Таблетки, покрытые пленочной кишечнорастворимой оболочкой белого или почти белого цвета, овальные, двояковыпуклые; на поперечном разрезе виден один слой белого цвета.
Состав оболочки: ацетилфталилцеллюлоза, масло касторовое медицинское, титана диоксид.
Фармакологические свойства
[I] - Инструкция по медицинскому применению одобрена фармакологическим комитетом МЗ РФ
Бактериостатический антибиотик из группы макролидов, обратимо
связывается с 50S субъединицей рибосом в ее донорской части, что
нарушает образование пептидных связей между молекулами аминокислот и
блокирует синтез белков микроорганизмов (не влияет на синтез нуклеиновых
кислот). При применении в высоких дозах может проявлять бактерицидное
действие. Спектр действия включает грамположительные (Staphylococcus
spp., продуцирующие и непродуцирующие пенициллиназу, в т.ч.
Staphylococcus aureus; Streptococcus spp. (в т.ч. Streptococcus
pneumoniae, Streptococcus pyogenes), альфа-гемолитический стрептококк
(группы Viridans ), Bacillus anthracis, Corynebacterium diphtheriae,
Corynebacterium minutissimum) и грамотрицательные микроорганизмы
(Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis,
Brucella spp., Legionella spp., в т.ч. Legionella pneumophila) и другие
микроорганизмы: Mycoplasma spp. (в т.ч. Mycoplasma pneumoniae),
Chlamydia spp. (в т.ч. Chlamydia trachomatis), Treponema spp.,
Rickettsia spp., Entamoeba histolytica, Listeria monocytogenes.
Устоичивы грамотрицательные палочки : Escherichia coli, Pseudomonas
aeruginosa, а также Shigella spp., Salmonella spp. и другие. К группе
чувствительных относятся микроорганизмы, рост которых задерживается при
концентрации антибиотика менее 0.5 мг/л, среднечувствительных — 1-6
мг/л, умеренно устойчивых и устойчивых — 6-8 мг/л.
— мочеполовые инфекции у беременных, вызванные Chlamydia trachomatis;
— первичный сифилис (у пациентов с аллергией к пенициллинам);
— неосложненный хламидиоз у взрослых (с локализацией в нижних отделах
мочеполовых путей и прямой кишки) при непереносимости или
неэффективности тетрациклинов;
— инфекции верхних и нижних дыхательных путей (трахеит, бронхит, пневмония);
— инфекции кожи и мягких тканей (гнойничковые заболевания кожи, в
т.ч. юношеские угри, инфицированные раны, пролежни, ожоги II-III
степени, трофические язвы);
— инфекции слизистой оболочки глаз;
— профилактика обострений стрептококковой инфекции (тонзиллит, фарингит) у больных ревматизмом;
— профилактика инфекционных осложнений при лечебных и диагностических
процедурах (в т.ч. предоперационная подготовка кишечника,
стоматологические вмешательства, эндоскопия, у больных с пороками
сердца).
Противопоказания
— гиперчувствительность;
— потеря слуха;
— одновременный прием терфенадина или астемизола;
— период лактации.
С осторожностью: аритмии (в анамнезе); удлинение интервала QT; желтуха (в анамнезе); печеночная недостаточность; почечная недостаточность.
Способ применения и дозы
Внутрь.
Разовая доза для взрослых и подростков старше 14 лет составляет 250-500 мг, суточная — 1-2 г. Интервал между приемами — 6 ч. При тяжелых инфекциях суточная доза может быть увеличена до 4 г.
Детям от 4 мес до 18 лет, в зависимости от возраста, массы тела и тяжести инфекции - по 30-50 мг/кг/сут в 2-4 приема; детям первых 3 мес жизни — 20-40 мг/кг/сут. В случае более тяжелых инфекций доза может быть удвоена.
Для лечения дифтерийного носительства — по 250 мг 2 раза/сут. Курсовая доза для лечения первичного сифилиса — 30-40 г, продолжительность лечения — 10-15 дней.
При амебной дизентерии взрослым — по 250 мг 4 раза/сут, детям - по 30-50 мг/кг/сут; продолжительность курса — 10-14 дней.
