Кофеин-бензоат натрия Таблетки, 6 шт, 100 мг

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Стимулирует сосудодвигательный центр и оказывает непосредственное релаксирующее действие на сосудистую стенку, что приводит к расширению сосудов сердца, скелетных мышц и почек, при этом тонус церебральных артерий повышается (вызывает сужение сосудов головного мозга, что сопровождается снижением мозгового кровотока и давления кислорода в головном мозге)."}},{"type":"paragraph","data":{"text":"АД изменяется под действием сосудистых и сердечных механизмов влияния кофеина: при нормальном исходном АД кофеин не изменяет или слегка повышает его, при артериальной гипотензии нормализует его."}},{"type":"paragraph","data":{"text":"Оказывает спазмолитическое действие на гладкую мускулатуру (в т.ч. бронходилатирующий эффект), на поперечнополосатую - стимулирующее."}},{"type":"paragraph","data":{"text":"Повышает секреторную активность желудка."}},{"type":"paragraph","data":{"text":"Оказывает умеренное диуретическое действие, что обусловлено снижением реабсорбции ионов натрия и воды в проксимальных и дистальных почечных канальцах, а также расширение сосудов почек и увеличение фильтрации в почечных клубочках."}},{"type":"paragraph","data":{"text":"Снижает агрегацию тромбоцитов и высвобождение гистамина из тучных клеток."}},{"type":"paragraph","data":{"text":"Повышает основной обмен: увеличивает гликогенолиз, повышает липолиз."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Снижение умственной и физической работоспособности сонливость головная боль сосудистого генеза (в т.ч. мигрень) умеренная артериальная гипотензия."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Гиперчувствительность к компонентам препарата (в т.ч. к другим ксантинам) тревожные расстройства (агорафобия панические расстройства) органические заболевания сердечно­сосудистой системы (в т.ч. острый инфаркт миокарда атеросклероз) пароксизмальная тахикардия желудочковая экстрасистолия артериальная гипертензия нарушения сна детский возраст до 12 лет."}}]},{"id":10,"name":"С осторожностью","slug":"cautions","body":[{"type":"paragraph","data":{"text":"Глаукома повышенная возбудимость пожилой возраст эпилепсия и склонность к судорожным припадкам."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"Использование возможно только после консультации с врачом если ожидаемая польза для матери превышает потенциальный риск для плода."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Назначают внутрь независимо от приема пищи. Не принимать перед сном."}},{"type":"paragraph","data":{"text":"При снижении умственной и физической работоспособности сонливости - взрослым и детям старше 12 лет - по 50 - 100 мг 2-3 раза в день. Курс лечения от нескольких недель до нескольких месяцев в зависимости от состояния больного."}},{"type":"paragraph","data":{"text":"При головной боли сосудистого генеза (в т.ч. мигрень) - взрослым и детям старше 12 лет - по 50-100 мг 2-3 раза в день в течение несколышх дней."}},{"type":"paragraph","data":{"text":"При умеренной артериальной гипотензии - взрослым и детям старше 12 лет - по 50 - 100 мг 2-3 раза в день. Курс лечения несколько недель."}},{"type":"paragraph","data":{"text":"Высшая разовая доза для взрослых - 300 мг высшая суточная доза для взрослых - 1000 мг;"}},{"type":"paragraph","data":{"text":"Высшая разовая доза для детей с 12 лет - 150 мг высшая суточная доза для детей - 500 мг."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны центральной нервной системы: психомоторное возбуждение тревога тремор беспокойство головная боль головокружение эпилептические припадки усиление рефлек­сов тахипноэ бессонница; при внезапной отмене - усиление торможения центральной нервной системы повышенная утомляемость сонливость мышечное напряжение."}},{"type":"paragraph","data":{"text":"Со стороны сердечнососудистой системы: ощущение сердцебиения тахикардия повышение артериального давления."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота рвота обострение язвенной болезни."}},{"type":"paragraph","data":{"text":"Прочие: заложенность носа при длительном применении - привыкание лекарственная зависимость."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: гастралгия ажитация тревога возбуждение двигательное беспокойство спутанность сознания делирий обезвоживание тахикардия аритмия гипертермия учащенное мочеиспускание головная боль повышенная тактильная или болевая чувствительность тремор или мышечные подергивания; тошнота и рвота иногда с кровью; звон в ушах судороги (при острой передозировке - тонико-клонические)."}},{"type":"paragraph","data":{"text":"Кофеин в дозах более 300 мг/сут (в т.ч. на фоне злоупотребления кофе - более 4 чашек натурального кофе по 150 мл) может вызывать состояние тревоги тремор головную боль спутанность сознания экстрасистолию."}},{"type":"paragraph","data":{"text":"Лечение: промывание желудка; - если кофеин был принят в последние 4 ч в дозе более 15 мг/кг и не было рвоты вызванной кофеином; прием активированного угля слабительных лекарственных средств; при геморрагическом гастрите - введение антацидных лекарственных средств и промывание желудка ледяным 09 % раствором натрия хлорида; поддержание вентиляции легких и оксигенации; при судорогах - в/в диазепам фенобарбитал или фенитоин; поддержание водно-электролитного баланса."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Кофеин является антагонистом аденозина (могут потребоваться большие дозы аденозина)."