Блокирует нейромышечную передачу у чувствительных гельминтов.
Фармакодинамика
Действует на гельминты в ранней фазе развития и на зрелые формы, не влияет на личинки в стадии миграции. Активен в отношении Enterobius vermicularis, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Trichostrongylus orientalis, Trichostrongylus colubriformis.
Фармакокинетика
Практически не абсорбируется в ЖКТ. После приема внутрь в разовой дозе 10 мг/кг массы тела Cmaxсоставляет 0,005–0,13 мкг/мл и достигается в течение 1–3 ч. Частично метаболизируется в печени до N-метил-1,3-пропандиамина.
Выводится с фекалиями (50% принятой дозы — в неизмененном виде) и с мочой (около 7% — в неизмененном виде и в виде метаболита).
Применение при беременности и в период грудного вскармливания
При беременности применять в случае крайней необходимости (только под строгим наблюдением врача). На время лечения следует прекратить грудное вскармливание (пирантел проникает в грудное молоко).
Способ применения и дозы
Препарат назначают внутрь во время или после еды и дозировку устанавливают индивидуально в зависимости от возраста и массы тела пациента.
Аскаридоз и энтеробиоз, а также смешанные инвазии – однократно в дозе 10 мг/кг массы тела.
Дети 3 года - 6 лет - 250 мг (1 таблетка)
Дети 6 лет - 12 лет - 500 мг (2 таблетки)
Дети старше 12 лет и взрослые весом менее 75 кг - 750 мг (3 таблетки)
Взрослые весом более 75 кг - 1000 мг (4 таблетки)
Таблетку следует тщательно разжевать.
Анкилостомидоз: препарат назначают из расчета 10- мг/кг массы тела в сутки в течение 3 дней.
Некатороз: при тяжелых формах препарат назначают в дозе из расчета 20 мг/кг массы тела в сутки в течение 2 дней.
Побочное действие
Со стороны нервной системы и органов чувств: головная боль, головокружение, сонливость/бессонница, слабость; в отдельных случаях— нарушение слуха, галлюцинации, спутанность сознания, парестезии.Со стороны органов ЖКТ: тошнота, рвота, диарея, боль в желудке, анорексия, повышение активности печеночных трансаминаз.Аллергические реакции: зуд, крапивница, экзантема.
Особые указания
После приема пирантела слабительное не назначают.
При энтеробиозе следует провести одновременное лечение всех совместно проживающих лиц.
После завершения лечения необходимо провести контрольное исследование кала на наличие яиц паразитов.
Необходимо тщательное соблюдение гигиены (уборка жилых помещений и чистка одежды для уничтожения яиц гельминтов служит профилактикой реинфекции).
Условия хранения
В сухом, защищенном от света месте, при температуре не выше 25°C. Хранить в недоступном для детей месте.
Срок годности
3 года. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России
Для описания товара использована информация от партнера ЭркаФарм
Мобильное приложение «Все аптеки»
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Информация предоставляется в справочных целях. Не занимайтесь самолечением. При первых признаках заболевания обратитесь к врачу.
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