Левомицетин Таблетки, 10 шт, 500 мг, для приема внутрь

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Детям назначают под контролем концентрации препарата в сыворотке крови в зависимости от возраста: недоношенным и доношенным новорожденным в возрасте до 2 недель - по 6.25 мг/кг каждые 6 ч; грудным детям 2 нед. и старше - по 12.5 мг/кг каждые 6 ч или по 25 мг/кг каждые 12 ч., при тяжелых инфекциях (бактериемия, менингит) - до 75-100 мг/кг/су"}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\n\nСо стороны пищеварительной системы: диспепсия, тошнота, рвота (вероятность развития снижается при приеме через 1 ч после еды), диарея, раздражение слизистой оболочки полости рта и зева, дерматит (в т.ч. перианальный дерматит - при ректальном применении), дисбактериоз (подавление нормальной микрофлоры)."}},{"type":"paragraph","data":{"text":"Со стороны органов кроветворения: ретикулоцитопения, лейкопения, гранулоцитопения, тромбоцитопения, эритроцитопения,; редко - апластическая анемия, агранулоцитоз."}},{"type":"paragraph","data":{"text":"Со стороны нервной системы: психомоторные расстройства, депрессия, спутанность сознания, периферический неврит, неврит зрительного нерва, зрительные и слуховые галлюцинации, снижение остроты зрения и слуха, головная боль."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь, ангионевротический отек."}},{"type":"paragraph","data":{"text":"Прочие: вторичная грибковая инфекция, коллапс (у детей до1 года).\n\n"}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Одновременное назначение с ЛС, угнетающими кроветворение (сульфаниламиды, цитостатики), влияющими на обмен веществ в печени, а также с лучевой терапией, увеличивает риск развития побочных действий."}},{"type":"paragraph","data":{"text":"При одновременном приеме этанола возможно развитие дисульфирамовой реакции."}},{"type":"paragraph","data":{"text":"При назначении с пероральными гипогликемическими препаратами отмечается усиление их действия (за счет подавления метаболизма в печени и повышения их концентрации в плазме)."}},{"type":"paragraph","data":{"text":"При одновременном применении с эритромицином, клиндамицином, линкомицином отмечается взаимное ослабление действия за счет того, что хлорамфеникол может вытеснять эти препараты из связанного состояния или препятствовать их связыванию с субъединицей 50S бактериальных рибосом."}},{"type":"paragraph","data":{"text":"Снижает антибактериальный эффект пенициллинов и цефалоспоринов."}},{"type":"paragraph","data":{"text":"Хлорамфеникол подавляет ферментную систему цитохрома Р450, поэтому при одновременном применении с фенобарбиталом, фенитоином, непрямыми антикоагулянтами отмечается ослабление метаболизма этих препаратов, замедление выведения и повышение их концентрации в плазме."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Вследствие высокой токсичности не рекомендуется без необходимости применять для лечения и профилактики банальных инфекций, простудных заболеваний, гриппа, фарингита, бактурионосительства. Тяжелые осложнения со стороны кроветворной системы, как правило, связаны с применением больших доз (более 4 г/сут) длительное время. В процессе лечения необходим систематический контроль картины периферической крови. У плода и новорожденных печень недостаточно развита, чтобы связывать хлорамфеникол, и препарат может накапливаться в токсической концентрации и приводить к развитию серого синдрома, поэтому детям в первые месяцы жизни препарат назначают только по жизненным показаниям. С осторожностью назначают пациентам, получавшим ранее лечение цитостатическими препаратами или лучевую терапию."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"таблетки"}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"В сухом, защищенном от света месте, при температуре не выше 30 °C."}},{"type":"paragraph","data":{"text":"Хранить в недоступном для детей месте."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Открытое акционерное общество \"Ирбитский химико-фармацевтический завод\" (ОАО \"Ирбитский химфармзавод\")"}}]}],"source":null},"description_toggle":false,"short_description":"Левомицетин - антибиотик широкого спектра действия. Механизм противомикробного действия связан с нарушением синтеза белков микроорганизмов. Действует бактериостатически. Активен в отношении грамположительных (Staphylococcus spp., Streptococcus spp.) и грамотрицательных кокков (Neisseria gonorrhoeae, N.meningitidis), бактерий (Escherichia coli, Haemophilus influenza, Salmonella spp., Shigella spp., Klebsiella spp., Serratia spp., Yersinia spp., Proteus spp.), риккетсий, спирохет, некоторых крупных вирусов. Препарат активен в отношении штаммов, устойчивых к пенициллину, стрептомицину, сульфаниламидам. Устойчивость микроорганизмов к хлорамфениколу развивается относительно медленно.","substance":[{"id":286,"title":"Хлорамфеникол","title_latin":"Chloramphenicolum","slug":"hloramfenikol_286"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Левомицетин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/86185/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/86185/share_default/"}},"diseases":[],"other_packages":[{"id":144404,"title":"Левомицетин","subtitle":{"full":"Таблетки, 10 шт, 500 мг","short":"Таблетки, 10 шт, 500 мг","package":"10 шт, 500 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