Бактериальные инфекции вызванные чувствительными к линкомицину микроорганизмами (прежде всего стафилококками и стрептококками особенно микроорганизмами устойчивыми к пенициллинам а также при аллергии к пенициллинам): подострый септический эндокардит абсцесс легкого эмпиема плевры плеврит отит остеомиелит (острый и хронический) гнойный артрит послеоперационные ...
Повышенная чувствительность к линкомицину и другим компонентам препарата беременность (за исключением случаев когда это необходимо по "жизненным" показаниям) тяжелая печеночная и/или почечная недостаточность; дефицит сахаразы/изомальтазы непереносимость фруктозы глюкозо-галактозная мальабсорбция; детский возраст до 12 лет (для данной лекарственной формы)....
Активное вещество: линкомицина гидрохлорид моногидрат (в пересчете на линкомицин) - 250 мг;
вспомогательные вещества: сахароза - 20,16 мг, кальция стеарат - 1,75 мг, крахмал картофельный - достаточное количество до массы содержимого капсулы 350 мг; состав капсулы твердой желатиновой: желатин - 80,751 мг, глицерол (глицерин) - 0,121 мг, вода очищенная - 13,92 мг, титана диоксид - 1,153 мг, натрия лаурилсульфат - 0,055 мг.
Описание
Капсулы твердые желатиновые, белого цвета № 0. Содержимое капсул -порошок белого цвета. Допускается наличие уплотнений капсульной массы в виде столбика или таблетки, которые при легком надавливании стеклянной палочкой рассыпаются.
Фармакотерапевтическая группа
Антибиотик-линкозамид
Фармакологические свойства
Фармакодинамика:
Антибиотик продуцируемый Streptomyces lincolnensis оказывает бактериостатическое действие. Подавляет белковый синтез бактерий вследствие обратимого связывания с 50S-субъединицей рибосом нарушает образование пептидных связей.
Чувствительны invivo: Staphylococcus aureus (пенициллиназопродуцирующие и непродуцирующие штаммы) Streptococcus pneumoniae.
Неэффективен в отношении большинства штаммов Enterococcus faecalis; не действует на Neisseria gonorrhoeae Neisseria meningitidis Haemophilus influenzae и др. грамотрицательные бактерии а также грибы и вирусы.
Оптимум действия находится в щелочной среде (pH 8-85). Устойчивость к линкомицину развивается медленно. В высоких дозах обладает бактерицидным эффектом.
Фармакокинетика:
Абсорбция - 30-40 % (прием пищи замедляет скорость и степень всасывания). Время достижения максимальной концентрации в плазме крови - 2-3 ч. Хорошо проникает в ткани легких печени почек через плацентарный барьер в грудное молоко; в высоких концентрациях обнаруживается в костной ткани и суставах. Через гемато-энцефалический барьер (ГЭБ) линкомицин проникает незначительно при менингите - проницаемость повышается. Частично метаболизируется в печени. Период полувыведения - 5 ч. Выводится в неизмененном виде и в виде метаболитов с желчью и почками.
Показания к применению
Бактериальные инфекции вызванные чувствительными к линкомицину микроорганизмами (прежде всего стафилококками и стрептококками особенно микроорганизмами устойчивыми к пенициллинам а также при аллергии к пенициллинам): подострый септический эндокардит абсцесс легкого эмпиема плевры плеврит отит остеомиелит (острый и хронический) гнойный артрит послеоперационные гнойные осложнения раневая инфекция инфекции кожи и мягких тканей (пиодермия фурункулез флегмона рожистое воспаление).
Противопоказания
Повышенная чувствительность к линкомицину и другим компонентам препарата беременность (за исключением случаев когда это необходимо по "жизненным" показаниям) тяжелая печеночная и/или почечная недостаточность; дефицит сахаразы/изомальтазы непереносимость фруктозы глюкозо-галактозная мальабсорбция; детский возраст до 12 лет (для данной лекарственной формы).
Применение при беременности и в период грудного вскармливания
Не рекомендуется применять препарат в период беременности и лактации. Во втором и третьем триместре беременности возможно назначение препарата только по "жизненным" показаниям. При необходимости применения препарата в период грудного вскармливания необходимо решить вопрос о прекращении грудного вскармливания.
Способ применения и дозы
Внутрь за 1-2 ч до еды.