При легионеллезе — по 500 мг-1 г 4 раза/сут в течение 14 дней.
При гонорее — по 500 мг каждые 6 ч в течение 3 дней, далее - по 250 мг каждые 6 ч в течение 7 дней.
Для предоперационной подготовки кишечника с целью профилактики инфекционных осложнений — внутрь, по 1 г за 19 ч, 18 ч и 9 ч до начала операции (всего 3 г).
Для профилактики стрептококковой инфекции (при тонзиллите, фарингите) взрослым — 20—50 мг/кг/сут, детям — 20-30 мг/кг/сут, продолжительность курса — не менее 10 дней.
Для профилактики септического эндокардита у больных с пороками сердца — по 1 г длявзрослых и по 20 мг/кг — для детей, за 1 ч до лечебной или диагностической процедуры, далее по 500 мг — для взрослых и 10 мг/кг для детей, повторно через 6 ч.
При коклюше — 40-50 мг/кг/сут в течение 5-14 дней. При пневмонии у детей — 50 мг/кг/сут в 4 приема, в течение не менее 3 нед. При мочеполовых инфекциях во время беременности —
500 мг 4 раза/сут в течение не менее 7 дней или (при плохой
переносимости такой дозы) — по 250 мг 4 раза/сут в течение не менее 14
дней.
У взрослых, при неосложненном хламидиозе и непереносимости тетрациклинов — по 500 мг 4 раза/сут в течение не менее 7 дней.
Побочное действие
Реакции гиперчувствительности: кожные аллергические реакции (крапивница, другие формы сыпи), эозинофилия; редко - анафилактический шок.
Тошнота, рвота, гастралгия, тенезмы, абдоминальные боли, диарея,
дисбактериоз; редко - кандидоз полости рта, псевдомембранозный
энтероколит (как во время лечения, так и после него), нарушение функции
печени, холестатическая желтуха, повышение активности печеночных
трансаминаз, панкреатит, снижение слуха и/или шум в ушах (при применении
высоких доз — более 4 г/сут, снижение слуха после отмены препарата
обычно обратимо).
Редко — тахикардия, удлинение интервала QT на ЭКГ, желудочковые
аритмии, включая желудочковую тахикардию (типа "пируэт") у больных с
удлиненным интервалом QT.
Передозировка
Симптомы: нарушение функции печени, вплоть до острой печеночной недостаточности, потеря слуха.
Лечение: активированный уголь,
тщательный контроль за состоянием дыхательной системы. Промывание
желудка эффективно при приеме дозы, пятикратно превышающей среднюю
терапевтическую. Гемодиализ, перитонеальный диализ, форсированный диурез
неэффективны.
Взаимодействие с другими лекарственными средствами
Несовместим с линкомицином, клиндамицином и хлорамфениколом (антагонизм).
Снижает бактерицидное действие бета-лактамных антибиотиков (пенициллины, цефалоспорины, карбопенемы).
При одновременном приеме с препаратами, метаболизм которых осуществляется в печени (теофиллин,
карбамазепин, вальпроевая кислота, гексобарбитал, фенитоин,
альфентанил, дизопирамид, ловастатин, бромокриптин), может повышаться
концентрация этих препаратов в плазме (является ингибитором
микросомальных ферментов печени).
Усиливает нефротоксичность циклоспорина (особенно у больных с
сопутствующей почечной недостаточностью). Снижает клиренс триазолама и
мидазолама, в связи с чем может усиливать фармакологические эффекты
бензодиазепинов.
При одновременном приеме с терфенадином или астемизолом — возможность
развития аритмии, с дигидроэрготамином или негидрированными алкалоидами
спорыньи — сужение сосудов до спазма, дизестезии.
Замедляет элиминацию (усиливает эффект) метилпреднизолона, фелодипина и антикоагулянтов кумаринового ряда.
При совместном приеме с ловастатином усиливается рабдомиолиз.
Повышает биодоступность дигоксина.
Снижает эффективность гормональной контрацепции.
Особые указания
При длительной терапии необходимо осуществлять контроль лабораторных показателей функции печени.
