Спазган Нео Таблетки, коробка, 20 шт, 400+5+0,1 мг, для приема внутрь, в пленочной оболочке

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мг) — 19,2 мг "}}]},{"id":1,"name":"Описание","slug":"common_description","displayInMenu":true,"body":[{"type":"paragraph","data":{"text":"Вокхард Лимитед, Индия, таблетки, покрытые пленочной оболочкой , №20 - 10 шт. - блистер (2) - пачка картонная; Ибупрофен 400 мг, Питофенон 5мг, Фенпивериния бромид 0,1 мг"}}]},{"name":"Фармакотерапевтическая группа","slug":"","id":5,"body":[{"type":"paragraph","data":{"text":"Фармакологическое действие — спазмолитическое, анальгезирующее."}}]},{"name":"Фармакологические свойства","slug":"pharmacologic_effects","id":6,"body":[{"type":"paragraph","data":{"text":"Комбинированный препарат, оказывает анальгезирующее, противовоспалительное и спазмолитическое действие. Подавляет синтез ПГ. В состав препарата входит НПВП ибупрофен, миотропное спазмолитическое средство питофенона гидрохлорид и м-холиноблокирующее средство центрального и периферического действия фенпивериния бромид."}},{"type":"paragraph","data":{"text":"\u003ci\u003eИбупрофен\u003c/i\u003e является производным фенилпропионовой кислоты. Обладает болеутоляющим, противовоспалительным и жаропонижающим действием. Основной механизм действия — угнетение биосинтеза ПГ — модуляторов болевой чувствительности, терморегуляции и воспаления в ЦНС и периферических тканях. У женщин с первичной дисменореей снижает повышенный уровень ПГ в миометрии, за счет чего уменьшает внутриматочное давление и частоту маточных сокращений."}},{"type":"paragraph","data":{"text":"\u003ci\u003eПитофенона гидрохлорид\u003c/i\u003e, подобно папаверину, оказывает прямое миотропное действие на гладкую мускулатуру внутренних органов и вызывает ее расслабление."}},{"type":"paragraph","data":{"text":"\u003ci\u003eФенпивериния бромид\u003c/i\u003e за счет м-холиноблокирующего действия оказывает дополнительное расслабляющее воздействие на гладкую мускулатуру."}},{"type":"paragraph","data":{"text":"Сочетание трех компонентов препарата приводит к взаимному усилению их фармакологического действия."}}]},{"name":"Показания к применению","slug":"indications","id":7,"body":[{"type":"paragraph","data":{"text":"слабо и умеренно выраженный болевой синдром при спазмах гладкой мускулатуры внутренних органов: почечная и желчная колика, дискинезия желчевыводящих путей, кишечная колика;"}},{"type":"paragraph","data":{"text":"гинекологические заболевания: дисменорея;"}},{"type":"paragraph","data":{"text":"головная боль, в т.ч. мигренозного характера;"}},{"type":"paragraph","data":{"text":"кратковременное симптоматическое лечение при болях в суставах, невралгии, ишиалгии, миалгии."}}]},{"name":"Противопоказания","slug":"contraindications","id":8,"body":[{"type":"paragraph","data":{"text":"гиперчувствительность к любому из ингредиентов, входящих в состав препарата;"}},{"type":"paragraph","data":{"text":"эрозивно-язвенные изменения слизистой оболочки желудка или двенадцатиперстной кишки, активное желудочно-кишечное кровотечение;"}},{"type":"paragraph","data":{"text":"воспалительные заболевания кишечника в фазе обострения, в т.ч. язвенный колит;"}},{"type":"paragraph","data":{"text":"анамнестические данные о приступе бронхообструкции, ринита, крапивницы, после приема ацетилсалициловой кислоты или иного НПВП (полный или неполный синдром непереносимости ацетилсалициловой кислоты — риносинусит, крапивница, полипы слизистой оболочки носа, бронхиальная астма);"}},{"type":"paragraph","data":{"text":"печеночная недостаточность или активное заболевание печени;"}},{"type":"paragraph","data":{"text":"почечная недостаточность (Cl креатинина менее 30 мл/мин), прогрессирующее заболевание почек;"}},{"type":"paragraph","data":{"text":"подтвержденная гиперкалиемия;"}},{"type":"paragraph","data":{"text":"гемофилия и другие нарушения свертываемости крови (в т.