Колистин Порошок, флакон, 100 шт, 1 млн ед, для раствора для ингаляций

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Незначительная часть препарата, попавшая в системный кровоток, выводится преимущественно путем клубочковой фильтрации. В течение 8 ч почками в неизмененном виде выводится около 60% поступившей дозы."}},{"type":"paragraph","data":{"text":"После ингаляции препарата в дозе 2 млн. ЕД средний кумулятивный показатель выведения почками составляет приблизительно 1%."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФармакокинетика в особых клинических случаях\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Фармакокинетика колистиметата натрия у пациентов с почечной недостаточностью не изучена. 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Не имеется временных ограничений продолжительности терапии при хронической инфекции, вызванной Pseudomonas aeruginosa."}},{"type":"paragraph","data":{"text":"У пациентов с \u003cb\u003eнарушением функции почек\u003c/b\u003e дозу препарата снижать не требуется."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"\u003ci\u003eАллергические реакции:\u003c/i\u003e ангионевротический отек."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны ЦНС и периферической нервной системы:\u003c/i\u003e головокружение, парестезии."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны дыхательной системы:\u003c/i\u003e бронхоспазм (>10%), усиление кашля, усиление образования мокроты, мукозит (воспаление слизистой оболочки дыхательных путей), фарингит, одышка."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны пищеварительной системы:\u003c/i\u003e тошнота, изжога."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСо стороны мочевыделительной системы:\u003c/i\u003e острая почечная недостаточность."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении Колистина с ингаляционными средствами для наркоза (эфиром, галотаном), миорелаксантами или курареподобными препаратами (тубокурарином, сукцинилхолином) или аминогликозидами следует тщательно следить за возможностью развития нейротоксических реакций."}},{"type":"paragraph","data":{"text":"При одновременном применении Колистина с потенциально нефротоксическими препаратами (аминогликозиды, цефалоспорины, циклоспорин) возможно усиление нефротоксичности."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФармацевтическое взаимодействие\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"Приготовленный раствор Колистина не следует смешивать \u003ci\u003eс \u003c/i\u003eдругими лекарственными препаратами."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Ингаляционные лекарственные препараты, в т.ч. Колистин, у чувствительных пациентов могут вызывать острую бронхоконстрикцию. Поэтому применение первой дозы Колистина для ингаляций следует осуществлять под наблюдением опытного медицинского персонала, при этом ингаляции должно предшествовать применение бронхолитика, если он входит в режим терапии данного пациента. До и после ингаляции Колистина следует измерить ФОВ за 1 сек. Если у пациента, не получающего бронхолитики, имеются признаки медикаментозно обусловленной бронхиальной обструкции, при следующем применении Колистина следует повторить пробу, добавив бронхолитик."}},{"type":"paragraph","data":{"text":"Первое применение Колистина следует проводить под наблюдением медицинского персонала, имеющего опыт работы с пациентами, страдающими муковисцидозом."}},{"type":"paragraph","data":{"text":"У пациентов с нарушением функции почек следует тщательно следить за возможностью развития побочных эффектов со стороны нервной системы и регулярно контролировать функцию почек."}},{"type":"paragraph","data":{"text":"Между ингаляциями дорназы альфа и ингаляцией Колистина необходимо сделать перерыв."}},{"type":"paragraph","data":{"text":"При лечении Колистином в редких случаях возможно появление резистентных штаммов Pseudomonas aeruginosa. После отмены и/или модификации терапии возможно восстановление эффективности препарата."}},{"type":"paragraph","data":{"text":"В период лечения препаратом пациент должен воздерживаться от употребления алкоголя."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность к управлению транспортными средствами и механизмами\u003c/i\u003e"}},{"type":"paragraph","data":{"text":"В период лечения необходимо воздерживаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}},{"type":"paragraph","data":{"text":"\u003cb\u003eПравила использования препарата\u003c/b\u003e"}},{"type":"paragraph","data":{"text":"1. Флакон с порошком вскрывают путем удаления алюминиевого колпачка с контролем первого вскрытия и открыванием резиновой пробки."