Аммифурин® представляет собой сумму фурокумаринов: изопимпин... Инструкция
Показания к применению
Аммифурин® применяют у взрослых при витилиго, гнездной и тотальной плешивости, псориазе.
Противопоказания
Непереносимость УФО и псораленов, заболевания, сопровождающиеся повышенной чувствительностью к свету (альбинизм, системная красная волчанка и др.), в сочетании с УФО при следующих заболеваниях: туберкулез, тиреотоксикоз, заболевания крови, печени, почек, сердечно-сосудистой системы, гипертоническая болезнь II-III степени, заболевания центральной нервной ...
Аммифурин® - 0,3 г (амми большой плодов сумма фурокумаринов) (в пересчете на 100 % вещество)
Вспомогательные вещества:
Спирт этиловый 95 % - 74 мл (этанол 95 %);
глицерин -13 мл;
вода очищенная - до 100 мл.
Фармакологические свойства
Аммифурин® представляет собой сумму фурокумаринов: изопимпинеллина, бергаптена и ксантотоксина выделенную из плодов амми большой - Ammi majus L, семейства сельдерейных (зонтичных) - Apiaceae (Umbelliferae).
Аммифурин® оказывает фотосенсибилизирующее действие.
Показания к применению
Аммифурин® применяют у взрослых при витилиго, гнездной и тотальной плешивости, псориазе.
Противопоказания
Непереносимость УФО и псораленов, заболевания, сопровождающиеся повышенной чувствительностью к свету (альбинизм, системная красная волчанка и др.), в сочетании с УФО при следующих заболеваниях: туберкулез, тиреотоксикоз, заболевания крови, печени, почек, сердечно-сосудистой системы, гипертоническая болезнь II-III степени, заболевания центральной нервной системы, диабет, беременность, период лактации, катаракта, множественные пигментные невусы, доброкачественные и злокачественные опухоли.
Способ применения и дозы
Аммифурин® назначают в сочетании с ультрафиолетовым облучением (УФО). Раствор Аммифурина® применяют наружно, нанося на очаги поражения за 1 час до облучения.
При распространенных формах заболевания наружную аппликацию препарата комбинируют с его приемом внутрь.
При псориазе процедуры проводят 4 раза в неделю. УФ-облучение начинают с 1/2 биодозы, постепенно увеличивают до 5-6 биодоз, что соответствует (в зависимости от индивидуальной чувствительности больного к УФ- излучению) продолжительности облучения от 1-2 минут до 10-15 минут. Общее количество облучения составляет 15-20 процедур. Лечение больных псориазом можно проводить в сочетании с длинноволновым УФ- излучением.
При витилиго, гнездной и тотальной плешивости облучение проводят 3 раза в неделю (через день) - 20-25 облучений. Всего проводят 4-6 курсов.
Больным с ограниченными очагами поражения Аммифурин® назначают только наружно в виде 0,3% раствора с последующим УФО. Очаг поражения смазывают 0,3% раствором Аммифурина® за 1 час до облучения. Процедуры проводят 3-4 раза в неделю. УФО начинают с 1/2 биодозы, постепенно увеличивают до 5-6 биодоз. Количество процедур зависит от результатов лечения и составляют в целом 20-25 облучений. В летнее время облучение кварцевой лампой во всех случаях можно заменить дозированной солнечной инсоляцией.
Курсовая доза Аммифурина® 1-2 флакона 0,3 % раствора по 50 мл (0,15-0,3 г). Повторные курсы проводят с интервалом в 1-1,5 месяца.
Взаимодействие с другими лекарственными средствами
Усиливает действие других фотосенсибилизаторов (в том числе фотосенсибилизирующих пищевых продуктов и косметических средств).
Указанную терапию можно проводить на фоне общепринятого медикаментозного лечения, включающего применение пенициллина, лидазы, сосудистых препаратов, наружных средств.
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