушения; сухость слизистой оболочки полости рта кишечная колика гастралгия боль или дискомфорт в животе тошнота рвота метеоризм. Редко - задержка мочи крайне редко - кишечная непроходимость.
Передозировка
Симптомы: угнетение центральной нервной системы (ступор нарушение координации сонливость миоз мышечная гипертония угнетение дыхания) кишечная непроходимость.
Лечение: антидот - налоксон; учитывая что продолжительность действия лоперамида больше чем у налоксона возможно повторное введение последнего. Симптоматическое лечение: активированный уголь промывание желудка искусственная вентиляция легких.
Необходимо медицинское наблюдение по крайней мере в течение 48 часов.
Взаимодействие с другими лекарственными средствами
Не отмечалось.
Особые указания
При отсутствии эффекта после 2-х суток применения Лоперамида необходимо обратиться к врачу.
Если при лечении развиваются запоры или вздутие живота лоперамид следует отменить.
У пациентов с нарушением функции печени необходим тщательный контроль за признаками токсического поражения ЦНС.
В период лечения диареи необходимо восполнять потерю жидкости и электролитов.
Влияние на способность управлять автомобилем и движущимися механизмами
В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии др. потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций.
Форма выпуска
Капсулы 2 мг.
Условия хранения
Хранить в сухом защищенном от света недоступном для детей месте при температуре не выше 25 °С.
Срок годности
2 года. Не применять по истечении срока годности указанного на упаковке.
Условия отпуска
Без рецепта
Производитель
ООО "Производство Медикаментов"
Организация, принимающая претензии потребителей
ООО "Производство Медикаментов"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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Повышает тонус анального сфинктера способствует удержанию каловых масс и урежению позывов к дефекации. Действие наступает быстро и продолжается 4-6 часов."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Абсорбция - 40 %. Время необходимое для достижения максимальной концентрации (ТСcmах) - 25 часа. Связь с белками плазмы - 97 %. Период полувыведения - 9-14 ч. Не проникает через гематоэнцефалический барьер. Практически полностью метаболизируется в печени путем конъюгации. 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