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В I и II триместрах беременности применение кетопрофена возможно в случаях, когда потенциальная польза для матери превышает потенциальный риск для плода."}},{"type":"paragraph","data":{"text":"При необходимости применения кетопрофена в период лактации грудное вскармливание рекомендуется прекратить."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"Устанавливают индивидуально в зависимости от клинической ситуации."}},{"type":"paragraph","data":{"text":"Применяют внутрь, в/м, в/в (в виде инфузии), ректально или наружно в соответствующих лекарственных формах."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Со стороны пищеварительной системы: боли в эпигастральной области, тошнота, рвота, запор или диарея, анорексия, гастралгии, нарушения функции печени; редко - эрозивно-язвенные поражения ЖКТ, кровотечения и перфорации ЖКТ."}},{"type":"paragraph","data":{"text":"Со стороны ЦНС: головная боль, головокружение, шум в ушах, сонливость."}},{"type":"paragraph","data":{"text":"Со стороны мочевыделительной системы: нарушения функции почек."}},{"type":"paragraph","data":{"text":"Аллергические реакции: кожная сыпь; редко - бронхоспазм."}},{"type":"paragraph","data":{"text":"Местные реакции: при применении в форме свечей возможны раздражение слизистой оболочки прямой кишки, болезненная дефекация; при применении в форме геля - зуд, кожная сыпь в месте нанесения."}}]},{"id":14,"name":"Передозировка","slug":"overdose","body":[{"type":"paragraph","data":{"text":"Симптомы: тошнота, рвота, боли в животе, рвота с кровью, мелена, нарушение сознания, угнетение дыхания, судороги, нарушение функции почек, почечная недостаточность."}},{"type":"paragraph","data":{"text":"В случае передозировки следует проводить симптоматическую терапию, мониторинг дыхательной и сердечно-сосудистой деятельности, показано применение блокаторов гистаминовых Н2-рецепторов, ингибиторов простагландина. Специфического антидота не существует. Гемодиализ малоэффективен."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"При одновременном применении кетопрофена с другими НПВС повышается риск развития эрозивно-язвенных поражений ЖКТ и кровотечений; с антигипертензивными средствами (в т.ч. с бета-адреноблокаторами, ингибиторами АПФ, диуретиками) - возможно уменьшение их действия; с тромболитиками - повышение риска развития кровотечений."}},{"type":"paragraph","data":{"text":"При одновременном применении с ацетилсалициловой кислотой возможно уменьшение связывания кетопрофена с белками плазмы крови и увеличение его плазменного клиренса; с гепарином, тиклопидином - повышение риска развития кровотечений; с препаратами лития - возможно повышение концентрации лития в плазме крови до токсической за счет снижения его почечной экскреции."}},{"type":"paragraph","data":{"text":"При одновременном применении с диуретиками повышается риск развития почечной недостаточности вследствие уменьшения почечного кровотока, обусловленного ингибированием синтеза простагландинов, и на фоне гиповолемии."}},{"type":"paragraph","data":{"text":"При одновременном применении с пробенецидом возможно уменьшение клиренса кетопрофена и его связывания с белками плазмы крови; с метотрексатом – возможно усиление побочного действия метотрексата."}},{"type":"paragraph","data":{"text":"При одновременном применении варфарина возможно развитие тяжелых, иногда фатальных кровотечений."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Во время лечения необходим контроль картины периферической крови и функционального состояния печени и почек."}},{"type":"paragraph","data":{"text":"При необходимости определения 17-кетостероидов препарат следует отменить за 48 ч до исследования."}},{"type":"paragraph","data":{"text":"Прием кетопрофена может маскировать признаки инфекционного заболевания."}},{"type":"paragraph","data":{"text":"При нарушении функции почек и печени необходимо снижение дозы и тщательное наблюдение."}},{"type":"paragraph","data":{"text":"Для снижения риска развития нежелательных явлений со стороны ЖКТ следует использовать минимальную эффективную дозу минимально возможным коротким курсом."}},{"type":"paragraph","data":{"text":"Влияние на способность к вождению автотранспорта и управлению механизмами"}},{"type":"paragraph","data":{"text":"В период лечения необходимо соблюдать осторожность при управлении транспортными средствами и занятии другими потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."}},{"type":"paragraph","data":{"text":"Симптомы: тошнота, рвота, боли в животе, рвота с кровью, мелена, нарушение сознания, угнетение дыхания, судороги, нарушение функции почек, почечная недостаточность."}},{"type":"paragraph","data":{"text":"В случае передозировки следует проводить симптоматическую терапию, мониторинг дыхательной и сердечно-сосудистой деятельности, показано применение блокаторов гистаминовых Н2-рецепторов, ингибиторов простагландина. Специфического антидота не существует. Гемодиализ малоэффективен."}}]},{"id":18,"name":"Форма выпуска","slug":"","body":[{"type":"paragraph","data":{"text":"Раствор для в/в и в/м введения бесцветный или слегка окрашенный, прозрачный."}}]},{"id":19,"name":"Условия хранения","slug":"storage","body":[{"type":"paragraph","data":{"text":"Препарат следует хранить в недоступном для детей месте при температуре не выше 25°С."}}]},{"id":20,"name":"Срок годности","slug":"expiry_date","body":[{"type":"paragraph","data":{"text":"2 года."}}]},{"id":21,"name":"Условия отпуска","slug":"release_condition","body":[{"type":"paragraph","data":{"text":"Препарат отпускается по рецепту."}}]},{"id":22,"name":"Производитель","slug":"","body":[{"type":"paragraph","data":{"text":"Велфарм."}}]}],"source":null},"description_toggle":false,"short_description":"НПВП, оказывает противовоспалительное, анальгезирующее и жаропонижающее действие, связанное с подавлением активности циклооксигеназы-1 (ЦОГ-1) и циклооксигеназы-2 (ЦОГ-2), регулирующих синтез 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