Симптомы холестатической желтухи могут развиться через несколько дней
после начала терапии, однако риск развития повышается после 7-14 дней
непрерывной терапии. Вероятность развития ототоксического эффекта выше у
больных с почечной и печеночной недостаточностью, а также у пожилых
пациентов.
Некоторые устойчивые штаммы Haemophilus influenzae чувствительны к одновременному приему эритромицина и сульфаниламидов.
Может помешать определению катехоламинов в моче и активности
печеночных трансаминаз в крови (колориметрическое определение с помощью
дефинилгидразина).
При нарушениях функции почек
Противопоказано при почечной недостаточности.
При нарушениях функции печени
Противопоказано при печеночной недостаточности.
Применение в пожилом возрасте
Вероятность развития ототоксического эффекта выше у пожилых пациентов.
Применение в детском возрасте
Детям от 4 мес до 18 лет, в зависимости от возраста, массы тела и
тяжести инфекции - по 30-50 мг/кг/сут в 2-4 приема; детям первых 3 мес
жизни — 20—40 мг/кг/сут. В случае более тяжелых инфекции доза может быть
удвоена.
Условия хранения
В сухом, защищенном от света месте, при температуре не выше 25°C. Хранить в недоступном для детей месте.
Срок годности
2 года. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России
Для описания товара использована информация от партнера ЭркаФарм
Мобильное приложение «Все аптеки»
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покрытые пленочной кишечнорастворимой оболочкой белого или почти белого цвета, овальные, двояковыпуклые; на поперечном разрезе виден один слой белого цвета."}},{"type":"paragraph","data":{"text":"\n1 таб.эритромицин500 мг"}},{"type":"paragraph","data":{"text":"Вспомогательные вещества: крахмал картофельный, \nполивинилпирролидон (повидон), коллидон CL-M (кросповидон), полисорбат \n80 (твин 80), кальция стеарат, тальк."}},{"type":"paragraph","data":{"text":"Состав оболочки: ацетилфталилцеллюлоза, масло касторовое медицинское, титана диоксид."}}]},{"id":12,"name":"Фармакологические свойства","slug":"pharmacologic_effects","body":[{"type":"paragraph","data":{"text":"[I] - Инструкция по медицинскому применению одобрена фармакологическим комитетом МЗ РФ"}},{"type":"paragraph","data":{"text":"Бактериостатический антибиотик из группы макролидов, обратимо \nсвязывается с 50S субъединицей рибосом в ее донорской части, что \nнарушает образование пептидных связей между молекулами аминокислот и \nблокирует синтез белков микроорганизмов (не влияет на синтез нуклеиновых\n кислот). При применении в высоких дозах может проявлять бактерицидное \nдействие. Спектр действия включает грамположительные (Staphylococcus \nspp., продуцирующие и непродуцирующие пенициллиназу, в т.ч. \nStaphylococcus aureus; Streptococcus spp. (в т.ч. Streptococcus \npneumoniae, Streptococcus pyogenes), альфа-гемолитический стрептококк \n(группы Viridans ), Bacillus anthracis, Corynebacterium diphtheriae, \nCorynebacterium minutissimum) и грамотрицательные микроорганизмы \n(Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, \nBrucella spp., Legionella spp., в т.ч. Legionella pneumophila) и другие \nмикроорганизмы: Mycoplasma spp. (в т.ч. Mycoplasma pneumoniae), \nChlamydia spp. (в т.ч. Chlamydia trachomatis), Treponema spp., \nRickettsia spp., Entamoeba histolytica, Listeria monocytogenes."}},{"type":"paragraph","data":{"text":"Устоичивы грамотрицательные палочки : Escherichia coli, Pseudomonas \naeruginosa, а также Shigella spp., Salmonella spp. и другие. К группе \nчувствительных относятся микроорганизмы, рост которых задерживается при \nконцентрации антибиотика менее 0.5 мг/л, среднечувствительных — 1-6 \nмг/л, умеренно устойчивых и устойчивых — 6-8 мг/л."