Магния сульфат Раствор, 10 шт, 5 мл, 25 %, для инъекций

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Дозу устанавливают индивидуально в зависимости от клинической ситуации. Доза насыщения - 2-4 г через 5-20 мин (инфузия). Поддерживающая доза-1-2 г в час."}},{"type":"paragraph","data":{"text":"Тетания матки. Доза насыщения - 4 г через 20 мин (инфузия). Поддерживающая доза - сначала - 1-2 г в час позже - 1 г в час (можно вводить капельно 24-72 ч)."}},{"type":"paragraph","data":{"text":"Гипомагниемия."}},{"type":"paragraph","data":{"text":"У новорожденных. Суточная доза - 02- 08 мг/кг в/в медленно."}},{"type":"paragraph","data":{"text":"У взрослых. Раствор магния сульфата применяют парентерально если невозможен или нецелесообразен пероральный путь введения препаратов магния (из-за тошноты рвоты нарушенной резорбции в желудке и др.). Легкая. Суточная доза - 1-2 г."}},{"type":"paragraph","data":{"text":"Тяжелая. Начальная доза - 5 г."}},{"type":"paragraph","data":{"text":"Дозу вливают в 1л инфузионного раствора и медленно вводят в/в. Дозируют в зависимости от концентрации препарата в сыворотке крови."}},{"type":"paragraph","data":{"text":"Профилактика гипомагниемии у больных получающих только парентеральное питание. Если в питательных растворах нет магния его добавляют дополнительно. Суточная доза - 15-4 г. Обычно в 1 л раствора парентерального питания прибавляют 1 г магния сульфата."}},{"type":"paragraph","data":{"text":"Максимальная суточная доза магния сульфата взрослым - 40 г."}},{"type":"paragraph","data":{"text":"При гипертонических кризах вводят в/в (медленно!!) 5-20 мл 25 % раствора магния сульфата. Для купирования аритмий в/в вводят 1-2 г в течение около 5 минут возможно повторное введение."}},{"type":"paragraph","data":{"text":"Дозы Магния сульфата указаны в граммах."}},{"type":"paragraph","data":{"text":"Им соответствует количество раствора: 1 г -5 мл (20 %) - 4 мл (25 %); 2 г -10 мл (20 %) - 8 мл (25 %); 3 г -15 мл (20 %) -12 мл (25 %); 4 г - 20 мл (20 %) - 16 мл (25 %); 5 г - 25 мл (20 %) - 20 мл (25 %); 10 г - 50 мл (20 %) - 40 мл (25 %);15 г - 75 мл (20 %) -60 мл (25 %); 20 г -100 мл (20 %) - 80 мл (25 %); 30 г -150 мл (20 %) - 120 мл (25 %); 40 г - 200 мл (20 %) - 160 мл (25%)."}},{"type":"paragraph","data":{"text":"Раствор магния сульфата в ампулах разбавляют инъекционными растворами: 09 % натрия хлорида или 5 % декстрозы (глюкозы).\n\n"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nЗамедление частоты дыхания; одышка; острая недостаточность кровообращения; ослабление рефлексов; гиперемия; артериальная гипотензия; гипотермия; ослабление мышечного тонуса; атония матки; гипергидроз; тревожность; выраженная седация; полиурия; урежение частоты сердечных сокращений; изменения в электро-кардиограмме. Препарат понижает возбудимость дыхательного центра большие дозы препарата при парентеральном введении легко могут вызвать паралич дыхательного центра."}},{"type":"paragraph","data":{"text":"Ранние признаки и симптомы гипермагниемии: брадикардия диплопия внезапный прилив крови к лицу головная боль снижение АД тошнота одышка смазанная речь рвота общая слабость."}},{"type":"paragraph","data":{"text":"Признаки гипермагниемии ранжированные в порядке повышения концентрации ионов магния в сыворотке крови: снижение глубоких сухожильных рефлексов (2- 35 ммоль/л) удлинение интервала PQ и расширение комплекса QRS на электро¬кардиограмме (25-5 ммоль/л) снижение сухожильных рефлексов (4-5 ммоль/л) угнетение дыхательного центра (5-65 ммоль/л) нарушение проводимости сердца (75 ммоль/л) остановка сердца (125 ммоль/л).\n\n"}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"\n\nСимптомы:исчезновение коленного рефлекса тошнота рвота резкое снижение АД брадикардия угнетение дыхания и ЦНС."}},{"type":"paragraph","data":{"text":"Лечение: следует внутривенно медленно ввести раствор кальция хлорида или каль­ция глюконата - 5-10 мл 10 % проводят оксигеиотерапию вдыхание карбогена ис­кусственное дыхание перитонеальный диализ или гемодиализ симптоматическую терапию.\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"\n\nПациенты которые вместе с магния сульфатом применяют и другие лекарственные средства должны сообщить об этом врачу."}},{"type":"paragraph","data":{"text":"Усиливает эффект других лекарственных средств угнетающих ЦНС."}},{"type":"paragraph","data":{"text":"Сердечные гликозиды увеличивают риск нарушения проводимости и атриовентрикулярной блокады (особенно при одновременном в/в введении солей кальция). Миорелаксанты и нифедипин усиливают нервно-мышечную блокаду При совместном применении магния сульфата для парентерального введения с другими вазодилататорами возможно усиление гипотензивного эффекта."}},{"type":"paragraph","data":{"text":"Барбитураты наркотические анальгетики гипотензивные препараты повышают вероятность угнетения дыхательного центра."}},{"type":"paragraph","data":{"text":"Нарушает всасывание антибиотиков группы тетрациклина ослабляет действие стрептомицина и тобрамицина."}},{"type":"paragraph","data":{"text":"Соли кальция уменьшают действие магния сульфата."}},{"type":"paragraph","data":{"text":"Фармацевтически несовместим (образует осадок) с препаратами кальция карбонатами бикарбонатами и фосфатами щелочных металлов клиндамицина фосфатом гидрокортизона натрия сукцинатом полимиксина В сульфатом прокаина гидрохлоридом салицилатами и тартратами."