Фармакологическое действие — антиангинальное, антигипертензивное, антиаритмическое.
Способ применения и дозы
Внутрь, перед едой, не разжевывая, запивая небольшим количеством жидкости.Артериальная гипертензия: лечение начинают с 50 мг 1 раз в сутки. Для достижения стабильного гипотензивного эффекта требуется 1–2 нед приема. При недостаточной выраженности гипотензивного эффекта дозу повышают до 100 мг в один прием. Дальнейшее увеличение дозы не рекомендуется, т.к. оно не сопровождается усилением клинического эффекта.Стенокардия: начальная доза составляет 50 мг/сут. Если в течение недели не достигнут оптимальный терапевтический эффект, увеличивают дозу до 100 мг/сут.Пациентам пожилого возраста и больным с нарушениями выделительной функции почек необходима коррекция режима дозирования. При наличии почечной недостаточности рекомендуют коррекцию дозы в зависимости от клиренса креатинина. У больных с почечной недостаточностью, при значениях Cl креатинина выше 35 мл/мин/1,73м2 (нормальные значения составляют 100–150 мл/мин/1,73 м2) значительной кумуляции Атенолола Белупо не происходит.В таблице представлены рекомендуемые максимальные дозы для больных с почечной недостаточностью:Таблица Cl креатинина, мл/мин/1,73 м2 T1/2 Атенолола, ч Максимальная доза Атенолола 15–35 16–27 50 мг в сутки или 100 мг через день менее 15 более 27 50 мг через день или 100 мг 1 раз в 4 дня Больным, находящимся на гемодиализе, Атенолол Белупо назначают по 50 мг/сут сразу после проведения каждого диализа, что необходимо проводить в стационарных условиях, т.к. может иметь место снижение АД.Для пожилых пациентов: начальная однократная доза— 25 мг (может быть увеличена под контролем АД, ЧСС).Острый инфаркт миокарда со стабильными гемодинамическими показателями— 100 мг 1 раз в сутки или по 50 мг 2 раза в день в течение 6–9 дней или до выписки из стационара (под контролем АД, ЭКГ, уровня глюкозы в крови). Повышение суточной дозы свыше 100 мг не рекомендуется, т.к. терапевтический эффект не усиливается, а вероятность развития побочных эффектов возрастает.
Условия хранения
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Срок годности
3 года. Не применять по истечении срока годности, указанного на упаковке.2000-2017. Регистр лекарственных средств России
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