Для взрослых и детей старше 12 лет по 500 мг 2-3 раза в сутки.
Продолжительность лечения в зависимости от формы и тяжести заболевания составляет 7-14 дней (при остеомиелите - 3 недели и более).
При длительных или повторных курсах лечение следует проводить под контролем функции печени и почек.
Побочное действие
Со стороны пищеварительной системы: глоссит стоматит тошнота рвота диарея зуд ануса; желтуха нарушение функции печени (в т.ч. повышение активности "печеночных" трансаминаз); при длительном применении в больших дозах возможно развитие псевдомембранозного колита.
Со стороны органов кроветворения: нейтропения лейкопения агранулоцитоз тромбоцитопеническая пурпура апластическая анемия панцитопения.
Аллергические реакции: ангионевротический отек сывороточная болезнь анафилактические реакции; многоформная эритема (в некоторых случаях сходная с синдромом Стивенса-Джонсона).
Со стороны кожных покровов: сыпь крапивница эксфолиативный или везикулобуллезный дерматит.
Со стороны мочеполовой системы: нарушение функции почек (азотемия олигурия протеинурия) вагинит.
Со стороны сердечнососудистой системы: остановка дыхания и сердца (при быстром внутривенном введении).
Со стороны органов чувств: шум в ушах вертиго.
При появлении каких-либо побочных эффектов необходимо обратиться к врачу.
Передозировка
Симптомы: усиление побочных эффектов со стороны пищеварительной системы при длительном применении препарата особенно в высоких дозах возможно развитие кандидозной инфекции и псевдомембранозного колита.
Лечение: промывание желудка прием активированного угля симптоматическая терапия плохо удаляется при гемо- и перитонеальном диализе. При развитии псевдомембранозного колита необходимо отменить терапию линкомицином.
Взаимодействие с другими лекарственными средствами
Антагонизм с эритромицином хлорамфениколом ампициллином и другими бактерицидными антибиотиками синергизм - с аминогликозидами.
Противодиарейные лекарственные средства снижают эффект линкомицина (интервал между их применением должен составлять не менее 4 ч).
Усиливает действие лекарственных средств для ингаляционного наркоза миорелаксантов и опиоидных анальгетиков повышая риск нервно-мышечной блокады и остановки дыхания.
При одновременном применении с линкомицином ингибитором цитохрома Р450 сила действия теофиллина может увеличиваться и потребовать снижения его дозы.
Особые указания
На фоне длительного лечения необходим периодический контроль активности "печеночных" трансаминаз и функции почек. Назначение пациентам с печеночной недостаточностью допустимо лишь по "жизненным" показаниям. При появлении признаков псевдомембранозного колита (диарея лейкоцитоз лихорадка боль в животе выделением каловыми массами крови и слизи) в легких случаях достаточно отмены препарата и назначения ионообменных смол (колестирамин) в тяжелых случаях показано возмещение потери жидкости электролитов и белка ванкомицин как раствор для приема внутрь в суточной дозе 05-2 г (за 3-4 приема) в течение 10 дней или бацитрацин.
Препарат в суточной дозе (15 г) содержит 005 ХЕ углеводов что следует учитывать при лечении пациентов с сахарным диабетом.
Влияние на способность управлять автомобилем и движущимися механизмами
Не влияет.
Форма выпуска
Капсулы 250 мг.
Условия хранения
В сухом защищённом от света месте при температуре не выше 25 °С.
Хранить в недоступном для детей месте.
Срок годности
4 года.
Не применять после истечения срока годности указанного на упаковке.