ч. гипокоагуляция), геморрагические диатезы;"}},{"type":"paragraph","data":{"text":"период после проведения аорто-коронарного шунтирования;"}},{"type":"paragraph","data":{"text":"острая перемежающаяся порфирия; гранулоцитопения;"}},{"type":"paragraph","data":{"text":"нарушения кроветворения;"}},{"type":"paragraph","data":{"text":"дефицит глюкозо-6-фосфатдегидрогеназы;"}},{"type":"paragraph","data":{"text":"тахиаритмия;"}},{"type":"paragraph","data":{"text":"закрытоугольная глаукома;"}},{"type":"paragraph","data":{"text":"заболевания зрительного нерва;"}},{"type":"paragraph","data":{"text":"гиперплазия предстательной железы;"}},{"type":"paragraph","data":{"text":"кишечная непроходимость;"}},{"type":"paragraph","data":{"text":"беременность и период грудного вскармливания;"}},{"type":"paragraph","data":{"text":"возраст до 16 лет."}},{"type":"paragraph","data":{"text":"."}}]},{"name":"С осторожностью","slug":"cautions","id":9,"body":[{"type":"paragraph","data":{"text":"пожилой возраст; застойная сердечная недостаточность; цереброваскулярные заболевания; артериальная гипертензия; ишемическая болезнь сердца; дислипидемия/гиперлипидемия; сахарный диабет; заболевания периферических артерий; нефротический синдром; Cl креатинина менее 30–60 мл/мин; гипербилирубинемия; язвенная болезнь желудка и двенадцатиперстной кишки (в анамнезе); наличие инфекции \u003ci\u003eHelicobacter pylori;\u003c/i\u003e гастрит; энтерит; колит; длительное использование НПВП; заболевания крови неясной этиологии (лейкопения, анемия); курение; частое употребление алкоголя (алкоголизм); тяжелые соматические заболевания; сопутствующая терапия следующими препаратами: антикоагулянты (например, варфарин); антиагреганты (например, ацетилсалициловая кислота, клопидогрел); пероральные глюкокортикостероиды (например, преднизолон); селективные ингибиторы обратного захвата серотонина (например, циталопрам, флуоксетин, пароксетин, сертралин)"}}]},{"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","id":10,"body":[{"type":"paragraph","data":{"text":"Применение препарата во время беременности противопоказано."}},{"type":"paragraph","data":{"text":"При назначении препарата в период грудного вскармливания следует решить вопрос о его прекращении."}}]},{"name":"Способ применения и дозы","slug":"dosage","id":11,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eВнутрь,\u003c/i\u003e за 1 ч до или через 3 ч после еды. Во избежание раздражающего действия на желудок можно принимать препарат сразу после еды или запивать молоком."}},{"type":"paragraph","data":{"text":"При отсутствии особых предписаний врача рекомендуется принимать СПАЗГАН НЕО при спастических болях по 1 таблетке до 3 раз в день. Максимальная суточная доза — 3 табл. Не следует превышать указанной дозы!"}},{"type":"paragraph","data":{"text":"Курс лечения препаратом СПАЗГАН НЕО без консультации врача не должен превышать 5 дней. Более длительное применение возможно под наблюдением врача с контролем показателей периферической картины крови и функционального состояния печени."}}]},{"name":"Побочное действие","slug":"side_effects","id":12,"body":[{"type":"paragraph","data":{"text":"Частота развития нежелательный реакций классифицирована согласно рекомендациям ВОЗ: очень часто (≥1/10); часто (≥1/100, <1/10); нечасто (≥1/1000, <1/100); редко (≥1/10000, <1/1000); очень редко (<1/10000); неизвестно (нельзя оценить на основе доступных данных)."}},{"type":"paragraph","data":{"text":"В рекомендуемых дозах препарат СПАЗГАН НЕО не вызывает побочных эффектов."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЖелудочно-кишечные нарушения:\u003c/i\u003e часто — НПВП-гастропатия (абдоминальная боль, тошнота, рвота, изжога, снижение аппетита, диарея, метеоризм, запор); нечасто — изъязвления слизистой оболочки желудочно-кишечного тракта, которые в ряде случаев осложняются перфорацией и кровотечением; раздражение и сухость слизистой оболочки ротовой полости, боль во рту, изъязвление слизистой оболочки десен, афтозный стоматит; очень редко — панкреатит, гепатит, нарушение функции печени, гепатотоксичность."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны дыхательной системы, органов грудной клетки и средостения:\u003c/i\u003e редко — одышка, бронхоспазм."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны\u003c/i\u003e \u003ci\u003eоргана слуха и лабиринта:\u003c/i\u003e редко — снижение слуха, звон или шум в ушах."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны органа зрения\u003c/i\u003e: нечасто — нечеткость зрительного восприятия, скотома, сухость и раздражение глаза, отек конъюнктивы и век (аллергического генеза), амблиопия; очень редко — парез аккомодации, токсическое поражение зрительного нерва."