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Курс лечения в зависимости от тяжести болезни"}},{"type":"paragraph","data":{"text":"составляет 7-14 дней."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Головная боль, диспепсия, лейкопения, агранулоцитоз, тошнота, рвота, аллергические реакции, холестатический гепатит."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cfont\u003eСимптомы: \u003c/font\u003e\u003c/i\u003e\u003cfont\u003eслучаи передозировки неизвестны.\u003c/font\u003e"}},{"type":"paragraph","data":{"text":"\u003ci\u003e\u003cfont\u003eЛечение: \u003c/font\u003e\u003c/i\u003e\u003cfont\u003eпромывание желудка, контроль жизненно важных функций, симптоматическая терапия.\u003c/font\u003e"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Действие сульфадиметоксина усиливается при комбинированном приёме с производными диаминопиримидина (триметоприм тетроксоприм пириметамин)."}},{"type":"paragraph","data":{"text":"Снижает эффективность бактерицидных антибиотиков действующих только на делящиеся микроорганизмы (в т.ч. пенициллины цефалоспорины). Фенитоин увеличивает риск развития токсических реакций."}},{"type":"paragraph","data":{"text":"Метотрексат и другие антагонисты фолиевой кислоты увеличивают риск развития дефицита фолиевой кислоты."}},{"type":"paragraph","data":{"text":"Прокаин бензокаин и тетракаин снижают антибактериальную активность. ПАСК и барбитураты усиливают противомикробное действие. Салицилаты повышают активность и токсичность сульфадиметоксина. Метоксален способствует развитию фотосенсибилизации. Негормональные противовоспалительные препараты тиоацетазон хлорамфеникол усиливают токсическое действие на кровь (лейкопения агранулоцитоз)."}},{"type":"paragraph","data":{"text":"Усиливает действие антикоагулянтов непрямого действия фенитоина сульфаниламидов с гипогликемическим действием;"}},{"type":"paragraph","data":{"text":"Производные пиразолона индометацин и салицилаты увеличивают свободную фракцию препарата в крови."}},{"type":"paragraph","data":{"text":"Снижает эффективность пероральных контрацептивов. Усиливает метаболизм циклоспорина."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Во время терапии рекомендуется обильное питье регулярный контроль показателей крови и мочи."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения следует соблюдать осторожность при управлении транспортными средствами и занятиями другими потенциально опасными видами деятельности требующими повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки 500 мг "}},{"type":"paragraph","data":{"text":"По 10 таблеток в контурной ячейковой упаковке. 1 2 или 3 контурные ячейковые упаковки вместе с инструкцией но применению в пачке из картона. Допускается контурные ячейковые упаковки помещать в групповую упаковку с равным количеством инструкций."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Хранить при температуре не выше 25 °С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"5 лет. Не использовать позже срока годности указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"по рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Фармстандарт-Лексредства ОАО, 305022, Курск, 2-ая Агрегатная, 1А/18, Россия"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"Фармстандарт-Лексредства ОАО"}}]}],"source":null},"description_toggle":false,"short_description":"Противомикробное бактериостатическое средство. Механизм действия обусловлен конкурентным антагонизмом с парааминобензойной кислотой угнетением дигидроптероатсинтетазы нарушением синтеза тетрагидрофолиевой кислоты необходимой для синтеза пуринов и пиримидинов. Активен в отношении грамположительных и грамотрицательных микроорганизмов: Staphylococcus spp. Streptococcus spp. в т.ч. Streptococcus pneumoniae палочки Фридлендера Escherichia coli Shigella spp. Chlamydia trachomatis.Сульфадиметоксин не действует на штаммы бактерий устойчивых к сульфаниламидам. При приеме внутрь всасывается относительно медленно обнаруживается в крови через 30 мин. При однократном приеме (в дозе 1-2 г) время достижения максимальной концентрации в крови (Тсmах) - 8-12 ч.Терапевтическая концентрация у взрослых достигается при приеме 1 -2 г в 1 день и 0.5-1 г - в последующие дни. Связь с белками крови - 90-99%.Препарат накапливается в крови прежде всего за счет высокой степени связывания с протеинами крови (90-99%). Хорошо распределяется по органам и системам. Но в отличие от иных представителей сульфаниламидов длительного действия плохо проникает через гемато-энцефалический барьер (ГЭБ) и его концентрация в ликворе низкая. Однако при воспалении менингеальных оболочек проницаемость ГЭБ резко возрастает. Хорошо проникает в плевральную жидкость (60-90% от концентрации в крови) в билиарную систему где его концентрации в 1.5-4 раза выше чем в крови.Преимущественный метаболизм осуществляется по пути микросомального глюкуронирования связанного с цитохромом Р450 и НАДФН-зависимого.Прочная связь с белками плазмы крови и высокая реабсорбция в канальцах почек (93-975%) способствует медленному выведению препарата из организма. В крови содержится 5-15% ацетилированных метаболитов в моче - 10-25% ацетильных производных и 75-90% - глюкуронида сульфадиметоксина; последний хорошо растворим и не провоцирует развитие кристаллурии. Ацетильное производное не реабсорбируется и полностью выводится почками. 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