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При лечении больных клещевым энцефалитом, гепатитом С, герпесом."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Индивидуальная непереносимость."}},{"type":"paragraph","data":{"text":"Беременность и период лактации, детский возраст."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Противопоказано при беременности и в период лактации."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"При лечении ВИЧ-инфекции или СПИДа, взрослым препарат назначается внутримышечно: 5 мл (15 мг/мл) раствора для внутримышечного введения (75 мг в пересчете на сухое вещество) 2 раза в сутки (150мг), в течение 14 дней. При необходимости через 1-1,5 месяца назначается повторный курс терапии."}},{"type":"paragraph","data":{"text":"При лечении герпеса - 5 мл (15 мг/мл) раствора для внутримышечного введения 2 раза в сутки, в течение 10 дней."}},{"type":"paragraph","data":{"text":"При лечении гепатита С Ферровир вводится внутримышечно 2 раза в сутки по 5 мл (15 мг/мл) раствора для внутримышечного введения в течение 14 дней. В последующие 14 дней препарат вводится в той же суточной дозе через день."}},{"type":"paragraph","data":{"text":"При клещевом энцефалите препарат вводится 2 раза в сутки по 5 мл (15 мг/мл) раствора для внутримышечного введения в течение 5-10 дней."}},{"type":"paragraph","data":{"text":"При использовании внутримышечного раствора по 2 мл производить перерасчет до достижения курсовой дозы 750 - 2100 мг."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Возможно кратковременное повышение температуры тела (до 38°С), гиперемия и умеренная болезненность в месте инъекции."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Негативных явлений от передозировки не выявлено."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Умеренно потенцирует действие антикоагулянтов."}},{"type":"paragraph","data":{"text":"В комплексной терапии снижает токсичность и негативное воздействие применяемых препаратов (головная боль, тошнота и т.д.)"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Для уменьшения болезненности Ферровир вводят внутримышечно медленно, в течение 1-2 мин."}},{"type":"paragraph","data":{"text":"Раствор для инъекций следует полностью использовать сразу после вскрытия флакона, не допускается хранение открытых флаконов."}},{"type":"paragraph","data":{"text":"Внутривенное введение препарата не допускается!"}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутримышечного введения 15 мг/мл во флаконах по 2 мл, 5 мл из нейтрального или темного стекла."}},{"type":"paragraph","data":{"text":"Оригинальная упаковка по 5 флаконов по 5 мл или по 10 флаконов по 2 мл в поддоне-блистере с инструкцией в картонной коробке."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре от +4°С до +20°С. Хранить в местах недоступных для детей."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. Не использовать препарат после истечения срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускается по рецепту врача."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ЗАО «ФП «Техномедсервис»"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ЗАО «ФП «Техномедсервис»"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакодинамика Ферровир представляет собой биологически активное вещество — вытяжку из молок осетровых или лососевых рыб (очищенная и стандартизованная комплексная соль дезоксирибонуклеата натрия с железом). Препарат оказывает противовирусное и иммуномодулирующее действия, активизирует противовирусный, противогрибковый и противомикробный иммунитеты. Проявляет противовирусное действие в отношение различных РНК- и ДНК-содержащих вирусов. Клинический опыт применения препарата показал его высокую активность, хорошую переносимость, отсутствие токсичности (IС50\u003e4000мкг/мл), и нежелательных побочных эффектов. При терапии СПИД/ВИЧ-инфекции 14-ти дневное курсовое применение Ферровира повышает уровень СD4+лимфоцитов в крови. Это повышение продолжается в течение 1-1,5 месяца после окончания курса лечения. Одновременно снижается вирусная нагрузка в организме, выражающаяся в снижении концентрации РНК ВИЧ в сравнении с исходным уровнем. При рецидивирующей герпетической инфекции сокращается тяжесть и продолжительность рецидива, наступает быстрая и длительная ремиссия после 10-ти дневного курсового лечения. Применение Ферровира в комплексном лечении больных хроническим гепатитом С способствует улучшению переносимости лечения (уменьшение головокружения, тошноты и т.д.), снижению репликативной активности всех генотипов вируса HCV, переведению процесса в латентную фазу с восстановлением клеток печени и отсутствием вирусной репликации. Препарат характеризуется высокой степенью активности при совместном присутствии вирусов основного и оппортунистического заболеваний. Химиотерапевтический индекс препарата -более 20, что характерно для высокоактивных лекарственных средств. Фармакокинетика При внутримышечном введении рекомендуемой дозы, препарат быстро всасывается и распределяется в органах и тканях с участием эндолимфатического пути транспорта; обладает высокой тропностью к органам кроветворной системы; принимает активное участие в клеточном метаболизме, встраиваясь в клеточные структуры. В процессе ежедневного курсового применения обладает свойством кумулироваться в органах и тканях. Время достижения максимальной концентрации при одноразовом введении - 0,5 часа, после чего начинается снижение концентрации препарата в крови, связанное с его распределением в органах и тканях. При многократном введении препарата каждые 24 часа в течение 4 суток, наблюдается наибольшее его накопление в селезенке, лимфоузлах и костном мозге. После 5-го введения концентрация препарата при последующих введениях во всех органах и тканях не повышается, наблюдается его постепенное снижение. Метаболизм и выведение Препарат экскретируется из организма (в виде метаболитов), частично с калом и в большей степени - с мочой. Среднее время удержания препарата в органах и тканях - 72 часа. 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