транзиторные ишемические атаки и другие нарушения мозгового кровообращения;
атеросклероз коронарных сосудов, гиперхолестеринемия и гипертриглицеридемия;
внутриутробная и послеродовая асфиксия плода;
мигрень, синдром Меньера.
Противопоказания
острое кровотечение;
геморрагический инсульт;
острый инфаркт миокарда;
митральный стеноз;
острая сердечная недостаточность;
хроническая сердечная недостаточность в стадии декомпенсации;
артериальная гипотензия;
язвенная болезнь желудка и двенадцатиперстной кишки в фазе обострения;
острая почечная недостаточность;
глаукома;
беременность (особенно I триместер);
грудное вскармливание;
повышенная чувствительность к ксантинола никотинату.
Способ применения и дозы
Применяют внутримышечно и внутривенно.
Взрослым внутримышечно вводят в дозе 300 - 900 мг (2 – 6 мл 15% раствора) в сутки ежедневно, в течение 2 - 3 недель.
Внутривенно струйно медленно вводят, в дозе 1 – 2 мл 15% раствора 1 - 2 раза/сут, в течение 5 - 10 дней (пациент должен находиться в горизонтальном положении).
Внутривенно капельно вводят со скоростью 40 - 50 кап/мин, доза составляет в среднем 150 – 900 мг. Разводят 15% раствором до 10 мл в растворе декстрозы 5% от 200 до 500 мл или в растворе натрия хлорида 0,9% до 200 мл.
При острых нарушениях кровоснабжения тканей одновременно с парентеральным введением ксантинола никотината применяют внутрь по 300 мг 3 раза/сут.
при длительном применении – нарушение толерантности к глюкозе, повышение уровня трансаминаз и щелочной фосфатазы, мочевой кислоты в сыворотке крови;
аллергические реакции.
Передозировка
Симптомы интоксикации возникают через 4 - 5 ч после введения ксантинола никотината и продолжаются на протяжении 12 ч.
Вначале возможны приливы жара, гиперемия верхней половины туловища, тошнота, головокружение, тахикардия, снижение артериального давления; в дальнейшем – повышение температуры, возбуждение, потеря сознания, арефлексия, тонико-клонические судороги, рвота.
Специфического антидота не существует. Меры помощи включают отмену лекарственного средства, поддерживающую и симптоматическую терапию, направленную на устранение возникших нарушений, респираторную поддержку, контроль уровня артериального давления и купирование судорожного синдрома.
Взаимодействие с другими лекарственными средствами
При одновременном применении с лекарственными средствами, оказывающими гипотензивное действие (бета-адреноблокаторы, алкалоиды спорыньи, альфа-адреноблокаторы, симпатолитики, ганглиоблокаторы), со строфантином возможно резкое усиление их действия.
При одновременном применении ксантинола никотината с лекарственными средствами теофиллина наблюдается увеличение концентрации теофиллина в плазме крови и возрастание риска его токсического действия.
Противосудорожные средства (карбамазепин, дифенин), барбитуровые лекарственные средства ускоряют метаболизм ксантинола никотината и снижают его концентрации в плазме.
Комбинированные оральные контрацептивы, макролидные антибиотики (кларитромицин, эритромицин), лекарственные средства интерферона и противогрибковые средства (кетоконазол, флуконазол) изменяют выраженность эффекта ксантинола никотината, замедляют его метаболизм и повышают концентрацию лекарственного средства в плазме.
При использовании ксантинола никотината у курящих лиц его концентрации в плазме крови ниже, чем у некурящих пациентов.
Особые указания
С осторожностью применяют при лабильном артериальном давлении.
С особой осторожностью применяют одновременно с гипотензивными лекарственными средствами.
Влияние на способность к вождению автотранспорта и управление механизмами.
С осторожностью применять у водителей транспортных средств, а также у пациентов, занимающихся потенциально опасными видами деятельности.
Для описания товара использована информация от партнера 36.6
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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