}},{"type":"paragraph","data":{"text":"2. Ампула с растворителем вскрывается с использованием пилки или устройства для открывания ампул."}},{"type":"paragraph","data":{"text":"3. Содержимое ампулы полностью переливают во флакон с порошком. Порошок растворяется при легком встряхивании. Сильного взбалтывания следует избегать в связи с избыточным образованием пены."}},{"type":"paragraph","data":{"text":"4. Раствор переливают в небулайзер и применяют путем ингаляций согласно инструкции производителя небулайзера."}},{"type":"paragraph","data":{"text":"5. Процедуру ингаляции Колистина пациент выполняет в положении сидя или стоя, в нормальном спокойном состоянии, производя как можно более глубокие вдохи через мундштук небулайзера. Облегчить вдох через рот позволяет использование зажима для носа."}},{"type":"paragraph","data":{"text":"6. После каждого использования ингалятор следует промыть и продезинфицировать, соблюдая инструкции производителя."}},{"type":"paragraph","data":{"text":"У пациентов, получающих и другие виды ингаляционной терапии, ингаляционное применение Колистина следует проводить непосредственно после применения бронходилататора, а также после физиотерапевтических процедур на грудной клетке."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Список Б. Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С. Хранить в оригинальной упаковке для защиты содержимого от воздействия света."}}]}],"source":null},"description_toggle":false,"short_description":"Антибиотик полипептидный циклический. Колистиметат натрия образуется Bacillus polymyxa, подвидами colistinus. Колистиметат представляет собой метансульфонат колистина. Колистиметат натрия оказывает бактерицидное действие на грамотрицательные микроорганизмы, находящиеся в стадии деления и покоя, путем изменения структуры и функции наружной и цитоплазматической мембраны. Препаратактивен в отношенииPseudomonas aeruginosa, Haemophilus influenzae, Acinetobacter spp., Citrobacter spp., Enterobacter spp., Klebsiella spp., Salmonella spp., Shigella spp. Не активен в отношении Burkholderia cepacia и Staphylococcus aureus. При определении чувствительности или резистентности возбудителей при применении колистиметата натрия путем ингаляции требуется осторожность.ВсасываниеВсасывание колистиметата натрия после ингаляции характеризуется выраженными индивидуальными различиями. Cmaxколистиметата натрия в сыворотке крови после ингаляции в дозе 2 млн.ЕД находится в диапазоне от неопредяемого уровня до 280 мкг/л. При сравнении этих показателей с концентрацией препарата в сыворотке после парентерального введения можно сделать вывод о том, что всасывание составляет менее 2%.РаспределениеЧерез 1 ч и 4 ч после ингаляции препарата в дозе 1 млн. ЕД концентрация колистиметата натрия в мокроте составляет 183.6 мг/л и 22.8 мг/л соответственно. В легких кумулируется около 15% введенной дозы. Колистиметат натрия проникает через плацентарный барьер, выделяется с грудным молоком.ВыведениеКолистиметат натрия выводится с отхаркиваемой мокротой. Незначительная часть препарата, попавшая в системный кровоток, выводится преимущественно путем клубочковой фильтрации. В течение 8 ч почками в неизмененном виде выводится около 60% поступившей дозы. После ингаляции препарата в дозе 2 млн. ЕД средний кумулятивный показатель выведения почками составляет приблизительно 1%.Фармакокинетика в особых клинических случаяхФармакокинетика колистиметата натрия у пациентов с почечной недостаточностью не изучена. Однако в связи с низкой системной биодоступностью препарата риск развития нежелательных реакций является низким.","substance":[{"id":1838,"title":"Колистиметат натрия","title_latin":null,"slug":"kolistimetat_natriya_1838"}],"branding":null,"valid_for_quick_buy":false,"is_available_to_delivery":false,"comments":null,"image_alt":"Колистин - фото упаковки","image_share":{"isTouch":{"default":"https://vseapteki.ru/cropping/thumbnails/101/80872/share_default/"},"isFromTablet":{"default":"https://vseapteki.ru/cropping/thumbnails/101/80872/share_default/"}},"diseases":[],"other_packages":[],"other_product_forms":[],"related_products":{"title":"Похожие товары","type":"similar","products":[{"id":92747,"title":"Колбиоцин гл.","subtitle":{"full":"Мазь, 5 г","short":"Мазь, 5 г","package":"5 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