Условия отпуска
По рецепту
Производитель
Республиканское унитарное производственное предприятие "Белмедпрепараты" (РУП "Белмедпрепараты")
Организация, принимающая претензии потребителей
РУП "Белмедпрепараты"
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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30.06.10"}}]},{"id":2,"name":"Торговое название препарата","slug":"","body":[{"type":"paragraph","data":{"text":"Линкомицин"}}]},{"id":3,"name":"Лекарственная форма","slug":"","body":[{"type":"paragraph","data":{"text":"капсулы"}}]},{"id":4,"name":"Состав","slug":"ingredients","body":[{"type":"paragraph","data":{"text":"На одну капсулу:"}},{"type":"paragraph","data":{"text":"Активное вещество: линкомицина гидрохлорид моногидрат (в пересчете на линкомицин) - 250 мг;"}},{"type":"paragraph","data":{"text":"вспомогательные вещества: сахароза - 20,16 мг, кальция стеарат - 1,75 мг, крахмал картофельный - достаточное количество до массы содержимого капсулы 350 мг; состав капсулы твердой желатиновой: желатин - 80,751 мг, глицерол (глицерин) - 0,121 мг, вода очищенная - 13,92 мг, титана диоксид - 1,153 мг, натрия лаурилсульфат - 0,055 мг."}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Капсулы твердые желатиновые, белого цвета № 0. Содержимое капсул -порошок белого цвета. Допускается наличие уплотнений капсульной массы в виде столбика или таблетки, которые при легком надавливании стеклянной палочкой рассыпаются."}}]},{"id":6,"name":"Фармакотерапевтическая группа","slug":"","body":[{"type":"paragraph","data":{"text":"Антибиотик-линкозамид"}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"header","data":{"text":"Фармакодинамика:","level":3}},{"type":"paragraph","data":{"text":"Антибиотик продуцируемый Streptomyces lincolnensis оказывает бактериостатическое действие. Подавляет белковый синтез бактерий вследствие обратимого связывания с 50S-субъединицей рибосом нарушает образование пептидных связей."}},{"type":"paragraph","data":{"text":"Чувствительны invivo: Staphylococcus aureus (пенициллиназопродуцирующие и непродуцирующие штаммы) Streptococcus pneumoniae."}},{"type":"paragraph","data":{"text":"Чувствительны in vitro: аэробные грамположительные кокки - Streptococcus pyogenes Streptococcus spp. группы viridans; аэробные грамположительные палочки - Corynebacterium diphthieriae; анаэробные грамположительные споронеобразующие палочки - Propionibacterium acnes; анаэробные грамположительные спорообразующие палочки - Clostridium tetani Clostridium perfringens."}},{"type":"paragraph","data":{"text":"Неэффективен в отношении большинства штаммов Enterococcus faecalis; не действует на Neisseria gonorrhoeae Neisseria meningitidis Haemophilus influenzae и др. грамотрицательные бактерии а также грибы и вирусы."}},{"type":"paragraph","data":{"text":"Оптимум действия находится в щелочной среде (pH 8-85). Устойчивость к линкомицину развивается медленно. В высоких дозах обладает бактерицидным эффектом."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Абсорбция - 30-40 % (прием пищи замедляет скорость и степень всасывания). Время достижения максимальной концентрации в плазме крови - 2-3 ч. Хорошо проникает в ткани легких печени почек через плацентарный барьер в грудное молоко; в высоких концентрациях обнаруживается в костной ткани и суставах. Через гемато-энцефалический барьер (ГЭБ) линкомицин проникает незначительно при менингите - проницаемость повышается. Частично метаболизируется в печени. Период полувыведения - 5 ч. Выводится в неизмененном виде и в виде метаболитов с желчью и почками."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Бактериальные инфекции вызванные чувствительными к линкомицину микроорганизмами (прежде всего стафилококками и стрептококками особенно микроорганизмами устойчивыми к пенициллинам а также при аллергии к пенициллинам): подострый септический эндокардит абсцесс легкого эмпиема плевры плеврит отит остеомиелит (острый и хронический) гнойный артрит послеоперационные гнойные осложнения раневая инфекция инфекции кожи и мягких тканей (пиодермия фурункулез флегмона рожистое воспаление)."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к линкомицину и другим компонентам препарата беременность (за исключением случаев когда это необходимо по \"жизненным\" показаниям) тяжелая печеночная и/или почечная недостаточность; дефицит сахаразы/изомальтазы непереносимость фруктозы глюкозо-галактозная мальабсорбция; детский возраст до 12 лет (для данной лекарственной формы)."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Сахарный диабет грибковые заболевания кожи слизистой оболочки полости рта влагалища."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Не рекомендуется применять препарат в период беременности и лактации. Во втором и третьем триместре беременности возможно назначение препарата только по \"жизненным\" показаниям. При необходимости применения препарата в период грудного вскармливания необходимо решить вопрос о прекращении грудного вскармливания."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь за 1-2 ч до еды."