}}]},{"id":1,"name":"Показания к применению","slug":"indications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Бактериальные инфекции, вызванные чувствительной микрофлорой:"}},{"type":"paragraph","data":{"text":"— дифтерия (в т.ч. бактерионосительство);"}},{"type":"paragraph","data":{"text":"— коклюш (в т.ч. профилактика);"}},{"type":"paragraph","data":{"text":"— трахома;"}},{"type":"paragraph","data":{"text":"— бруцеллез;"}},{"type":"paragraph","data":{"text":"— болезнь легионеров;"}},{"type":"paragraph","data":{"text":"— эритразма;"}},{"type":"paragraph","data":{"text":"— листериоз;"}},{"type":"paragraph","data":{"text":"— скарлатина;"}},{"type":"paragraph","data":{"text":"— амебная дизентерия;"}},{"type":"paragraph","data":{"text":"— гонорея;"}},{"type":"paragraph","data":{"text":"— конъюнктивит новорожденных;"}},{"type":"paragraph","data":{"text":"— пневмония у детей;"}},{"type":"paragraph","data":{"text":"— мочеполовые инфекции у беременных, вызванные Chlamydia trachomatis;"}},{"type":"paragraph","data":{"text":"— первичный сифилис (у пациентов с аллергией к пенициллинам);"}},{"type":"paragraph","data":{"text":"— неосложненный хламидиоз у взрослых (с локализацией в нижних отделах\n мочеполовых путей и прямой кишки) при непереносимости или \nнеэффективности \u003ca href=\"https://health.mail.ru/drug/tetratsiklin_1/\"\u003eтетрациклинов\u003c/a\u003e;"}},{"type":"paragraph","data":{"text":"— инфекции ЛОР-органов (тонзиллит, отит, синусит);"}},{"type":"paragraph","data":{"text":"— инфекции желчевыводящих путей (холецистит);"}},{"type":"paragraph","data":{"text":"— инфекции верхних и нижних дыхательных путей (трахеит, бронхит, пневмония);"}},{"type":"paragraph","data":{"text":"— инфекции кожи и мягких тканей (гнойничковые заболевания кожи, в \nт.ч. юношеские угри, инфицированные раны, пролежни, ожоги II-III \nстепени, трофические язвы);"}},{"type":"paragraph","data":{"text":"— инфекции слизистой оболочки глаз;"}},{"type":"paragraph","data":{"text":"— профилактика обострений стрептококковой инфекции (тонзиллит, фарингит) у больных ревматизмом;"}},{"type":"paragraph","data":{"text":"— профилактика инфекционных осложнений при лечебных и диагностических\n процедурах (в т.ч. предоперационная подготовка кишечника, \nстоматологические вмешательства, эндоскопия, у больных с пороками \nсердца)."}}]},{"id":2,"name":"Противопоказания","slug":"contraindications","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"— гиперчувствительность;"}},{"type":"paragraph","data":{"text":"— потеря слуха;"}},{"type":"paragraph","data":{"text":"— одновременный прием терфенадина или астемизола;"}},{"type":"paragraph","data":{"text":"— период лактации."}},{"type":"paragraph","data":{"text":"С осторожностью: аритмии (в анамнезе); удлинение интервала QT; желтуха (в анамнезе); печеночная недостаточность; почечная недостаточность."}}]},{"id":15,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Внутрь."}},{"type":"paragraph","data":{"text":"Разовая доза для взрослых и подростков старше 14 лет составляет 250-500 мг, суточная — 1-2 г. Интервал между приемами — 6 ч. При тяжелых инфекциях суточная доза может быть увеличена до 4 г."}},{"type":"paragraph","data":{"text":"Детям от 4 мес до 18 лет, в зависимости от возраста, массы тела и тяжести инфекции - по 30-50 мг/кг/сут в 2-4 приема; детям первых 3 мес жизни — 20-40 мг/кг/сут. В случае более тяжелых инфекций доза может быть удвоена."}},{"type":"paragraph","data":{"text":"Для лечения дифтерийного носительства — по 250 мг 2 раза/сут. Курсовая доза для лечения первичного сифилиса — 30-40 г, продолжительность лечения — 10-15 дней."}},{"type":"paragraph","data":{"text":"При амебной дизентерии взрослым — по 250 мг 4 раза/сут, детям - по 30-50 мг/кг/сут; продолжительность курса — 10-14 дней."