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Активен в отношении Haemophilus influenzae некоторых штаммов Enterobacter spp. и Enterococcus spp.Неэффективен в отношении Pseudomonas aeruginosa индолположительных штаммов Proteus spp. Mycobacterium tuberculosis Serratia spp. анаэробных микроорганизмов метициллин-устойчивых штаммов Staphylococcus spp."}},{"type":"header","data":{"text":"Фармакокинетика:","level":3}},{"type":"paragraph","data":{"text":"Время достижения максимальной концентрации (ТСmах) при внутримышечном введении в дозе 0.5 и 1 г соответственно - 2 и 1 ч; максимальная концентрация (Сmах) - 38 и 64 мкг/мл; после внутривенного введения ТСшах - в конце инфузии после внутривенного введения 1 г Сmах - 180 мкг/мл. Проникает в суставы ткани сердца и сосудов в брюшную полость почки и мочевыводящие пути плаценту среднее ухо дыхательные пути кожу и мягкие ткани. В небольших количествах выделяется с грудным молоком. Концентрация в ткани желчного пузыря и желчи значительно выше чем в сыворотке крови. 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Для профилактики послеоперационной инфекции -внутривенно 1 г за 05-1 ч до операции 05-1 г - во время операции и по 05-1 г - каждые 8 ч в течение первых суток после операции."}},{"type":"paragraph","data":{"text":"Больным с нарушениями функции почек требуется изменение режима дозирования в соответствии со значениями клиренса креатинина (КК): при КК 55 мл/мин и более или при концентрации креатинина в плазме 15 мг% и менее можно вводить полную дозу; при КК 54-35 мл/мин или концентрации креатинина в плазме 3-16 мг% можно вводить полную дозу но интервалы между инъекциями необходимо увеличить до 8 ч; при КК 34-11 мл/мин или концентрации креатинина в плазме 45-31 мг% - 1/2 дозы с интервалами 12 ч; при КК 10 мл/мин и менее или при концентрации креатинина в плазме 46 мг% и более - 1/2 обычной дозы каждые 18-24 ч. Все рекомендуемые дозы вводят после начальной дозы 05 г. Детям 1 мес и старше - 25-50 мг/кг/сут; при тяжелом течении инфекции доза может быть увеличена до 100 мг/кг/сут. Кратность введения - 3-4 раза в сутки. У детей с нарушениями функции почек коррекцию режима дозирования проводят в зависимости от значений КК: при КК 70-40 мл/мин - 60 % от средней суточной дозы и вводят каждые 12 ч; при КК 40-20 мл/мин - 25 % средней суточной дозы с интервалом в 12 ч; при КК 5-20 мл/мин - 10 % средней суточной дозы каждые 24 ч. Все рекомендуемые дозы вводят после начальной дозы. Для внутримышечного введения 0.5 г препарата растворяют в 2-3 мл раствора натрия хлорида 09 % раствора прокаина 025-05 % или воды для инъекций 1 г - в 4-5 мл раствора натрия хлорида 09 % раствора прокаина 025-05 % или воды для инъекций. Полученный раствор вводят глубоко в мышцу."}},{"type":"paragraph","data":{"text":"Для внутривенного струйного введения разовую дозу препарата разводят в 10 мл раствора натрия хлорида 09 % и вводят медленно в течение 3-5 минут. При внутривенном капельном введении препарата (05 г и 1 г) разводят в 100-250 мл раствора натрия хлорида 09 % или раствора декстрозы 5 % и вводят в течение 20-30 минут (скорость введения 60-80 капель в 1 минуту)."}},{"type":"paragraph","data":{"text":"Во время разведения флаконы необходимо энергично встряхивать до полного растворения."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции: гипертермия кожная сыпь крапивница кожный зуд бронхоспазм эозинофилия ангионевротический отек артралгия анафилактический шок мультиформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона)."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: судороги."}},{"type":"paragraph","data":{"text":"Со стороны мочевыделителъной системы: у больных с заболеваниями почек при лечении большими дозами (6 г) - нарушение функции почек (в этих случаях дозу снижают и лечение проводят под контролем динамики концентрации азота мочевины и креатинина в крови)."}},{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: тошнота рвота диарея боль в животе псевдомембранозный энтероколит редко - холестатическая желтуха гепатит."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: лейкопения нейтропения тромбоцитопения тромбоцитоз гемолитическая анемия."}},{"type":"paragraph","data":{"text":"При длительном лечении - дисбактериоз суперинфекция вызываемая устойчивыми к антибиотику штаммами кандидамикоз (в т.ч. кандидозный стоматит)."}},{"type":"paragraph","data":{"text":"Лабораторные показатели: положительная реакция Кумбса повышение активности \"печеночных\" трансаминаз гиперкреатининемия увеличение протромбинового времени."}},{"type":"paragraph","data":{"text":"Местные реакции: при внутримышечном введении - болезненность (в месте введения) при внутривенном введении - флебит."