Индивидуальная повышенная чувствительность к компонентам препарата угнетение костномозгового кроветворения острая интермиттируюшая порфирия заболевания кожи (псориаз экзема грибковые поражения) беременность и период лактации детский возраст до 3-х лет и/или с массой тела менее 20 кг выраженные нарушения печени и/или почек дефицит глюкозо-6-фосфатдегидрогеназы....
Таблетки белого или белого со слабым желтоватым оттенком цвета плоскоцилиндрической формы с фаской и риской.
Фармакотерапевтическая группа
Антибиотик
Фармакологические свойства
Антибиотик широкого спектра действия. Механизм противомикробного действия связан с нарушением синтеза белка в микробной клетке на стадии переноса аминокислот т-РНК на рибосомы. Оказывает бактериостатическое действие. Активен в отношении грамположительных бактерий: Staphylococcus spp., Streptococcus spp.; грамотрицательных бактерий: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; активен также в отношении Spirochaetaceae, некоторых крупных вирусов.
Хлорамфеникол активен в отношении штаммов, устойчивых к пенициллину, стрептомицину, сульфаниламидам.
Устойчивость микроорганизмов к хлорамфениколу развивается относительно медленно.
Индивидуальная повышенная чувствительность к компонентам препарата угнетение костномозгового кроветворения острая интермиттируюшая порфирия заболевания кожи (псориаз экзема грибковые поражения) беременность и период лактации детский возраст до 3-х лет и/или с массой тела менее 20 кг выраженные нарушения печени и/или почек дефицит глюкозо-6-фосфатдегидрогеназы.
С осторожностью
С осторожностью назначают хлорамфеникол пациентам получавшим ранее лечение цитостатическими препаратами или лучевую терапию.
Применение при беременности и в период грудного вскармливания
Хлорамфеникол противопоказан к применению при беременности и в период лактации (грудного вскармливания).
Способ применения и дозы
Внутрь за 30 мин до еды.
Взрослым - по 250-500 мг 3-4 раза в день. Суточная доза - 2000 мг. При тяжелых формах инфекций в условиях стационара возможно повышение дозы до 3000-4000 мг/сут (максимальная суточная доза для взрослых под строгим контролем состояния крови и функции печени и почек).
Детям с 3-х лет и/или массой тела более 20 кг - по 25 мг/кг каждые 12 ч. При тяжелом течении инфекции - до 75 мг/кг/сут. Средняя продолжительность курса лечения -8-10 дней.
Побочное действие
Со стороны пищеварительной системы: раздражение слизистой оболочки полости рта и зева диспепсия тошнота рвота (вероятность развития снижается при приеме через 1 ч после еды) диарея дерматит дисбактериоз (подавление нормальной микрофлоры).
Со стороны органов кроветворения: ретикулоцитопения лейкопения гранулоцитопения тромбоцитопения эритроцитопения; редко - апластическая анемия агранулоцитоз.
Со стороны нервной системы: психомоторные расстройства депрессия спутанность сознания периферический неврит неврит зрительного нерва зрительные и слуховые галлюцинации снижение остроты зрения и слуха головная боль.
Аллергические реакции: кожная сыпь ангионевротический отек.
Прочие: вторичная грибковая инфекция.
Передозировка
Данных по передозировке у взрослых нет.
Взаимодействие с другими лекарственными средствами
При одновременном применении с фенобарбиталом фенитоином. непрямыми антикоагулянтами отмечается ослабление метаболизма этих лекарственных средств замедление выведения и повышение их концентрации в плазме (подавляет ферментную систему цитохрома Р450).
При одновременном применении с препаратами угнетающими костномозговое кроветворение с лучевой терапией увеличивается риск развития побочного действия.
При одновременном применении с эритромицином клиндамицином линкомицином отмечается взаимное ослабление действия за счет того что левомицетин может вытеснять эти препараты из связанного состояния или препятствовать их связыванию с субъединицей 50S бактериальных рибосом.
При одновременном приеме этанола возможно развитие дисульфирамовой реакции.
Снижает антибактериальный эффект пенициллинов и цефалоспоринов. Миелотоксические лекарственные средства усиливают проявление гематотоксичности препарата.