}},{"type":"paragraph","data":{"text":"Для взрослых и детей старше 12 лет по 500 мг 2-3 раза в сутки."}},{"type":"paragraph","data":{"text":"Продолжительность лечения в зависимости от формы и тяжести заболевания составляет 7-14 дней (при остеомиелите - 3 недели и более)."}},{"type":"paragraph","data":{"text":"При длительных или повторных курсах лечение следует проводить под контролем функции печени и почек."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: глоссит стоматит тошнота рвота диарея зуд ануса; желтуха нарушение функции печени (в т.ч. повышение активности \"печеночных\" трансаминаз); при длительном применении в больших дозах возможно развитие псевдомембранозного колита."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: нейтропения лейкопения агранулоцитоз тромбоцитопеническая пурпура апластическая анемия панцитопения."}},{"type":"paragraph","data":{"text":"Аллергические реакции: ангионевротический отек сывороточная болезнь анафилактические реакции; многоформная эритема (в некоторых случаях сходная с синдромом Стивенса-Джонсона)."}},{"type":"paragraph","data":{"text":"Со стороны кожных покровов: сыпь крапивница эксфолиативный или везикулобуллезный дерматит."}},{"type":"paragraph","data":{"text":"Со стороны мочеполовой системы: нарушение функции почек (азотемия олигурия протеинурия) вагинит."}},{"type":"paragraph","data":{"text":"Со стороны сердечнососудистой системы: остановка дыхания и сердца (при быстром внутривенном введении)."}},{"type":"paragraph","data":{"text":"Со стороны органов чувств: шум в ушах вертиго."}},{"type":"paragraph","data":{"text":"При появлении каких-либо побочных эффектов необходимо обратиться к врачу."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: усиление побочных эффектов со стороны пищеварительной системы при длительном применении препарата особенно в высоких дозах возможно развитие кандидозной инфекции и псевдомембранозного колита."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка прием активированного угля симптоматическая терапия плохо удаляется при гемо- и перитонеальном диализе. При развитии псевдомембранозного колита необходимо отменить терапию линкомицином."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Антагонизм с эритромицином хлорамфениколом ампициллином и другими бактерицидными антибиотиками синергизм - с аминогликозидами."}},{"type":"paragraph","data":{"text":"Противодиарейные лекарственные средства снижают эффект линкомицина (интервал между их применением должен составлять не менее 4 ч)."}},{"type":"paragraph","data":{"text":"Усиливает действие лекарственных средств для ингаляционного наркоза миорелаксантов и опиоидных анальгетиков повышая риск нервно-мышечной блокады и остановки дыхания."}},{"type":"paragraph","data":{"text":"При одновременном применении с линкомицином ингибитором цитохрома Р450 сила действия теофиллина может увеличиваться и потребовать снижения его дозы."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"На фоне длительного лечения необходим периодический контроль активности \"печеночных\" трансаминаз и функции почек. Назначение пациентам с печеночной недостаточностью допустимо лишь по \"жизненным\" показаниям. При появлении признаков псевдомембранозного колита (диарея лейкоцитоз лихорадка боль в животе выделением каловыми массами крови и слизи) в легких случаях достаточно отмены препарата и назначения ионообменных смол (колестирамин) в тяжелых случаях показано возмещение потери жидкости электролитов и белка ванкомицин как раствор для приема внутрь в суточной дозе 05-2 г (за 3-4 приема) в течение 10 дней или бацитрацин."}},{"type":"paragraph","data":{"text":"Препарат в суточной дозе (15 г) содержит 005 ХЕ углеводов что следует учитывать при лечении пациентов с сахарным диабетом."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Не влияет."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Капсулы 250 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом защищённом от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"4 года."}},{"type":"paragraph","data":{"text":"Не применять после истечения срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Республиканское унитарное производственное предприятие \"Белмедпрепараты\" (РУП \"Белмедпрепараты\")"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"РУП \"Белмедпрепараты\""}}]}],"source":null},"description_toggle":false,"short_description":"Антибиотик продуцируемый Streptomyces lincolnensis оказывает бактериостатическое действие. 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Абсорбция - 30-40 % (прием пищи замедляет скорость и степень всасывания). Время достижения максимальной концентрации в плазме крови - 2-3 ч. Хорошо проникает в ткани легких печени почек через плацентарный барьер в грудное молоко; в высоких концентрациях обнаруживается в костной ткани и суставах. Через гемато-энцефалический барьер (ГЭБ) линкомицин проникает незначительно при менингите - проницаемость повышается. Частично метаболизируется в печени. Период полувыведения - 5 ч. 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