}},{"type":"paragraph","data":{"text":"При совместном применении кофеина и барбитуратов примидона противосудорожньк лекарственных средств (производные гидантоина особенно фенитоин) возможно усиление метаболизма и увеличение клиренса кофеина; циметидина пероральных контрацептивов дисульфирама ципрофлоксацина норфлоксацина - снижение метаболизма кофеина в печени .. (замедление его выведения и увеличение концентрации в крови)."}},{"type":"paragraph","data":{"text":"Кофеинсодержащие напитки и другие лекарственные средства стимулирующие центральнyю нервную систему - возможна чрезмерная стимуляция центральной нервной системы."}},{"type":"paragraph","data":{"text":"Мексилетин - снижает выведение кофеина на 50 %; никотин - увеличивает скорость выведения кофеина."}},{"type":"paragraph","data":{"text":"Ингибиторы моноаминоксидазы фуразолидон прокарбазин и селегилин - большие дозы кофеина (более 300 мг/сут) могут вызывать развитие жизнеугрожающих аритмий сердца или - выраженного повышения артериального давления."}},{"type":"paragraph","data":{"text":"Кофеин снижает всасывание препаратов кальция в желудочно-кишечном тракте."}},{"type":"paragraph","data":{"text":"Снижает эффективность наркотических и снотворных лекарственных средств."}},{"type":"paragraph","data":{"text":"Увеличивает выведение препаратов лития с мочой;"}},{"type":"paragraph","data":{"text":"Ускоряет всасывание и усиливает действие сердечных гликозидов повышает их токсичность. Совместное применение с бета-адреноблокаторами может приводить к взаимному подавлению терапевтических эффектов; с β-адреномиметиками - к дополнительной стимуляции центральной нервной системы и другим аддитивным токсическим эффектам."}},{"type":"paragraph","data":{"text":"Кофеин может снижать клиренс; теофиллина и возможно других ксантинов увеличивая возможность аддитивных фармакодинамических и токсических эффектов."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Следует иметь в виду что внезапное прекращение приема может приводить к усилению торможения центральной нервной системы (сонливость депрессия)."}},{"type":"paragraph","data":{"text":"Влияние на центральную нервную систему зависит от типа нервной системы и может проявляться как возбуждением так и торможением высшей нервной деятельности."}},{"type":"paragraph","data":{"text":"В связи с тем что действие кофеина на артериальное давление складывается из сосудистого и кардиального компонентов в результате может развиваться как эффект стимуляции сердца так и угнетение (слабое) его деятельности."}},{"type":"paragraph","data":{"text":"Не принимать перед сном."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения необходимо соблюдать осторожность при вождении автотранспорта и занятии друтами потенциально опасными видами деятельности требующими концентрации внимания и быстрота психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Таблетки 100 мг."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом защищенном от света месте при температуре не выше 25 °С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. Не использовать по истечении срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное общество \"Татхимфармпрепараты\" (ОАО \"Татхимфармпрепараты\" )"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ОАО \"Татхимфармпрепараты\""}}]}],"source":null},"description_toggle":false,"short_description":"Психостимулирующее и аналептическое средство, производное метилксантина. Конкурентно блокирует центральные и периферические А1 и А2 аденозиновые рецепторы. Тормозит активность ФДЭ в ЦНС, сердце, гладкомышечных органах, скелетных мышцах, жировой ткани, способствует накоплению в них цАМФ и цГМФ (данный эффект наблюдается при применении только в высоких дозах). Стимулирует центры продолговатого мозга (дыхательный и сосудодвигательный), а также центр n.vagus, оказывает прямое возбуждающее влияние на кору головного мозга. В высоких дозах облегчает межнейрональную проводимость в спинном мозге, усиливая спинномозговые рефлексы. Повышает умственную и физическую работоспособность, стимулирует психическую деятельность, двигательную активность, укорачивает время реакций, временно уменьшает утомление и сонливость. В малых дозах преобладает эффект стимуляции, а в больших - эффект угнетения нервной системы. Учащает и углубляет дыхание. Обычно оказывает положительный ино-, хроно-, батмо- и дромотропный эффект (поскольку влияние на ССС складывается из прямого стимулирующего действия на миокард и одновременного возбуждающего влияния на центры n.vagus, результирующий эффект зависит от преобладания того или иного действия). Стимулирует сосудодвигательный центр и оказывает непосредственное релаксирующее действие на сосудистую стенку, что приводит к расширению сосудов сердца, скелетных мышц и почек, при этом тонус церебральных артерий повышается (вызывает сужение сосудов головного мозга, что сопровождается снижением мозгового кровотока и давления кислорода в головном мозге). АД изменяется под действием сосудистых и сердечных механизмов влияния кофеина: при нормальном исходном АД кофеин не изменяет или слегка повышает его, при артериальной гипотензии нормализует его. Оказывает спазмолитическое действие на гладкую мускулатуру (в т.ч. бронходилатирующий эффект), на поперечнополосатую - стимулирующее. Повышает секреторную активность желудка. Оказывает умеренное диуретическое действие, что обусловлено снижением реабсорбции ионов натрия и воды в проксимальных и дистальных почечных канальцах, а также расширение сосудов почек и увеличение фильтрации в почечных клубочках. Снижает агрегацию тромбоцитов и высвобождение гистамина из тучных клеток. 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