При назначении с пероральными гипогликемическими препаратами отмечается усиление их действия за счет подавления метаболизма этих препаратов в печени и повышения их концентрации в плазме крови.
Особые указания
Вследствие высокой токсичности не рекомендуется без необходимости применять для лечения и профилактики банальных инфекций простудных заболеваний гриппа фарингита бактерионосительства. Тяжелые осложнения со стороны кроветворной системы как правило связаны с применением больших доз (более 4 г/сут) длительное время.
При одновременном приеме алкоголя возможно развитие дисульфирамовой реакции (гиперемия кожных покровов тахикардия тошнота рвота рефлекторный кашель судороги).
В процессе лечения необходим систематический контроль картины периферической крови.
Форма выпуска
Таблетки 250 мг
Условия хранения
В защищенном от света месте при температуре не выше 30 °С.
Хранить в недоступном для детей месте.
Срок годности
5 лет. Не использовать позже срока указанного на упаковке.
Условия отпуска
По рецепту
Производитель
ОАО "Органика"
Организация, принимающая претензии потребителей
ОАО "Органика"
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Механизм противомикробного действия связан с нарушением синтеза белка в микробной клетке на стадии переноса аминокислот т-РНК на рибосомы. Оказывает бактериостатическое действие. Активен в отношении грамположительных бактерий: Staphylococcus spp., Streptococcus spp.; грамотрицательных бактерий: Neisseria gonorrhoeae, Neisseria meningitidis, Escherichia coli, Haemophilus influenzae, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp., Rickettsia spp.; активен также в отношении Spirochaetaceae, некоторых крупных вирусов."}},{"type":"paragraph","data":{"text":"Хлорамфеникол активен в отношении штаммов, устойчивых к пенициллину, стрептомицину, сульфаниламидам."}},{"type":"paragraph","data":{"text":"Устойчивость микроорганизмов к хлорамфениколу развивается относительно медленно."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Инфекционно-воспалительные заболевания вызванные чувствительными микроорганизмами инфекции мочевыводящих путей инфекции желчевыводящих путей."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Индивидуальная повышенная чувствительность к компонентам препарата угнетение костномозгового кроветворения острая интермиттируюшая порфирия заболевания кожи (псориаз экзема грибковые поражения) беременность и период лактации детский возраст до 3-х лет и/или с массой тела менее 20 кг выраженные нарушения печени и/или почек дефицит глюкозо-6-фосфатдегидрогеназы."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"С осторожностью назначают хлорамфеникол пациентам получавшим ранее лечение цитостатическими препаратами или лучевую терапию."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Хлорамфеникол противопоказан к применению при беременности и в период лактации (грудного вскармливания)."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь за 30 мин до еды."}},{"type":"paragraph","data":{"text":"Взрослым - по 250-500 мг 3-4 раза в день. Суточная доза - 2000 мг. При тяжелых формах инфекций в условиях стационара возможно повышение дозы до 3000-4000 мг/сут (максимальная суточная доза для взрослых под строгим контролем состояния крови и функции печени и почек)."}},{"type":"paragraph","data":{"text":"Детям с 3-х лет и/или массой тела более 20 кг - по 25 мг/кг каждые 12 ч. При тяжелом течении инфекции - до 75 мг/кг/сут. 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Миелотоксические лекарственные средства усиливают проявление гематотоксичности препарата."}},{"type":"paragraph","data":{"text":"При назначении с пероральными гипогликемическими препаратами отмечается усиление их действия за счет подавления метаболизма этих препаратов в печени и повышения их концентрации в плазме крови."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Вследствие высокой токсичности не рекомендуется без необходимости применять для лечения и профилактики банальных инфекций простудных заболеваний гриппа фарингита бактерионосительства. Тяжелые осложнения со стороны кроветворной системы как правило связаны с применением больших доз (более 4 г/сут) длительное время."}},{"type":"paragraph","data":{"text":"При одновременном приеме алкоголя возможно развитие дисульфирамовой реакции (гиперемия кожных покровов тахикардия тошнота рвота рефлекторный кашель судороги)."}},{"type":"paragraph","data":{"text":"В процессе лечения необходим систематический контроль картины периферической крови."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 250 мг"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В защищенном от света месте при температуре не выше 30 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. 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