Гидрокортизон Мазь, туба, 10 г, 1 %

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При длительном применении мази или использовании окклюзионной повязки, особенно на больших участках поражения, возможно развитие гиперкортицизма, как проявление резорбтивного действия гидрокортизона ацетата."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы.\u003c/i\u003e Острая передозировка маловероятна. При длительном применении препарата в больших дозах возможно появление симптомов гиперкортицизма (гипергликемия, глюкозурия, обратимое угнетение функции коры надпочечников, синдром Иценко-Кушинга)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение\u003c/i\u003e симптоматическое; рекомендуется постепенная отмена препарата."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eПри длительном применении,\u003c/i\u003e вследствие возможной резорбции в системный кровоток, \u003ci\u003eгидрокортизон может снижать эффективность\u003c/i\u003e инсулина, пероральных гипогликемических, гипотензивных лекарственных средств, антикоагулянтов, \u003ci\u003eконцентрацию \u003c/i\u003eсалицилатов и празиквантела в плазме крови."}},{"type":"paragraph","data":{"text":"\u003ci\u003eРиск развития побочных эффектов гидрокортизона повышают:\u003c/i\u003e"}},{"type":"list","data":{"style":"ordered","items":["андрогены, эстрогены, пероральные контрацептивы, анаболические стероиды (гирсутизм, угревая сыпь);","антипсихотические лекарственные средства, карбутамид, азатиоприн (катаракта);","холиноблокаторы, антигистаминные лекарственные средства, трициклические антидепрессанты, нитраты (глаукома);","диуретики (гипокалиемия);","нестероидные противовоспалительные препараты (повышение риска язвообразования в желудочно-кишечном тракте);","парацетамол (гепатотоксичность)."]}},{"type":"paragraph","data":{"text":"При применении с сердечными гликозидами возможно развитие дигиталисной интоксикации."}},{"type":"paragraph","data":{"text":"Одновременное применение с препаратами свинца и серебра приводит к взаимной инактивации."}},{"type":"paragraph","data":{"text":"При совместном применении с амфотерицином B возможно развитие дилатационного поражения миокарда и сердечной недостаточности."}},{"type":"paragraph","data":{"text":"Барбитураты, противоэпилептические и антигистаминные препараты снижают эффективность гидрокортизона."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"В случаях применения препарата у детей, на область лица или под окклюзионные повязки продолжительность курса лечения необходимо уменьшить."}},{"type":"paragraph","data":{"text":"В детском возрасте подавление функции коры надпочечников может развиться быстрее. Кроме того, может наблюдаться снижение экскреции гормона роста. При применении препарата в течение длительного времени необходимо наблюдать за массой тела, ростом, уровнем кортизола плазмы. Детям до 12 лет препарат назначают только под врачебным контролем."}},{"type":"paragraph","data":{"text":"Следует избегать попадания мази в глаза."}},{"type":"paragraph","data":{"text":"Если после 7 дней применения не наступает улучшения или наблюдается ухудшение состояния, а также в случае возобновления симптомов через несколько дней после отмены препарата, применение препарата следует прекратить и проконсультироваться с врачом."}},{"type":"paragraph","data":{"text":"При длительном лечении и/или нанесении на большие поверхности рекомендуется назначать диету с ограничением натрия и повышенным содержанием K+; вводить в организм достаточное количество белка."}},{"type":"paragraph","data":{"text":"Необходимо контролировать артериальное давление, содержание глюкозы в крови, свертываемость крови, диурез, массу тела больного, уровень кортизола плазмы."}},{"type":"paragraph","data":{"text":"Для предупреждения инфекционных поражений кожи препарат рекомендуют назначать в сочетании с антибактериальными и противогрибковыми средствами."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"Отсутствуют данные о негативном влиянии препарата Гидрокортизон мазь для наружного применения 1 % на способность к управлению транспортными средствами и выполнение других потенциально опасных видов деятельности."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Мазь для наружного применения 1 %. По 10 г в тубы алюминиевые или в тубы полиэтиленовые ламинатные."}},{"type":"paragraph","data":{"text":"Каждую тубу вместе с инструкцией по медицинскому применению лекарственного препарата в пачку из картона."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"При температуре не выше 20˚С. Хранить в недоступном для детей месте."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"3 года."}},{"type":"paragraph","data":{"text":"Не применять препарат по истечении срока годности, указанного на упаковке."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Отпускают без рецепта."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\n\nАО «Нижфарм», Россия"}},{"type":"paragraph","data":{"text":"603950, г. Нижний Новгород, ул. Салганская, д. 7"}},{"type":"paragraph","data":{"text":"Тел.: (831) 278-80-88; факс: (831) 430-72-28"}},{"type":"paragraph","data":{"text":"E-mail: \u003ca href=\"mailto:med@stada.ru\"\u003emed@stada.ru\u003c/a\u003e"}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"\n\nАО «Нижфарм», Россия"}},{"type":"paragraph","data":{"text":"603950, г. Нижний Новгород, ул. Салганская, д. 7"}},{"type":"paragraph","data":{"text":"Тел.: (831) 278-80-88; факс: (831) 430-72-28"}},{"type":"paragraph","data":{"text":"E-mail: \u003ca href=\"mailto:med@stada.ru\"\u003emed@stada.ru\u003c/a\u003e"}}]}],"source":null},"description_toggle":false,"short_description":"Фармакологическое действиеГидрокортизон является синтетическим глюкокортикостероидным препаратом для местного применения, оказывает противовоспалительное, противоотечное, противозудное действие. Тормозит высвобождение цитокинов (интерлейкинов и интерферона) из лимфоцитов и макрофагов, угнетает высвобождение эозинофилами медиаторов воспаления, снижает метаболизм арахидоновой кислоты и синтез простагландинов. Стимулируя стероидные рецепторы, индуцирует образование липокортина. Уменьшает воспалительные клеточные инфильтраты, снижает миграцию лейкоцитов и лимфоцитов в область воспаления. Местное применение препарата в рекомендуемых дозах не вызывает побочных системных эффектов.ФармакокинетикаПосле аппликации накапливается в эпидермисе (в основном в зернистом слое). Метаболизируется непосредственно в эпидермисе, а в дальнейшем в печени. 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