Бензилпенициллина новокаиновая соль Порошок, флакон, 50 шт, 600000 ед, для суспензии для внутримышечного введения

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Прокаиновая соль бензилпенициллина в сравнении с калиевой и натриевой солями характеризуется большей продолжительностью действия."}}]},{"id":8,"name":"Показания к применению","slug":"indications","body":[{"type":"paragraph","data":{"text":"Бактериальные инфекции, вызванные чувствительными возбудителями: крупозная и очаговая пневмония, эмпиема плевры, бронхит. сепсис, септический эндокардит (острый и подострый), перитонит. менингит. остеомиелит. инфекции мочеполовой системы (пиелонефрит, пиелит, цистит, уретрит, гонорея, бленнорея, сифилис, цервицит), желчевыводящих путей (холангит, холецистит). раневая инфекция, инфекции кожи и мягких тканей: рожа, импетиго, вторично инфицированные дерматозы. дифтерия. скарлатина. сибирская язва. актиномикоз. ЛОР-заболевания, глазные болезни."}}]},{"id":9,"name":"Противопоказания","slug":"contraindications","body":[{"type":"paragraph","data":{"text":"Повышенная чувствительность к группе пенициллинов, аллергия к прокаину. С осторожностью применяют у пациентов: с бронхиальной астмой, сенной лихорадкой и другими аллергическими заболеваниями. с снижением свертывающей активности крови. у пациентов с почечной недостаточностью."}}]},{"id":11,"name":"Применение при беременности и в период грудного вскармливания","slug":"pregnancy_warnings","body":[{"type":"paragraph","data":{"text":"С осторожностью применяют во время беременности и в период лактации."}}]},{"id":12,"name":"Способ применения и дозы","slug":"dosage","body":[{"type":"paragraph","data":{"text":"В/м, глубоко (в/в или эндолюмбально вводить запрещается). Средняя терапевтическая доза для взрослых: разовая - 300000 ЕД, суточная - 600000 ЕД. Максимальная суточная доза для взрослых - 1,2 млн ЕД. Детям в возрасте до года назначают по 50000-100000 ЕД/кг/сут, старше 1 года - по 50000 ЕД/кг/сут. Кратность введения 1-2 раза в сутки. Растворы готовят ex tempore, добавляя к содержимому флакона 2-4 мл воды для инъекций или изотонического раствора натрия хлорида. Содержимое флакона интенсивно встряхивают, образующуюся суспензию быстро набирают в шприц, для введения рекомендуется применять иглы 0,8 мм. Длительность лечения бензилпенициллином в зависимости oт формы и тяжести течения заболевания - oт 7-10 дней до 2 мес и более (септический эндокардит, сепсис). При отсутствии клинического эффекта через 3-5 дней после начала лечения переходят на прием других антибиотиков или их комбинаций с аминогликозидами (стрептомицин, канамицин, гентамицин) и пенициллиназоустойчивыми пенициллинами (оксациллин)."}}]},{"id":13,"name":"Побочное действие","slug":"side_effects","body":[{"type":"paragraph","data":{"text":"Аллергические реакции: гипертермия, крапивница, кожная сыпь, сыпь на слизистых оболочках, артралгия, эозинофилия, ангионевротический отек, интерстициальный нефрит, бронхоспазм. редко - анафилактический шок. Местно: болезненность и уплотнение в месте инъекции. При попадании в сосудистое русло: шум в ушах, нарушение зрения, страх, головокружение, кратковременная потеря сознания. При введении очень больших доз могут наблюдаться нейротоксические явления: тошнота, рвота, повышение рефлекторной возбудимости, симптомы менингизма, судороги, кома."}}]},{"id":15,"name":"Взаимодействие с другими лекарственными средствами","slug":"drugs_interaction","body":[{"type":"paragraph","data":{"text":"Бактерицидные антибиотики (в том числе цефалоспорины, ванкомицин, рифампицин, аминогликозиды) оказывают синергидное действие. бактериостатические (в том числе макролиды, хлорамфеникол, линкозамиды, тетрациклины) - антагонистическое. Повышает эффективность непрямых антикоагулянтов (подавляя кишечную микрофлору, снижает протромбиновый индекс). снижает эффективность пероральных контрацептивов, лекарственных средств, в процессе метаболизма которых образуется пара-аминобензойная кислота, этинилэстрадиола - риск развития кровотечений \"прорыва\". Диуретики, аллопуринол, блокаторы канальцевой секреции, фенилбутазон, нестероидные противовоспалительные препараты, снижая канальцевую секрецию, повышают концентрацию бензилпенициллина. Аллопуринол повышает риск развития аллергических реакций (кожной сыпи)."}}]},{"id":16,"name":"Особые указания","slug":"","body":[{"type":"paragraph","data":{"text":"Если через 2-3 дня (максимум 5 дней) после начала применения препарата эффекта не отмечается, следует перейти к применению других антибиотиков или комбинированной терапии. В связи с возможностью развития грибковых поражений целесообразно при длительном лечении бензилпенициллином назначать витамины группы В и витамин С, а при необходимости - нистатин и леворин. Необходимо учитывать, что применение недостаточных доз препарата или слишком раннее прекращение лечения часто приводит к появлению резистентных штаммов возбудителей. 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