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Не рекомендуется одновременный прием с антикоагулянтами и диуретиками. При одновременном применении цефазолина и \"петлевых диуретиков\" происходит блокада его канальцевой секреции. Аминогликозиды увеличивают риск развития поражения почек. Фармацевтически несовместим с аминогликозидами (взаимная инактивация). Лекарственные средства блокирующие канальцевую секрецию увеличивают концентрацию в крови замедляют выведение и повышают риск развития токсических реакций."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Пациенты имевшие в анамнезе аллергические реакции на пенициллины карбапенемы могут иметь повышенную чувствительность к цефалоспориновым антибиотикам. Во время лечения цефазолином возможно получение положительных прямой и непрямой проб Кумбса а также ложноположительной реакции мочи на глюкозу. При назначении препарата возможно обострение заболеваний желудочно-кишечного тракта особенно колита."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"С осторожностью применять водителям транспортных средств и людям деятельность которых требует повышенной концентрации внимания и хорошей координации движений."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Порошок для приготовления раствора для внутривенного и внутримышечного введения 05 г 1 г."}},{"type":"header","data":{"text":"Упаковка:","level":3}},{"type":"paragraph","data":{"text":"0.5 г и 1 г активного вещества во флаконе бесцветного стекла вместимостью 10 мл или 20 мл или во флаконе тёмного стекла вместимостью 10 мл или 20 мл.1 5 и 10 флаконов с инструкцией по применению в пачке из картона. 50 . флаконов с равным количеством инструкций по применению в коробке из картона для стационаров.Растворитель:- \"Вода для инъекций\" в стеклянных ампулах по 5 мл;или- \"Натрия хлорид растворитель для приготовления лекарственных форм для инъекций 09 %\" в стеклянных ампулах по 5 мл;1 флакон с препаратом 1 или 2 ампулы растворителем в контурной ячейковой упаковке из плёнки поливинилхлоридной.1 контурная ячейковая упаковка инструкцией по применению скарификатором ампульным в пачке из картона.1 флакон с препаратом 1 или 2 ампулы с растворителем с инструкцией применению и скарификатором ампульным в пачке или коробке из картона.5 флаконов препарата в контурной ячейковой упаковке из плёнки поливинилхлоридной.1 2 контурные ячейковые упаковки флаконами препарата и инструкцией применению в пачке из картона.1 контурная ячейковая упаковка флаконами препарата 1 или 2 контурные ячейковые упаковки с ампулами растворителя (по 5 ампул) инструкция применению и скарификатор ампульный в пачке из картона.При использовании ампул с кольцом излома или с надрезом и точкой скарифитор не вкладывают."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом защищенном от света месте при температуре не выше 25 °С. Хранить местах недоступных для детей."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года. Не использовать после истечения срока годности."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное общество \"Акционерное Курганское общество медицинских препаратов и изделий \"Синтез\" (ОАО \"Синтез\"), 640008, Курганская обл., г. Курган, проспект Конституции, д. 7, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ОАО \"Синтез\""}}]}],"source":null},"description_toggle":false,"short_description":"Цефалоспориновый антибиотик I поколения для парентерального применения. Действует бактерицидно нарушая синтез клеточной стенки микроорганизмов. Имеет широкий спектр действия активен в отношении грамположительных (Staphylococcus spp. Staphylococcus aureus (не продуцирующие и продуцирующие пенициллиназу) Streptococcus pneumoniae Corynebacterium diphtheriae Bacillus anthracis) и грамотрицательных (Neisseria meningitidis Neisseria gonorrhoeae Shigella spp. Salmonella spp. Escherichia coli Klebsiella spp. Treponema spp. Leptospira spp.) микроорганизмов. Активен в отношении Haemophilus influenzae некоторых штаммов Enterobacter spp. и Enterococcus spp.Неэффективен в отношении Pseudomonas aeruginosa индолположительных штаммов Proteus spp. Mycobacterium tuberculosis Serratia spp. анаэробных микроорганизмов метициллин-устойчивых штаммов Staphylococcus spp. Время достижения максимальной концентрации (ТСmах) при внутримышечном введении в дозе 0.5 и 1 г соответственно - 2 и 1 ч; максимальная концентрация (Сmах) - 38 и 64 мкг/мл; после внутривенного введения ТСшах - в конце инфузии после внутривенного введения 1 г Сmах - 180 мкг/мл. Проникает в суставы ткани сердца и сосудов в брюшную полость почки и мочевыводящие пути плаценту среднее ухо дыхательные пути кожу и мягкие ткани. В небольших количествах выделяется с грудным молоком. Концентрация в ткани желчного пузыря и желчи значительно выше чем в сыворотке крови. При обструкции желчного пузыря концентрация в желчи меньше чем в плазме. Объем распределения - 0.12 л/кг. Связь с белками плазмы - 85%. Период полувыведения (Т1/2) при внутримышечном введении - 1.8 ч при внутривенном введении -2 ч. При нарушении функции почек Т1/2 - 20-40 ч. Выводится преимущественно почками в неизмененном виде: в течение первых 6ч- 60-90% через 24 ч - 70-95%. 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