}},{"type":"paragraph","data":{"text":"При легионеллезе — по 500 мг-1 г 4 раза/сут в течение 14 дней."}},{"type":"paragraph","data":{"text":"При гонорее — по 500 мг каждые 6 ч в течение 3 дней, далее - по 250 мг каждые 6 ч в течение 7 дней."}},{"type":"paragraph","data":{"text":"Для предоперационной подготовки кишечника с целью профилактики инфекционных осложнений — внутрь, по 1 г за 19 ч, 18 ч и 9 ч до начала операции (всего 3 г)."}},{"type":"paragraph","data":{"text":"Для профилактики стрептококковой инфекции (при тонзиллите, фарингите) взрослым — 20—50 мг/кг/сут, детям — 20-30 мг/кг/сут, продолжительность курса — не менее 10 дней."}},{"type":"paragraph","data":{"text":"Для профилактики септического эндокардита у больных с пороками сердца — по 1 г длявзрослых и по 20 мг/кг — для детей, за 1 ч до лечебной или диагностической процедуры, далее по 500 мг — для взрослых и 10 мг/кг для детей, повторно через 6 ч."}},{"type":"paragraph","data":{"text":"При коклюше — 40-50 мг/кг/сут в течение 5-14 дней. При пневмонии у детей — 50 мг/кг/сут в 4 приема, в течение не менее 3 нед. При мочеполовых инфекциях во время беременности —\n 500 мг 4 раза/сут в течение не менее 7 дней или (при плохой \nпереносимости такой дозы) — по 250 мг 4 раза/сут в течение не менее 14 \nдней."}},{"type":"paragraph","data":{"text":"У взрослых, при неосложненном хламидиозе и непереносимости тетрациклинов — по 500 мг 4 раза/сут в течение не менее 7 дней."}}]},{"id":3,"name":"Побочное действие","slug":"side_effects","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Реакции гиперчувствительности: кожные аллергические реакции (крапивница, другие формы сыпи), эозинофилия; редко - анафилактический шок."}},{"type":"paragraph","data":{"text":"Тошнота, рвота, гастралгия, тенезмы, абдоминальные боли, диарея, \nдисбактериоз; редко - кандидоз полости рта, псевдомембранозный \nэнтероколит (как во время лечения, так и после него), нарушение функции \nпечени, холестатическая желтуха, повышение активности печеночных \nтрансаминаз, панкреатит, снижение слуха и/или шум в ушах (при применении\n высоких доз — более 4 г/сут, снижение слуха после отмены препарата \nобычно обратимо)."}},{"type":"paragraph","data":{"text":"Редко — тахикардия, удлинение интервала QT на ЭКГ, желудочковые \nаритмии, включая желудочковую тахикардию (типа \"пируэт\") у больных с \nудлиненным интервалом QT."}}]},{"id":16,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: нарушение функции печени, вплоть до острой печеночной недостаточности, потеря слуха."}},{"type":"paragraph","data":{"text":"Лечение: \u003ca href=\"https://health.mail.ru/drug/activated_charcoal/\"\u003eактивированный уголь\u003c/a\u003e,\n тщательный контроль за состоянием дыхательной системы. Промывание \nжелудка эффективно при приеме дозы, пятикратно превышающей среднюю \nтерапевтическую. Гемодиализ, перитонеальный диализ, форсированный диурез\n неэффективны."}}]},{"id":17,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Препараты, блокирующие канальцевую секрецию, удлиняют T1/2 эритромицина."}},{"type":"paragraph","data":{"text":"Несовместим с \u003ca href=\"https://health.mail.ru/drug/linkomitsin_2/\"\u003eлинкомицином\u003c/a\u003e, клиндамицином и хлорамфениколом (антагонизм)."}},{"type":"paragraph","data":{"text":"Снижает бактерицидное действие бета-лактамных антибиотиков (пенициллины, цефалоспорины, карбопенемы)."}},{"type":"paragraph","data":{"text":"При одновременном приеме с препаратами, метаболизм которых осуществляется в печени (\u003ca href=\"https://health.mail.ru/drug/theophylline/\"\u003eтеофиллин\u003c/a\u003e,\n карбамазепин, вальпроевая кислота, гексобарбитал, фенитоин, \nальфентанил, дизопирамид, ловастатин, бромокриптин), может повышаться \nконцентрация этих препаратов в плазме (является ингибитором \nмикросомальных ферментов печени)."