Стимфорте оказывает иммуностимулирующее действие, активируя... Инструкция
Показания к применению
У взрослых в составе комплексной терапии вторичных иммунодефицитных состояний, вызванных острыми и хроническими бактериальными и вирусными инфекциями (в стадии обострения и ремиссии):
генитальный герпес;
рецидивирующий фурункулез;
хронический вирусный гепатит В ( в стадии обострения);
Стимфорте оказывает иммуностимулирующее действие, активируя различные звенья иммунитета, в том числе продукцию цитокинов. Препарат в 1.5-2.5 раза усиливает фагоцитоз в макрофагах и функциональную активность NK-клеток, повышая их цитотоксические свойства. Индуцирует образование гамма-интерферона, фактора некроза опухолей альфа, интерлейкина-6 и интерлейкина-1. Под действием препарата увеличивается количество лимфоцитов, нейтрофилов и моноцитов, а также происходит активация последних. При изучении фармакологической активности Стимфорте было установлено, что препарат неспецифически усиливает противовирусный иммунитет.
Фармакокинетика
Период полураспределения в организме - 25-30 мин, полувыведения - 24 часа. Продукты метаболизма выводятся через почки и легкие. Не кумулирует.
Показания к применению
У взрослых в составе комплексной терапии вторичных иммунодефицитных состояний, вызванных острыми и хроническими бактериальными и вирусными инфекциями (в стадии обострения и ремиссии):
генитальный герпес;
рецидивирующий фурункулез;
хронический вирусный гепатит В ( в стадии обострения);
острый гепатит В (среднетяжелые формы).
Противопоказания
повышенная индивидуальная чувствительность;
аутоиммунные заболевания;
беременность, период лактации (эффективность и безопасность не установлены);
детский возраст до 18 лет.
Применение при беременности и в период грудного вскармливания
Противопоказано при беременности и в период лактации.
Способ применения и дозы
Стимфорте предназначен для внутримышечного введения. Препарат растворяют непосредственно перед применением - 3 мг в 3 мл и 6 мг в 6 мл 0,9% раствора натрия хлорида. Курс лечения состоит из 4 инъекций, по одной инъекции каждые 72 часа в дозах 0.75; 1.5; 1.5; 1.5 мг. В случае недостаточной эффективности дозу можно увеличить в 2 раза - 1.5; 3.0; 3.0; 3.0 мг через каждые 72 часа. В комплексной терапии острого и хронического гепатита используют следующую схему из 4-х инъекций: 1,5 мг, через 72 часа - 1,5 мг, перерыв 7 дней, далее еще 2 инъекции по 3 мг с перерывом в 72 часа. При необходимости повторный курс лечения можно проводить через 14 дней.
Побочное действие
Возможно кратковременное повышение температуры тела до субфебрильных значений, головная боль, преходящие гиперемия и болезненность в месте инъекции.
Передозировка
О случаях передозировки не сообщалось.
Взаимодействие с другими лекарственными средствами
Стимфорте совместим с противовирусными препаратами и цитостатиками.
Особые указания
Противопоказано детям до 18 лет. В период лечения препаратом необходимо исключить употребление алкоголя.
Форма выпуска
Раствор.
Условия хранения
Хранить в защищенном от света месте при температуре не выше 8°С.
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