}},{"type":"paragraph","data":{"text":"При концентрациях ионов магния выше 10 ммоль/мл в смесях для полного парентерального питания возможно разделение жировых эмульсий.\n\n"}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Магния сульфат следует применять осторожно чтобы не возникла токсическая концентрация препарата. Лицам пожилого возраста обычно следует применять уменьшенную дозу так как у них снижена функция почек. Больные с нарушением функции почек (если клиренс креатинина более 20 мл/мин) и олигурией не должны получать более 20 г магния сульфата (81 Ммоль Mg 2+) в течение 48 ч не следует вводить магния сульфат в/в слишком быстро. Рекомендуется контроль концентрации ионов магния в сыворотке крови (должна быть не выше 08- 12 ммоль/л) диуреза (не менее 100 мл/ч) частоты дыхания (не менее 16/мйн) АД. При введении магния сульфата необходимо иметь приготовленный для в/в введения раствор кальция например 10 % раствор кальция глюконата. При необходимости одновременного в/в введения магния и кальция их вводят в разные вены. При применении магния сульфата могут быть искажены результаты радиологических исследований для которых применяется технеций."}}]},{"id":17,"name":"Влияние на способность управлять автомобилем и движущимися механизмами","slug":"","body":[{"type":"paragraph","data":{"text":"В период лечения пациентам следует воздержаться от управления транспортными средствами и занятий другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций (риск развития диплопии, головокружения, головной боли)."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для внутривенного введения 250 мг/мл."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"\n\nПри температуре от 0 до 25° С."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте.\n\n"}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"\n\n3 года."}},{"type":"paragraph","data":{"text":"Не применять по истечении срока годности указанного на упаковке.\n\n"}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"По рецепту"}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"ОАО \"ДАЛЬХИМФАРМ\""}}]},{"id":23,"name":"Организация, принимающая претензии потребителей","body":[{"type":"paragraph","data":{"text":"ОАО \"ДАЛЬХИМФАРМ\""}}]}],"source":null},"description_toggle":false,"short_description":"При парентеральном введении оказывает седативное диуретическое артериодилатирующее противосудорожное антиаритмическое гипотензивное спазмолитическое в больших дозах - курареподобное (угнетающее влияние на нервно-мышечную передачу) токолитическое снотворное и наркотическое действие подавляет дыхательный центр. Магний является физиологическим антагонистом кальция и способен вытеснять его из мест связывания. Регулирует обменные процессы межнейрональную передачу и мышечную возбудимость препятствует поступлению кальция через пресинаптическую мембрану снижает количество ацетилхолина в периферической нервной системе и центральной нервной системе (ЦНС). Расслабляет гладкую мускулатуру снижает артериальное давление (АД) (преимущественно повышенное) усиливает диурез. Противосудорожное действие - магний уменьшает высвобождение ацетилхолина из нервно-мышечных синапсов подавляя при этом нервно-мышечную передачу оказывает прямое угнетающее Действие на ЦНС. Антиаритмическое действие - магний снижает возбудимость кардиомиоцитов восстанавливает ионное равновесие стабилизирует клеточные мембраны нарушает ток натрия медленный входящий ток кальция й односторонний ток калия. Кардиопротекторный эффект обусловлен расширением коронарных артерий снижением общего периферического сосудистого сопротивления и агрегации тромбоцитов. Токолитическое действие - магний угнетает сократительную способность миометрия (снижение поглощения связывания и распределения кальция в клетках гладкой мускулатуры) усиливает кровоток в матке в результате расширения ее сосудов. Является антидотом при отравлениях солями тяжелых металлов. Системные эффекты развиваются почти мгновенно после внутривенного (в/в) введения. Длительность действия при в/в введении - 30 мин. Противосудорожная равновесная концентрация (Css) - 2-35 ммоль/л. Проникает через гематоэнцефалический и плацентарный барьеры создает в материнском молоке концентрации в 2 раза превышающие концентрации в плазме. Выведение осуществляется почками скорость почечной экскреции пропорциональна концентрации в плазме и уровню клубочковой фильтрации.","substance":[{"id":892,"title":"Магния сульфат","title_latin":"Magnesii sulfas","slug":"magniya_sulfat_892"}],"branding":null,"valid_for_quick_buy":true,"is_available_to_delivery":false,"comments":null,"image_alt":"Магния сульфат - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/50705/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/50705/share_default/"}},"diseases":[{"id":"424","title":"Недостаточность магния","slug":"424-nedostatochnost_magniya"},{"id":"552","title":"Эпилепсия","slug":"552-epilepsiya"},{"id":"717","title":"Эссенциальная [первичная] гипертензия","slug":"717-essentsialnaya_pervichnaya_gipertenziya"},{"id":"744","title":"Желудочковая 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