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны нервной системы:\u003c/i\u003e нечасто — головная боль, головокружение, бессонница, тревожность, нервозность и раздражительность, психомоторное возбуждение, сонливость, депрессия; очень редко — спутанность сознания, галлюцинации, асептический менингит (чаще у пациентов с аутоиммунными заболеваниями)."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сердца:\u003c/i\u003e нечасто — тахикардия; редко — сердечная недостаточность."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны сосудов:\u003c/i\u003e нечасто — повышение АД. "}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны почек и мочевыводящих путей:\u003c/i\u003e нечасто — нефротический синдром (отеки), олигурия, анурия, полиурия, протеинурия, цистит, окрашивание мочи в красный цвет; редко — острая почечная недостаточность, аллергический нефрит."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны кожи и подкожной клетчатки\u003c/i\u003e: нечасто — кожная сыпь (обычно эритематозная или крапивница), кожный зуд, очень редко — отек Квинке, анафилактоидные реакции, анафилактический шок, бронхоспазм или диспноэ, лихорадка, многоформная экссудативная эритема (в т.ч. синдром Стивенса-Джонсона), токсический эпидермальный некролиз (синдром Лайелла), аллергический ринит; очень редко — усиление или снижение потоотделения."}},{"type":"paragraph","data":{"text":"\u003ci\u003eНарушения со стороны крови и лимфатической системы:\u003c/i\u003e нечасто — тромбоцитопения и тромбоцитопеническая пурпура; очень редко — анемия (в т.ч. гемолитическая, апластическая), агранулоцитоз, лейкопения, эозинофилия."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛабораторные и инструментальные данные:\u003c/i\u003e время кровотечения (может увеличиваться),  концентрация глюкозы в сыворотке  (может снижаться), клиренс креатинина (может уменьшаться), гематокрит или гемоглобин (могут уменьшаться), сывороточная концентрация креатинина (может увеличиваться), активность печеночных трансаминаз (может повышаться)."}},{"type":"paragraph","data":{"text":"Если прием препарата вызвал изменение обычного состояния пациента, прекратите его принимать и немедленно обратитесь к врачу."}}]},{"name":"Передозировка","slug":"overdose","id":13,"body":[{"type":"paragraph","data":{"text":"Не следует превышать указанную дозу. Если вы превысили дозу, немедленно обратитесь к врачу или в ближайшее медицинское учреждение. Возьмите с собой упаковку препарата."}},{"type":"paragraph","data":{"text":"\u003ci\u003eСимптомы:\u003c/i\u003e боль в животе, тошнота, рвота, заторможенность, сонливость, депрессия, головная боль, шум в ушах, метаболический ацидоз, кома, острая почечная недостаточность, снижение АД, брадикардия, тахикардия, фибрилляция предсердий, остановка дыхания."}},{"type":"paragraph","data":{"text":"\u003ci\u003eЛечение:\u003c/i\u003e промывание желудка (только в течение часа после приема), активированный уголь, щелочное питье, форсированный диурез, симптоматическая терапия (коррекция кислотно-основного состояния, АД). Специфического антидота нет."}}]},{"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","id":14,"body":[{"type":"paragraph","data":{"text":"В терапевтических дозах препарат СПАЗГАН НЕО не вступает в значимые взаимодействия с широко применяемыми препаратами."}},{"type":"paragraph","data":{"text":"Индукторы ферментов микросомального окисления в печени (фенитоин, этанол, барбитураты, флумецинол, рифампицин, фенилбутазон, трициклические антидепрессанты) увеличивают продукцию гидроксилированных активных метаболитов, повышая риск развития тяжелых интоксикаций."}},{"type":"paragraph","data":{"text":"Ингибиторы микросомального окисления снижают риск развития гепатотоксического действия."}},{"type":"paragraph","data":{"text":"Снижает гипотензивную активность вазодилататоров и натрийуретический эффект фуросемида и гидрохлоротиазида."}},{"type":"paragraph","data":{"text":"Снижает эффективность урикозурических препаратов. Усиливает действие непрямых антикоагулянтов, антиагрегантов, фибринолитиков (что повышает риск развития кровотечений)."