Бесцветная или почти бесцветная прозрачная жидкость.
Фармакологические свойства
Противоконгестивное средство - вазоконстриктор (альфа-адреномиметик)АТХ:
R.01.A.A.07 Ксилометазолин
Фармакодинамика:Ксилометазолин является производным имидазола с симпатомиметическим действием. В низких концентрациях действует наα2-адренорецепторы, а в высоких концентрациях оказывает действие на α1-адренорецепторы.
При местном применении ксилометазолин вызывает сужение кровеносных сосудов слизистой оболочки, что приводит к уменьшению отека и гиперемии слизистых оболочек носоглотки, уменьшению количества отделяемого, облегчению носового дыхания.
Фармакокинетика:
При местном применении практически не абсорбируется, концентрации в плазме настолько малы, что их невозможно определить современными аналитическими методами. Действие наступает через 5-10 минут, и сохраняется на протяжении 5-6 часов.
Показания к применению
острый ринит вирусного или бактериального генеза;
- аллергический ринит;
- острый или хронический синусит;
- поллиноз;
- средний отит - с целью уменьшения отека слизистой оболочки носоглотки.
Противопоказания
- повышенная чувствительность к компонентам препарата;
- атрофический ринит;
- закрытоугольная глаукома;
- артериальная гипертензия;
- выраженный атеросклероз;
- тахикардия;
- гипертиреоз;
- беременность;
- хирургические вмешательства на мозговых оболочках (в анамнезе);
- детский возраст до 6 лет (для 0,1 % раствора) и до 2 лет (для 0,05 % раствора);
- одновременный прием ингибиторов моноаминооксидазы (МАО) и период до 14 дней после окончания их применения.
С осторожностью
- период лактации;
- сахарный диабет;
- стенокардия III - IV функционального класса;
- гиперплазия предстательной железы;
- феохромоцитома.
Способ применения и дозы
0,05 % капли назальные
Дети в возрасте от 2 до 6 лет: средняя доза составляет 1 - 2 капли в каждый носовой ход 1-2 раза в сутки.
0,1 % капли назальные
Взрослые и дети старше 6 лет: средняя доза составляет 2-3 капли в каждый носовой ход 2-3 раза в сутки.
Не следует применять препарат более 3-х раз в сутки.
Продолжительность применения препарата - не более 3-5 дней.
Редко - отек слизистой оболочки полости носа, сердцебиение, тахикардия, аритмии, повышение АД, головная боль, рвота, бессонница, нарушение зрения; депрессия (при длительном применении в высоких дозах).
Передозировка
Не отмечены случаи передозировки лекарственным препаратом у взрослых.
В случае применения слишком большой дозы или неправильного применения может наступить заглатывание капель и всасывание действующего вещества из желудочно-кишечного тракта. Такие ситуации, в основном, наблюдались у детей. В таком случае, основным побочным действием был выраженный седативный эффект.
При случайном проглатывании препарата (чаще у детей) отмечается тахикардия, аритмия, повышение артериального давления, сонливость, спутанность сознания, угнетение дыхания или нерегулярное дыхание. Лечение симптоматическое.
Взаимодействие с другими лекарственными средствами
Несовместим с ингибиторами МАО и трициклическими антидепрессантами.
Особые указания
Перед применением необходимо очистить носовые ходы.
Не следует применять препарат у пациентов с хроническим или вазомоторным ринитом, поскольку у них отмечается тенденция к применению препарата дольше 2 недель.
Продолжительное применение лекарственного препарата (более 2 недель) может привести к вторичному расширению кровеносных сосудов и впоследствии к ятрогенному риниту (rhinitis medicamentosa). Причиной данного заболевания является угнетение высвобождения норадреналина из нервных окончаний посредством возбуждения пресинаптических α2-рецепторов.
Влияние на способность управлять автомобилем и движущимися механизмами
Не оказывает влияние на способность к управлению транспортными средствами и обслуживанию движущихся механизмов.
Форма выпуска
Капли назальные 0,05 % и 0,1 %.
Упаковка:10 мл препарата помещают в полиэтиленовый флакон со встроенной капельницей и навинчиваемой крышкой или навинчиваемой крышкой с контролем первого вскрытия.
Флакон вместе с инструкцией по применению помещают в картонную пачку.
Условия хранения
В защищенном от света месте при температуре от 15 до 25 °С. Хранить в недоступном для детей месте.
Срок годности
4 года. Срок хранения после первого вскрытия флакона - 12 недель. Не использовать по истечении срока годности, указанного на упаковке.
Условия отпуска
Без рецепта
Производитель
Польша,Варшавский фармацевтический завод.
Для описания товара использована информация от партнера 36.6
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дигидрофосфата моногидрат, натрия хлорид, динатрия эдетат, бензалкония хлорида раствор, сорбитол, вода очищенная. "}}]},{"id":5,"name":"Описание","slug":"common_description","body":[{"type":"paragraph","data":{"text":"Бесцветная или почти бесцветная прозрачная жидкость."}}]},{"id":7,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"Противоконгестивное средство - вазоконстриктор (альфа-адреномиметик)АТХ: "}},{"type":"paragraph","data":{"text":"R.01.A.A.07 Ксилометазолин"}},{"type":"paragraph","data":{"text":"Фармакодинамика:Ксилометазолин является производным имидазола с симпатомиметическим действием. В низких концентрациях действует наα\u003csub\u003e2\u003c/sub\u003e-адренорецепторы, а в высоких концентрациях оказывает действие на α\u003csub\u003e1\u003c/sub\u003e-адренорецепторы."}},{"type":"paragraph","data":{"text":"При местном применении \u003ca target=\"_blank\" href=\"http://www.lsgeotar.ru/pharma_mnn/1330.html?XFrom=www.lsgeotar.ru\"\u003eксилометазолин\u003c/a\u003e вызывает сужение кровеносных сосудов слизистой оболочки, что приводит к уменьшению отека и гиперемии слизистых оболочек носоглотки, уменьшению количества отделяемого, облегчению носового дыхания."}},{"type":"paragraph","data":{"text":"Фармакокинетика:"}},{"type":"paragraph","data":{"text":"При местном применении практически не абсорбируется, концентрации в плазме настолько малы, что их невозможно определить современными аналитическими методами. 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Такие ситуации, в основном, наблюдались у детей. В таком случае, основным побочным действием был выраженный седативный эффект."}},{"type":"paragraph","data":{"text":"При случайном проглатывании препарата (чаще у детей) отмечается тахикардия, аритмия, повышение артериального давления, сонливость, спутанность сознания, угнетение дыхания или нерегулярное дыхание. 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