}},{"type":"paragraph","data":{"text":"Усиливает нефротоксичность циклоспорина (особенно у больных с \nсопутствующей почечной недостаточностью). Снижает клиренс триазолама и \nмидазолама, в связи с чем может усиливать фармакологические эффекты \nбензодиазепинов."}},{"type":"paragraph","data":{"text":"При одновременном приеме с терфенадином или астемизолом — возможность\n развития аритмии, с дигидроэрготамином или негидрированными алкалоидами\n спорыньи — сужение сосудов до спазма, дизестезии."}},{"type":"paragraph","data":{"text":"Замедляет элиминацию (усиливает эффект) метилпреднизолона, фелодипина и антикоагулянтов кумаринового ряда."}},{"type":"paragraph","data":{"text":"При совместном приеме с ловастатином усиливается рабдомиолиз."}},{"type":"paragraph","data":{"text":"Повышает биодоступность дигоксина."}},{"type":"paragraph","data":{"text":"Снижает эффективность гормональной контрацепции."}}]},{"id":4,"name":"Особые указания","slug":"","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"При длительной терапии необходимо осуществлять контроль лабораторных показателей функции печени."}},{"type":"paragraph","data":{"text":"Симптомы холестатической желтухи могут развиться через несколько дней\n после начала терапии, однако риск развития повышается после 7-14 дней \nнепрерывной терапии. Вероятность развития ототоксического эффекта выше у\n больных с почечной и печеночной недостаточностью, а также у пожилых \nпациентов."}},{"type":"paragraph","data":{"text":"Некоторые устойчивые штаммы Haemophilus influenzae чувствительны к одновременному приему эритромицина и сульфаниламидов."}},{"type":"paragraph","data":{"text":"Может помешать определению катехоламинов в моче и активности \nпеченочных трансаминаз в крови (колориметрическое определение с помощью \nдефинилгидразина)."}},{"type":"paragraph","data":{"text":"При нарушениях функции почек"}},{"type":"paragraph","data":{"text":"Противопоказано при почечной недостаточности."}},{"type":"paragraph","data":{"text":"При нарушениях функции печени"}},{"type":"paragraph","data":{"text":"Противопоказано при печеночной недостаточности."}},{"type":"paragraph","data":{"text":"Применение в пожилом возрасте"}},{"type":"paragraph","data":{"text":"Вероятность развития ототоксического эффекта выше у пожилых пациентов."}},{"type":"paragraph","data":{"text":"Применение в детском возрасте"}},{"type":"paragraph","data":{"text":"Детям от 4 мес до 18 лет, в зависимости от возраста, массы тела и \nтяжести инфекции - по 30-50 мг/кг/сут в 2-4 приема; детям первых 3 мес \nжизни — 20—40 мг/кг/сут. 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Регистр лекарственных средств России"}}]},{"id":20,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":" По рецепту "}}]},{"id":21,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"\u003ca href=\"https://www.eapteka.ru/goods/manufacturer/sintez/\"\u003eСинтез ОАО, Россия\u003c/a\u003e"}}]}],"source":{"title":"ЭркаФарм","url":"https://erkapharm.com"}},"description_toggle":false,"short_description":"[I] - Инструкция по медицинскому применению одобрена фармакологическим комитетом МЗ РФ Бактериостатический антибиотик из группы макролидов, обратимо связывается с 50S субъединицей рибосом в ее донорской части, что нарушает образование пептидных связей между молекулами аминокислот и блокирует синтез белков микроорганизмов (не влияет на синтез нуклеиновых кислот). При применении в высоких дозах может проявлять бактерицидное действие. 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