}},{"type":"paragraph","data":{"text":"Усиливает побочные эффекты минералокортикостероидов, ГКС (повышается опасность желудочно-кишечного кровотечения), эстрогенов, этанола. При одновременном применении препарата с гипогликемическими средствами для приема внутрь может усиливать их действие, тем самым способствуя риску возникновения гипогликемии."}},{"type":"paragraph","data":{"text":"Антациды и колестирамин снижают абсорбцию ибупрофена."}},{"type":"paragraph","data":{"text":"Увеличивает концентрацию в крови дигоксина, препаратов лития и метотрексата."}},{"type":"paragraph","data":{"text":"Усиливает действие м-холиноблокаторов, Н1-гистаминоблокаторов, бутирофенонов, фенотиазинов, амантадина и хинидина."}},{"type":"paragraph","data":{"text":"Одновременное назначение других НПВП повышает частоту побочных эффектов."}},{"type":"paragraph","data":{"text":"Кофеин усиливает анальгезирующий (обезболивающий) эффект."}},{"type":"paragraph","data":{"text":"При одновременном назначении снижает противовоспалительное и антиагрегантное действие ацетилсалициловой кислоты (возможно повышение частоты развития острой коронарной недостаточности у больных, получающих в качестве антиагрегантного средства малые дозы ацетилсалициловой кислоты, после начала приема препарата СПАЗГАН НЕО)."}},{"type":"paragraph","data":{"text":"Цефамандол, цефоперазон, цефотетан, вальпроевая кислота, пликамицин увеличивают частоту развития гипопротромбинемии при одновременном назначении."}},{"type":"paragraph","data":{"text":"Миелотоксические лекарственные средства усиливают проявления гематотоксичности препарата."}},{"type":"paragraph","data":{"text":"Циклоспорин и препараты золота усиливают влияние ибупрофена на синтез ПГ в почках, что проявляется повышением нефротоксичности. Ибупрофен повышает плазменную концентрацию циклоспорина и вероятность развития его гепатотоксических эффектов."}},{"type":"paragraph","data":{"text":"ЛС, блокирующие канальцевую секрецию, снижают выведение и повышают плазменную концентрацию ибупрофена."}}]},{"name":"Особые указания","slug":"","id":15,"body":[{"type":"paragraph","data":{"text":"При длительном применении необходим контроль картины периферической крови и функционального состояния печени и почек."}},{"type":"paragraph","data":{"text":"Для снижения риска развития нежелательных явлений со стороны желудочно-кишечного тракта следует использовать минимально эффективную дозу. При появлении симптомов гастропатии показан тщательный контроль, включающий проведение эзофагогастродуоденоскопии, анализ крови с определением гемоглобина и гематокрита, анализ кала на скрытую кровь."}},{"type":"paragraph","data":{"text":"При необходимости определения 17-кетостероидов препарат следует отменить за 48 ч до исследования."}},{"type":"paragraph","data":{"text":"В период лечения следует воздержаться от приема алкоголя."}},{"type":"paragraph","data":{"text":"\u003ci\u003eВлияние на способность управлять транспортными средствами и механизмами.\u003c/i\u003e В период лечения пациент должен воздержаться от занятий потенциально опасными видами деятельности, требующих повышенной концентрации внимания и быстроты психомоторных реакций."}}]},{"name":"Форма выпуска","slug":"","id":17,"body":[{"type":"paragraph","data":{"text":"\u003ci\u003eТаблетки, покрытые пленочной оболочкой, 400 мг + 5 мг + 0,1 мг.\u003c/i\u003e По 10 табл. в ПВХ/ПВДХ/алюминиевый блистер. По 2 блистера с инструкцией по применению в пачку картонную. По 10 блистеров с равным количеством инструкций по применению в пачку картонную."}},{"type":"paragraph","data":{"text":"По 6 табл. в ПВХ/ПВДХ/алюминиевый блистер. По 1 блистеру с инструкцией по применению в пластиковую упаковку. По 6 пластиковых упаковок в пачку картонную."}}]},{"name":"Срок годности","slug":"expiry_date","id":19,"body":[{"type":"paragraph","data":{"text":"3 года"}}]},{"name":"Условия отпуска","slug":"release_condition","id":20,"body":[{"type":"paragraph","data":{"text":"Без рецептв"}}]}],"source":{"title":"ЗдравСити","url":"https://zdravcity.ru"}},"description_toggle":false,"short_description":"Комбинированный препарат, оказывает анальгезирующее, противовоспалительное и спазмолитическое действие. Подавляет синтез ПГ. 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